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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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The Effect of Providing Tomato Juice on the Hemoglobin Concentration of Pregnant Women Hatima, Husnul; Hafsah, Hafsah; Sulistyowati, Endang
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5171

Abstract

Pregnant women are a vulnerable group prone to malnutrition-induced anemia. In 2023, Puskesmas Tamamaung reported a staggering 73.9% prevalence of anemia among pregnant women. Anemia in pregnancy poses risks such as maternal mortality, miscarriage, intrauterine growth retardation, and postpartum hemorrhage. To address this, tomato juice, rich in vitamin C crucial for iron absorption, is proposed as a potential solution to enhance hemoglobin levels.The objective of this quasi-experimental study is to assess the efficacy of tomato juice supplementation in increasing hemoglobin (Hb) levels among pregnant women diagnosed with anemia. A quasi-experimental study utilizing a pre-test post-test non-equivalent control group design was conducted. The study population comprised 28 second and third-trimester pregnant women with anemia registered at Puskesmas Tamamaung from February to March 2024. All 28 participants were included as the total sample. Data were collected using observation sheets and hemoglobin measurement tools. Paired t-tests and independent t-tests were employed for data analysis.Significant differences were observed in hemoglobin levels before and after tomato juice consumption among pregnant women at Puskesmas Tamamaung. Tomato juice supplementation was found to be more effective in increasing hemoglobin levels compared to iron tablet supplementation alone.Tomato juice facilitates hemoglobin synthesis by expediting the process from erythroblasts to normoblasts and reticulocytes, thereby accelerating hemoglobin formation.The administration of tomato juice effectively increases hemoglobin levels among pregnant women with anemia. This underscores the potential of tomato juice as a supplementary intervention in combating maternal anemia during pregnancy.
Boosting Hemoglobin: The Power of Dates and Honey for Third Trimester Pregnant Women Nurseha, Nurseha; Utami Subagio, Sri; Arifiati, Nurce; Suwardiman, Deni
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5186

Abstract

Anemia poses a significant health challenge, particularly among pregnant women, with Indonesia facing a notable burden in maternal mortality rates (MMR). This study investigates the efficacy of date fruit and honey supplementation in addressing anemia among third-trimester pregnant women attending Kramatwatu Community Health Center. Drawing on a quantitative approach with a quasi-experimental design, the research aims to elucidate the impact of this intervention on hemoglobin (HB) levels. The prevalence of anemia among pregnant women is alarming, with all respondents in the study experiencing anemia before the intervention. However, following the provision of date fruit and honey, a substantial increase in HB levels was observed, indicating a promising avenue for improving maternal health outcomes. Utilizing SPSS for analysis, univariate and bivariate analyses were conducted to describe variables and test intervention effects. The study underscores the potential effectiveness of date fruit and honey supplementation in ameliorating anemia among pregnant women, although further research is warranted to ascertain long-term efficacy and optimal dosages. Comprehensive interventions addressing nutritional deficiencies and healthcare access are crucial for advancing maternal health goals and reducing MMR in Indonesia.
Boosting Infant Growth: Exploring the Influence of Baby Massage on Weight Gain in 1-6 Month-Olds Lailaturohmah, Lailaturohmah; Soya Nita, Elin; Merita Sari, Pety
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5246

Abstract

Massage therapy is one of the oldest healing methods worldwide, encompassing both healthcare and treatment. Baby massage offers numerous benefits, including the enhancement of infant weight gain. In Kediri, East Java, child growth and development issues persist, with a prevalence of underweight children at 17.5% and wasted children at 9.0%. This research aims to analyze the impact of baby massage classes on infant weight gain. This study adopts a quasi-experimental design with a Two Group Pretest-Posttest format. The research subjects were divided into two groups: control and treatment. Pretest and posttest measurements were conducted. Statistical analysis using paired t-tests yielded a significance level of p=0.000 (p<0.05), indicating a significant influence of baby massage classes on weight gain in infants aged 1-6 months. The average weight gain after intervention was 5200 grams.Of the total respondents, 19 infants (63.3%) experienced weight gain, with 13 from the intervention group and 6 from the control group. However, 9 infants (30%) maintained their weight, with 2 from the intervention group and 7 from the control group, while 2 infants (6.7%) experienced weight loss, all from the control group.Baby massage classes have a positive impact on infant weight gain at the Ibu Hawa Clinic in Kediri Regency.
Sabun Cair Antiseptik Sari Air Kulit Buah Salak (Salacca zalacca) Gunawan, Muhammad; Fatimah, Cut; Panjaitan, Sariatmaja
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5327

Abstract

In addition to removing dirt that sticks to the skin, skin wash soap also functions as an antiseptic to ward off skin diseases caused by germs, many antiseptic soaps on the market contain synthetic antibacterials but often have negative side effects. Therefore, it is important to make soap with natural ingredients. For example, salak (Salacca zalacca) fruit peel contains saponin and polyphenol compounds that are antibacterial. To test the antibacterial activity and make liquid soap containing salak fruit peel juice as a cleanser and antibacterial, this study conducted phytochemical screening on salak fruit peel. The research stages include, phytochemical screening of salak fruit peel, liquid soap formulation with 10%, 20%, and 30% salak fruit peel juice (SKBS), liquid soap assessment related to stability, foam height, pH, irritation, and liking test. Antibacterial activity test against germs from volunteer hand wash water specimens against Escherichia coli, and Staphylococcus aureus bacteria. The results showed that salak fruit peel juice can be used to make liquid soap that meets physical quality standards because it contains alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. The strongest antibacterial activity with inhibition diameters against Staphylococcus aureus (18.63 ± 0.33) mm and Escherichia coli (16.17 ± 0.33) mm) made 20% SKBS liquid soap the best choice, which was determined by the results of the study.
Uji Sitotoksisitas Ekstrak Etanol Daun Bayam Duri (Amaranthus spinosus L.) dengan Metode Brine Shrimp Lethality Test (BSLT) Fauzi, Ziza Putri Aisyia; Ridwanto, Ridwanto; Rani, Zulmai; Arifin, Khairil Fikri
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5398

Abstract

Free radicals can cause chronic disease, it takes years for the disease to become real or accumulative. One possibility that can occur as a result of the work of free radicals such as cancer. Cancer is one of the non-communicable diseases that is a public health problem, both in the world and in Indonesia. One of the plants that has the potential as an anticancer is Amaranthus spinosus L. The results showed that thorn spinach leaves contain strong antioxidants. This study aims to determine the class of secondary metabolites contained in the ethanolic extract of thorn spinach leaves and the cytotoxicity of the ethanolic extract of A.spinosus by looking at the LC50 value which was tested using the Brine Shrimp Lethality Test (BSLT) method. This research includes phytochemical screening of A.spinosus extract and Brine Shrimp Lethality Test (BSLT) method by looking at the number of larvae mortality of Artemia salina leach (LC50). The results of the phytochemical screening test showed that A.spinosus were positive for flavonoids, alkaloids, saponins, tannins, steroids and glycosides. The results of the cytotoxicity test using probit analysis showed an LC50 value of 269.15 g/mL, so it can be concluded that the ethanolic extract of A.spinosus is toxic and has potential as an anticancer.
Perbandingan Metode Ekstraksi terhadap Kadar Flavonoid Total Ekstrak Etanol Daun Kersen (Muntingia Calabura L.) Alfiraza, Ery Nourika; Nurhidayati, Lailiana Garna; Fahamsya, Arifina; Wahyuningtias, Arum
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5136

Abstract

Flavonoid compounds, triterpenes, tannins, polyphenols, and saponins can be found in cherry leaves (Muntingia calabura L.). Flavonoids are proven to be able to reduce free radicals, and thus can act as an antioxidant. The use of extraction methods can affect the content of flavonoid compounds contained in the extract . Thus, to extract flavonoids from plant leaves, it is necessary to optimize the right extraction method. Objective of this study was to compare the effect of using three different extraction methods, namely maceration, reflux, and sonication, on the total flavonoid content of cherry leaf ethanol extract. Cherry leaves were extracted with ethanol (1:10), using three different extraction methods, namely maceration, reflux, and sonication. The viscous extract obtained was then measured for total flavonoid content using UV-VIS spectrophotometry at 431 nm, using a standard solution of quercetin as a comparison. Total flavonoid content of ethanol extract of cherry leaf extracted by maceration, reflux, and sonication method respectively were 73.98 ± 0.06 mgQE/g; 60.55 ± 0.05 mgQE/g; and 92.53 ± 0.12 mgQE/g. Conclusion of this study was The extraction process influences the overall flavonoid concentration of cherry leaf ethanol extract.
Hubungan Kemampuan Aktivitas Antioksidan dengan Pelarut Ekstraksi Daun Pecut Kuda (Stachytarpheta jamaicensis L.) Amin, Asni; Waris, Risda; Aminah, Aminah; Yuliana, Dewi; Fitri, Nurul
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5221

Abstract

The increasing prevalence of degenerative diseases, cancer and other non-communicable diseases is due to exposure to free radicals, so that currently research on antioxidants is increasingly being carried out. This research aims to prove the relationship between antioxidant activity and extraction solvents of different polarities in reducing DPPH radicals ((1,1-Diphenyl-2-picryl hydrazyl) from horse whip (DPK) leaves (Stachytarpheta jamaicensis L.) from North Kolaka district. The research was carried out using a post test only control experiment. Samples were extracted by maceration with 96% ethanol solvent and n-hexane solvent, then each extract was evaporated using a rotary evaporator, the thick extract was screened for phytochemicals with a second color reagent. The extract was tested for antioxidants against DPPH and measured absorbance using a UV-Vis spectrophotometer at a wavelength of 515 nm, and compared with the quercetin standard. The results of the phytochemical screening showed the content of anthraquinone glycosides, phenols, and flavonoids for the DPK ethanol extract, while the hexane extract contained alkaloids, phenols, flavonoids, tannins and steroids. The antioxidant activity of DPK extract can capture DPPH free radicals with the IC50 value of 96% ethanol extract being 12.17 μg/mL and hexane extract being 5.904 μg/mL. Both extracts are classified as very strong antioxidants like quercetin. There is a relationship between the extraction solvent and the antioxidant ability of HWL extract which is significant at p < 0.05, while the relationship between quercetin, ethanol extract and hexane extract significantly influences the antioxidant ability. Abstrak Meningkatnya prevalensi penyakit degeneratif, kanker, dan penyakit tidak menular lainnya diakibatkan adanya paparan radikal bebas, sehingga saat ini penelitian antioksidan semakin banyak dilakukan. Penelitian ini bertujuan untuk membuktikan adanya hubungan aktivitas antioksidan dengan pelarut ekstraksi yang berbeda kepolaran dalam meredam radikal DPPH ((1,1-Diphenyl-2-picryl hydrazyl) dari ekstrak etanol 96% dan ekstrak heksan daun pecut kuda (DPK) (Stachytarpheta jamaicensis L.) asal kabupaten Kolaka Utara. Penelitian dilaksanakan menggunakan post test only control eksperiment. Sampel diekstraksi secara maserasi dengan pelarut etanol 96%, dan pelarut n-heksan, kemudian tiap-tiap ekstrak dievaporasi menggunakan rotavapor, ekstrak kental diskrining fitokimia dengan pereaksi warna. Uji peredaman radikal bebas ekstrak dengan konsentrasi 1; 2; 3; 4 dan 5 μg/mL diukur absorbansinya dengan spektrofometer UV-Vis pada panjang gelombang 515 nm, dan dibandingkan dengan standar kuersetin. Hasil skrining fitokimia didapatkan kandungan glikosida antrakinon, fenol, flavonoid untuk ekstrak etanol DPK, sedangkan ekstrak heksan mengandung alkaloid, fenol, flavonoid, tanin, dan steroid. Aktivitas antioksidan ekstrak DPK dapat meredam radikal bebas DPPH dengan nilai IC50 ekstrak etanol 96% adalah 12,17 μg/mL dan ekstrak heksan adalah 5,904 μg/mL. Kedua ekstrak tergolong antioksidan sangat kuat seperti kuersetin. Terdapat hubungan antara pelarut ekstraksi dengan kemampuan antioksidan ekstrak DPK yang signifikan pada p < 0,05, sedangkan hubungan antara kuersetin, ekstrak etanol dan ekstrak heksan secara signifikan berpengaruh dengan kemampuan antioksidan.
Analisis Minimalisasi Biaya (AMiB) Antihipertensi Irbesartan dengan Candesartan pada Pasien Hipertensi Rawat Jalan Nurlaela, Nurlaela; Fauziah, Fauziah; K, Khamdiyah Indah; Kusuma, Ikhwan Yuda
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5599

Abstract

Cost minimization of antihypertensive therapy is very essential to optimize patient care and allocation of hospital resources. This study aimed to compare the most cost-minimized cost of irbesartan and candesartan therapy treatment in hypertensive patients at Goeteng Taroenadibrata Purbalingga in the periods January to December 2023. The research method used quantitative with a retrospective approach. Data were analyzed using normality kormogorov smirnov test and continued by mann whitney test. population in this were hypertensive patients at Goeteng Taroenadibrata Purbalingga with a sample of 100 hypertensive patients.The results showed that out of 100 samples, 37 samples used irbesartan and 63 candesartan samples with an average total direct medical cost of antihypertensive treatment, laboratory costs and consultation costs required by patients using irbesartan therapy Rp. 158,665, and candesartan Rp. 116,874. Statistical analysis has a p-value that shows a significant difference between irbesartan treatment and candesartan treatment. the conclusion in this study is that the most cost-minimizing antihypertensive therapy is the candesartan group compared to the irbesartan group. Further research is needed to analyze a broader CMA of blood pressure control and comorbid diseases.
Analisis Pengaruh Vaksin Covid-19 Terhadap Nilai HbA1c Pasien DM Tipe-2 Di Puskesmas: Studi Retrospektive Setyaningsih, Intan Wiji; Kurniasih, Khamdiyah Indah; Setianingsih, Siti
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5666

Abstract

Coronavirus Disease 2019 (Covid-19) is a dangerous type of infection that causes death and is at risk in DM patients, so the selection of vaccines is very selective, especially moderna or pfizer vaccines that will know the increase in blood glucose. The purpose of this study was to determine the description and relationship of HbA1c values in type 2 DM patients after the 2nd dose of moderna or pfizer Covid-19 vaccine at Mrebet Health Center. The method used was analytical research with a retrospective observational approach conducted by conducting interviews with DM patients in the form of compliance with drug use, remaining drug use in 1 month, and sugar diet. Measurement of HbA1c values obtained from 3 months before and 3 months after the 2nd dose of moderna or pfizer vaccine. The results of the study obtained 32 DM prolanis patients, where the most patients were aged 45 - 65 years as many as 28 (87.5%), and female gender 27 (84.4%). The type of vaccine obtained was 25 (78.1%) moderna vaccine and 7 (21.9%) pfizer vaccine. The average pre-vaccine and post-vaccine HbA1c values increased by 0.3% from 8.0% to 8.3% and a standard deviation of 0.10. Based on the analysis, the p-value of 0.000 <0.050 was obtained, so statistically there was a slight increase with almost the same value between HbA1c values in type 2 DM patients after the Covid-19 moderna vaccine or the 2nd dose of pfizer. Conclusion There is an increase between pre-vaccine and post-vaccine HbA1c values and there is a relationship between HbA1c values in patients with type 2 DM after the Covid-19 moderna or pfizer 2nd dose vaccine.
Penentuan Nilai SPF (Sun Protection Factor) Sediaan Serum Anti-Aging Ekstrak Rimpang Galoba (Horstedtia Alliacceae) Safaruddin, Safaruddin; Suleman, Abdul Wahid; Zahira, Saliza
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5760

Abstract

The rhizome of Galoba (Horstedtia alliacceae) contains flavonoids, alkaloids, saponins, tannins, and triterpenoids which are secondary metabolite compounds that have antioxidant activity. The most antioxidants are flavonoids where antioxidants are used as anti-aging agents because free radicals are involved in the aging process of the skin. Objectives of the study to determine whether ethanol extract of galoba rhizome (Horstedtia alliacceae) can be formulated into a physically and chemically stable serum preparation, as well as to determine the SPF (Sun Protection Factor) value in serum preparations. The research method used an experimental method in vitro using a UV-Vis spectrophotometer, extraction by maceration method using 96% ethanol solvent, and then an anti-aging serum preparation formulation was made with concentrations of F1 (5%), F2 (10%), F3 (15%), F3 (20%). Then the SPF (Sun Protection Factor) value is determined. The results of the serum formula research showed that it was physically and chemically stable, which was marked by no difference before and after the cycling test, both in organoleptic, homogeneity, pH, viscosity, and humidity tests. The results of the SPF value of serum preparations at F1 (5%) were 4.51, F2 (10%) was 5.66, F3 (15%) was 8.67, and F4 (20%) was 13.06. The conclusion of this study is to show that Galoba rhizome extract (Hornstedtia alliacea) can be formulated into a physically and chemically stable anti-aging serum preparation, and the best SPF value obtained from the F4 formula (20%) is 13.06 with the maximum protection category.

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