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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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PENGGUNAAN ANTIBIOTIK PROFILAKSIS DENGAN METODE GYSSENS PADA PASIEN BEDAH ORTOPEDI DI RUMAH SAKIT X PROVINSI BANTEN Arrang, Jesica; Setiawan, Benny; Pramitaningastuti, Anastasia Setyopuspito
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p139-143

Abstract

Surgical wound infection (ILO) is one type of nosocomial infection that is commonly found in healthcare delivery in developing countries. Although most surgical patients receive prophylactic antibiotics, the incidence of ILO in orthopaedic surgery patients is still high. Therefore, it is necessary to evaluate the use of prophylactic antibiotics using the Gyssens method for orthopaedic surgery patients. This study is observational and retrospective data obtained from medical records of orthopedic surgery patients (Total Knee Replacement, Total Hip Replacement and Open Reduction, Internal Fixation) Hospital "X" in Banten Province for the period January 2022 - December 2022. Data were evaluated using the Gyssens method and presented descriptively. A total of 44 patient medical records that met the inclusion criteria. The results of the evaluation of prophylactic antibiotics using the Gyssens method showed that the appropriate use of prophylactic antibiotics was 93.18%, the time of administration of prophylactic antibiotics was 90.9%, the appropriate duration of antibiotic administration was 100%, and the use of antibiotics as follow-up therapy was carried out using Cefixime antibiotics as much as 22.73% and Cefadroxil as much as 2.27%, and the Gyssens Criteria for category 0 was 84.1%.
The Total Cholesterol And Body Weight Lowering Effect Of Wild Poinsettia Infusion (Euphorbia heterophylla L.) On The High Fat – Diet Induced Rats Novembrina, Metrikana; Wahyuni, Tri; Anggrahini, Siti Nur Muthia; Toyo, Eleonora Maryeta; Serang, Yithro
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p144-148

Abstract

Obesity is one of the risk factors which can lead to cardiovascular diseases such as hypertension, diabetes melitus and end stage renal failure. As a tropical archipelago, Indonesia has abundant potential of medicinal plantsuch as Wild Poinsettia (Euphorbia heterophilla L.), which is used by the locals as anherbal drinking to treat obesity. This research aimed to study the effectivenes of Wild poinsettia infusion in lowering total cholesterol level and body weight on the high fat – diet induced wistar male rats. The study used an experimental method with controlled post-test only design. As many as 30 high fat-diet induced male wistar rats were devided into six groups : normal control, negative control given 0,5% cmc Na as placebo, positive control given 27 mg/kgBB gemfibrozil and those given 1.25g/kgBW, 2.5g/kgBW and 5 g/kgBW Wild poinsettia infusion respectively. Prior to the treatment, the total cholesterol level of all groups were measured by using NESCO GCU®cholesterol test kit. After the treatment, the cholesterol levels were remeasured. The body weight of all testing animal was measured every week. Data was then collected and analyzed by using anava to evaluate the difference of total cholesterol level and body weight among the testing groups. According to data analysis’s results, it showed that the bodyweight and the total cholesterol level of all testing groups were significantly different (p < 0,05). Based on the results it was concluded that the Wild poinsettia infusion given to the high fat-diet induced rats can lower their total cholesterol level as well as the body weight. Keywords: high fat-diet induced rats, wild poinsettia infusion, obesity.
Analisis Drug Related Problems (DRPs) Pasien Diabetes Melitus Tipe 2 Handayani, Dian; Versita, Riana; Putri, Denaranny Gita; Hayati, Risda; Lestari, Feny
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p155-162

Abstract

Diabetes mellitus (DM) is a global health problem, DM patients are increasing every year. The presence of comorbidities and various risk factors for patients with type 2 diabetes mellitus causes patients to often consume more than two kinds of drugs and can risk ineffective treatment and allow drug related problems (DRPs) to occur.  The purpose of study was to determine the description of drug related problems (DRPs) in type 2 diabetes mellitus patients. His research is an analytic observational study with a cross sectional design. Prospective data collection. The analysis was carried out using univariate and bivariate analysis. types of drug related problems (DRPs) that occur include that 7 patients are not treated (20%), inappropriate drug selection 17 patients (48,6%), 1 patient over dose (2,8%), and drug interactions 3 patients (8,6%).
Aktivitas Psikostimulan Tanaman Bajakah (Spatholobus suberectus) : Studi In Silico Terhadap Protein 4M48-Dopamine Transporter Priyadi, Muhammad; Saputra, Rizki Rachmad; Gunawan, Yohanes Edy; Citrariana, Shesanthi; Decenly, Decenly; Febrianto, Yahya
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p149-154

Abstract

Bajakah plants (Spatholobus suberectus) have been widely used by Dayak tribes in Kalimantan with various properties that are believed and have also been studied for various tests of phytochemical compound content and pharmacological tests. Secondary metabolite compounds from bajakah (Spatholobus suberectus) have potential as psychostimulant compounds. The purpose of this study was to investigate the psychostimulant activity of bajakah plants (Spatholobus suberectus) through analysis of the interaction between bajakah secondary metabolite compounds and the 4M48-Dopamine Transporter receptor (PDB: 4M48), which is one of the dopamine transporter proteins. Ligand and receptor interactions were analyzed using molecular docking method with Autodock Vina 4 application with nortriptyline compound as native ligand and 15 secondary metabolite compounds for testing. The results of docking analysis showed that the standard ligand nortriptyline compound has an affinity value of -10.2 kcal/mol. There are 3 compounds from bajakah that have affinity values close to the standard compounds plathymenin, butein and eriodictyol with affinity values of -9.7 kcal/mol, -9.4 kcal/mol and -9.2 kcal/mol respectively. Based on the analysis conducted, it can be concluded that bajakah plants (Spatholobus suberectus) have the potential to be developed as psychostimulant therapy.
Hubungan Karakteristik dan Pengetahuan yang diukur dengan kuesioner HK-LS (Hyoertension Knawledge-Level Scale) pada Pasien Hipertensi di Puskesmas Banjarmasin Aryzki, Safti; Faisal, Ahmad; Noval, Noval
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p163-167

Abstract

Hypertension or often called high blood pressure is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg. Hypertension is called the silent killer disease because it often occurs without complaint because it shows no symptoms. Puskesmas is one of the health service facilities in indonesia which aims to increase awareness and ability to live a healthy life for everyone who lives in the work area. To determine the relationship between the characteristics and knowledge of hypertensive patients at the Pekauman Health Center, Banjarmasin City. The method used in the study is a quantitative method with a purposive sampling technique. This research was conducted from December to July 2023 at the Pekauman Health Center in Banjarmasin City with a sample of 96 respondents who met the inclusion and exclusion criteria. The results of the study obtained 96 respondent, the most respondent aged 46-55 years 53 people (55,21), the sex which was mostly female was 75 people (78,13%), the most education was  junior high school education 47 people (43,75%), the most jobs are housewives as many as 75 people (78,12%), the results obtained with the chi-square test based on age characteristics p= 0,002, in gender 0,026, in education 0,000, in jobs 0,036 means p<0,05, so there is a relationship between the characteristics and knowledge of hypertensive patients. Based on the results of research that has been done there is a relationshi
Penetapan Kadar Boraks Pada Makanan Yang Beredar Di Pasar Semarang Timur Menggunakan Metode Spektrofotometri UV-Vis Christina, Odilia Dea; Mahesa, Sandi; Wirawati, Ninik
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p168-173

Abstract

Borax (Sodium tetraborate) is a dangerous preservative that is not permitted to be used as a food ingredient. Borax is often misused to preserve various foods such as meatballs, wet noodles, banana molen, dumplings, lontong, ketupat, dumplings. In large quantities borax causes fever, anuria, coma, central nervous system damage, cyanosis, kidney damage, anemia, vomiting, diarrhea. The aim of this research is to determine borax levels in frequently consumed foods circulating in the East Semarang market. The food samples studied were meatballs, wet noodles and crackers sold at the East Semarang Market. Qualitative sample testing is organoleptic testing and TLC. In quantitative testing by determining levels using UV-Vis spectrophotometry using ethanol solvent. A total of 3 meatball samples, 1 noodle sample contained Borax. The borax levels in the meatball samples were B1 0.0052%, B2 0.0045%, B3 0.0046%. And the borax content in the wet noodle sample was M3 0.0045%.
Tingkat Pengetahuan Masyarakat Terhadap Ketepatan Swamedikasi Obat Anti Jamur di Apotek Indrasari, Ferika; Dewi, Novita Indah Permata; Wulandari, Agustina Ratna; Solichah, Ayu Ina
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p174-179

Abstract

Antifungal is a class of drugs that are fungicidal or fungistatic, these drugs can be used to treat and prevent mycoses such as water fleas, ringworm. People around Wahyu Farma Pharmacy often experience itching caused by fungi or allergies. One treatment that is often done by the community is self-medication (self-medication). In self-medication, the community needs good knowledge so that self-medication can have a positive impact. The purpose of this study was to determine the level of public knowledge about the accuracy of self-medication of antifungal drugs at the Wahyu Farma Pharmacy in the Jepon area of ​​Blora City. This type of research is a non-experimental descriptive with a quantitative approach. This study uses purposive sampling method with a questionnaire measuring instrument to 95 respondents. The data obtained is primary data from the results of filling out questionnaires distributed to the community who are self-medication of antifungal drugs. The results of the study showed that the level of knowledge about self-medication was 79.47% classified as sufficient, the right category of drugs 71.57% was sufficient, the right dose was 73.15% sufficient category, on time 67.36% sufficient category, alert for side effects 62, 10% is sufficient. The total percentage of self-medication, right drug, right dose, right drug, on time, alert for side effects is 70.73% which means that they are knowledgeable enough.
Hubungan Ketercapaian Kadar Gula Darah Dengan Aturan Pakai Obat Gula Darah Pada Pasien Diabetes Dengan Hipertensi Murdiana, Happy Elda; Mediastuti, Fitriani; Rosita , Melia Eka; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p180-185

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease that causes death in the world. The government’s effort to help patients with DM slow down to meet complications with the integrated health service system, namely Prolanis. This study aims to determine the relationship between the achievement of ideal blood glucose levels with the accuracy of the rules for using Antidiabetic Oral (ADO), and compliance with coming to health facilities, as well as the relationship between achieving ideal blood pressure with the accuracy of rules for using antihypertension drug and compliance with coming to health facilities. The research was conducted at the Darmarini Public Health Center, Temanggung with the research subject of DM patients with comorbid hypertension, the number of prolanis participants was 47 people. Data processing is analyzed by chi-square. There is a relationship if p<0,05 and expected count >5. This study showed that there was a significant relationship between the achievement of ideal blood glucose levels with the rules for using ADO, but there was no relationship between the achievement of ideal blood glucose levels with compliance with visits to health facilities, achieving ideal blood pressure level with the accuracy of the rules of use and compliance with visits to health facilities
Analisis Kepuasan Pengguna SIFITA (Sistem Informasi Fitofarmaka) pada Apoteker dengan Model End User’s Computing Satisfaction (EUCS) di Kota Semarang Suwarni, Sri; Atmodjo, Timmy Gondho; Setyaningrum, Pertiwi; Farizi, Gilang Rizki Al
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p186-192

Abstract

Pharmacists as pharmaceutical personnel who have the authority to be able to practice and provide direct and responsible services to patients. One of the provisions of pharmaceutical supplies is phytopharmaceutical preparations. Phytopharmaceutical preparations have been widely introduced to the community as an alternative therapy, but the problem is that there is still a lack of knowledge about the change from natural medicines to phytopharmaceuticals from Standardized Herbal Medicines or due to a lack of information for explaining the types of phytopharmaceutical preparations. Phytopharmaca Information System or SIFITA is an application designed using web-based software that contains information about phytopharmaca which is expected to help and facilitate pharmacists and the public in obtaining information about phytopharmaca. The purpose of this study was to determine the user satisfaction of SIFITA (Phytopharmaca Information System) with the End User's Computing Satisfaction (EUCS) Model by Pharmacists in Semarang City. Prospective observational method with questionnaire instruments that have been tested for validity and reliability. The population is pharmacists practicing in Semarang City with a sample size calculated using the Slovin Formula with a 90% confidence level of 250 sample responses. Presentation of results is using percentages. The results of the study, namely about the Content side of the use of the SIFITA Phytopharmaca Information System, stated that 76.00% had considered good and 22.00% were very good, the rest were those who said 0.4.00% were not good. Based on the Content variable, it can be seen that respondents' satisfaction is very high regarding the completeness of the application, meeting the needs for services. On the accuracy side, 85.40% said good and 12.60% very good, 0.4.00% not good. The Ease of use side states that 92.00% is good, 8.00% is very good. Form (Format) mentions very good 85.60% good as much as 14.40%.
Evaluasi Potensi Ekstrak Etanol Daun Kencur (Kaempferia galanga L.) sebagai Antimikroba terhadap Propionibacterium acnes melalui Teknik Disk Diffusion Sawal, Rizky Ardian Hartanto; Rahayu, Noel Asri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p193-199

Abstract

The galangal plant, which many people still don't know about, has a variety of interesting benefits. Among other things, kencur leaves contain chemical compounds such as flavonoids and essential oils which have antimicrobial properties. This study aims to activate the antibacterial activity of ethanol extract of kencur leaves against Propionibacterium acnes, as well as to measure how effective it is at different concentrations. The extraction process uses 96% ethanol solvent with the Remaceration method, which is then accompanied by phytochemical screening and TLC tests to strengthen the results. Antibacterial activity tests were carried out using the disc diffusion method at concentrations of 0.3%, 0.6%, 1.2% and 2.4%. The results show the inhibition zone at each concentration, namely 6.86 mm, 8.4 mm, 9.8 mm, and 10.96 mm. Phytochemical analysis identified secondary metabolite compounds such as tannins, saponins and flavonoids with Rf values of 0.925 each; 0.825; and 0.8125. Statistical analysis showed a significant difference between concentrations of 0.3% and 1.2%.

Page 13 of 25 | Total Record : 244

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