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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 178 Documents
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Studi in silico tentang naringin sebagai reseptor anti-HER-2 dalam pengobatan kanker payudara Abdurrahman, Abdurrahman; Rijal, Muh. Agus Syamsur; Yusuf, Helmy; Norhayati; Rizaldi, Gusti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.535

Abstract

Overexpression of Human Epidermal Receptor-2 (HER-2) is the cause of the development of breast cancer, so HER-2 can be a target for anticancer therapy. Trastuzumab is the drug of choice in inhibiting the HER-2 receptor and tyrosine kinase, but the weakness of this drug is that drug resistance can occur. Naringin has potential as a breast cancer therapy. The research aims to determine the inhibiting overexpression of the HER-2 receptor by naringin using in silico method. Molecular docking has been carried out by optimizing naringin and trastuzumab, preparing the HER-2 protein target (PDB ID 3PP0), validating the molecular docking protocol, and docking naringin and trastuzumab on HER-2. The research produced a binding energy of -8,66 kcal/mol, while the binding energies of the original ligand and trastuzumab to HER-2 were -9,94 kcal/mol and -5,87 kcal/mol, respectively. The binding energy shows that naringin has potential as an anti-breast cancer agent as indicated by its stronger affinity for HER2.
UJI EFEKTIVITAS ANALGETIK KOMBINASI EKSTRAK ETANOL DAUN KUMIS KUCING (Orthosiphon stamineus Benth) DAN DAUN SELEDRI (Apium graveolens) TERHADAP MENCIT JANTAN (Mus musculus) Hardianti, Sitti; Mahdi, Nur; Hamiddani Syaiful, Raisha
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.541

Abstract

Unpleasant sensory and emotional experiences arising from injury or damage to organs are often referred to as pain. Synthetic drugs are often used to treat the pain but often cause harmful side effects. Cat whisker leaves (Orthosiphon stamineus Benth) and celery leaves (Apium graveolens) are often an alternative choice of treatment for pain because they have potential as analgesics. The purpose of this study was to determine the analgesic effect of a combination of ethanol extracts of cat's whiskers and celery leaves on male mice (Mus musculus) using acetic acid as an inducer with a combination dose of 1:1, 1:5 and 5:1. The research is experimental using the writhing test method followed by data analysis including normality, homogeneity, one-way anova and LSD post hoc tests. The results obtained from the study showed that the analgesic effectiveness of the three doses of the combination was greater than the positive control of paracetamol, with a ratio of 2.9 times for combination I, 2.7 times for combination II and the largest comparison was in combination III which was 3 times with the highest percent protection of 74.64%. So it can be concluded that the combination of ethanol extracts of cat whisker leaves and celery leaves has an effect as an analgesic and can inhibit pain better than paracetamol.
GAMBARAN KARAKTERISTIK APOTEKER DI PUSKESMAS WILAYAH BARAT, TENGAH, DAN TIMUR INDONESIA Putra, Aditya Maulana Perdana; Sandi, Dita Ayulia Dwi; Sari, Okta Muthia; Intannia, Difa; Rizki, Muhammad Ikhwan; Rahmatullah, Satrio Wibowo; Lingga, Herningtyas Nautika
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.545

Abstract

In current global trends, pharmacy continues tobe a more clinical and patient-oriented profession, with greater responsibility and accountability for pharmaceutical services in the clinical environment. The participation of pharmacists is very important in the implementation of pharmaceutical services in accordance with the standards in the Community Health Centres. The study aims to describe the characteristics of pharmacists in the Community Health Centers of DKI Jakarta, South Kalimantan and South Sulawesi. This type of research is descriptive and observer-designed, conducted from June to August 2024 online in community health centres in DKI Jakarta, South Kalimantan and South Sulawesi. The data were collected by distributing online questionnaires through Googleforms, with the support of HISFARKESMAS. The collected data was processed descriptively by calculating the percentage of each feature. The characteristics of 359 pharmacists in the three regions (DKI Jakarta, South Kalimantan and South Sulawesi) were females (82.45%) and men (17.55%), with respondents aged 23-30 (32.87%), 31-40 (46.52%), 41-50 (18.38%) and 51-60 (2.23%). The most recent education in the pharmacist profession (93.87%) and in strata 2 (6.13%), the number of pharmacists in one health center is 58.22% with a pharmacist, 30.08% with two pharmacists and 11.70% more than two pharmacists. The duration of working as a pharmacist is 0-2 years, 3 to 5 years (27.02%), 6 to 10 years (16.16%) and more than 10 years (29.81%).
INOVASI ANTIDIABETES JAMU INSTAN KOMBINASI EKSTRAK DAUN RAMANIA DAN DAUN BINJAI TERHADAP PENURUNAN KADAR GLUKOSA SECARA IN-VIVO Amanah , Nurul; Saputri, Rina; Ridho, Muhammad Jafar; Luthfi, Luthfi; Zita, Syifa Nur
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.555

Abstract

Diabetes melitus (DM) saat ini menjadi ancaman kesehatan global, data epidemiologi menunjukkan adanya kecenderungan peningkatan angka insiden dan prevalensinya DM tipe 2 di berbagai penjuru dunia. World Health Organization (WHO) memprediksi adanya kenaikan jumlah pasien DM Tipe 2 yang cukup besar pada tahun-tahun mendatang. Di mana tanaman yang sering digunakan sebagai anti diabetes etnomedisin oleh masyarakat adalah ramania dan binjai. Tujuan dari riset ini mengombinasikan kedua ekstrak daun ramania dan daun binjai merupakan salah satu usaha untuk menghindari efek samping yang tidak diinginkan juga untuk mengecilkan dosis karena pengobatan diabetes dilakukan jangka panjang agar efektif dan aman di konsumsi masyarakat. Metode yang digunakan pada riset ini yaitu eksperimental dengan In Vivo dengan hewan tikus galuh wistar. Dari hasil semua formulasi dapat menurunkan gula darah tetapi yang menjadi dosis optimal adalah formulasi 2 dengan dosis kombinasi ekstrak 100mg (50 mg ramania dan 50 mg binjai). Kesimpulan hasil riset ini berpotensi digunakan sebagai anti diabetes karna mengandung senyawa metabolit sekunder yang mampu berperan terhadap penurunan kadar glukosa darah melalui mekanisme kerja yang berbeda. Tetapi karena ini adalah ini obat alternatif untuk penggunaannya tidak boleh digunakan tunggal jadi dapat digunakan sebagai terapi penunjang pengobatan anti diabetes.
Uji Aktivitas Antiglikemik In Vitro Ekstrak Etanol Daun Karamunting (Melastoma malabathricum L.) Dengan Metode Sokletasi Afra, Fairuz Yaumil; Muthia, Rahmi; Fauzana, Erwin; Nurmansyah, Dian; Normilawati, Santi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.564

Abstract

health problem, especially due to population growth, aging, poor lifestyle and diet, and high morbidity rates indicated by the increasing number of deaths each year. This study was conducted with the aim of determined the antidiabetic activity of samples used the Nelson-Somogi method. Samples were soxhleted used 96% ethanol solvent. The results of phytochemical screening, the extract showed positive content of phenol, flavonoid, saponin, tannin and steroid compounds. The in vitro glucose level reduction test used a UV-Vis spectrophotometer. The wavelength used was 740 nm and the incubation time was 25 minutes. The percentage of sugar level reduction after added the extract at a concentration of 1, 2 3; 4; 5 ppm was 28.56%; 40.48 percent; 51.99%; 60.74%; 70.72 percent. The linear regression equation obtained y = 10.458x + 19.128 R2 value = 0.9964. It can be concluded that the 96% ethanol extract of the sample has the potential to reduce blood sugar levels with an EC50 value of 2.95 ppm.
Formulasi Microneedle Acne Patch Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Fitriana, Mia; Sarwo, Laura; Maharani, Ni Ayu
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.574

Abstract

Belimbing wuluh leaves (Averrhoa bilimbi L.) contain flavonoids, saponins, and tannins that can be used as antibacterials in acne treatments. Acne treatment requires good delivery so that it can penetrate into the epidermis. A preparation that can deliver active substances directly into the epidermis is a microneedle patch (MN) preparation. This study aimed to formulate a microneedle acne patch of ethanol extract of A. bilimbi leaves. A. bilimbi leaves were extracted using maceration method. MN preparation base was optimized using different base combinations namely Na-CMC:PVA, HPMC: PVA and PVP:PVA until the ideal MN base was obtained. The MN preparations obtained were tested for physico-chemical properties which included macroscopic tests, weight uniformity, drying shrinkage, pH, folding power and moisture absorption. MN optimization results showed that the combination of PVP and PVA formed a flexible MN base and needle. Formulation was then continued by varying the concentration of extracts in the MN. The results of the physical and chemical properties test of the MN preparation formula showed flexible characteristics, homogeneous and no bubbles in MN, yellow to blackish green in color, weights ranging from 0,063-0,163 g, drying shrinkage of 3.349-4.513%, pH in the range of 5.61-7.15, folding power >300x, and moisture absorption of 6.472%-8.33%. The conclusion of the study showed that the MN preparation formulas of A. bilimbi extract, namely F1, F2, F3 and F4 meet the requirements of good physico-chemical MN preparations.
PENGGUNAAN OBAT GOLONGAN PROTON PUMP INHIBITTOR PADA PASIEN RAWAT INAP DI RUMAH SAKIT PKU MUHAMMADIYAH GAMPING YOGYAKARTA Sari, Chynthia Pradiftha; Rachman, Chintia Khairunnisa; Hanifah, Suci; Mutmainah, Isti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.575

Abstract

Proton pump inhibitor (PPI) is a drug with a good safety profile and effectiveness for patients with various conditions, so it is routinely prescribed around the world, one of them at PKU Muhammadiyah Gamping Yogyakarta. The aim of this study is to find out the profile of PPI drug use and the appropriate doses of the PPI group of drugs in hospitalized patients. This study is a descriptive observational study with a cross-sectional design. Data collection through secondary data is 200 patient medical records retrospectively. The results of the study showed the highest diagnosis of PPI drug use for gastro (60.50%) and non-gastro (39.50%). There are drugs that are given to patients at risk of gastrointestinal bleeding: NSAIDs (88.4%), glucocorticosteroids (8.97%), and anticoagulants (2.56%). The types of PPI used are pantoprazole injections 40 mg, lansoprazole tablets 30 mg, and lansoprazole injections 30 mg. The accurate dosage appropriate of PPI use is 100%.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN MASKER GEL PEEL OFF EKSTRAK ETANOL DAUN PEGAGAN (Centella asiatica (L.) Urban) Putri, Meilisa; Capritasari, Rafiastiana; Wijayatri, Ratna; Ningrum, Yessika Ardian; Pradani, Missya Putri Kurnia
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.612

Abstract

Free radicals damage cellular structures and accelerate the degradation of important elements in the skin, thereby accelerating premature aging. Antioxidants in skin care products can shield cells from harm brought on by oxidative stress. Pegagan leaves (Centella asiatica (L.) Urban) are a natural source of antioxidants. Pegagan leaf ethanolic extract has antioxidant properties and can perhaps be applied in cosmetic products like peel-off mask gel. The objective of this research is to measure the antioxidant behavior of a mask that peels off gel composed of ethanolic extract of Pegagan leaves (Centella asiatica (L.) Urban). This research applies a one-shot case study laboratory experimental method. Pegagan ethanolic extract was utilized in concentrations of F1 (0.5% ) F2 (1%) and F3 (1.5%). The level of antioxidant activity was measured. for three formulae using the DPPH (2,2-diphenyl-1-picrylhydrazyl) technique. Organoleptic, pH measurement, viscosity, homogeneity, spreadability, and drying time are all considered in the physical evaluation of the preparation. Based on evaluation outcomes of the preparations, three formulas met the test requirements with organoleptic test parameters, a drying time of 15-30 minutes, and a pH value between 4.5 and 6.5. For the spreadability test, only F2 meets the test requirements with 5-7 cm, while F1 and F3 do not follow the criteria because the A preparation's spreadability is influenced by viscosity. The thicker the mask gel preparation, the smaller the resulting spreading area. The result examination for antioxidant activity on the ethanolic extract Pegagan leaf showed an IC50 value for F1 of 28.68 ppm, F2 of 38.51 ppm, and F3 of 48.68 ppm. Study shows making the peel-off mask prepared gel Pegagan ethanol extract meets the criteria for a strong antioxidant. The results of this research indicate the quantity of antioxidant function in addition to the outcomes of the physical assessment have an impact on the concentration of pegagan leaf extract in the gel mask that peels off.
Pengetahuan Dan Kepatuhan Minum Obat Hipertensi : Pasien Di RSUD Brigjend H.Hasan Basry Kandangan Fitriah, Rahmayanti; Faisal, Muhammad; Akbar, Depy Oktapian
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.530

Abstract

Hypertension is the third cause of death after stroke and tuberculosis, accounting for 6.7% of all deaths of all ages in Indonesia. Knowledge is the level of patient behavior during treatment and behavior recommended by doctors. Hypertension sufferers must be aware of the importance of high blood pressure, the causes of high blood pressure, the symptoms that are often associated with it, the importance of taking medication regularly and continuously in the long term and the dangers of not taking medication. Patient adherence to treatment is very important because hypertension cannot be cured but must be controlled to avoid fatal complications. The aim of the researchers was to determine the relationship between knowledge level and medication adherence (hypertension patients at Brigjend H. Hasan Basry Kandangan Hospital). The method used is analytic observational with a cross sectional research design using a purposive sampling technique of 300 respondents with a questionnaire measuring instrument. The results of this study indicate that the level of knowledge of hypertension patients at Brigjend H. Hasan Basry Kandangan Hospital from 300 respondents included in the Good category as many as 279 respondents (93%), Enough 21 respondents (7%), and Less 0 respondents (0%). Compliance with taking medication in the high category was 69 respondents (23%), moderate 136 respondents (45.3%), and low 95 respondents (31.7%). The conclusion obtained using the Chi Square test states that there is a significant relationship between the level of knowledge and adherence to taking medication for hypertension patients at Brigjend H. Hasan Basry Kandangan Hospital.
Pengaruh Variasi Konsentrasi Sukrosa pada Formulasi Gummy Candies Sari Buah Belimbing Wuluh Kombinasi Lemon sebagai Produk Nutraceutical Chandra, Muhammad Andi; Alfina, Sophia; Dewi, Citra Kharisma; Pinanggi, Alfasyah Oktarini Pinanggi; Nur Mulia, Shilfa Nadira; Nurlifa, Mya; Chandra, M. Andi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.539

Abstract

Lemon and starfruit are fruit plants used in traditional medicineThe purpose of this study was to determine how differences in sugar content affected the way gummy candy was made. This study's methodology included the creation of five different gummy sweets using starfruit juice and lemon. Physical quality assessments, such as organoleptic testing, pH, weight uniformity, elasticity tests, water content tests, and hedonic tests, were also conducted. The study's findings demonstrated that the gummy sweets' flavor became sweeter with increasing sugar content. As can be seen, formula 5 has the maximum sucrose content at 1.5 grams. The conclusion reached is that changes in the amount of sucrose used as a sweetener may affect the preparation's physical quality evaluation test results as well as the respondent's hedonic test evaluation. It was discovered that formula 2 and 4, which included 0.5 grams and 0,2 grams of sucrose, was the one that responders liked the best.

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