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INDONESIA
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Published by Universitas 17 Agustus 1945 Jakarta
ISSN : -     EISSN : 25028413     DOI : https://doi.org/10.52447/scpij.v7i1
Core Subject : Health, Social,
Health Professions Medicine & Pharmacology Public Health Social Sciences
Social Clinical Pharmacy Indonesia Journal (SCPIJ) is a scientific journal managed by the Faculty of Pharmacy Universitas 17 Agustus 1945 Jakarta, which is published twice a year (April and October). SCPIJ is a scientific research journal in the field of community service with articles that have never been published online or in print before. SCPIJ aims to disseminate conceptual thoughts or ideas and research results that have been achieved in the fields of pharmacy and health, Regulatory Affairs and Pharmaceutical Marketing Research, Pharmaceutical Care,Pharmacotheraphy, Pharmacoepydemology, Pharmacogenetic, Rational Therapeutics, Evidence-Based Practice, Health Services Research, Medication Management, Drug Interactions, Drug Utilization, Drug Prescribing, Drug Information. The results of the service published in this journal are in the form of experimental and non-experimental service.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 10 Documents
 1 
Search results for , issue "Vol 11, No 1 (2026)" : 10 Documents clear
Effectiveness of Vitamin D Supplementation in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review Puspita, Okta; Meiliana, Made Laksmi; Ardhianto, Denny; Ulandari, Syaripah
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9367

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that significantly affects functioning and quality of life. Emerging evidence suggests that vitamin D may contribute to neurodevelopment and behavioral regulation, and children with ADHD have been reported to exhibit lower serum 25(OH)D concentrations. However, findings regarding the clinical effectiveness of vitamin D supplementation remain inconsistent. This study systematically reviewed the effectiveness of vitamin D supplementation in children with ADHD. A systematic review was conducted in accordance with PRISMA guidelines by searching PubMed, ScienceDirect, and Scopus for randomized controlled trials (RCTs) published between January 2016 and February 2026. Eligible studies included children aged ≤18 years diagnosed with ADHD who received oral vitamin D supplementation. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist, and a qualitative synthesis was performed. Six RCTs met the inclusion criteria. Across studies, vitamin D supplementation consistently increased serum 25(OH)D concentrations. However, clinical effects were heterogeneous. Although some trials reported modest improvements in specific symptom domains, particularly inattention, consistent reductions in overall ADHD severity were not observed. In conclusion, vitamin D supplementation effectively improves serum 25(OH)D levels but demonstrates variable clinical benefits in children with ADHD. Current evidence does not support its use as a definitive standalone treatment, although potential adjunctive benefits cannot be excluded. Further high-quality, large-scale RCTs are needed to clarify its clinical role. 
Pengaruh Rosmarinus officinalis dan Centella asiatica terhadap kadar TNF-α pada Larva Zebrafish yang Diinduksi Glukosa Tinggi Prastiwi, Fajar Dwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9378

Abstract

Diabetes gestasional adalah jenis diabetes yang terjadi selama masa kehamilan. GDM ditegakkan dengan kondisi hiperglikemi dalam darah. Hiperglikemi memicu respon inflamasi yang ditandai dengan ekskresi sitokin pro inflamasi, salah satunya adalah TNF-α. Centella asiatica dan Rosmarinus officinalis dikenal sebagai anti-diabetes dan anti-inflamasi. Penelitian ini bertujuan untuk mempelajari efek kombinasi nanoemulsi Centella asiatica dan Rosmarinus officinalis terhadap ekspresi TNF-α di larva Zebrafish yang diinduksi glukosa 3%. Hiperglikemi ditandai dengan terjadinya peningkatan kadar Phosphoenolpyruvate carboxykinase di larva Zebrafish. Phosphoenolpyruvate carboxykinase dan TNF-α akan diukur menggunakan metode PCR konvensional. Kombinasi nanoemulsi Rosmarinus officinalis dan Centella asiatica diberikan dengan tiga dosis yang berbeda yaitu dengan konsentrasi 2.5, 5 dan 10 πg/mL. Analisis statistic yang digunakan adalah One Way ANOVA untuk mengukur kadar ekspresi TNF-α. Hasil dari penelitian ini menunjukkan bahwa kombinasi nanoemulsi Rosmarinus officinalis dan Centella asiatica tidak signifikan mempengaruhi kadar ekspresi TNF-α. Dosis yang menurunkan kadar ekspresi TNF-α adalah kelompok dengan konsentrasi 2,5 πg/mL, meskipun hasil akhir memiliki nilai tidak signifikansi . Kesimpulan dari penelitian ini adalah mengkombinasikan nanoemulsi Rosmarinus officinalis dan Centella asiatica dengan dosis 2,5 πg/mL; 5 πg/mL; dan 10 πg/mL tidak signifikan mempengaruhi kadar TNF-α di larva Zebrafish yang diinduksi glukosa tinggi (3%).
EVALUATION OF PHARMACEUTICAL STORAGE MANAGEMENT IN PRIMARY CLINICS BASED ON PHARMACEUTICAL SERVICE QUALITY INDICATORS Astuti, Briandini Dwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9434

Abstract

Drug storage is a critical stage in pharmaceutical logistics management to ensure the quality of pharmaceutical preparations and budget efficiency. Inappropriate storage can trigger drug damage, expiration, and medication errors. Objective: This study aims to evaluate drug storage indicators in the pharmacy installation warehouse of a primary clinic. Methods: This research is a descriptive observational study with retrospective and prospective data collection. Indicators measured include the compatibility of physical stock with stock cards, the percentage of dead stock, the percentage of expired/damaged drugs, and the suitability of storage systems (alphabetical, FIFO, FEFO, and LASA). Results: The results showed that the percentage of match between the number of drugs and stock cards was 98.5%. The dead stock percentage was 7.29%, and expired drugs accounted for 0.72%. The placement of Look-Alike Sound-Alike (LASA) drugs and the implementation of alphabetical, FIFO, and FEFO systems both achieved 100% compliance. Conclusion:Overall, the drug storage system has met the efficiency indicator standards, although mitigation steps are still needed to minimize dead stock and optimize pharmaceutical supply management, thereby preventing financial loss.
EVALUASI FUNGSI GINJAL BERDASARKAN FARMAKOKINETIK EKSKRESI PADA PASIEN HIPERTENSI DI INSTALASI RAWAT INAP RSUD CILINCING JAKARTA UTARA Octaviani, Egy; Amirulah, Fajar; Sari, Dini Permata; Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.8932

Abstract

Hypertension is a major risk factor for impaired renal function, which may progress to chronic kidney disease (CKD). This study aimed to evaluate renal function based on excretory pharmacokinetic parameters (urea, creatinine, and creatinine clearance) in hypertensive inpatients, and to assess the impact of patient characteristics and types of antihypertensive drugs on renal function decline. This observational analytic study with a cross-sectional design utilized secondary data from 100 medical records of hypertensive inpatients at RSUD Cilincing, North Jakarta, collected during March–April 2025. Most patients were classified in CKD stages 2–3a. The most frequently prescribed therapies were calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs). Chi-Square analysis revealed significant associations between renal function and gender, age, and CCB use (p < 0.05), while diuretic use was not significantly associated (p = 0.134). These findings highlight the importance of appropriate antihypertensive drug selection and regular renal monitoring to prevent CKD progression in hypertensive patients.
EVALUASI PEMANTAUAN TERAPI OBAT PADA PASIEN CKD ON HD + ANEMIA DI RS “X” BENGKULU Ningtyas, Maria Sheila Setya
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9407

Abstract

Chronic kidney disease (CKD) merupakan masalah kesehatan global dengan insidensi, prevalensi dan angka mortalitas yang terus meningkat. Penyebabnya tidak hanya dikarenakan satu hal dan kerusakan umumnya ireversibel dan mengarah ke perburukan. Tujuan laporan ini dilakukan untuk mengetahui drug related problems (DRP’s) pada penatalaksanaan pengobatan pasien CKD (Chronic Kidney Disease) dengan hemodialisis, anemia di Rumah Sakit X Bengkulu. Selain itu, untuk memastikan penggunaan obat yang rasional, agar tidak terjadi peristiwa yang tidak diinginkan sehingga tercapai efek terapi yang optimal. Metode laporan kasus ini meggunakan rancangan case study dengan teknik pengambilan sampel purposive sampling. Data  yang digunakan yaitu data sekunder dari status rekam medik pasien. Hasil yang diperoleh dari laporan kasus ini yaitu terapi pengobatan yang diterima pasien telah sesuai dengan literatur/ rasional. Meskipun terdapat DRP yakni interaksi obat, tetapi dapat diatasi dengan lebih sering dilakukan pemantauan tekanan darah pasien. Dapat disimpulkan bahwa pasien telah mencapai efek terapi yang optimal dan tidak ada efek samping yang tidak diinginkan.
STUDI DRUG UTILIZATION REVIEW (DUR) TERHADAP PENGGUNAAN ANTIBIOTIK PADA INFEKSI SALURAN PERNAPASAN ATAS Amirulah, Fajar
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9411

Abstract

Upper respiratory tract infection (URTI) is a condition characterized by irritation and swelling of the upper respiratory tract without pneumonia, usually accompanied by a cough. According to the Indonesian Ministry of Health, the use of medication can be categorized as rational when the medication given meets the patient's needs. Treatment can only be considered rational if it meets several criteria, namely: the right patient, the right indication, the right drug, the right dose, the right interval of administration, the right duration of administration, and others. The objective of this study is to examine the use of antibiotics for ARI in pediatric patients at Jawilan Health Center. The research method employed is a descriptive method with a cross-sectional design to determine the pattern of antibiotic use for ARI in pediatric patients. Data collection was conducted retrospectively using secondary data obtained from medical records and prescriptions of patients with ARI during the period of May 2024–April 2025 at Puskesmas Jawilan, Serang Regency, Banten. The number of patients was 261 patients aged 1-17 years, diagnosed with ARI and given antibiotics. The most commonly used class of antibiotics was amoxicillin, with 253 administrations (96.9%), followed by cotrimoxazole with 8 administrations (3.1%). The results of the treatment rationality are as follows: correct patient 100%, correct indication 77%, correct drug 100%, correct dosage 86.6%, correct interval of antibiotic administration 100%, and correct duration of antibiotic administration 97.7%. From this research data, it can be concluded that there are still irrational drug administrations below 100% that have long-term effects on the patient's body.
Efektivitas Gel Ekstrak Etanol Daun Euphorbia hirta L. terhadap Penyembuhan Luka Bakar pada Kelinci rafsanjani, arief
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9427

Abstract

Luka bakar derajat dua merupakan cedera jaringan yang melibatkan epidermis dan sebagian dermis, sehingga memerlukan penanganan yang tepat untuk mempercepat penyembuhan serta mencegah komplikasi seperti infeksi. Pemanfaatan bahan alam sebagai alternatif terapi semakin berkembang, salah satunya daun patikan kebo (Euphorbia hirta L.) yang diketahui memiliki aktivitas antiinflamasi, antibakteri, dan antioksidan. Penelitian ini bertujuan untuk menguji efektivitas sediaan gel ekstrak etanol daun patikan kebo dalam mempercepat penyembuhan luka bakar derajat dua pada kelinci. Penelitian ini menggunakan metode eksperimental dengan rancangan post test only control group design. Hewan uji dibagi menjadi enam kelompok, yaitu kontrol positif, kontrol negatif, ekstrak 100%, serta tiga kelompok formulasi gel (Formulasi I, II, dan III). Parameter yang diamati meliputi diameter luka pada hari ke-1, 3, 6, 9, 12, dan 15 serta persentase kesembuhan luka.Hasil penelitian menunjukkan bahwa seluruh kelompok mengalami penurunan diameter luka seiring waktu, dengan tingkat penyembuhan yang berbeda. Kelompok kontrol positif menunjukkan penyembuhan tercepat dengan persentase kesembuhan 100% pada hari ke-15. Formulasi III menunjukkan efektivitas tertinggi di antara kelompok perlakuan dengan persentase kesembuhan 90% dan diameter luka 0,1 cm, mendekati kontrol positif. Sementara itu, Formulasi II, Formulasi I, ekstrak 100%, dan kontrol negatif masing-masing menunjukkan penyembuhan sebesar 80%, 70%, 65%, dan 50%.Berdasarkan hasil tersebut, dapat disimpulkan bahwa sediaan gel ekstrak etanol daun patikan kebo, khususnya Formulasi III, efektif dalam mempercepat penyembuhan luka bakar derajat dua. Sediaan gel juga terbukti lebih optimal dibandingkan ekstrak murni dan berpotensi dikembangkan sebagai terapi topikal berbasis bahan alam.
Evaluation of Dose Appropriateness in Patients Congestive Heart Failure and Comorbid Chronic Kidney Disease at RSUD Kabupaten Kediri Agustin, Ela; Fajriyah, Shofiatul; Widyaningrum, Esti Ambar; Putri, Adinda Sheisella; Wahyuni, Kumala Sari Poespita Dewi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9346

Abstract

Congestive heart failure (CHF) is a chronic condition requiring long-term therapy. Patients with heart failure accompanied by comorbid chronic kidney disease (CKD) require dose adjustment to prevent drug toxicity. This study aimed to determine the therapeutic profile and dosing appropriateness among patients with congestive heart failure and comorbid CKD hospitalized at RSUD Kabupaten Kediri during the January–December 2022 period. This study employed a retrospective observational design using medical record data with a total sampling technique, resulting in 72 eligible patients. Dose appropriateness was evaluated based on estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation and compared with recommendations from The Renal Drug Handbook. The results indicate that the majority of samples in this study were female (54.17%) and aged 45–54 years (41.67%). Most patients had additional comorbidities (80.56%), with anaemia being the most prevalent concomitant condition. Based on CKD staging, the majority of patients were classified as stage 5 CKD (77.78%). Combination therapy involving two medications was the most common treatment pattern (30.57%), with a diuretic plus ARB combination being the most frequently prescribed regimen. The evaluation of dosing appropriateness demonstrated that 69 patients (95.83%) received doses adjusted appropriately to their renal function, while 3 patients (4.17%) received inappropriate dosing. Inappropriate use was identified in prescriptions of spironolactone and acarbose, which should be avoided in patients with low eGFR values. In conclusion, most patients with congestive heart failure and comorbid CKD received therapy with doses appropriately adjusted to renal function. However, cases of inappropriate dosing were still identified, which may increase the risk of adverse effects.
ANALYSIS OF DRUG-RELATED PROBLEMS (DRPs) AND THERAPEUTIC RATIONALITY IN TWO DIFFERENT CLINICAL CASES: ABDOMINAL COLIC IN ADOLESCENTS AND VERTIGO IN ADULT PATIENTS IN HOSPITALS Astiani, Rangki; Piter, Piter; Anggraeni, Ria; Ningtyas, Maria Sheila Setya; Luthfiana, Farisa; Kezia, Valerie; Borean, Mardianti
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9418

Abstract

ABSTRACTDrug-Related Problems (DRPs) are common issues in healthcare services and can affect the success of patient therapy. Abdominal colic is a disorder of normal intestinal flow throughout the intestinal tract caused by infection in the abdominal organs, while vertigo is a sensation that the patient is moving or spinning, or that objects around the patient are moving or spinning, usually accompanied by nausea caused by an imbalance in the three types of AKT receptors (Body Balance System) due to excessive stimulation. The purpose of this report is to review the rationality of therapy in two different clinical cases. A retrospective case study was conducted by analyzing patient medical records, DRPS analysis, physical examination, laboratory tests, pharmacological therapy, and clinical response. The first patient was given analgesic, anti-inflammatory, antibiotic, and fluid therapy for hydration. The second patient was given first-line vertigo therapy, antihypertensive drugs, and gastric protection. Therapy adjustments were made according to patient response and laboratory parameters. Clinical pharmacy monitoring ensured pain control and monitored side effects and drug interactions. 
Evaluasi Kesesuaian Terapi Terhadap Pedoman Terapi pada Pasien Rawat Jalan Diabetes Melitus Tipe 2 Dewi, Novia Ariani; Anjani, Windi; Putri, Vera Dian Apsella; Hidiyaningtyas, Lutfi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9349

Abstract

Diabetes Mellitus (DM) merupakan penyakit metabolik kronis yang ditandai dengan hiperglikemia atau peningkatan kadar glukosa darah yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau kedua-duanya. Penderita DM rawat jalan di Kabupaten Sleman pada tahun 2022 menduduki peringkat kedua setelah hipertensi yaitu sebesar 5,39%. Salah satu faktor yang mempengaruhi keberhasilan terapi pada pasien DM adalah faktor terapi pasien (jumlah obat, frekuensi minum obat, dan produk obat). Dalam faktor ini, penting untuk menyesuaikan pemberian obat pada pasien dengan pedoman terapi yang digunakan. Penelitian ini bertujuan untuk mengevaluasi kesesuaian terapi yang diresepkan dokter dengan pedoman terapi yaitu PERKENI (2019) pada pasien rawat jalan DM tipe 2 di salah satu rumah sakit pada kabupaten Sleman. Sampel dalam penelitian ini adalah pasien DM tipe 2 rawat jalan pada bulan April – November 2023 yang memenuhi kriteria inklusi diperoleh 99 sampel. Jenis penelitian observasional analitik dengan metode pengambilan data secara retrospektif dengan teknik pengambilan sampel secara consecutive sampling. Hasil evaluasi kesesuaian penggunaan obat 100%, kesesuaian frekuensi penggunaan obat 97,98%, dosis obat 80,81%, jumlah obat 100%, kesesuaian golongan/nama obat 100 %. Pasien DM tipe 2 terbanyak adalah laki-laki, usia 45-59 tahun, komorbiditas pasien tertinggi adalah hipertensi, terdapat kesesuaian dibawah 100% yaitu kesesuaian frekuensi dan dosis obat.

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