cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Farhamzah
Contact Email
farhamzah@ubpkarawang.ac.id
Phone
+6281380007942
Journal Mail Official
buanafarma@ubpkarawang.ac.id
Editorial Address
JL. H.S. Ronggowaluyo Telukjambe Timur Karawang 41361
Location
Kab. karawang,
Jawa barat
INDONESIA
Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 20 Documents
 1   2 
Search results for , issue "Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi" : 20 Documents clear
A LITERATURE REVIEW: AKTIVITAS ANTIBAKTERI TANAMAN OBAT TERHADAP BAKTERI PENYEBAB PNEUMONIA Sinabutar, Rahel Margarenta; Nurfitriani, Iis; Maharani, Dinda Eka; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1382

Abstract

Pneumonia is an acute respiratory tract infection caused by various pathogenic bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and Klebsiella pneumoniae. The increasing prevalence of antibiotic resistance among these pathogens highlights the need for alternative therapeutic strategies derived from natural products. This study aimed to review the antibacterial potential of medicinal plants against pneumonia-causing bacteria and their underlying mechanisms. A systematic literature review was conducted by searching scientific articles in Google Scholar, PubMed, ScienceDirect, and MDPI. Articles were selected based on inclusion criteria covering antibacterial activity, active compounds, and reported mechanisms of action. A total of 30 eligible articles were analyzed descriptively. The medicinal plants reviewed include Etlingera elatior, Cassia alata, Morinda citrifolia, Melaleuca leucadendra, Momordica charantia, Guazuma ulmifolia, Artocarpus altilis, Acacia nilotica, Gynura procumbens, Trigona incisa propolis, and Ficus carica. These plants contain secondary metabolites such as flavonoids, alkaloids, saponins, tannins, and phenols, which exhibit antibacterial activity by disrupting cell membranes, inhibiting protein synthesis, interfering with essential enzymes, and inducing oxidative stress in bacteria. The findings indicate that medicinal plants hold great potential as complementary or alternative therapies for pneumonia caused by antibiotic-resistant bacteria; however, further research, particularly in vivo and clinical studies, is required to confirm their efficacy and safety.
REVIEW ARTIKEL: POTENSI FITOTERAPI DARI TANAMAN HERBAL DALAM PENANGANAN RHEUMATOID ARTHRITIS Nurhayati, Ismaya; Maulani, Sintia Putri; Lathifah, Meira H.; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1387

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the joints, resulting in progressive damage and a decreased quality of life for patients. Conventional therapies such as NSAIDs and DMARDs are indeed effective, but their long-term use carries the risk of serious side effects and high costs. Therefore, safer and more affordable alternative therapies are needed, one of which is through the use of medicinal plants. This study aims to examine the potential of herbal plants as an additional or alternative therapy for rheumatoid arthritis. The method employed is a literature study, involving the search and analysis of 31 scientific journals retrieved from academic databases, including Google Scholar, PubMed, ScienceDirect, and MDPI. The articles analyzed were selected based on certain criteria and contained information about the content of active compounds, pharmacological activity, and the mechanism of action of plants on the RA inflammation process. The results of the study showed that various herbal plants such as Zingiber officinale, Curcuma longa, Boswellia serrata, and Nigella sativa have significant anti-inflammatory and immunomodulatory activities. The active compounds in these plants work by inhibiting the inflammatory pathway and reducing the production of pro-inflammatory cytokines. In conclusion, medicinal plants have great potential to be used as additional therapy in the treatment of rheumatoid arthritis. However, further research is needed, especially clinical trials, to ensure the long-term safety and effectiveness of their use.
UJI AKTIVITAS EKSTRAK ETANOL 50% AKAR GINSENG JAWA (Talinum paniculatum Jacq. (Gaert)) SEBAGAI INHIBITOR STRESS OKSIDATIF Rachmawan, R. Lucky; Wahyuningsih, Sri; Suryani; Hermanto, Faizal; Rochmah, Nur Syifa
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1391

Abstract

Oxidative stress is a condition in which an imbalance occurs between the production of free radicals and the body’s antioxidant defense system, potentially leading to various degenerative diseases. Java ginseng (Talinum paniculatum Jacq. (Gaertn)) is a medicinal plant known to contain bioactive compounds with free radical–reducing potential. This study aimed to identify the mechanism of nitric oxide (NO) inhibition through the decomposition of sodium nitroprusside in the Reactive Nitrogen Species (RNS) pathway and to evaluate the increase of catalase enzyme activity in the Reactive Oxygen Species (ROS) pathway using 50% ethanol extract of Java ginseng root. The root extract was obtained using Soxhlet extraction with 50% ethanol as the solvent, and five different extract concentrations were tested: 20, 40, 60, 80, and 100 μg/mL. Antioxidant activity was assessed by measuring the inhibition of NO radical formation and the enhancement of catalase activity, with vitamin C as a comparator. The ethanol extract of Java ginseng root inhibited NO radical formation with an IC50 value of 42.45 μg/mL, which is classified as a very strong antioxidant. In comparison, vitamin C showed an IC50 of 6.47 μg/mL, also categorized as very strong. Furthermore, the extract increased catalase activity proportionally to its concentration, although the effect was still lower than that of vitamin C. These results indicate that the 50% ethanol extract of Java ginseng root possesses significant potential as an oxidative stress inhibitor through NO inhibition and catalase activation, though its effectiveness remains lower than vitamin C.
AKTIVITAS ANTIDIABETES FRAKSI ETANOL, ETIL ASETAT DAN N-HEXAN HERBA PEGAGAN (Centella asiatica L) TERHADAP MENCIT PUTIH JANTAN YANG DIINDUKSI ALOXAN Lestari, Sovi Ayu; Hidayat, Taufik Septiyan; Suharti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1392

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from impaired insulin production or function. Conventional treatments often come with side effects and high costs, prompting the exploration of herbal-based alternatives. Centella asiatica L. (commonly known as pegagan) contains various bioactive compounds with potential antidiabetic properties. This study aimed to evaluate the antidiabetic activity of ethanol, ethyl acetate, and n-hexane fractions of Centella asiatica herb in male white mice (Mus musculus) induced with alloxan, and to determine the most effective fraction in lowering blood glucose levels. The research employed a completely randomized design (CRD) in an experimental setting. Male mice were randomly assigned to five groups: negative control (1% Na-CMC), positive control (glibenclamide), and three treatment groups receiving ethanol, ethyl acetate, or n-hexane fractions of Centella asiatica at a dose of 120 mg/kg body weight. Diabetes was induced using alloxan at a dose of 100 mg/kg body weight. Blood glucose levels were measured before and after treatment at specific time intervals. The results demonstrated that all fractions of Centella asiatica exhibited blood glucose-lowering activity in diabetic mice. Among the three, the ethanol fraction produced the most significant hypoglycemic effect. Phytochemical screening revealed that the ethanol fraction contained flavonoids, triterpenoids, and saponins, which are suspected to contribute to its antidiabetic activity. In conclusion, the ethanol fraction of Centella asiatica exhibits the highest potential as an antidiabetic agent compared to the ethyl acetate and n-hexane fractions.
AKTIVITAS ANTIJAMUR FRAKSI KAYU SECANG TERHADAP Candida albicans DAN BIOAUTOGRAFI: Indonesia Senja, Salsadella Juwita; Indrayati, Ana; Harjanti, Reslely
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1415

Abstract

Sappan (Caesalpinia sappan L.) is a plant of the Caesalpiniaceae family that is used for traditional medicine. Utilized Secang (Caesalpinia sappan L.) is a plant from the Caesalpiniaceae family whose wood has long been used in traditional medicine and contains compounds such as brazilin, flavonoids, saponins, propane, tannins, and terpenoids with potential antifungal activity. Fungal infections, particularly Candida albicans, remain common health problems, and although antifungal drugs such as fluconazole are widely used, resistance cases continue to increase. This study aimed to evaluate the antifungal activity of secang wood extract and its fractions against C. albicans and to identify the most active compound group using thin-layer chromatography (TLC) bioautography. Secang wood was extracted by maceration with 96% ethanol and fractionated with n-hexane, ethyl acetate, and water, followed by antifungal testing using the paper disc diffusion method at concentrations of 6%, 9%, and 12%, with fluconazole as a positive control and 3% DMSO as a negative control. Data were analyzed using two-way ANOVA and showed normal distribution (Sig > 0.05). The results demonstrated that the extract, n-hexane fraction, ethyl acetate fraction, and water fraction inhibited the growth of C. albicans, with the water fraction at 12% producing the largest inhibition zone of 16.19 mm, categorized as strong activity. TLC bioautography of the water fraction revealed the presence of tannins as active compounds responsible for antifungal activity.
TINGKAT PENGETAHUAN DAN SIKAP PENGGUNAAN ANTIBIOTIK DI FASILITAS PELAYANAN KESEHATAN INDONESIA Dewi, Eva Rosdiyana; Wahyuningsih, Sri
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1424

Abstract

Inappropriate antibiotic use can lead to bacterial resistance, a serious global issue including in Indonesia. The level of public knowledge and attitudes regarding antibiotic utilization are crucial factors in controlling the occurrence of resistance. This literature review aims to assess the community's level of knowledge and attitudes toward antibiotic use in Indonesia, as well as the influencing factors. The methodology employed is a literature study, with data collected through electronic databases such as Google Scholar, PubMed, and ScienceDirect, using keywords like "knowledge," "attitude," "antibiotics," and "resistance" from 2015 to 2025. A total of 10 articles meeting the inclusion criteria were systematically explored, depicting various community experiences across different regions of Indonesia. The results indicate that public knowledge about antibiotics varies from low to adequate, depending on demographic factors such as educational level and personal experience. Additionally, improper attitudes, such as easily requesting antibiotics without a prescription, are closely related to a lack of understanding regarding indications and potential adverse outcomes. Demographic factors like education level, age, and income significantly influence community knowledge and attitudes toward antibiotic use. This review underscores the need for consistent and informative educational interventions through healthcare facilities to improve knowledge and motivate rational behavior regarding antibiotic use.
SYSTEMATIC LITERATURE REVIEW: KANDUNGAN SENYAWA BIOAKTIF DAN AKTIVITAS SITOTOKSIK EKSTRAK ALANG-ALANG TERHADAP SEL KANKER Nuh, Muhammad; Ma’rifah; Haq, Nasrul; Akrom
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1452

Abstract

Imperata cylindrica (Imperata cylindrica) is a traditional medicinal plant long used in various countries and is known to contain various bioactive compounds with anticancer potential. Research on the cytotoxic activity of Imperata cylindrica continues to develop, but results are still varied, requiring a systematic review to summarize the available scientific evidence. This study aims to review the bioactive compound content and cytotoxic activity of Imperata cylindrica extract against various cancer cells. A systematic literature review method was conducted by searching articles from international and national databases using relevant inclusion and exclusion criteria. Of the total 410 articles found, 10 articles were selected to meet the requirements for analysis. The results of the study showed that cogongrass extract with various solvents (ethanol, methanol, water, n-hexane fraction, ethyl acetate fraction, and chloroform) has cytotoxic activity against various cancer cell lines, such as breast (MCF-7), cervical (HeLa), colon (HT-29), lung (A549), liver (HepG2), prostate (PC-3), and leukemia (HL-60). The identified cytotoxic mechanisms include induction of apoptosis, cell cycle arrest, inhibition of migration, antioxidant, anti-inflammatory, and immunomodulatory activities. The dominant compounds that play a role include flavonoids, alkaloids, terpenoids, saponins, and tannins. In conclusion, cogongrass extract has great potential as a candidate for natural anticancer agents, although further research in the form of in vivo tests and clinical trials is still very necessary to ensure its effectiveness and safety.
FORMULASI SIRUP DEKOKTA KERANG TUDE BOMBANG (Atactodea striata) SEBAGAI HEPATOPROTEKTOR ALAMI Ashar, Muhammad; Pratiwi, Ines Septiani; Pratama, Andri Anugrah; Feriadi, Eva
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1477

Abstract

The Tude Bombang clam (Atactodea striata) is a potential hepatoprotective agent due to its bioactive protein content and low fat levels, which contribute to liver protection through antioxidant activity, hepatocellular repair, and prevention of lipid accumulation in liver cells. This study aimed to formulate a decoction syrup of Tude Bombang clam and evaluate its hepatoprotective effects against paracetamol-induced hepatotoxicity in mice, as well as assess its organoleptic properties, homogeneity, and pH. The results showed that SGOT and SGPT levels in the normal control group remained stable (SGOT: 17.7–17.2 U/L; SGPT: 7.5–7.2 U/L), whereas the negative control group exhibited persistent elevations (SGOT: 374.7–373 U/L; SGPT: 97.2–95.6 U/L), confirming liver damage. The positive control (curcumin) reduced SGOT to 220.3 U/L and SGPT to 102.4 U/L. The Tude Bombang clam syrup demonstrated dose-dependent hepatoprotective effects, with the 60% concentration producing the most significant reductions in SGOT (350.9 to 288.9 U/L) and SGPT (96 to 73.6 U/L), indicating its ability to stabilize liver enzymes and mitigate hepatocellular injury. Organoleptic evaluation revealed acceptable sensory characteristics, homogeneity testing confirmed uniform dispersion without sedimentation, and the pH values (7.02–7.20) fell within the neutral range recommended for oral syrups. Overall, the Tude Bombang clam syrup exhibited favorable physical properties and hepatoprotective potential through its bioactive protein content and low fat levels, making it a promising candidate for functional hepatoprotective formulations.
EFEK PENGGUNAAN BETA BLOCKER TERHADAP KEJADIAN HIPOGLIKEMIA PADA LANSIA: NARRATIVE REVIEW Adisaputra, Arya Dibyo; Susilawati, Ni Made; Fatkhiya, Musa Fitri; Gibran, Nabial Chiekal; Futihat, Chilyati Eky
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1501

Abstract

Elderly patients are considered a vulnerable population, as advanced age may exacerbate existing conditions or predispose individuals to adverse effects such as hypoglycemia. While hypoglycemia most frequently occurs in patients with diabetes who are treated with insulin or oral hypoglycemic agents, it may also develop in non-diabetic individuals under certain circumstances. The use of beta-blockers has been identified as one potential contributing factor to hypoglycemic events. This article aims to review the adverse effects of beta-blocker therapy in relation to hypoglycemia among older adults. A narrative review was conducted through electronic databases including PubMed, Google Scholar, and ScienceDirect. The inclusion criteria were studies published within the last 10 years involving older patients who experienced hypoglycemia while receiving beta-blocker therapy. The search yielded 38 articles, of which only 4 met the inclusion criteria. In conclusion, the use of β-blockers appears to be associated with an increased risk of severe hypoglycemia; however, evidence specifically addressing the geriatric population remains limited.
AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN NILAM (Pogostemon cablin Benth.) DAN DAUN KEMANGI (Ocimum basilicum L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Rindengan, Elvie Rifke; Gurning, Sri Handayani; Paputungan, Marcelia; Ulaen, Selfie Petronela Joice; Maramis, Rilyn Novita
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1503

Abstract

Infections caused by Staphylococcus aureus bacteria can lead to various health problems, including skin infections that result in redness, swelling, blisters, and pus-filled lumps. The use of herbal plants is an alternative treatment for infections. Plants known to have antibacterial potential include patchouli leaves (Pogostemon cablin Benth.) and basil leaves (Ocimum basilicum L.). This study aims to determine the antibacterial activity of a combination of patchouli leaf extract (Pogostemon cablin Benth.) and basil leaves (Ocimum basilicum L.) against the growth of Staphylococcus aureus bacteria. The type of research used is a laboratory experiment. Extraction of patchouli leaves and basil leaves was performed using the maceration method with 96% ethanol. The test solution was prepared in three concentrations: 10%, 15%, and 20%. The combination was made by mixing each concentration in 1:1 ratio. The antibacterial activity test was conducted using the disc diffusion method, with a positive control consisting of erythromycin discs and a negative control of a 1% Tween 80 solution. Observations were made for 24 hours, then the inhibition zone around the paper disc was measured using a caliper. The combination of patchouli and basil leaf extracts can inhibit the growth of Staphylococcus aureus bacteria.

Page 1 of 2 | Total Record : 20

 1   2 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 4 No. 1 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 4 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 3 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 2 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2023): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 4 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 3 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2022): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 4 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 3 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2021): Jurnal Buana Farma : Jurnal Ilmiah Farmasi More Issue