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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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Body Scrub Kombinasi Cangkang Telur Ayam Horn dan Ekstrak Daun Kenikir Sebagai Brightening Skin Yunitasari, Risky; Natasya, Leanasta Ina; Poppy, Leony Rayvina; Agustin, Nanda Nelly; Fatika, Diva Aulia Nur; Isnawati, Nafisah
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5870

Abstract

Maintaining beauty is an important aspect for every woman, including appearance and cleanliness of the entire body. One product that supports healthy skin is a body scrub, which can be made using egg shell waste as a scrub and kenikir leaf extract as the active ingredient for a body scrub. Egg shells contain calcium carbonate which is abrasive for exfoliation. Meanwhile, kenikir leaves are rich in antioxidants, vitamins C, A and E which play a role in brightening the skin. The method used is a qualitative and quantitative experimental research method which includes physical evaluation and antioxidant activity testing of body scrub preparations. The aim of this research is to determine the formulation, characteristics and antioxidant activity of a combination of horn chicken (Gallus gallus domesticus) egg shell waste and kenikir (Cosmos caudatus) leaf extract using the DPPH method and to evaluate the physical preparation. The research results showed that the physical evaluation of the body scrub preparation met the requirements and the best antioxidant activity was found in F3 with an IC50 value in the medium category of 111.121.
Pemanfaatan Limbah Ekstrak Metanol Dari Kulit Buah Kakao (Theobroma Cacao L.) Sebagai Antimikroba Mierza, Vriezka; Razali, Mariany; Hanafi, Muhammad; Pandiangan, Martina
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6137

Abstract

Microorganisms, which include bacteria, fungi, viruses, and parasites, are a large class of microscopic organisms with one or more cells. Among them are Staphylococcus epidermidis, Bacillus subtilis, Proteus mirabilis, and Streptococcus pyognes. One type of plant that has health benefits is the cocoa plant (Theobroma cacao L.) which belongs to the Malvaceae tribe. In this study, methanol extract of cocoa fruit peel (Theobroma cacao L.) was made as an inhibition test against Streptococcus pyognes, Bacillus subtilis, Proteus mirabilis, and Staphylococcus epidermidis bacteria. Cocoa pod peel (Theobroma cacao L.) was the test material used in the experimental methodology of this study. Simplisia preparation, ethanol solvent maceration extraction, agar diffusion method antibacterial activity testing, and phytochemical screening for chemical compound component analysis are part of the stages of this research. Drying of cocoa fruit peels produced 26.5 kg of simplisia, and maceration with ethanol produced 14.41 g of thick extract. Antibacterial activity of ethanol macerated extract of cocoa fruit peel was shown by inhibition against Streptococcus pyognes bacteria by 21 mm, Bacillus subtilis bacteria by 68 mm, Bacillus subtilis bacteria by 14.06 mm, Proteus mirabilis bacteria by 14.4 mm, and Staphylococcus epidermidis bacteria at a concentration of 100 mg/ml. The results of phytochemical screening of ethanol extract of cocoa pod skin showed the presence of anthraquinone glycosides, flavonoid chemical compounds, triterpenoids, tannins, and saponins.
Efektivitas Senyawa Bioaktif Biji Kopi Arabika (Coffea arabica L.) Sebagai Antibakteri Sari, Nurmala; Razali, Mariany; Kusuma, Ariyanti; Simanjuntak, Labora; Damanik, Mia; Silvany, Rika
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6138

Abstract

Arabica coffee has a myriad of benefits for the health of the human body, Arabica coffee contains secondary metabolites including flavonoids, tannins and saponins which have good antibacterial properties in leaves, seeds, and even coffee fruit skin, where Arabica coffee is taken in a mature state to see how much antibacterial is contained in coffee beans. The purpose of this study was to identify the chemical content of secondary metabolites contained in the ethanol extract of Arabica coffee beans and the antibacterial activity of the extract in terms of preventing the growth of Staphylococcus aureus and Escherichia coli bacteria. This research method is experimental, plant material is taken identified then made simplisia, Arabica coffee beans are extracted using ethanol p.a. solvent, phytochemical screening and antibacterial activity tests are carried out using the agar well diffusion method (Agar Well Plate Diffusion Assay Method). The diameter of the growth inhibition of microorganisms is one of the factors observed in the ethanol extract of Arabica coffee beans undergoing phytochemical screening which shows the presence of terpenoids / steroids, alkaloids, flavonoids, tannins and saponins. The concentrations used start from 100 mg / ml, 50 mg / ml, 25 mg / ml, 12.5 mg / ml, 6.25 mg / ml and 3.12 mg / ml in the ethanol extract of Arabica coffee beans (Coffea arabica L.). The ethanol extract of Arabica coffee beans showed antibacterial activity against Escherichia coli bacteria with the largest inhibition zone of 9.5 mm in diameter observed at a concentration of 100 mg/ml, while the smallest inhibition zone of 0.73 mm in diameter was observed at a concentration of 6.25 mg/ml, in contrast to Staphylococcus aureus bacteria which had the smallest inhibition zone at a concentration of 100 mg/ml and the largest inhibition zone at a concentration of 8.48 mm at 12.5 mg/ml with an inhibition zone diameter of 1.73 mm.
Uji Efektivitas Ekstrak Etanol Daun Ketapang (Terminalia cattapa L.) Terhadap Bakteri Patogen Saputri, Muharni; Mierza, Vriezka; Zebua, Nilsya Febrika; Panjaitan, M Ridho Pangestu
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6139

Abstract

Antiba Antibacterials work by preventing and managing the growth of pathogenic bacteria. The goal of controlling bacterial growth is to stop the spread of infection. Basically, people use synthetic drugs in antibacterial prevention but often there is a lot of resistance in the human body that can cause adverse effects. The active ingredients in ketapang leaves have the potential to act as natural antibiotics and antibacterials to combat antibiotic resistance. To determine the antibacterial effectiveness of these chemical compounds against bacteria Pseudomonas aeruginosa, Demacoccus nishinomiyaensi, Stapylococcus epidermidis and Micrococcus luteus, a study was conducted with the aim of knowing the content of chemical compounds contained in ketapang leaves based on maceration results. This study uses an experimental descriptive method with Ketapang leaf test material (Terminalia cattapa L.) This research stage includes making simplisia, maceration extraction using ethanol solvent, antibacterial activity test agar well diffusion method and analysis of chemical compound components by phytochemical screening.The results of drying fresh ketapang leaves produce as much as 1.6 kg of simplisia, and when 300 grams of ketapang leaf simplisia is macerated using ethanol pro analysis, 1.5 kg of simplisia is obtained. The ethanol extract from the maceration of ketapang leaves has antibacterial activity as shown by the inhibition of Pseudomonas aeruginosa bacteria by 18.38 mm, Dermacoccus nishinomiyaensis bacteria by 23.05 mm, Staphylococcus epidermidis bacteria by 18.71 mm, and Micrococcus luteus bacteria by 20.71 mm. After screening the ethanol extract of ketapang leaves, triterpenoid components, anthraquinone glycosides, saponins, and tannins were found. Flavonoid compounds were also found.
Uji Most Probable Number (MPN) Bakteri Coliform Pada Jamu Yang Beredar di Pasaran Kusumastuti, Yulia; Tanjung, Siti Aisyah; Fatimah, Cut; Ayi, Alicia
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6140

Abstract

Herbal Medicine is one of the traditional medicines used since the time of the ancestors until now with ingredients that have not been standardized. jamu has a myriad of benefits for the human body, one of which can maintain body health, prevent disease, maintain fitness and beauty. jamu has two types circulating in the market, namely jamu gendong and jamu kemasan. Processing of jamu gendong which is still done in a simple way with makeshift tools is very likely to cause bacterial contamination. Rich biological resources, especially medicinal plants, can be found in Indonesia. According to research, 90% of Asia's medicinal plants are estimated to be found in Indonesia, with 25% of them-about 7,500 plant species-having been proven effective. In the process of making herbal medicine, it is very important to look at its hygienity, this is because herbal medicine is very easily contaminated by bacteria such as Coliform bacteria, which are indicators of bacterial contamination in general. in this test carried out by the MPN method, the authors are interested in examining the Coliform bacteria mpn test on herbal medicine circulating in the sudirejo village, Medan city. This test sample was carried out using a simple random method on jamu gendong and jamu packaging located in sudirejo Medan. in testing bacterial contamination using Most Probable Number (MPN) with a 3:3:3 tube series with Lactose Broth (BGLB) media and a complete test using Eosin Methylen Blue Agar (EMBA) media, performing gram dye painting and observing microscopic colonies. The results in this study showed that all samples of jamu gendong and packaged jamu (K3) found in the Sudirejo Medan area were contaminated with Coliform bacteria, while the sample of packaged jamu (K6) was not contaminated with Coliform bacteria.
Formulasi Sediaan Krim Body Scrub Dari Ekstrak Daun Belimbing Wuluh (Averrhoa blimbi L.) dan Ampas Kopi Arabika Gayo (Coffea arabica L.) Sebagai Eksfolian Zarwinda, Irma; Elfariyanti, Elfariyanti; Safira, Rifa Risti; Rizki, Putri Humaira
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6164

Abstract

Abstrak− Body scrub adalah salah satu sediaan farmasi yang digunakan untuk mengangkat sisa kotoran, sel-sel kulit mati, debu, dan minyak pada kulit dengan bantuan bahan scrub sebagai pengampelas kulit. Daun belimbing wuluh dan ampas kopi arabika Gayo terbukti mengandung senyawa aktif antioksidan dan antibakteri, selain itu, penggunaannya dalam rangka memanfaatkan potensi kearifan lokal provinsi Aceh dan sangat pontensial sebagai bahan pembutan body scrub berbahan alam. Tujuan penelitian untuk mengetahui stabilitas mutu fisik sediaan body scrub ekstrak daun belimbing wuluh dan ampas kopi arabika Gayo serta efektivitasnya sebagai eksfolian. Metode penelitian yang digunakan adalah eksperimen. Formulasi krim body scrub dalam penelitian ini dibuat dalam 4 formula dengan memvariasikan proporsi ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) berturut-turut yaitu F0(0%), F1(1%), F3(2%), dan F3(3%), sedangkan proporsi bubuk ampas kopi arabika Gayo dibuat tetap. Parameter yang diuji adalah mutu fisik, uji iritasi dan uji efektivitas body scrub (eksfolian). Hasil penelitian selama 14 hari penyimpanan. Organoleptis keempat body scrub memiliki bentuk semi padat, berwarna coklat hingga coklat kehitaman, dan aroma kopi. Nilai pH berkisaran dari 7,7-8 dan semua sediaan homogen. Tipe emulsi minyak dalam air, memiliki daya sebar kisaran 5,4 – 5,9. Semua formula tidak menimbulkan iritasi dan tingkat kecerahan kulit sukaerelawan meningkat 1 tingkat dilihat dari kertas indikator. Hasil uji kelembaban kulit, F2 dan F3 menunjukkan hasil paling baik, dengan persentases kenaikan 13%, sedangkan F0 meningkat 5% dan F1 6%. Sehingga dapat disimpulkan bahwa sediaan body scrub yang telah dibuat memiliki hasil yang baik dan stabil serta dapat digunakan sebagai eksfolian. Kata Kunci: ampas kopi arabika Gayo; body scrub; daun belimbing wuluh; eksfolian.
Analisa Fitokimia dan Aktivitas Antioksidan Sirup Herbal Ekstrak Buah Labu (Curcubita Moschata) dan Rimpang Kunyit (Curcuma Domestica) dengan Metode DPPH Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Misworo, Misworo; Prismadito, Hansen
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6189

Abstract

Pumpkin is one of the natural ingredients with antioxidant properties, and it helps reduce symptoms of diabetes, hypertension, tumors, cholesterol, antibacterial, anthelmintic, and anti-inflammatory effects. The polyphenol and flavonoid contents in pumpkin are 97.4 mgGAE/gram and 28.6 mgQE/gram, respectively, with high antioxidant activity against DPPH radicals at 0.065 ± 0.010 mol TE/gram. Turmeric rhizome is also a plant with high antioxidant activity. Turmeric rhizome contains curcumin as the main active compound, with a content of 7.798%. The ethanol extract of turmeric rhizome exhibits antioxidant activity with an IC50 value of 41.95 µg/mL (DPPH). Studies on the composition and benefits of pumpkin and turmeric rhizome have been conducted. However, so far, there has been no standardization of the simplicia and extracts of these two plants from Central Java. The herbal syrup combining pumpkin and turmeric extracts is an herbal product that has not been scientifically proven regarding its metabolite compounds and antioxidant activity, which play a role in addressing various degenerative diseases. Therefore, standardization of the simplicia and verification of the phytochemical metabolites and antioxidant content are necessary. This study was conducted by comparing the IC50 values of three syrup formulas: turmeric rhizome syrup (F1), pumpkin syrup (F2), and a mixture of pumpkin and turmeric rhizome syrup (F3). The results showed that Formula 1 (F1) had the lowest IC50 value of 17.366 µg/mL, indicating the highest antioxidant potential, followed by F3 with an IC50 of 47.862 µg/mL, and F2 with the lowest antioxidant activity, with an IC50 value of 288.545 µg/mL.
Determination of Sunscreen Gel’s SPF (Sun Protecting Factor) Value Containing Cemba Leaf Extract (Acacia rugata (Lam.) Fawc. Rendle) Muzayyidah, Muzayyidah; Sukara, Muhammad Akmal A; Syahrianti, Andi
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6239

Abstract

Excessive sun exposure can have negative effects on the skin. One way to reduce this impact is to use sunscreen. This study aims to formulate cemba leaf ectract into a stable sunscreem gel preparation and to determine the resulting sun-protecting factor (SPF) value. Using the laboratory experimental method, cemba leaves were extracted using the maceration method and the extract was made as an active ingredient in a gel preparation with concentrations of each formula including 0.5% (F1), 1% (F2), and 1.5% (F3). The gel preparation that had been made was then tested for stability using the cycling test method at temperatures of 4oC and 40oC. The research results of the cemba leaf extract gel preparations showed good stability and met the quality requirements in term of organoleptic, homogeneity, pH viscosity, spreadability, and adhesiveness with no significant difference before and after the cycling test (p<0.05). Determination of SPF value using UV-Vis spectrophotometry obtained the values of each formula respectively are 31.99 (F1), 43.23 (F2), and 43.24 (F3). The three formulas show activity as sunscreen seen from the SPF value > 15 which is included in the ultra-category.
Uji Aktivitas Analgesik Dari Ekstrak Daun Ara Sungsang (Asystasia gangetica L.) Terhadap Mencit Jantan dengan Metode Hot Plate Fujiko, Muflihah; Saputri, Muharni; Sofia, Vivi; Mauliza, Indah
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6881

Abstract

Pain is a body response that indicates a disorder. The use of conventional drugs to treat pain is quite worrying because of its long-term effects. This causes people to use drugs derived from nature. Breech fig leaves contain flavonoids and alkaloids that are able to reduce pain. This study aims to see the potential of breech fig leaves as an analgesic induced to male mice using the hot plate method. This research began with plant identification, material collection, simplicia and extract, phytochemical screening, and testing on mice. This study was carried out in vivo using male mice. Twenty birds were divided into five groups, namely the negative control group (CMC-Na 0.5%), the positive control group (Ibuprofen 200 mg/kg BB), the breech fig leaf extract group (dosage 50 mg/kg BB, 100 mg/kg BB, 200 mg/kg BB). Then the analgesic activity test was carried out by looking at the responsse of mice who were given pain using the hot plate method with a temperature of 55ºC. Then the percent of analgesic power and percent of the effectiveness of the analgesic were calculated. The results of the study showed that flavonoid compounds, alkaloids, tannins, steroids, and saponins were contained in breech fig leaves (Asystasia gangetica L.). dose 200 mg/kg BB has the highest percent analgesic power and effectiveness percentage, which is 99.12% (p<0,05) and 99.67% (p<0,05). From dose 50 mg/kg BB, the analgesic effect can be seen, and the best analgesic effect is at a dose of 200 mg/kg BB. This shows that breech fig leaf extract has analgesic activity in male mice by hot plate method.
Cytotoxic Potential of Mangifera indica L var Arumanis Rind Extract and Fraction Against T47D Cells with Microtetrazolium (MTT) Method Ifmaily, Ifmaily; Oktafera, Oktafera
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6984

Abstract

Breast cancer is a major problem in the health sector, one type of malignant cancer in Indonesia and the world. Medical therapy for cancer patients has had side effects such as nausea, vomiting, weakness, diarrhea and hair loss. The arumanis mango rind, in previous research, contains secondary metabolites of flavonoids, phenolics, saponins and tannins. Arumanis mango rind extract has been studied to have antioxidant activity with an IC50 of 18.29 µg/ml and a toxic, toxicity test with an LC50 of 169.04 µg /ml. The aim of the research was to determine the cytotoxic potential of arumanis mango rind extract and fractions against T47D cancer cells using the Microtetrazolium (MTT) method from the percentage of cancer cell viability, IC50, and cancer cell morphology. It was using ethanol extract, n-hexane fraction, ethyl acetate fraction, and n-butanol fraction, with concentrations of 1000, 100, 10, 1, 0.1 μg/ml against T47D cancer cells. Data were the life cell absorbance obtained from the ELISA reader, to calculate the percentage of T47D cell viability, obtain IC50, then observe the morphology of the cancer cells. The results of the percentages of cell viability ( μg/ml ) from the ethanol extract were 81.1: 103.5; 137.3; 163; 165.5, n-hexane fraction were 28.5; 82.7; 105.1; 130.5; 132.5, ethyl acetate fraction were 15.9; 27.2; 101.7; 134.1; 162.7, n-butanol fraction were 32.6; 75.6; 82.8; 122.3; 146.4, doxorubicin as a comparison were 22.6; 38.4; 45.4; 53.4; 56. The IC50 results of the ethanol extract, the n-hexane fraction, the ethyl acetate fraction, the n-butanol fraction, and doxoburicin were 32.21; 616.59; 90.57; 338.84, and 1.44. The best of cancer cell morphology was doxorubicin, ethanol extract, and ethyl acetate fraction. The conclusion that the extract and fraction of arumanis mango rind had cytotoxic potential against T47D cancer cells from the percentages of cell viability, IC50 and cancer cell morphology, and the best of result are ethanol extract, ethyl acetat fraction, also doxorubicin as comparison drug.

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