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Jurnal Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Nasional
ISSN : 23027436     EISSN : 26568950     DOI : https://doi.org/10.37013/jf
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
JURNAL FARMASI (Journal Of Pharmacy) adalah jurnal ilmiah resmi yang dikeluarkan oleh Sekolah Tinggi Ilmu Kesehatan Nasional dengan nomor p-ISSN 2302-7436 e-ISSN 2656-8950. JURNAL FARMASI (Journal Of Pharmacy) berisikan jurnal-jurnal ilmiah dalam semua aspek ilmu pengetahuan dan teknologi di bidang Farmasi dan kesehatan antara lain: Farmakognosi dan Fitokimia meliputi Pengembangan Simplisia, Budidaya Tanaman Obat, Isolasi, Skrining Fitokimia, dan Identifikasi Obat Bahan Alam Indonesia. Biologi meliputi Biologi Molekuler, Bioteknologi, Mikrobiologi, Immunologi, Parasitologi, Biomedisinal Teknologi Farmasi meliputi Farmasetika, Teknologi dan Formulasi Sediaan Obat, Teknologi dan Formulasi Sediaan Obat Bahan Alam Indonesia. Ilmu Kimia meliputi Kimia Analisa, Kimia Organik, Sintesa Obat, Kimia Medisinal, Pemodelan Molekul, Biokimia, dan Kimia Lingkungan. Farmakologi meliputi Farmakologi, Farmakokinetik, Farmakoterapi, dan Toksikologi. Farmasi Klinik dan Komunitas meliputi Farmakoekonomi, Farmakovigilan, Analisis dan Evaluasi Penggunaan Obat, Monitoring Efek Samping Obat, Analisa Kebijakan Kefarmasian, Evaluasi kegiatan Kefarmasian, Evaluasi Efektifitas Penggunaan Obat, Evaluasi Kualitas Hidup Pasien.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 193 Documents
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Analisa Karakteristik Mutu Sabun Padat Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Berbahan Dasar Minyak Jelantah Mita Susanti, Maria; Toni Juliantoro, Benediktus
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The use of used cooking oil can cause various diseases when consumed and will even cause environmental pollution if disposed of without processing. Therefore, efforts need to be made to utilize used cooking oil into products that can increase economic value, one of which is oil-based products such as solid soap. A good soap is not only able to clean the skin from dirt, but also contains substances that can counteract the effects of free radicals such as antioxidants. Mangosteen rind (Garcinia mangostana L.) is a source of natural antioxidants containing xanthones with an IC50 of 2.710 ppm. This study aims to make and analyze the quality characteristics of solid soap mangosteen rind extract based on used cooking oil. This study analyzed the quality characteristics of solid soap preparations including organoleptic tests, pH, free fatty acid levels, foam stability, water content and free alkali levels. Data analysis was done descriptively. The results showed that the quality characteristics of solid soap were in accordance with the quality requirements, namely organoleptic solid form, pH 10, foam stability 89.33%, moisture content 14.33%, free fatty acid content 1.54% and free alkali content 0.07%.
Pembentukan Biofilm Pseudomonas aeruginosa pada Beberapa Media Cair Wahyudi, Didik; Sutariningsih Soetarto, Endang
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Pseudomonas aeruginosa is a Gram-negative rod-shaped bacterium that is an opportunistic pathogen that is the main cause of nosocomial infections and is able to form biofilms on growth media, biofilms often make the treatment of infectious diseases more difficult. There are several types of bacterial growth media, compositions and brands. The purpose of this study was to determine the ability of P. aeruginosa to form biofilms on several liquid culture media. P. aeruginosa was isolated from clinical samples from hospitals, the liquid media used were nutrient broth, lactose broth, brain-heart infusion (BHI), luria bertani broth, and tripticase soy broth. The biofilm formation test used the microtiter plate culture technique method, the ability to form biofilms was measured based on optical density using a microtiter plate reader at a wavelength of 570nm, with 0.1% crystal violet staining, after 24 hours incubation at 37oC, with 8 replications. The results showed that P. aeruginosa had the ability to form biofilms in nutrient broth 0.926±0.081, lactose broth 0.521±0.041, BHI 1.283±0.031, luria bertani 1,301±0.043, and trypticase soy broth media 1.563±0.032. The highest biofilm formation was in trypticase soy broth, and the lowest was in lactose broth, while in BHI and luria farming media the biofilm formation abilities were equivalent. The conclusion of this study is that P. aeruginosa has different abilities in forming biofilms when grown on different liquid media.
Efektivitas Rendaman Daun Jati (Tectona grandis Linn.f) Dalam Mewarnai Stadium Telur Parasit STH (Soil Transmitted Helminth) Hastuti, Puji; Haryatmi, Dwi
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Worm disease is a health problem that is widely found in the world, nearly 2 billion people are infected with the Soil Transmitted Helminth (STH). Worms belonging to STH are Ascaris lumbricoides, Trichuris trichiura and hookworms (Ancylostoma duodenale and Necator americanus). The diagnosis of intestinal worms is confirmed by microscopic examination of the feces supported by staining. Eosin and lugol have been used as dyes on microscopic examination of feces. Teak leaf (Tectona grandis Linn.f) contain anthocyanin compounds that can be used as natural dyes. The purpose of this study was to determine the ability of soaked teak leaf to color the egg stage of the STH parasite when compared with eosin 2% and lugol 2%. The stool examination method used was sedimentation method. The teak leaf soak was obtained by soaking teak leaf with ethanol 96% and concentrated HCL for 24 hours. The results of staining using teak leaf gave an effective value of 100% on Ascaris sp. ang Trichuris sp. eggs, and gave an effective value of 66,7% on Hookworm eggs. Based on the Chi-square test calculations and the Fisher Exact tables, it can be determined that the teak leaf has such significant capabilities as eosin 2% and lugol 2% in coloring the eggs stage of the STH parasites.
Penentuan Nilai SPF pada Serum Fraksi Etil Asetat Ekstrak Etanol Kelopak Bunga Rosela (Hibiscus sabdarifa L.) Nopiyanti, Vivin; Harjanti, Reslely; Aisiyah, Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/0c0qrh09

Abstract

The ethyl acetate fraction of the ethanol extract of roselle flower petals (Hibiscus sabdariffa L.) was reported to have an SPF value of 13.83 ± 1.50 which was higher than the ethanol extract. So with the SPF value, the ethyl acetate fraction of roselle flower ethanol extract can be used as a sunscreen. One of the cosmetic preparations that is currently growing rapidly is serum. The purpose of this study was to formulate the ethyl acetate fraction of roselle petals into a serum that had good physical quality with variations in the concentration of xanthan gum and then the SPF value was determined. This research begins with the manufacture of ethanol extract of roselle petals. Then fractionation (liquid-liquid partition) was carried out using solvents with different polarities, namely n-hexane and ethyl acetate. Furthermore, the ethyl acetate fraction was formulated into serum with variations in the concentration of xanthan gum 0.3%, respectively; 0.6% and 1.2% were then tested for physical quality and stability. The next step is to determine the SPF value of the serum by using the UV spectrophotometric method and its calculation using the Mansur equation. The results showed that the serum ethyl acetate fraction of the ethanolic extract of roselle petals could be made into gel preparations with good physical qualities including organoleptic, viscosity, pH and homogeneity. Serum ethyl acetate fraction ethanol extract of roselle flower formulas 1, 2 and 3 had SPF values ​​F1 respectively, namely 6.8595 ± 0.08 which included moderate protection potential; F2 is 7.0089 ± 0.17; and F3 which is 8.2251 ± 0.32 with extra protection potential. Variations in the concentration of xanthan gum in the serum formula affect the physical quality of the viscosity and potency of sunscreen preparations.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI Staphylococcus aureus PAPERSOAP EKSTRAK DAUN SIRSAK (Annona muricata L.) DENGAN VARIASI GLISERIN SEBAGAI PLASTICIZER Samsudin, Din; Nopiyanti, Vivin; Nilawati, Anita
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/xrkc0m26

Abstract

Papersoap is a thin printed solid soap product as a unique innovation because it resembles paper. Soursop leaves contain flavonoid compounds, tannins, alkaloids and saponins that are useful as antibacterial. preparations papersoap with soursop leaf extract require glycerin as a plasticizer is believed to produce good physicochemical properties. This study aims to determine the physical quality of papersoap from the effect of soursop leaf extract and variations of glycerin and to test the antibacterial activity of the Papersoap against Staphylococcus aureus ATCC 25923. Soursop leaf extract was obtained by maceration method with 96% ethanol as solvent. The concentration of soursop leaf extract 5% was formulated into papersoap with three variations of glycerin formula, namely 10%, 15%, and 20%.preparation papersoap includes organoleptic, pH, homogeneity, foam stability, water content, and free alkali tests which have passed the curing for two weeks as the preparation evaluation stage. Antibacterial activity test against Staphylococcus aureus ATCC 25923 using well diffusion method. The data obtained were processed using Shapiro-wilk, one way ANOVA/Kruskal. The results showed that the formula of the papersoap preparation of soursop leaf ethanol extract (Annona muricata L.) with glycerin variations can provide differences in the physical quality of papersoap preparations and have an inhibitory diameter against Staphylococcus aureus bacteria ATCC 25923 successively 25.26; 24,67; 23.47 mm.
OPTIMASI SEDIAAN GUMMY CANDY PARASETAMOL DENGAN VARIASI KONSENTRASI GELATIN DAN GLISERIN MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN Nisa, Zaitun; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/35yaf041

Abstract

Paracetamol gummy candy is a chewy candy that is composed of a mixture of sweeteners and hydrocolloid components containing paracetamol and is designed to crumble and melt on the tongue. This study aims to see the effect of variations in the concentration of gelatin and glycerin on the physical quality of paracetamol gummy candy preparations, and to determine the best concentration of gelatin and glycerin to obtain paracetamol gummy candy preparations with optimum physical properties. Preparation of the preparation using the casting method and using 8 formula designs from Design Expert Simplex Lattice Design with a ratio of gelatin and glycerin concentrations. The results of the physical quality test with the critical parameters of elasticity and moisture content were analyzed using the Simplex Lattice Design method. This method can be used to optimize the dosage formula in various variations in the amount of material composition, so as to produce the optimum formula with the expected physical characteristics. The results showed that gelatin had more effect on elasticity and glycerin had more effect on the water content of paracetamol gummy candy. The proportions of gelatin 998,723 mg and glycerin 51.277 mg resulted in the optimum formula with the best elasticity and water content of gummy candy paracetamol.
IDENTIFIKASI INTERAKSI OBAT PADA PERESEPAN PASIEN DIABETES MELLITUS TIPE 2 DI PUSKESMAS X Khusna, Khotimatul
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/d2sp8553

Abstract

Indonesia occupies the top ten countries with the highest population of people with Diabetes Mellitus in the world, which is ranked 5th with a range of 19.5 million people, and it is estimated that in 2045 it will increase to 28.6 million. Diabetes Mellitus is a chronic disease that is often accompanied by complications. This can lead to drug interactions. Drug interactions can affect the body's response to treatment. The purpose of this study was to determine the percentage of drug interactions on prescriptions received by patients with Type 2 Diabetes Mellitus at a health center in Surakarta. This research is a descriptive observational study. Data collection was carried out retrospectively through tracking records of drug use by patients with Diabetes Mellitus Type 2 at Puskesmas X. The sample in this study was all prescriptions for patients with Diabetes Mellitus Type 2 in April-December 2018. The results showed that the most prescribed antihyperglycemic drugs were 38, 89%, analgesics 16.20%, vitamins 14.2%, and antihypertensives 12.19%. The types of drugs that were most widely used in prescriptions were metformin at 18.98%, amlodipine at 11.57%, and paracetamol at 8.64%. The potential incidence of drug interactions is 62.5% of prescriptions. The conclusion of this study showed that the potential for pharmacokinetic drug interactions was 1.36%, the potential for pharmacodynamic drug interactions was 46.94%, and the incidence of unknown drug interactions was 51.70%.
UJI ANTIINFLAMASI TOPIKAL SEDIAAN KRIM FRAKSI ETIL ASETAT DAUN JOHAR (Cassia siamea L.) TERHADAP MENCIT PUTIH Nandia Apriyanti, Audri; Pratimasari, Diah; Wisnu Kusuma, Eka
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 1 (2023): Jurnal Farmasi (Journal of Pharmacy), April 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/es2f1c91

Abstract

Johar leaves contain chemical compounds, there are alkaloids, saponins, tannins, flavonoids, barracol, sitosterol. This study aims to determine the anti-inflammatory effect of the johar leaf ethyl acetate fraction topically, to determine the optimum concentration of johar leaf ethyl acetate fraction in cream preparations, and to determine the physical properties of the johar cream and cream stability. The leaves of johar (Cassia siamea L.) were extracted using the maceration method with 70% ethanol. The ethanol extract of johar leaves was fractionated with water, n- hexane and ethyl acetate as solvents. The ethyl acetate fraction of johar leaves was made cream with a concentration of 2.5%, 5% and 10%. The basis and the three formulas were tested for the physical quality of the cream including the organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type, pH and cream stability. The anti- inflammatory effect was determined by measuring the thickness of the back skin of the mice. The data obtained were analyzed statistically One Way Anova with a confidence level of 95% to determine that there were significant differences between treatment groups. The results showed that the leaf ethyl acetate fraction cream could provide topical anti-inflammatory effects on carrageenan-induced white mice with an effective concentration of 5% with (% PI) of 36.67%. The ethyl acetate fraction of johar leaves with a concentration of 2.5% and 5% fulfilled the requirements for the physical properties of the cream, but the cream with a concentration of 10% did not meet the requirements in the pH test. And the ethyl acetate fraction cream of johar leaves was stable in 1 month storage
UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP Staphylococcus epidermidis Wandan Wisdyafanny, Marcelina; Silviani, Yusianti
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 1 (2023): Jurnal Farmasi (Journal of Pharmacy), April 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/050nm603

Abstract

Acne vulgaris or acne can be caused by bacteria, one of them is Staphylococcus epidermidis which will produce lipolytic enzymes that turn sebum into a solid mass, then it will clog the ducts of the sebaceous glands. Nutmeg leaves contain saponins, triterpenoids, tannins, and flavonoids used as an antibacterial. The purpose of this study was to determine the inhibition of the ethanol extract of nutmeg (Myristica fragrans Houtt) leaves on the growth of Staphylococcus epidermidis. This study used a descriptive experimental research method to determine the antibacterial effectiveness of the ethanol extract of nutmeg (Myristica fragrans Houtt) leaves against Staphylococcus epidermidis. The data source for this study was primary data based on the results of the inhibition zone on Staphylococcus epidermidis by administering ethanol extract of nutmeg (Myristica fragrans Houtt) with concentrations of 20%, 40%, 60%, 80%, and 100%. The results showed that the ethanol extract of nutmeg leaves could be used as an antibacterial against Staphylococcus epidermidis. The average diameter of the inhibition zone of nutmeg leaf extract formed at 20% concentration was 10,45 mm, at 40% concentration was 11,4 mm, at 60% concentration was 11,9 mm, at 80% concentration was 12,35 mm, and at a concentration of 100% that is equal to 12,6 mm. The concentration of 100% was able to inhibit Staphylococcus epidermidis with the widest average diameter of the inhibition zone, which was 12,6 mm.
KAJIAN ETNOFARMASI PENGGUNAAN TUMBUHAN OBAT SEBAGAI ALTERNATIF PENGOBATAN DIARE OLEH MASYARAKAT SUKU OSING DUSUN KRAJAN Septa, Amira; Hartono; Dian Anggraini, Truly
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 1 (2023): Jurnal Farmasi (Journal of Pharmacy), April 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/rn63em44

Abstract

Diarrhea is a disease that is still a health problem worldwide, including Indonesia. Diarrhea is included in the top 10 diseases that still occur frequently and is ranked 5th in the Osing Tribe. The Osing tribe community treats diarrhea by utilizing plants as medicinal plants that are used from generation to generation. This study was conducted to determine the use of ethnopharmaceuticals in the Osing tribe as a preliminary study for the development of traditional medicine by the Osing tribe as a standardized herbal medicine or phytopharmaca. This research is a descriptive study using qualitative methods with snowball sampling techniques through open- ended interviews with filling out informant information sheets and involving 22 community informants from the Osing tribe, Krajan Hamlet, Kemiren, Glagah, Banyuwangi, East Java. The results of ethnopharmaceutical research in the Osing tribe showed that there were 8 types of plants used for the treatment of diarrhea. Analysis using ICF (Informant Consensus Factor) with a result of 0.6 means that the plant is trusted and used as a hereditary treatment of diarrhea treatment. In the PPV (Plant Part Value) value analysis, which is to calculate the part of the plant used, the results obtained were 50% of the leaves, 23% of the fruit, 27% of the rhizome. Fidelity Level (FL) to determine the type of plant that is most often used in treating diarrhea with the highest result of 100% from among others Guava (Psidium guajava L.) and Cassava (Manihot esculenta).

Page 17 of 20 | Total Record : 193

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