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JOURNAL LA MEDIHEALTICO
Published by Newinera Publisher
ISSN : 27211215     EISSN : 27211231     DOI : 10.37899/journallamedihealtico.v6i2.1959
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Journal La Medihealtico is peer reviewed, open access Academic and Research Journal which publishes Original Research Articles, Review Article, Case Report editorial comments etc. in all fields of medical sciences and health sciences including Health Care Delivery, Health Care Research, Epidemiology, Medical Care, Nursing, Nursing Education, Neonatal nurse, Home Health Nursing Community and Homecare, Information Technology in Nursing, Occupational Health and Safety, Midwifery, Health Care Administration, Hospital Science and Management, Innovations in Patient Care, Public Health, Health Psychology, Social Health, Physical health, Quaternary Care, Secondary Care, Veterinary Nursing, Medical Sciences and Pharmaceutical Sciences, Hospital and Clinical Pharmacy, Pathology, Physiotherapy & Rehabilitation, Ergonomics, Food and Nutrition, Veterinary Medicines.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 466 Documents
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The Effect of Nigella Sativa L. Extract on Blood Glucose Levels in Alloxan-Induced Hyperglycemic Mus musculus Khoirunnisa, Nur; Makmun, Armanto; Surdam, Zulfiyah; Nur, Muhammad Jabal; Ardiansar, Abdul Mubdi; Zulfahmidah, Zulfahmidah
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2055

Abstract

Hyperglycemia is one of the conditions of increasing blood glucose levels. There are various treatment options in patients with hyperglycemia, one of which is non-drug therapy with traditional medicine. A traditional medicinal plant with various benefits, namely black cumin which is known to have a variety of ingredients that can lower blood glucose levels. Knowing the effect of black cumin extract on blood glucose levels in mice with alloxane-induced hyperglycemia. The research design used was a pre and post test with control group design with a total sample of 27 mice divided into 3 groups where each group consisted of 9 heads. Group 1 is the control group while group 2 and group 3 will be treated respectively. The analysis was carried out with a paired sample t-test to see the differences between each group before and after treatment. The results of the study on the average blood glucose levels before treatment and after the administration of black cumin treatment there were changes in each group obtained a significance value of 0.000 at both doses of black cumin extract. Based on the results obtained, it is known that black cumin extract can reduce blood glucose levels where the greater the dose is directly proportional to the decrease in blood glucose levels.
Incidence of Maxillofacial Trauma at Royal Prima Hospital Fauziah, Dinda; Febrini, Dewi; Alexander, Rico
Journal La Medihealtico Vol. 6 No. 2 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i2.2056

Abstract

A study investigated the prevalence rates together with the sociodemographic features and the types of maxillofacial fractures and their causes for patients seeking treatment at Royal Prima Hospital in Medan during 2021–2023. This research employed a cross-sectional descriptive observational design using data retrieved from past records which documented 26 maxillofacial trauma patients. Selection of proper cases followed a purposive sampling method. The researchers used descriptive statistics in combination with cross-tabulations to evaluate associations among variables including gender distribution and patient age as well as fracture type and trauma etiology. The population of male patients exceeded females (69.2%) at a rate of 42.3% within the 11–20-year age category. Traffical accidents represented the primary reason behind traumatic injuries (61.5%) which mostly happened during motorcycle accidents. Lesions of the Le Fort I region of the maxilla occurred in 38.5 percent of cases and became the most prevalent fracture type. Hospital admission occurred for 65.4% of patients while surgical treatment became necessary for almost half of the total patients. The management of trauma patients became more complicated because 38.5% of patients presented systemic injuries with their facial trauma. Traffic accidents caused most of the maxillofacial trauma cases which mainly affected young male individuals at Royal Prima Hospital. The most common confrontational facial fracture presented as Le Fort I types among patients. The results demonstrate an immediate demand to create specific public health programs together with intensified traffic regulations and improved trauma medical systems in order to decrease facial injuries and achieve better patient recovery.
Vitamin D and its Role in Cell Cycle Dynamics: A Review of the Molecular and Clinical Studies Sastradinata, Irawan; Murti, Krisna; Saleh, Irsan; Nurseta, Tatit
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2096

Abstract

Vitamin D is an essential nutrient that not only plays a role in calcium homeostasis and bone health, but also has broad functions in the regulation of various biological processes, including cell cycle dynamics. This study aims to examine in depth the role of vitamin D in cell cycle dynamics based on evidence from molecular and clinical studies. The method used was qualitative research with a literature study approach, where data was collected from relevant articles such as PubMed, EuropePMC, and Google Scholar. Analysis was carried out through the process of filtering, presenting data, and drawing conclusions. The results showed that vitamin D in its active form, 1,25-dihydroxyvitamin D3, interacts with the vitamin D receptor (VDR) in cells and modulates the expression of genes involved in cell proliferation. This mechanism involves an increase in the expression of cell cycle inhibitory genes, such as p21 and p27, and a decrease in the expression of cell cycle promoting genes, such as cyclin D1, which contributes to the arrest effect on the cell cycle. Thus, in addition to being important for bone health, vitamin D has a significant role in cell cycle regulation, and its deficiency can increase the risk of various diseases, including cancer. Therefore, maintaining optimal vitamin D levels through sun exposure, consumption of foods rich in vitamin D, or supplementation is essential. Further research is needed to understand the role of vitamin D in genetic regulation, particularly in relation to cancer.
Pattern of Cytology and Lung Biopsy Findings in Patients with Chronic Inflammation, Atypical Lesions and Cancer by Age Group Chakramurty, Alendra; Bahri, Syamsul
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2097

Abstract

Lung diseases, both non-neoplastic such as chronic pneumonia and neoplastic such as lung cancer, have similar clinical characteristics so that they are difficult to differentiate. Cytological studies and lung biopsies are important diagnostic methods in determining the pattern of findings between the two conditions, especially when related to the patient's age group. This study used a retrospective descriptive design to analyze patterns of cytology and lung biopsy findings in patients with chronic lung inflammation, inflammation with atypical cells, and lung cancer based on age group. Data was taken from patient medical records at Sidawangi Hospital, West Java, in the period July 2024 – January 2025. Of the 109 patients who met the inclusion criteria, 87 patients were diagnosed with chronic pneumonia and 36 patients with lung cancer. The results showed that the average age of lung cancer patients was 62.78 years, while chronic lung inflammation patients had an average age of 56.12 years. Patients with atypical lesions had a mean age of 47.82 years. These findings indicate differences in cytology and lung biopsy patterns between chronic pneumonia and lung cancer patients, with a higher prevalence of lung cancer in the elderly.
Relationship Between Eosinophil Levels and Histopathological Grading of Colorectal Carcinoma Mubdi, Abdul; Muthma'innah, Gadista Mayssi; Wahid, Syarifuddin
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2103

Abstract

Colorectal cancer (CRC) is a multifactorial disease and a leading cause of cancer-related mortality. CRC ranks as the second most common cancer globally and the third most frequently diagnosed malignancy worldwide. Several studies have suggested that elevated eosinophil levels in peripheral blood correlate with poor prognosis in colorectal cancer cases. This study aims to analyze the relationship between eosinophil levels and histopathological grading of colorectal carcinoma by evaluating peripheral blood eosinophil counts in correlation with CRC histopathology grading. This research employs a descriptive-correlational approach, utilizing univariate and bivariate analyses. The study findings indicate a significant correlation between eosinophil levels and histopathological grading of colorectal carcinoma at Wahidin Sudirohusodo General Hospital, Makassar.
Social Determinants and Community Behavior Against Implementation of the Covid-19 Health Protocol: Systematic Review Purnomo, Teguh; Aji, Budi
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2106

Abstract

The incidence of coronavirus disease (Covid-19) is the latest challenge facing the international community. Health protocols such as social distancing, wearing masks, washing hands and limiting community activities are implemented in the community to prevent a spike in coronavirus cases. The policy of implementing health protocols in the community results in the community itself not complying with the guidelines. For this reason, researchers conducted research to determine social determinants and explanations of community behavior regarding the implementation of the 2019 coronavirus disease (Covid-19) health protocol. This study used a systematic review design where researchers searched for articles from the Google Scholar and PubMed databases. From the search results, six articles were then considered that met the inclusion criteria. Findings show that community knowledge, education, attitudes and behavior, age and gender influence the implementation of medical procedures related to COVID-19. Factors that influence the implementation of health protocols to prevent the spread of the corona virus disease (Covid-19) in society include awareness of the implementation of health protocols, limited infrastructure, limited health personnel; and public attitudes towards health protocols. Apart from that, behavioral, psychosocial and cognitive factors of the population in accordance with socio-cultural, demographic and health characteristics also influence the implementation of health protocols during the COVID-19 pandemic. The need for community attitudes such as the perception of high risk of COVID-19 encourages individuals to follow health protocols with more discipline, and the existence of social environmental support such as positive social interactions can increase individual motivation to comply with existing rules.
Malnutrition with Secondary Hypothyroidism in Children: A Case Report and Pathophysiological Review of Patients in One of the Hospitals in Surabaya Puspita, Angela; Setiadi, Alexander Wignyo
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2115

Abstract

Malnutrition in children remains a global health problem that has a broad impact on growth, development and metabolic balance. One complication that receives less attention is secondary hypothyroidism, a condition that occurs due to metabolic adaptation to prolonged energy deficit. This situation can worsen the patient's prognosis and increase the risk of neurological complications and infections. This case report aims to describe the clinical course of a child with severe malnutrition who experienced secondary hypothyroidism and discuss the pathophysiological mechanisms underlying the link between malnutrition and thyroid dysfunction. Case: A 2 year 1 month old boy with a body weight of 5 kg (< -3 SD) and a height of 69 cm presented with complaints of diarrhea, fever, recurrent cough and episodes of seizures. Laboratory examination showed leukocytosis, increased CRP, and electrolyte disturbances. Evaluation of thyroid function revealed low FT4 levels (0.85 ng/dL) with depressed TSH (0.19 µIU/mL), leading to a diagnosis of secondary hypothyroidism. Metabolic adaptations due to malnutrition lead to decreased production of thyroid binding proteins as well as low TSH secretion in response to metabolic stress. This situation contributes to a slowdown in metabolism and worsens nutritional recovery, as well as increasing the risk of infectious and neurological complications. The literature supports that secondary hypothyroidism in children with malnutrition is reversible with optimal nutritional recovery. A multidisciplinary approach that includes clinical stabilization, electrolyte correction, and monitoring of thyroid function is very important in the management of children with malnutrition and secondary hypothyroidism.
Evidence-Based Nursing: Management of Radial Access Complications Post PCI Ali, Abda; Anshar, Rizadin
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2118

Abstract

The advancement of interventional cardiology technology has enhanced the effectiveness of patient care for coronary artery disease, particularly through Percutaneous Coronary Intervention (PCI) using radial access. Although this approach is safer than femoral access, post-procedural complications such as hematoma, radial artery occlusion, and neuropathy remain clinical challenges. Evidence-Based Nursing Management plays a crucial role in minimizing the risk of complications through evidence-based interventions, including nurse education, optimization of compression techniques, and rehabilitation strategies. This study aims to analyze research trends related to evidence-based management in addressing post-radial PCI complications using bibliometric analysis with VOSviewer. The methodology includes a systematic literature review following the PRISMA protocol and bibliometric analysis of publications from 2020 to 2025 sourced from Google Scholar, ScienceDirect, and Wiley Online Library. The analysis results highlight emerging research trends in post-radial PCI complication management, identification of research gaps, and evidence-based policy recommendations. This study contributes to strengthening evidence-based nursing practices to enhance patient safety and care efficiency in PCI procedures.
Analysis of Treatment Compliance Factors in Type 2 Diabetes Mellitus Patients Desia, Maya; Yetti, Husna; Lestari, Yuniar
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2119

Abstract

Non-compliance with taking medication in DM patients can reduce a person's quality of life and become the main cause of a number of microvascular problems. Therefore, complex problems related to diabetes are one of the global health problems that must be addressed immediately. The purpose of this study was to determine the factors related to medication compliance in type 2 DM patients. This study used a mixed method study approach or a combination of two types of research, namely quantitative research and qualitative research. The type of mixed method research design used is explanatory sequential design. The sampling method in this study was by proportional sampling. Furthermore, to determine the target sample, a simple random block sampling technique was used, namely 347 DM patients. The results of the analysis showed no significant relationship between gender p-value = 1,000 (> 0.05), education p-value = 0.232 (>, 0.05), knowledge p-value = 0.076 (> 0.05), dxuration of suffering p-value = 0.162 (> 0.05), belief p-value = 0.680 (> 0.05), access to health services p-value = 0.602 (> 0.05), and there was a significant relationship between family support and DM treatment compliance with p-value = 0.020 (<0.05). The conclusion of this study is that more than half of DM patients have low treatment compliance, are female, have low education, have a duration of <5 years, have access to health that takes a long time, and lack of family support. More than half of DM patients have high knowledge and positive beliefs.
The Relationship Between Nutritional Status and History of LBW on Child Development Khaera, Ummul; Gama, Arlina Wiyata; Larasati, Iip; Rahman, Abd; Pababbari, Musafir
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2138

Abstract

Optimal child development reflects the future of a nation. Malnutrition and low birth weight (LBW) history are significant determinants impacting children’s development, especially in low-income settings. This study examines the relationship between nutritional status and LBW history with the development of 4-year-old children using the Developmental Pre-Screening Questionnaire (KPSP). The aim is to identify the relationship between nutritional status and LBW history with the developmental outcomes of children aged 4 years. An observational analytic study with a cross-sectional design was conducted in the working area of Jongaya Health Center, Makassar. The study included 56 children, divided into groups based on their nutritional status and LBW history. Data were collected using anthropometric measurements and KPSP. Statistical analysis was performed to determine significant relationships. The results showed a significant relationship between nutritional status and child development (p<0.05). Additionally, children with LBW history showed delayed development compared to those without LBW history (p<0.05). It concludes that nutritional status and LBW history significantly influence the developmental outcomes of 4-year-old children. Early interventions addressing malnutrition and LBW are crucial to ensure optimal development.

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