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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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Uji Aktivitas Antioksidan Ekstrak Terpurifikasi dari Selada Laut (Ulva lactuca L.) dari Perairan Pantai Pidakan Pacitan dengan Metode DPPH (1,1-Diphenyl-2-picrylhydrazyl) Ainiyah, Nur; Erikania, Susanti; Nurmaulawati, Rina
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p61-70

Abstract

Free radicals in the absence of antioxidants can damage important cells in the body so that they can cause degenerative diseases. Natural antioxidants can be found from plants that contain phenolic compounds throughout plant parts such as wood, seeds, fruits, roots, flowers, and leaves. One plant that has antioxidant activity is sea lettuce. This study aims to determine the antioxidant activity of purified sealettuce extract results expressed with IC50. The method chosen to make lettuce ethanol extract was the maceration used 96% ethanol solvent, then purified with a split funnel using 96% ethanol solvent and n-hexane. Purified extracts was screened for phytochemicals. Furthermore, antioxidant testing was carried out with the DPPH method by UV-Vis spectrophotometry. After antioxidant testing, data and statistics were analyzed using the SPSS Independent Samples T-Test. The results of this study showed that purified extracts contained flavonoids, alkaloids, saponins, phenols and tannins. In purified extracts of sea lettuce, an average IC50 value of 47.99 ppm was obtained and an average IC50 value of 4,38 ppm was obtained. Based on the Independent Samples T-Test of purified sea lettuce extract and vitamin C showed a significant difference from each treatment as evidenced by a significance value (p < 0.05).
Tingkat Pengetahuan Swamedikasi Terhadap Penanganan Penyakit Skabies (Sarcopies scabiei) di Pondok Pesantren Se-Kota Singkawang Apriliyanti, Dea Nur; Kusharyanti, Indri; Purwanti, Nera Umilia
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p71-80

Abstract

Data obtained from the Indonesian Ministry of Health, in Indonesia the number of scabies sufferers was 6,915,135 (2.9%) out of a population of 238,452,952 people in 2017. The factor that is believed to be related to the incidence of scabies is a person's level of knowledge. This research method is quantitative with a cross-sectional approach, presenting the level of knowledge with primary data obtained through a questionnaire. The sampling technique used non-probability sampling and obtained a total of 106 respondents who met the inclusion criteria. The results of the study were 48.1% of respondents who got results in the good range, 28.3% sufficient, and 23.6% lacking.
Skrining Fitokimia, Formulasi, dan Karakteristik Fisik Sediaan Soothing Gel Daging Daun Lidah Buaya (Aloe vera (L.) Burm.f.) Sinaga, Rosalinda Mahdalena; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Rahayu, Yayuk Putri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p81-88

Abstract

Aloe vera (Aloe vera (L.) Burm.f.) can make the skin not dry quickly and feel moisturised. Soothing gel works effectively to restore skin moisture, provide comfort and a cooling effect on red and irritated skin so that the skin condition returns to normal, and prevents skin dryness. The aim of the study was to determine the various secondary metabolites in aloe vera leaf extract to determine differences in concentrations of aloe vera leaf extract in soothing gel preparations on the physical characteristics of the preparations and to determine physical changes before and after stability tests were carried out using the cycling test method. The research method was used experimental, with the independent variables varying the concentration of aloe vera leaf extract 0% (blank), 1%, 2%, and 3%, the dependent variable secondary metabolites and physical characteristics. The sample preparation method is wet sorting and other methods used are phytochemical screening, viscometry, and cycling tests. The results of the phytochemical screening showed that aloe vera leaf extract contains secondary metabolites of flavonoids, glycosides, tannins, saponins, and steroids.
FORMULASI SABUN TRANSPARAN BERBASIS MINYAK KELAPA MURNI (VCO) Ropiqa, Meri; Azmi, Khulul; Septina, Diani Ria
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p89-93

Abstract

VCO has been widely used as a base of soap formulation. It was used due to its high fatty acid contain resists to oxidation causing stinky smell. The highest abundant of fatty acid in VCO was reported as lauric acid (52%). Lauric acid was known contribute to moisturize the skin. Hence widely used as a base of soap manufacture. The type of soap formulate in this study was the transparent soap due its appealing appearance. To find the best formulation of transparent soap according to SNI. Methods: transparent soap was formulated using hot process technique with two different concentrations of VCO which were 20% and 30%. The obtained soaps were then tested using SNI criteria such as organoleptic, pH, foam stability, and fatty acid. According to T-test, it was resulted p value>0,05 showing those two formulation did not have significance differentiation on pH test and foam stability test. The fatty acid concentration test of those two formulation showed different result significantly but it was still fulfilling the SNI requirement (≤ 2,5%). The formulas obtained of transparent soap using VCO as the base was known fulfill the quality standard of SNI.
Kelayakan Kopi Robusta Dan Tawas Sebagai Bahan Dasar Deodorant Stick Netasya, Ajeng Bunga; Agustin, Eny Widhia
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p94-101

Abstract

Body odor is the decomposition of sweat compounds into acid compounds that cause odor. Body odor can be treated with deodorant cosmetics. Using deodorant triggers changes in underarm color because the alcohol content causes irritation. Research objectives 1) To determine the validity of deodorant products made from robusta coffee. 2) alum and to determine the suitability of deodorant products made from robusta coffee and alum. Data collection methods are observation, documentation, questionnaires and descriptive percentage analysis using lab tests, organoleptic tests, product validity, clinical tests and preference tests. The research results of the pH 5.78 lab test, positive vitamin C lab test, 83% organoleptic test, 82% product validation, 100% irritation clinical test, 3.5% panelist skin color level clinical test, 4% respondents, 91.6% anti-body odor clinical test, and 80% favorability test. In conclusion, product validation was declared valid, product suitability was declared suitable in organoleptic tests, lab tests, liking tests, clinical tests for irritation and body odor, and not suitable for clinical tests on skin color level. Suggestions for adding more effective ingredients by developing existing materials around and made in the form of a spray.
Uji Aktivitas Soyghurt Ekstrak Daun Pucuk Merah (Syzygium myrtifolium [Roxb] Walp.) dan Soyghurt Ekstrak Bunga Telang (Clitoria ternatea L.) Terhadap Bakteri Escherichia coli Susanti, Susanti; Afriliani, Sindy; Mardianingrum, Richa
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p102-111

Abstract

Diarrhea is a disease characterized by changes in the form of feces and an increase in the frequency of bowel movements that are more frequent than usual. One of the causes of diarrhea is infection by Escherichia coli which is a normal microflora in the human large intestine that helps the process of food spoilage, but can be pathogenic if the number increases. Red shoot leaves (Syzygium myrtifolium [Roxb] Walp.) and butterfly pea (Clitoria ternatea L.) contain anthocyanins, which are compounds derived from flavonoids which have antibacterial properties. The purpose of this study was to determine the presence of antibacterial activity in soyghurt preparations with a combination of red shoots and soyghurt leaf extract with a combination of butterfly pea flowers, and to determine the most effective concentration for inhibiting the growth of Escherichia coli bacteria using the well-diffusion method. The results showed that soyghurt red shoots leaf extract had antibacterial activity against Escherichia coli bacteria with an inhibition zone diameter of 4.60 mm at a concentration of 10% and 7.95 mm at a concentration of 20%. Whereas in soyghurt butterfly pea flower has antibacterial activity against Escherichia coli bacteria with an inhibition zone diameter of 35.35 mm at a concentration of 5%, 38.68 mm at a concentration of 10% and 40.18 mm at a concentration of 20%.
Evaluasi Rasionalitas Penggunaan Antibiotik Infeksi Saluran Kemih Bawah di Rsd Gunung Jati Cirebon Periode Januari–Desember 2022 Efriani, Like; Irawan, Ade; Yunita, Fina
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p112-118

Abstract

Urinary tract infection is an infection caused by the presence of microorganisms in the urinary tract, including the prostate bladder. Antibiotics are drugs to treat infections caused by bacteria. Giving antibiotics to people with infectious diseases aims to inhibit the growth or kill microorganisms, especially bacteria that cause disease. The aim of this research is to find out whether giving medication to patients with lower urinary tract infections at RSD Gunung Jati is rational or irrational. This research was carried out in an analytical observational manner using a retrospective research design, namely by taking patient data from medical records and prescriptions for patients suffering from lower urinary tract infections at RSD Gunung Jati, Cirebon City for the period January-December 2022. The number of samples in the study was 85 samples. according to the inclusion criteria. Statistical analysis used in this research is chi-square and mann whitney. The parameters taken in this study were the right dose, the right diagnosis, the right indication, and the right drug. The results of the study showed that lower urinary tract infections were mostly experienced by women, amounting to 58 people (68%), sufferers of lower urinary tract infections were mostly experienced by patients aged 46-55 years, amounting to 22 patients (26%). The drug most commonly received by patients with lower urinary tract infections was cefixime, 49 times (53%). Most patients with lower urinary tract infections were given in single form in 84 people (99%). Patients suffering from lower urinary tract infections most often experienced symptoms of pain when urinating, with 71 patients (47%). The evaluation results showed that the right dose by 96%, the right drug by 100%, the right indication by 100%, and the right  diagnosis by 100%. In the statistical analysis, the results showed that the medication given to patients with lower urinary tract infections met the rational requirements and had a significant rationality value.
Toksisitas Subkronis Ekstrak Biji Salak (Salacca Zalacca) Terhadap Fungsi Hati Mencit Putih Octasari, Paulina Maya; Rukminingsih, Fef; Vita, Cristin Yulia
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p119-125

Abstract

Salak seeds (Salacca zalacca) contain several secondary metabolites like as 0.059% flavonoids, 0.082% tannins and 0.063% alkaloids. Salak is a potential plant as a medicinal ingredient, so it is necessary to conduct a drug safety study. Subchronic toxicity test needs to be done in traditional drug therapy because it is given continuously. This study objective was to examine the subchronic toxicity of salak seed extract on liver function in male Swiss strain mice. This type of research is an experimental study with a completely randomized design with a one-way pattern with one treatment factor. There are four treatment groups with a total of 7 mice replications. Variations in the dose of salak seed extract administration were 91 mg/20 gBW of mice, 114 mg/20 gBW of mice, and 137 mg/20 gBW of mice. The toxicity test were SGPT and SGOT values on days 0 and 14. The data tested with one-way ANOVA followed by a t-test. The Salak Seed Extract (EBS) is a viscous extract with a dark brown colour, a distinctive smell of salak, and a chelate taste. The amount of the extraction result was 12.26%. Positive EBS contains flavonoids with a reddish-orange colour. The treatment of Salak Seed Extract ( 91 mg/20 g BW and 137 mg/20 g BW) was not increased significantly the SGPT and SGOT levels for 14 days (p-value 0.896 and 0.072). Although the second dose (114 mg/20 g BW) was increased the SGPT and SGOT levels (p-value 0.002), this enhancement was less than twice
HUBUNGAN POLA TERAPI DENGAN KUALITAS HIDUP PASIEN TB PARU DI BALAI KESEHATAN MASYARAKAT WILAYAH PATI Timur, Willi Wahyu; Sabiti, Farroh Bintang; Amajida, Neva Linsya
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p126-130

Abstract

Tuberculosis (TB) until 2018 has been a major global health issue, with an annual incidence rate of 9 million cases worldwide and contributing to up to 2 million deaths. TB falls within the top 10 diseases that can cause significant mortality worldwide. Indonesia accounts for 9.2% of these cases, ranking second in the highest number of TB cases after India. This research aims to determine the relationship between treatment patterns and the quality of life in pulmonary TB patients at the Pati District Public Health Center. Data was processed using the SPSS application with Spearman correlation analysis. The study involved 50 respondents diagnosed with pulmonary TB. The independent variable was the treatment pattern of pulmonary TB patients measured using the patient's treatment phase, while the dependent variable was the quality of life measured using the SF-36 Quality of Life Questionnaire. Results from 20 respondents in the intensive phase show that 6 (30.0%) individuals had good quality of life, while 14 (70.0%) individuals had poor quality of life. In the advanced phase, with 30 respondents, 7 (23.3%) had low quality of life, while 23 (76.7%) had good quality of life. The p-value was found to be 0.001, indicating a significant relationship between the treatment pattern and the quality of life in pulmonary TB patients at the Pati District Public Health Center.
Potensi Antibakteri Daun Kresen (Muntingia calabura L.) dan Daun Teh Hijau (Camellia sinensis L.) Terhadap Staphylococcus epidermis Pramiastuti, Oktariani; Hidayah, Nuriatul; Istriningsih, Endang; Fisrty, Girly Risma
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p131-138

Abstract

Acne is an inflammatory condition that can appear on the face, neck, chest and back. This disease is caused by the sebaceous glands producing too much sebum and is made worse by bacterial infections. One of the bacteria that causes acne is Staphylococcus epidermis. The aim of this research was to determine whether the combination of ethanol extracts of cherry leaves and green tea leaves had better antibacterial activity than single extracts against Staphylococcus epidermidis. This research is experimental research. The plants used are cherry leaves (Muntingia calabura L.) and green tea leaves (Camellia sinensis L.) which have secondary metabolite compounds as antibacterials. Compounds that act as antibacterials in tea leaves are catechins, tannins, flavonoids, steroids, triterpenoids and alkaloids. Meanwhile, compounds that act as antibacterials in cherry leaves are flavonoids, saponins, triterpenoids, steroids and tannins. The method used is disc diffusion, seen based on the clear zone around the disc. Test solutions of 5% single extract of cherry leaves and 0.5% single extract of green tea leaves obtained inhibition zones of 5.75 and 5.17mm. The combination of cherry leaf extract and green tea leaves with a ratio of 5:1, 4:2, 3:3, 2:4 and 1:5 obtained results of 9, 8.67, 8.5, 8.67, and 8.67mm wich showed antibacterial activity in the moderate category. The combination extract test solution showed synergistic antibacterial activity with other combination extracts.

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