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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 142 Documents
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Sintesis Khalkon dan Uji Aktivitas Tabir Surya Secara In Vitro Dewi Darmiyani Napu
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.19326

Abstract

Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test of its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde and 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis was performed by using KOH 40% under stirring at room temperature for 48 h. The synthesized compounds was characterized using FTIR, GC-MS and 1H NMR spectrometers. Further, the chalcone were screened for its in vitro sunscreen activity by using UV-Vis spectrophotometer. The result showed that the chalcone has been succesfully synthesized in 36.94% Yield. The activity of invitro test showed the chalcone has SPF values with maximal protection category at the consentration 15 µ/mL produce SPF 9.749
Kepatuhan Minum Obat Antidiabetika Oral Pasien Ulkus Diabetikum Rawat Jalan di Klinik X Kota Pontianak Menggunakan Metode Kuantitatif Prita Laoura; Nurmainah Nurmainah; Ressi Susanti
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.19276

Abstract

Non-communicable diseases (PMT) have increased globally and nationally which have occupied the top ten causes of death with the most cases being diabetes mellitus. Diabetes Mellitus is a chronic disease that occurs due to impaired insulin action which causes blood sugar levels to increase. Uncontrolled sugar levels cause complications, one of which is diabetic ulcers. This study aims to analyze the level of adherence in taking medication in patients and the factors that influence adherence in taking medication in diabetic ulcer patients at Clinic Pontianak. The method used in this research is analytic observational method with the research design used is a cohort study. Compliance with drug use was measured using the Medication Possession Ratio (MPR) method. Data collection was carried out retrospectively based on manual and electronic data collection (medical records) and outpatient diabetic ulcer patient prescriptions at the Clinic Pontianak from January to December. Analysis of compliance relationship data using the chi square test. The results of this study showed that patients tended to be 45 years old (16.7%), female sex (87.5%), and monotherapy regimen (87.3%), this stated that there was no significant relationship between compliance with patient characteristics. Based on the results of the research, the percentage of compliance with the use of oral anti-diabetic drugs in outpatient diabetic ulcer patients at the Pontianak Clinic  in 2021 is 26.1%.
Evaluation of The Use of Antibiotic Drugs in Outstanding Patients with Diabetes Mellitus with Complications of Diabetic Ulcus in Clinic X Pontianak Oni Astri Herdani; Nurmainah Nurmainah; Ressi Susanti
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.19277

Abstract

Diabetic ulcers are a complication of diabetes mellitus. Diabetic ulcers are caused by poor circulation associated with peripheral neuropathy and peripheral vascular disease that can lead to infection. To prevent or treat infections, proper treatment is needed, one of which is by using antibiotic therapy. Inappropriate use of antibiotics can lead to an increased risk of antibiotic resistance. This study aims to describe the pattern of antibiotic use in patients with type 2 diabetes mellitus with complications of diabetic ulcers and the rationale for their use. This study uses a descriptive observational method with a cross-sectional research design. Retrospective data collection using a purposive sampling method. The results showed that the characteristics of patients with type 2 diabetes mellitus with complications of diabetic ulcers by gender were most common in women (65%) compared to men (35%), and most occurred in the age range 55-64 years (44%) with the most severe level in grade III (86%). The pattern of antibiotic use used was antibiotics with single therapy (93%) compared to combination antibiotics (7%). The single most widely used antibiotic was cefixime (31%). Evaluation of the accuracy of the use of antibiotics is the right dose (93.45%) and the right time interval of administration (83.17%).
Tingkat Pengetahuan Dan Persepsi Masyarakat Tentang Vaksin Covid-19 Studi Kasus : Kota Gorontalo Teti Sutriyati Tuloli; Widy Susanti Abdulkadir; Mohamad Aprianto Paneo; Nurain Abdullah
Indonesian Journal of Pharmaceutical Education Vol 3, No 1 (2023): Januari-April 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i1.18063

Abstract

Covid-19 is a source of problem in the world because of the continuous increse. Due to the number of cases exposed, thus it is necessary to take preventive measures to break the spread of the Covid-19 virus. Covid-19  for Covid-19 is an effort to protect oneself against or to attack the disease and increase the immune system. In general, the sommunities cannot receive vaccinations becaus they are concerned about the safety and effectiveness of vaccines. However, understanding and accepting the Covid-19 vaccine in Indonesia continues to increase. This research aims to detemine the level of public knowledge and perception and the relationship between knowledge and perception of the Covid-19 vaccine in the Limba U II Village, Kota Selatan Subdistric, Gorontalo City. This research employs observational research with a descriptive quantitative design and a cross-sectional approach. In this research, 372 samples are obtained from the questionnaire distribution. Data are analyzed using Chi-Square. The results indicate that the level of public knowledge in Limba U II Village about the Covid-19 vaccine is the high category (60%), and the public perception in Limba U II Village is in a postivie category (62,1%). The relationship between the two shows significant results with P-Value = 0,000, where the value is less than 0,05.
Aktivitas Antioksidan Ekstrak Air Kombinasi Kulit Pisang Kepok (Musa paradisiaca L.) dan Nanas (Ananas comosus L.) dengan Metode DPPH dan FRAP Vivian Fu; Pratiwi Apridamayanti; Sri Luliana
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19781

Abstract

Banana kepok (Musa paradisiaca L.) and pineapple (Ananas comosus L.) are types of fruit that are widely consumed by the community. However, the skin is only disposed of as waste, where the waste of the fruit skin reaches 30% of the whole fruit. Kepok banana peels and pineapples contain phenols and flavonoids which are proven to function as antioxidants. This study aims to determine the IC50 value of the combined sample using the DPPH and FRAP methods. The extract samples were divided into 2 groups, namely the combination of kepok banana peel extract and pineapple with a ratio of 1:1 and 1:3. Extraction is done by infusion method. Analysis of the content of phenolic and flavonoid compounds was carried out by the TLC method on single samples of kepok banana peels and pineapple peels. Antioxidant activity test was carried out by 2 methods, namely DPPH and FRAP. The yield of the extract in the 1:1 combination was found to be 48% and the 1:3 combination was 47%. The chromatogram profile showed that each single sample was positive for phenols and flavonoids. The results of the analysis of the antioxidant activity of the DPPH method showed the IC50 value in the 1:1 combination group was 1188.27 ppm while in the 1:3 combination group it was 740.98 ppm. In the FRAP method, the IC50 value in the 1:1 combination group was 1251.85 ppm, while in the 1:3 combination group it was 2218.94 ppm. Based on the results of the test, there are differences in the measurement of antioxidant activity with 2 different methods based on the antioxidants action that contains in the sample, so that the more recommended method is DPPH based on the type of antioxidant compounds contained in the sample.
Analisis Potensi Farmakokinetik dan Toksisitas Pada Curcumin (Curcuma xanthorrhiza) Sebagai Brightening Terhadap Reseptor Protein Tirosinase Secara in Silico Anjas wilapangga
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.18878

Abstract

Tyrosinase enzyme is an enzyme that plays an important role in melanin synthesis. This enzyme will oxidize the amino acid L-tyrosine into L- 3,4 dihydroxyphenylalanine (L-DOPA) and convert L-DOPA into DOPAquinone. Tyrosinase protein from Bacillus megaterium in complex with inhibitor kojic acid is the target protein that will interact with the ligand (Drug Candidate), Temulawak (Curcuma xanthorrhiza) is one of the medicinal plants of the Zingiberaceae family which is widely grown and used as a raw material for traditional medicine in Indonesia, the main content in Temulawak is curcumin which has antioxidant properties. Antioxidants in curcumin content can be used as ingredients for whitening preparations. In silico tests are used to predict pharmacokinetic activity and toxicity by docking using the Molegro Virtual Docker computer program. The receptor used was Protein Tyrosinase PDB code 3NQ1 with ligand KOJ_B_1351. Prediction of pharmacokinetic properties (ADME) and toxicity of Curcumin and Kojic Acid was performed using the pkCSM online tool program. Data analysis was performed by comparing the binding energy of docking results between Curcumin, Kojic Acid, and ligand on the target receptor. The in silico test results showed that the binding energy of Kurkumin =-142.766 kcal/mol, Kojic Acid = -60.6899 kcal/mol, and KOJ_B_1351 ligand =-62.266 kcal/mol. The results of in silico tests using the pkCSM online tool program show that Kurkumin compounds have good pharmacokinetic properties, and cause relatively low toxicity, and can be used as candidates for whitening materials.
The Use of Prophylactic Antibiotics for Cesarean Section Delivery and The Incident of Surgical Site Infection Shofiatul Fajriyah; Umul Farida; Sri Agustina; Lelly Winduhani Astuti; Esti Ambar Widyaningrum
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19864

Abstract

According to the 2018 Riskesdas data, the ratio of deliveries by cesarean section in 2018 was recorded at 17.6% of a total of 78,736 deliveries. One of the serious problems in postoperative treatment that has an impact on increasing morbidity, mortality, and increasing medical costs is surgical site infection (SSI). To reduce the risk of infection, efforts are made by giving prophylactic antibiotics followed by surgical procedures. The aim of this study was to determine the use of prophylactic antibiotics in cesarean section surgery and to determine the incidence of surgical site infection (SSI) in patients after Sectio Caesarea surgery in one of a private hospital in Kediri City. This study was an observational descriptive study with retrospective data collection through tracing of medical record data of patients who underwent Caesarean section surgery in 2021. The samples that entered the inclusion criteria were patients who received surgical prophylaxis with antibiotics and returned to the hospital for control after 1 week postoperatively. Samples that met the inclusion criteria were 89 patients. The sampling technique used purposive sampling. This study collected data on prophylactic antibiotics used and the incidence of SSI on days 1, 3 and (7-10) postoperatively.  The results showed that the types of prophylactic antibiotics in patients undergoing sectio caesarea were ceftriaxone 2 g (99%) and cefotaxime 2 g (1%). Whereas there were 3 patients (3%) who had SSI on days 7-10 postoperatively.
Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya Riski dwi utami; olvaria misfa; Bimby Irenesia; deinike wanita marwan
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19268

Abstract

Fibroblasts play a role in the wound healing process. The active compound content of Spirulina sp. has fibroblastic activity. The use of extracts from S. platensis can play a role in the wound healing process. To analyze the effectiveness of Spirulina platensis extract on the number of fibroblasts in rats that were incised in their skin. This study used a randomized post test only control group design. Forty-eight male Wistar rats were skin incised and infected with S.aureus divided into 4 groups, namely the group given S.platensis extract at a dose of 500 mg/kgBW/day, a dose of 750 mg/kgBW/day, the negative control group was given saline solution and positive control group with diclofenac 20 mg/kgBW orally. The number of fibroblasts was counted on histopathological examination of the wound tissue on the 7th and 14th days covering 5 visual fields. Data analysis was carried out with a one way ANOVA test and continued with the LSD Post Hoc Test. The mean number of fibroblasts on the 7th day in the 500 mg/kgBW/day group, 750 mg/kgBW/day, positive control and negative control was 13.33 ± 3.615; 117.42±3.980; 9.58±2.417; and 4.00 ± 1.761 with p 0.001. The number of fibroblasts on the 14th day in the 500 mg/kgBW/day, 750 mg/kgBW/day group, positive control and negative control was 16.17 ± 3.251; 19.67±1.633; 12.17±2.137; and 8.33 ± 2.317 with p 0.001. The post hoc test found that the number of fibroblasts on day 7 significantly increased in the 500 mg/kgBB/day S. platensis group compared to the positive and negative control groups. While at a dose of 750 mg/kg/day, the number of fibroblasts was higher than the positive and negative control groups after 14 days of treatment.Administration of Spirulina platensis extract at doses of 500 and 750 mg/kg/day significantly increased the number of fibroblasts in the incision wounds of Wistar rats.
Analisis Kadar Kalsium pada Kulit Pisang Ambon dan Pisang Raja dengan Metode Spektrofotometri Serapan Atom Margaretha Margaretha; Pratiwi Apridamayanti; Hadi Kurniawan
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19905

Abstract

Indonesia is one of the countries known as the world's banana producer. Banana is one of the local fruits that are widely spread in Pontianak, West Kalimantan. Ambon banana and raja banana are classified as bananas that can be consumed directly, so banana peels are often discarded and considered as waste. Whereas banana peels are rich in nutrients such as macro and micro minerals. The purpose of this study was to determine the mineral levels of calcium in the peels of ambon banana and raja banana. Sample preparation using dry digestion method with 0.5 M HNO3 solvent. Method verification was carried out with parameters of linearity, LOD, LOQ, precision and accuracy. The assay was carried out with atomic absorption spectrophotometry at a wavelength of 422.67 nm. The results showed that the mineral levels of calcium in the wet peels of ambon banana are 104.29 mg/kg and raja banana are 314.79 mg/kg. Based on the research conducted, it can be concluded that the levels of calcium mineral in raja banana peels are higher than ambon banana peels
Pengaruh Metode Pengeringan terhadap Kadar Flavonoid Total pada Daun Jinten (Coleus amboinicus Lour) Elok Widayanti; Jasmine Mar’ah Qonita; Retno Ikayanti; Nurma Sabila
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19787

Abstract

Cumin leaf are medicinal plants that are used as treatment and useful for health. Cumin leaf contain secondary metabolites, one of which is flavonoids. Flavonoids are the largest phenolic compounds found in plants and function as antioxidant, antibacterial, antiviral, anti-inflammatory, antiallergic, and anticancer activities. The flavonoid content of a plant can be affected by the drying temperature in the manufacture of simplicia. The purpose of this study was to determine the total flavonoid content in cumin leaf if dried by several drying methods. In this study, cumin leaf simplicia was used with different drying methods, namely sun drying, wind drying, and oven drying. The simplicia powder was extracted using ethanol and then tested quantitatively using a UV-Visible Spectrophotometer at a wavelength of 440 nm. Total flavonoid content by sun drying, oven drying, and wind drying was 3,38 mg QE/g extract, 3,58 mg QE/g extract, and 5,83 mg QE/g extract respectively. Based on the research on the flavonoid test on cumin leaves with different drying methods, the lowest average total flavonoid content was obtained on Sun drying was 3.38 mg QE/g extract and the highest was wind drying with 5.83 mg QE/g extract while oven drying was 3.58 mg QE/g extract.

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