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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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Formulasi Sediaan Body Scrub Pencerah Kulit Dari Serbuk Kopi Robusta (Coffea Robusta L) dan Lidah Buaya (Aloe Vera) Lidyawati, Lidyawati; Mardiana, Rosa; Pratiwi, Silvia Putri
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6220

Abstract

Body scrub is one form of pharmaceutical preparation that functions to clean the skin from dirt, dead skin cells, dust, and oil with the help of scrub particles that act as abrasives. Currently, the use of natural body scrubs is more popular because of the minimal risks and side effects. Robusta coffee beans and aloe vera extract contain flavonoid compounds that function as free radical scavengers. This study aims to determine whether robusta coffee beans (Coffea Robusta) and aloe vera extract (Aloe vera) can be used as a body scrub preparation to ward off free radicals, and to evaluate their physical stability through organoleptic testing, pH testing, homogeneity, accompanied by irritation testing. This study used an experimental method in the laboratory. The body scrub formulation was developed in three variations of the proportion of coffee extract and powder, namely F0 (0%), F1 (4.6%), and F2 (6.13%). Evaluation of the body scrub preparation includes organoleptic testing, homogeneity testing, pH testing, and skin irritation testing. The results showed that robusta coffee beans and aloe vera extract can be formulated into a body scrub preparation. The results of the pH test show that the pH of the body scrub is 6, according to the pH of the skin, so it is safe when applied to the skin. The results of the volunteer skin irritation test are also safe, having no irritating effect on the skin.
Optimization of HPMC Aand Carbopol 940 Bases in the Formulation of Red Beet (Beta vulgaris L.) Gel Preparations as Hair Dye Hartini, Putri Tri; Fauzi, Ziza Putri Aisyia; Utami, Dinda Sari; Karo-Karo, Sry Ulina; Puteri, Cut Intan Annisa
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6661

Abstract

Red beet (Beta vulgaris L.) is grass-shaped plant with short stems. Betacyianine is a red or purplish red pigment, while the betaxantin pigment has yellow colour and when diluted in water will form a red solution. This study aims to formulate hair dye gel with red beet juiceas colorant, evaluate the coloring capacity of the gel, and evaluate the stability of the formulation. 114.43 grams red beet juice was obtained using juicer, with yield percentage 55.76%. Phytochemical screening indicated alkaloid, tannin, flavonoid and saponin content. Hair dye gel is formulated in three different concentrations, F1 (10%), F2 (20%), F3 (30%) using combination of Carbopol 940 (0.5%) and HPMC (1%) as gel base. Hair dye gel obtained has beet distinctive smell. Evaluation results for the three-formulation showed that the color changed in all formulas. Color changing is influenced by pH degree of the formulation and temperature. The original color of the preparation only stable for 5 days, then the color changed due to oxidation at room temperature. Stability evaluation was conducted using Cycling Test method for 6 cycles in 12 days. All formula showed discoloration after 6 cycles from purple to brownish and they also showed viscosity change, F1 13673,34 cPs; F2 11826,67 cPs; dan F3 10673,34 cPs.
Evaluasi Sediaan Ekstrak Etanol Daun Sawi Langit (Cyanthillium cinereum (L) H.Rob) Sebagai Formulasi Krim Alas Bedak Tambunan, Ika Julianti; Sudewi, Sudewi; Nasyabila, Aura
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6992

Abstract

Sky mustard leaf (Cyanthillium cinereum (L.) H.Rob) is a herbaceous plant that is used as a natural medicine in the community, especially in the treatment of irritation, intestinal diseases and febrile diseases. Sky mustard leaves are known to contain secondary metabolites such as flavonoids, alkaloids, saponins, tannins, phenolics and triterpenoids. Foundation cream is very popular among women as a powder base during the process of using makeup on the face but few foundation creams use natural ingredients compared to synthetic ingredients. This study aims to determine whether sky mustard leaf extract can be formulated in a foundation cream preparation that at certain doses has antioxidant activity and does not irritate facial skin. The sample used was sky mustard leaves, the research stages began, plant identification, ethanol extract preparation, phytochemical screening, selection of standard formulas, making foundation cream preparations with concentrations of 1%, 1.5%, 2%, blank physical quality assessment of preparations and antioxidant activity tests are some of the tests carried out. The results of this study indicate that the leaves of sky mustard (Cyanthillium cinereum (L.) H.Rob) The foundation cream preparation is homogeneous, stable and has an oil-in-water (M/A) emulsion type. The cream has a pH of 5.7-5.9 after cycle testing and can be applied up to 5-7 cm with an increase in moisture content of 36.86 which is included in the “moist” category, 2% preparation (F3) is the most preferred preparation, the IC50 value of the mustard leaf extract foundation cream formulation is in the “strong” category of 63.08 ppm “very strong” 47.37 ppm at a concentration of 1%, 1.5%. So it is concluded that mustard leaf extract IC50 value is in the “very strong” category of 14.75 ppm. The IC50 value of mustard leaf extract including the “very strong” category is 14.75 ppm. so it can be concluded that sky mustard leaves can be formulated as a foundation cream preparation without irritation.
Antibacterial Activity of Formulated Guava Leaf Extract (Psidium Guajava L.) Hand Wash Soap on Staphylococcus Aureus Puteri, Cut Intan Annisa; Rani, Zulmai; Fauzi, Ziza Putri Aisyia; Ningtias, Anggitha; Dalimunthe, Gabena Indrayani
Journal of Pharmaceutical and Health Research Vol 6 No 2 (2025): June 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i2.5709

Abstract

During the Covid-19 pandemic, the use of hand-washing soap increased. Hand-washing soap using natural ingredients as active ingredients is still not widely developed. One plant that has been proven to inhibit the growth of bacteria is guava leaves. This research aimed to formulate and test the antiseptic activity of liquid hand-washing soap from guava leaf extract. The research method used was laboratory experimental, with stages including; preparation of guava leaf extract, liquid soap formulation with a preparation concentration of FI 5%, FII 6%, FIII 7%, FIV 8%, then the physical properties of the soap will be tested to determine its quality and quality. Apart from the physical test, an antibacterial activity test was also carried out to determine the antibacterial effectiveness of the liquid hand wash soap formulation using the disc diffusion method to determine the diameter of inhibition or area of the inhibition zone. The preparation formula of 7% to 8% concentration of the preparation can inhibit growthStaphylococcus aureus. The diameter of the inhibition zone formed is included in the strong category. Based on research, it can be concluded that guava leaves have the potential to inhibit bacteria S. aureus, and evaluation of the preparations of all formulas shows stability and good characteristics. Each concentration has a good antibacterial effect, where the higher the extract concentration, the greater the diameter of the bacterial growth inhibition zones. aureusresulting from.
Analisa Perbandingan Metode Sokletasi dan Maserasi Daun Sisik Naga (Drymoglossum piloselloides (L.) C.Presl) sebagai Penyembuh Luka Sayat Febriani, Yessi; Tambunan, Ika Julianti; Pratiwi, Nur Hanifa; Putri, Gewa Hadyaksa
Journal of Pharmaceutical and Health Research Vol 6 No 2 (2025): June 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i2.6232

Abstract

Dragon scale leaves (Pyrrosia piloselloides (L.) M. G. Price) have activity as antibacterial, antioxidant, antipyretic and as a febrifuge. In addition, dragon scale leaves also contain secondary metabolites such as flavonoids, polyphenols, saponins, tannins and steroids. the wound healing process includes abrasions, cuts, burns, stab wounds. The wound healing process has 3 phases, namely the inflammatory phase, proliferation phase, and maturation phase. The purpose of this study was to determine the effectiveness of total flvanoid by comparing the extraction of dragon scale leaves in healing cuts on boiler chickens (Gallus domesticus). The methods used are sokletation and maceration in the process of making thick extracts while in the research using experimental methods this research was carried out starting from the sample of dragon's scale leaves (Drymoglossum piloselloids) (L.) Presl), plant identification, making simplisia powder, making extracts, phytochemical screening, and determining total flavonoid levels using UV spectrophotometry and incision wound healing tests on broiler chickens (Gallus dzomesticus).The results of research on dragon scale leaf extracts using both maceration and sokletation methods in the process of making extractions on this plant have the same secondary metabolite content, namely flavonoids, saponins, tannins, steroids and glycosides, based on testing the total flavonoid content obtained of 3.875% in the sokletation method getting lower results compared to maceration, which is 4.235%. 235%, while in this wound test carried out by ANOVA and DUNCAN statistical methods in both methods get the same results that are significant, which means there is a significant difference between wound healing or the effect of the extract given. Dragon scale leaves with a percentage of 80% provide the best wound healing process, so it can be concluded that the two methods do not have much difference, it's just that when testing the total flavonoid content obtained the largest amount in the maceration method.
Formulasi Sediaan Facial Wash Dari Ekstrak Etanol Kulit Pisang Raja (Musa Paradisiaca L.) Secara In Vitro Julianty, Siti Muliani; Nadia, Syarifah; Yushfi, Melza Rizqan
Journal of Pharmaceutical and Health Research Vol 6 No 2 (2025): June 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i2.6392

Abstract

Banana peel (Musa paradisiaca L.) has long been known to have various substances that are beneficial to health. The use of ethanol extract as a solvent also shows great potential to extract bioactive compounds from natural ingredients. One of the most common skin care products used in the skin care industry is Facial Wash. This product is made to cleanse and care for facial skin, such as acne control, anti-aging, or other skin care. This study aims to make a facial wash preparation with active ingredients from natural ingredients, so that it is rational to use as a facial cleanser. The basic facial wash is made first with a mixture of facial wash bases formulated into 4 formulas with varying concentrations. Evaluation of the preparation includes organoleptic tests, homogeneity, pH, spreadability, and irritation tests. All formulas with various homogeneous concentrations, pH 6 - 8, are stable in storage for 8 weeks. The results of the spreadability test meet the requirements of 5-7 cm, the average viscosity ranges from 30.7-34 cPs, the average foam height ranges from 4.0 - 6.2 cm and the results of the irritation test show that it does not cause irritation to the volunteer's skin.
Pengaruh Campuran Ekstrak Etanol Buah Pare dan Biji Pinang Terhadap Kadar Testosteron Tikus dengan Menggunakan Metoda ELISA Sofia, Vivi; Rahmawanti, Salsabila
Journal of Pharmaceutical and Health Research Vol 6 No 2 (2025): June 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i2.6580

Abstract

Testosterone is a hormone that plays an important role in sexual development and reproductive function. Infertility problems, decreased libido and erectile dysfunction are closely related to decreased testosterone levels in the blood. This study aims to see the effect of a mixture of ethanol extracts of bitter melon (Momordica charantia L.) and areca nut (Areca catechu L) on testosterone levels in male white rats. This study used the Sexual Behavior method. 30 Wistar rats were divided into 5 groups consisting of distilled water control, positive control (X-Gra®) 45 mg/kg BW, ethanol extract of bitter melon (EEBP) dose of 100 mg/kg BW, ethanol extract of areca nut (EEP) dose of 50 mg/kg BW and mixed group of EEBP:EEP (1:1), after 15 days, blood samples were taken and testosterone levels were analyzed. The data obtained were statistically analyzed with one-way ANOVA test and continued with Tukey's HSD test with 95% confidence level (p<0.05) using SPSS ver.20 software. The results showed that testosterone levels in the EEBP group at a dose of 100 mg / kg BW and a mixture of EEBP: EEP (1: 1) of 2.31 ± 0.84 ng/ml and 1.65 ± 0.54 ng/ml were not significantly different when compared to the distilled water control group (p < 0.05). Testosterone levels in the EEP group at a dose of 50 mg/kg BW of 3.43 ± 0.98 ng/ml showed a significant difference with the aquades control group (p<0.05). The mixture of bitter melon ethanol extract at a dose of 100 mg/kg BW and areca nut seeds at a dose of 50 mg/kg BW was not able to increase testosterone levels, while the ethanol extract of areca nut seeds given singly at a dose of 50 mg/kg BW could increase testosterone hormone levels in male white rats. Based on the results obtained in this study, it can be concluded that a mixture of bitter melon ethanol extract at a dose of 100 mg / kg BW and areca nut seeds at a dose of 50 mg / kg BW is not able to increase testosterone levels, while areca nut ethanol extract given singly at a dose of 50 mg / kg BW can increase testosterone levels in male white rats.
Pemanfaatan Kolagen Tulang Ayam Broiler dalam Sediaan Serum: Nilai SPF, Eritema, Pigmentasi, Kelembapan Kulit Suleman, Abdul Wahid; Safaruddin, Safaruddin; Mustamin, Sharnawati; Wahyuningsih, Sri; Jannah, Miftahul
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8459

Abstract

Chicken bones (Gallus gallus domestica) are a type of solid waste that contain protein sources in the form of collagen. Collagen is one of the main connective tissue proteins in animals, widely used as a biomedical material, and is effective as an anti-aging agent that helps prevent the appearance of aging signs on the skin. This study aims to determine the potential of broiler chicken bone collagen in serum formulations as a photoprotective, anti-pigmentation, and skin moisturizing agent. The research method used was an in vitro experimental method using a UV-Vis spectrophotometer. Collagen was extracted using NaOH and CH₃COOH 1 M, and serum formulations were prepared with concentrations F1 (1%), F2 (1.5%), F3 (2%), and F4 (2.5%). The SPF value, erythema and pigmentation levels, as well as skin moisture, were then determined. The results of the serum formulation showed physical and chemical stability, indicated by no significant differences before and after the cycling test in organoleptic, pH, homogeneity, viscosity, and spreadability evaluations. The SPF values of the serum preparations were: F1 (1%) = 2.814999, F2 (1.5%) = 3.287317, F3 (2%) = 4.659954, and F4 (2.5%) = 8.574363. The %Te and %Tp tests showed that F0 (without extract) fell under the “Sunblock <1” category, while F1, F2, F3, and F4 were categorized as “Fast tanning” with values between 45–86. In conclusion, this study demonstrates that chicken bone extract can be formulated into a serum preparation that is physically and chemically stable. The best SPF, %Te, and %Tp values were obtained in the F4 formula, categorized as optimal, with %Te and %Tp values in the fast tanning category. Additionally, the F4 formula increased skin moisture by 5%.
Aktivitas Antibakteri dan Formulasi Krim Dari Ekstrak Etanol Daun Kemangi (Ocimum basilicum L.) dan Daun Kari (Murraya koenigii L.) Safrina, Safrina; Novita, Eva; Mardhatillah, Mardhatillah; Syaddry, Alfi Yanna
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8510

Abstract

The use of medicinal plants as active ingredients in topical formulations has been increasingly explored as a natural alternative to synthetic antimicrobial agents. This study aimed to formulate and evaluate a topical cream containing a combination of ethanolic extracts of curry leaves (Murraya koenigii L.) and basil leaves (Ocimum basilicum L.) as a natural antibacterial agent against Staphylococcus aureus. The extracts were prepared through maceration using 96% ethanol, followed by phytochemical screening and antibacterial testing using the well-diffusion method against Staphylococcus aureus ATCC 25923. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, phenolics, saponins, and steroids in both extracts. The antibacterial assay showed that the 1:1 extract combination produced an average inhibition zone of 14.17 mm, classified as strong and exhibiting a partial synergistic effect compared with single extracts. Several oil-in-water (O/W) cream formulations were then developed to determine optimal physical stability. Formula F2 (2:1) demonstrated the best physical stability, with pH 6 ± 0.1, spreadability of ±5 cm, adhesion time >140 seconds, and viscosity of 4500–5000 cP, all meeting the SNI 16-4399-1996 standard. These findings indicate that the 1:1 combination ratio provides the highest antibacterial activity, while the 2:1 ratio yields the most stable physical characteristics, suggesting that both can serve as the basis for developing a safe, stable, and effective natural topical antibacterial cream against Staphylococcus aureus.
Formulasi Sediaan Masker Peel off dari Ekstrak Buah Batok Aceh (Limonia Acidissima L.) Sebagai Pencerah Kulit Mukhlisa, Ida; Riska, Riska; Mardiana, Rosa; Yusrawati, Yusrawati
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8385

Abstract

Batok fruit or known as Limonia acidissima is a fruit commonly found in South and Southeast Asia, with content that has the potential to provide benefits for skin health. Batok fruit contains many antioxidants that can improve skin brightness. This study aims to formulate and evaluate the physical characteristics of peel-off mask preparations to brighten the skin containing Aceh batok fruit extract (Limonia acidissima). The extract was obtained by maceration method using 96% ethanol solvent. The mask preparations were made in four formulations: F0 as a base without extract, and F1, F2, and F3 with extract concentrations of 10%, 20%, and 30%, respectively. Evaluation of the quality of the preparations included organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and irritation test. The results showed that the addition of the extract affected the color of the preparation from yellow to yellowish brown and gave the extract a distinctive aroma. All formulas were proven safe, with pH values ​​within the physiological range of the skin (6.2-6.4) and did not irritate the panelists' skin. The drying time for all formulas was uniform, at 15 minutes. Formula F3 (30% extract) demonstrated the best spreadability (4.5 cm) compared to the other formulas. However, all formulas showed inhomogeneous results and had adhesion below the ideal standard for topical preparations, which is less than 2 seconds. It was concluded that formula F3 was the most optimal among those tested because it had the best spreadability, did not cause irritation, and improved skin brightness after washing for 1 week. However, further research is needed to improve the homogeneity and adhesion of the formulations.

Page 17 of 18 | Total Record : 174

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