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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 189 Documents
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Pengaruh Amilum Singkong (Manihot esculenta, Crantz) Native dan Pregelatinized Terhadap Laju Disolusi Tablet Parasetamol Ngurah Agung Dewantara Putra, I Gusti; Murwanti, Retno; Rohman, Abdul; Nanda Saifullah Sulaiman, Teuku
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Amylum is widely used as an excipient in pharmaceutical formulations, one of which is inert and can be mixed with any drug without causing a chemical reaction. The aim of this research is to know the preparation method of cassava amylum (Manihot esculenta, Crantz) native and pregelatinized which is used as binder to dissolution rate of paracetamol tablet with granulation method. The native and pregelatinized amylum produced from cassava is carried out by a preliminary test to determine the nature of physical characteristics and to know the ability as a binder of the tablet. The paracetamol tablets produced from the two methods were tested dissolution using medium buffer phosphate at 37 ± 0,5 ° C (pH 5.8, 50 rpm). The results showed that cassava starch preparation method had an effect on dissolution rate of tablet. Pregelatinized amylum as binder on paracetamol tablet showed Q value (93,17 ± 0,01)% while native amylum showed value of Q (81,76 ± 0,20)%. The use of pregelatinized cassava starch as a binder on paracetamol tablet has better characteristic properties compared with native starch.
Modul Edukasi Untuk Peningkatan Pengetahuan Orang Tua dalam Melatih Anak Cerebral Palsy di Yogyakarta Awanis, Almas; Astriyana, Sevy
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
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In Indonesia, children with cerebral palsy (CP) are classified into groups of Children whit special needs with a low prevalence of occurance. From the prefalence of low incidence does not mean without problems for parents in taking care of children with cerebral palsy. Support for children with special needs is proven by Yogyakarta being designated as a Child-Friendly City in 2016. However, in the preliminary study carried out there was still a rare exercise program carryout at home for supporting the achievement of training program for children with cerebral palsy. So, there needs to be education in form of modules that can help parent do the home program of exercise. This research was quantitative research with one group pre and posttest design. The study was conducted on Forty parents (biological relatives or babysitters) who accompanied children with CP sisorders during therapy session at the Rehabilitasi Medik RSA UGM, RSUD Yogyakarta and Wahana Keluarga Cerebral Palsy (WKCP) community. Bivariable analysis uses the paired t-test to find out the differenceinfluence before and after being given an educational module. Bivariable analysis showed that have an influence of education module distribution on the improvement of competence with the mean difference of 1.6 (p < 0,001). The result showed was an increase in parental knowledge of providing education module to perform home program for their children with cerebral palsy disorders.
Problem Kompatibilitas dan Stabilitas Pencampuran Sediaan Intravena Pada Pasien Anak di RSUP Dr. Sardjito Rahmawati, Reza; Rahmawati, Fita; Azhar Syed Sulaiman, Syed
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
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Inappropriate preparation and administration intravenous drug may caused harm and therapeutic failure for the patient. In pediatric patient, intravenous drug administration is very critical because of poor venous access especially when simultaneously drug administration required which is can lead into incompatibilities occurence. Errors in intravenous drug administration can affect the drug stability also. Therefore, this research aims to investigate the prevalence of incompatibility and stability in pediatric hospitalized patient. This research was done with prospective study at RSUP Dr. Sardjito in Pediatric Intensive Care Unit (PICU) and pediatric ward from November-December 2017. Data collection was done with pediatric hospitalized patient that used at least 1 intravenous drug. Compatibility and stability were analyzed using standard reference Handbook of Injectable Drugs and other references. A total pediatric hospitalized patients are 75 patients, 34 patients are from PICU and 41 patients are from pediatric ward. Intravenous drugs used are 49.1% with the mean of intravenous drugs are 3.3 drugs/patient. Compatible drug combinations are 73.3% and unknown are 26.3%. There are no incompatible drug combination found in this research. Stability problems were found in 3 drug combination that administered by continuous infusion.
Formulasi Dan Uji Aktivitas Tabir Surya Gel Kitosan Menggunakan Karbopol 940 Dan Hpmc K100 Sebagai Gelling Agent Ahmad Fahrezi, Mukhlis; Nopiyanti, Vivin; Priyanto, Widodo
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
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Ultraviolet (UV) radiation can penetrate the epidermis layer of the skin so that it can irritate and damage skin tissue. Chitosan containing chitin compounds has the potential to provide protection against ultraviolet (UV) exposure. This study aims to determine the activity of chitosan gel sunscreen seen from the SPF value, the influence of the use of variations in concentration in a combination of carbopol and HPMC as a gelling agent on the activity of chitosan gel sunscreens, concentration variations in the combination of carbopol and HPMC which are able to provide good physical properties and gel stability. The variation of concentration in the combination of carbopol and HPMC as a gelling agent was made into 3 formulas, F1 (100% carbopol: 0% HPMC), F2 (50% carbopol: 50% HPMC), F3 (0% carbopol: 100% HPMC). Chitosan gel sunscreen activity test was carried out with the SPF (Sun Protection Factor) test using UV-VIS spectrophotometry. The SPF value price is calculated using the mansyur method. SPF test results were statistically analyzed using One Way ANOVA. SPF test results from variations in concentration in a combination of carbopol and HPMC as a gelling agent, F1 (9,091348), F2 (5,419107), F3 (6,437869). SPF test results that were statistically analyzed using One Way ANOVA showed that all the data tested were significantly different from the most active formula, F1 (100% carbopol: 0% HPMC) with the SPF value price 9,091348.
Uji Daya Hambat Rebusan Daun Kitolod (Hippobroma longiflora) Terhadap Pertumbuhan Staphylococcus aureus Puji Hastuti, Handayani; Prian Nirwana, Ardy
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
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Conjunctivitis is inflammation of the conjunctiva. One of the bacteria that causes conjunctivitis most often is Staphylococcus aureus. Hippobroma longiflora is widely used by traditional people to treat eye disorders such as conjunctivitis because it has antimicrobial substances such as flavonoids, saponins, and alkaloids. This study aims to determine the radical zones that can be formed from the decoction of H. longiflora leaves against the growth of S.aureus. This research method is descriptive experimental. The sampling technique used was quota sampling. This study used a negative control with sterile distilled water and a positive control for 30 µg chloramphenicol. The decoction of H. longiflora leaves can inhibit the growth of S. aureus as indicated by the results obtained that form a radical zone of each concentration variation of 20%, 40%, 60%, 80%, and 100% respectively 6.18 mm. 6.23 mm, 6.68 mm, 7.20 mm and 8.18 mm.
Pengaruh Ekstrak Alpinia galanga L Terhadap Produksi Biofilm pada Escherichia coli Wahyudi, Didik; Wael, Syahran
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
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Escherichia coli is a Gram-negative rod-shaped bacteria, capable of causing infection in several parts of the body, and has been found to be resistant to various antibiotics, one of the contributing factors is its ability to form biofilms in tissues. Alpinia gallanga L has the ability to inhibit biofilm formation against several bacteria. The purpose of this study was to determine the ability of Alpinia galangl L extract in inhibiting the production of Escherichia coli biofilm. This research began with the extraction of galangal rhizome with ethanol using the masersion method, then made the concentrations of 10%, 20%, 30%, 40%, and 50%. Escherichia coli was isolated from cases of Urinary Tract Infection (UTI). then do the physiological characterization and sensitivity test to antibiotics. Inhibition test for Escherichia coli biofilm was carried out using the microtiter plate culture method using a spectrophotometer at a wavelength of 595nm. The measurement results of biofilm production were 0.1% Optical Density crystal violet value, each treatment used 8 replications, the data obtained were analyzed by One Way Anova. . The results showed that the extract of Alpinia galanga L was able to inhibit the production of Escherichia coli biofilm at a concentration of 30%.
Identifikasi Potensi Interaksi Obat pada Peresepan Pasien Rawat Jalan Diabetes Melitus Tipe 2 dengan Hipertensi di RSUD dr. Soediran Mangun Sumarso Wonogiri Syahrullah Murwati, Isna; Murtisiwi, Lusia
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
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This study aims to determine the prescription profile of diabetes mellitus type 2 with hypertension include classes and types of drugs and the potential of drug interactions theoretically, based on the mechanism drug interactions in outpatient installation of RSUD dr. Soediran Mangun Sumarso Wonogiri 2018. This research is a non-experimental study with descriptive retrospective. The data collected from medical records of patients between period January-June 2018 are identified based on the literature and processed by calculating the percentage. Class of diabetes drugs most widely used is a sulfonylurea (19,64%) and hypertension drug classes ARB (19,03%). Types of diabetic drugs most widely used was glimepirid (17,33%) and hypertension was irbesartan ( 17,21%). The percentage result of drug interactions theoretically was 62% (106 patiens), drug interactions type that the most occured was pharmacodynamic interactions 64,5%.
Uji Aktivitas Antihiperglikemia Ekstrak Etanol Daun Delima Putih (Punica granatum L.) pada Mencit Jantan (Mus musculus L.) yang Diinduksi Aloksan Pangesti, Clara; Nopiyanti, Vivin; Hayu Widyasti, Jena
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
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Pomegranate leaves (Punica granatum L.) contain flavonoids as a decrease in blood glucose levels and prevent tissue damage due to oxidative stress. This study aims to determine the effect of white pomegranate leaf ethanol extract on blood glucose levels, body weight, and the effective dose of white pomegranate leaf ethanol extract in reducing blood glucose levels in mice induced by alloxan. A total of 30 male mice were divided into 6 treatment groups, namely group I (normal), group II (negative control of CMC-Na 0.5%), group III (positive control of glibenclamide), group IV (extract 140 mg/Kg BW), group V (extract 280 mg/Kg BW) and group VI (extract 560 mg/Kg BW). The treatment was given for 14 days by measuring blood glucose levels and body weight on days 0, 3,10, and 17. The results of the analysis of blood glucose levels and body weight were carried out statistically through the Multivariate Test and Tukey Post Hoc test, while the decrease in glucose levels analyzed using One-Way Anova test and Tukey Post Hoc test. The results showed that the extract had antihyperglycemic activity in alloxan-induced mice. The ethanol extract of white pomegranate leaves at a dose of 280 mg/Kg BW had an effective antihyperglycemic activity compared to doses of 140 mg/Kg BW and 560 mg/Kg BW which were comparable to the positive control group.
Formulasi Mouthwash Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr) dengan Variasi Konsentrasi Gliserin sebagai Antibakteri Terhadap Streptococcus mutans ATCC 25175 Maharani, Novita; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
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Dental caries is a major disease in problems in the oral cavity especially in the teeth. The main cause of dental caries is the bacterium Streptococcus mutans which is a normal inhabitant of the oral cavity. Dental caries can be overcome using a mouthwash preparation containing antibacterial substances. Pineapple skin (Ananas comosus (L.) Merr) is one of the plants that contains substances that have antibacterial activity. The purpose of this study was to determine the physical quality and stability, and activity antibacterial of mouthwash pineapple skin extract. Pineapple skin extract was made in three mouthwash formulations using various concentrations of glycerin 5%, 10%, and 15%. Mouthwash were tested for physical quality and stability. Antibacterial activity test against Streptococcus mutans ATCC 25175 using the well method. The data obtained are presented in the form of tables and graphs processed with SPSS ver22 with the Paired T-Test method for testing viscosity and testing pH and ANOVA for measuring the diameter of the inhibition zone. The results showed that mouthwash preparations in all formulas with organoleptic physical qualities, viscosity, and stability produced good preparations, while in testing the physical quality of the pH did not meet the pH requirements of mouthwash preparations because of the influence of pineapple skin extract (Ananas comosus (L.) Merr). In testing the antibacterial activity of mouthwash, the diameter of the inhibition zone was obtained the base 0 mm; F1 11.08 mm; F2 13.08 mm; F3 15.08 mm; and control positive 16,75 mm.
Uji Ketoksikan Akut Ekstrak Etanol Kangkung darat (Ipomoea reptans Poir) dan air (Ipomoea aquatic Forsk) Menggunakan Metode OECD 423 Hesti Wulan S, A.Ariani; Putri Sekar Langit, Navtalina
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
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Kangkung have two types, namely Ipomoea reptans Poir and Ipomoea aquatic Forsk. Spinach can be used for herbal terapy including sedative, hypnotic, antidiabetic, analgetic and anxiolytic. Herbal medicine are used for a long time, which is more than a week, so it is necessary to know their safety so that they do not cause unwanted harmful effects. The purpose of this study was to determine the effect of toxicity and to determine the LD50 value of ethanolic extract Ipomoea reptans Poir and Ipomoea aquatic Forsk using the OECD 423 method. This study used mice as test animals, Mus musculus, using a dose of 300 mg/KgBW, followed by a dose of 2000 mg/KgBW. Given orally once during the treatment, physical symptoms such as cyanosis, seizures, respiratory rate for the first 4 hour and the number of deaths were calculated. Observations were continued until day 14. If death occurred in the first 24 hours, it was repeated. The results of py phytochemical screening of ethanol extract Ipomoea reptans Poir and Ipomoea aquatic Forsk were positif for flavonoids, tannins, steroidal, saponins, and vitamins C and E. Based on the results of observations, the number of deaths was then adjusted to GHCS ethanol extract Ipomoea reptans Poir and Ipomoea aquatic Forsk LD50 > 2000-5000 mg/KgBW

Page 16 of 19 | Total Record : 189

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