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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 140 Documents
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Studi Farmakologi Ikan Zebra sebagai Model Obesitas dan Hiperglikemia: Pengembangan Induksi Diet-Induced Obesity Elfita, Lina; Nurfakhrurajab, Irfan; Fitriana, Narti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.45453

Abstract

Obesity and hyperglycemia are major risk factors for type 2 diabetes mellitus and various other metabolic disorders. The use of relevant animal models is essential to support pharmacological studies. The aim of this research was to develop an effective DIO (Diet-Induced Obesity) inducer for commercially available zebrafish as a model for obesity and hyperglycemia. Adult zebrafish were induced for obesity and hyperglycemia through administration of a high-fat diet for 4 weeks. The observed parameters included body weight, body length, body mass index (BMI), and blood glucose levels. The results showed that DIO induction significantly increased body weight, BMI, and blood glucose levels (P < 0.05) compared to the control group. In conclusion, zebrafish can be developed as a model for obesity and hyperglycemia through DIO induction, thus potentially serving as an alternative test animal for pharmacological studies of metabolic diseases
Extraction of Polyphenol From Turmeric (Curcuma longa), Red Ginger (Zingiber officinale), and Aromatic Ginger (Kaempfeiria galanga l) Using Natural Deep Eutectic Solvent Based On Choline Chloride and Sugar Maulia, Gina; Maimulyanti, Askal; Nurhidayati, Isna; Mellisani, Bella; Nurhasanah
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.45812

Abstract

Indonesia is a tropical country rich in biodiversity, including a wide variety of herbal plants. Herbs and spices are abundant in Indonesia and have been used in local customs since ancient times. Turmeric, ginger, and curcuma are rhizomes used as spices in Indonesian cooking and natural medicine. This study investigates the efficiency of natural deep eutectic solvents (NADES) synthesized from choline chloride and various sugars—fructose, glucose, maltose, and xylose in extracting polyphenolic compounds from Indonesian rhizomes: turmeric (Curcuma longa), red ginger (Zingiber officinale), and aromatic ginger (Kaempferia galanga L). The NADES were prepared using choline chloride as hydrogen bond acceptor (HBA). The hydrogen bond donor (HBD) is a sugar such as fructose, xylose, maltose, and glucose. The total phenolic content (TPC) was quantified and reported in mg gallic acid equivalent (GAE)/g extract.  Kaempferia galanga exhibited the highest TPC among the rhizomes, reaching 32.21 mg GAE/g when extracted with ChCl–Fructose NADES.  Curcuma longa and Zingiber officinale yield 20.05 mg GAE/g and 25.84 mg GAE/g under the same solvent conditions, respectively. When comparing the performance of the solvents, the following order was observed: ChCl–Fr > ChCl–Xyl > ChCl–Mal > ChCl–Glu. These findings suggest that solvent polarity and hydrogen bonding capacity significantly influence polyphenol solubility and extraction efficiency. NADES based on ChCl–Fructose showed the greatest potential for eco-friendly extraction of bioactive phenolics from medicinal rhizomes.
Profil Asam Lemak Minyak Ikan Belanak (Chelon planiceps) Sebagai Sumber Omega-3 Asal Desa Lembo Kabupaten Konawe Utara Hikmah, Nurull -; Trinovitasari, Nita; A.Sida, Nurramadhani; Sida, Nurramadhani A.; Anwar, Irvan; Fadhilah, Nurul Aliah; Irnawati
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.41029

Abstract

Ikan Belanak (Mullet) is a small pelagic fish that lives in shallow coastal waters. This type of fish lives in the coastal area of Lembo Village, North Konawe Regency. The objective of this study was to characterize physicochemicals and determine the fatty acid profile of mullet oil, which is a source of fish oil that contains unsaturated fatty acids that are beneficial to health. The reflux process is used to remove mullet flesh, which yields fish oil. The findings demonstrated that the physicochemical properties of mullet oil varied. These properties included the acid number, peroxide number, iodine number, and saponification number, which were, respectively, 0.81 mg KOH/g, 8.30 meqO2/kg, 50.98 I2/100 g, and 109.07 mg KOH/g. The fatty acid profile of mullet oil is dominated by palmitic acid, cis-9-oleic acid and DHA. Based on the test results, mullet oil can be used as edible oil according to SNI and IFOS standards. 
Korelasi Tingkat Pengetahuan denngan Perilaku Swamedikasi Obat Analgesik di Masyarakat Semper Barat, Jakarta Utara Islam, Zainul; Sulistyaningsih, Endang; Luthfianti, Fanni
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.41623

Abstract

Self-medication is a person's action in determining and using medicine independently to treat a disease or its symptoms. The benefits of this practice include cost efficiency and helping to ease the burden of health services. However, there are risks if done without adequate knowledge; it can cause side effects or additional costs. Good knowledge greatly supports correct self-medication behavior in the community. The type of drug that is often used during self-medication is analgesics, which function to suppress pain. This study aims to analyze the correlation between the level of knowledge and self-medication behaviour in the use of analgesic drugs in the community in Semper Barat Village, North Jakarta. The research design used a quantitative approach with an instrument in the form of a questionnaire that had passed validity and reliability tests. Four hundred respondents from 9 RW in Semper Barat Village participated in this study. Data were processed through Chi-square and Spearman-rho analysis. The research data showed that the majority of respondents had a sufficient level of knowledge (64.3%) and behaved sufficiently (52.5%). In the chi-square analysis, except for education, most characteristics did not correlate significantly with knowledge or behaviour. The results of the Spearman-rho test showed a significant correlation (p = 0.011) between knowledge and analgesic self-medication behaviour.
Review Kandungan Metabolit Sekunder Tanaman Berkhasiat terhadap Tulang dan Sendi menurut Al-Qanun Fi’l Tibb II Siregar, Barita Juliano; Sangadji, Sarah Nahdah Zhaafirah; Betha, Ofa Suzanti; Dhilasari, Estu Mahanani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 4 No. 2 (2022)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.25611

Abstract

Al-Qanun Fi’l Tibb II merupakan buku materia medica karya Ibnu Sina yang terkenal di dunia. Buku tersebut menjelaskan secara rinci mengenai monografi tanaman berkhasiat terhadap organ tubuh, salah satunya terhadap tulang dan sendi. Akan tetapi dalam buku tersebut belum memuat komponen major metabolit sekunder yang diduga berperan penting dalam memberikan efek farmakologis. Penelitian ini ditujukan untuk menginventarisasi tumbuhan yang terdapat di dalam buku Al-Qanun Fi’l Tibb II dan melakukan literatur review terkait kandungan metabolit sekunder yang terdapat dalam tanaman tersebut. Metode penelitian dilakukan dengan literature review melalui studi kepustakaan. Hasil pengambilan data menunjukan terdapat 74 tanaman yang berkhasiat terhadap tulang dan sendi diantaranya memiliki komponen major metabolit sekunder seperti senyawa terpen, flavonoid, alkaloid, tanin, alil isotiosianat, saponin, glikosida, alkohol lemak, asam fenolat, benzofenon, kuinon, sekoiridoid, kumarin, stilbene, anthrone, naftalen, benzaldehida dan asam karboksilat. Terpen merupakan metabolit sekunder yang paling banyak ditemukan dalam tanaman yang berkhasiat terhadap tulang dan sendi. Bioaktivitas yang ditemukan pada tanaman diantaranya antigout, antioksidan, osteoprotektif, antiosteoporosis, antibakteri, antiinflamasi dan analgesik.
Hubungan Karakteristik Sosiodemografi dengan Hasil Terapi Tuberkulosis Paru di RSUD Banyumas Shavira, Rurynta Ferly; Restinia, Mita; Nurmeilis, Nurmeilis; Maula, Charisma Soffa
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.29973

Abstract

Pulmonary tuberculosis (TB) is one of the infectious diseases caused by Mycobacterium tuberculosis and is one of the highest causes of morbidity and mortality rates with a low level of treatment outcome. Indonesia is the second country in the world with the largest tuberculosis burden. This study aims to determine the relationship of sociodemographic characteristics with the results of pulmonary tuberculosis therapy at Banyumas Regional Public Hospital for the period 2019-2021. This study used a case-control method. The inclusion criteria in this study were new pulmonary tuberculosis patients at the Banyumas Regional Public Hospital and patients aged ≥18 years, both male and female.  Multi-drug resistance (MDR) TB patients and patients with incomplete medical record data were excluded. There were 166 patients enrolled in this study. Data analysis was performed by univariate analysis and bivariate analysis by chi-square test. The results showed that the sociodemographic characteristics were dominated by male patients (57,2%), patients aged <65 years (66,3%), patients weighing <55 kg (53%), not graduating from college (94%), currently working (64,5%), married (68,7%), have health insurance (94%), and close distance (<10 km) to the hospital (53%). The conclusion is that gender ((P=0,028; OR 2,112; 95%Cl(1,129 – 3,951)), age (P=0,014; OR 2,413; 95% Cl (1,242 – 4,689)), body weight (P=0,000; OR 3,306; 95%Cl (1,748 – 6,252)), and distance from the patient's house to the hospital (P=0,020; OR 2,190; 95% CI (1,176 – 4,077)) have a significant relationship with the outcome of pulmonary TB therapy at Banyumas Regional Public Hospital.
Perbandingan Mutu dan Profil Disolusi Tablet Griseofulvin Merek Dagang Generik Gumala, Azhoma; Lucida, Henny; Salman, Salman
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 4 No. 2 (2022)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.29982

Abstract

Abstract: Griseofulvin is an active pharmaceutical ingredient in Biopharmaceutic Classification Systems Class II and the price of the dosage form from commercial brands four times higher than the generic.  A comparative study on physical properties and dissolution profiles between generic and commercial brands of griseofulvin tablets has been conducted to assess whether there is difference between their qualities. The pharmaceutical properties were assessed based on the Indonesian and the United State Pharmacopeias. Results showed that the tablets fulfilled the requirements for size uniformity, weight uniformity (0.5995± 0.0075) gram - (0.6989±0.0080) gram, friability 0.08-1.10 %, hardness (10±0.7746) - (19.6±0.9165) kg/cm2, disintegration time 07.12 - 17.17 minutes with drug content of 94.20 - 99.67%. The commercial brand griseofulvin tablets A1& A2 and generic B1 met the official specification for physical characteristics. Results of dissolution test for commercial brand A1 & A2 and generic B1 showed that griseofulvin had T60min (Q ≤ 70%) and the dissolution test profiles did not follow neither first order, Higuchi, Korsmeyer Peppas, nor Langenbucher kinetic models (r < 0,95). The dissolution test for griseofulvin tablet A1 met the USP specification, T90min (Q ≥ 75%) with the release mechanism follow Langenbucher kinetic model. Abstrak: Griseofulvin merupakan zat aktif golongan Sistem Klasifikasi Biofarmasetik kelas II dengan perbedaan harga antara tablet merek dagang lebih mahal hingga empat kalinya dibandingkan tablet generik. Uji disolusi terbanding dilakukan untuk melihat adakah perbedaan mutu yang signifikan antar tablet tersebut. Metode evaluasi mutu dilakukan sesuai dengan ketentuan Farmakope Indonesia dan USP. Hasil evaluasi mutu fisik tablet meliputi keseragaman ukuran, keseragaman bobot yaitu (0,5995± 0,0075) – (0,6989±0,0080) gram, kerapuhan 0,08 - 1,10%, kekerasan (10±0,7746) - (19,6±0,9165) kg/cm2, & waktu hancur  07.12 - 17.17 menit dan penetapan kadar  94,20 - 99,67%, memenuhi ketentuan Farmakope Indonesia. Profil disolusi tidak mengikuti model kinetika orde satu, Higuchi, Korsmeyer Peppas, ataupun Langenbucher (r < 0,95). Hasil uji disolusi tablet A1 yang dilakukan berdasarkan  USP memenuhi persyaratan T90 min  (Q ≥ 75%) dan memiliki profil disolusi mengikuti  persamaan Langenbucher (r>0,95). Keywords: Profil disolusi, tablet griseofulvin, mutu tablet, model matematika
Penetapan Kadar Fenol Total dengan Spektrofotometer UV-Vis dan Uji Sitotoksisitas Ekstrak Air Daun Lidah Mertua (Sansevieria masoniana C.) Terhadap Sel Kanker Paru A-549 Febriyanti, Lilis; Haerussana, Ayu Nala El Muna
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.30080

Abstract

Cancer is the second most common cause of mortality globally, following cardiovascular disease, according to the World Health Organization (WHO). Leading the list of fatal cancers annually are lung, breast, stomach, liver, and colorectal cancers. Hence, the discovery and development of effective agents to treat various types of cancer is urgently needed. Mother-in-law tongue (Sansevieria masoniana Chahin) leaves contain flavonoids and saponins. However, information regarding the total phenolic content of the aqueous extract of the S. masoniana Chahin leaves is currently unavailable. Hence, this research aims to determine the total phenol content using a UV-Vis spectrophotometer and assess the invitro anticancer activity of the water extract of S. masoniana Chahin through the MTT Assay. From the results of measuring the total phenolic content, the water extract of the leaves contained a phenol content of 3.3061 mgGAE/g. Meanwhile, the results of the cytotoxicity assay on lung cancer cells A-549 showed that the IC50 value of the aqueous extract of S. masoniana Chahin leaves was above 100 ppm, indicating that the extract has less potential as an anti-lung cancer agent.
Efek Antinyeri Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa bilimbi L) pada Mencit yang Diinduksi Asam Asetat Kemila, Mira; Suprasetya, Edy; Laga, ,Arifson Umbu
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.31287

Abstract

Pain is an unpleasant combination of sensory and emotional experience linked to the potential or actual of tissue damage. Typically, pain arises from stimulation of peripheral receptors, which send impulses through pain pathways to the brain. Starfruit is a medicinal plant that is used empirically as an analgesic. This study aims to determine the analgesic effect of starfruit extract on the stretch index and pain protection ratio against acetic acid-induced mice. This study used 25 mice divided into three test groups: one control group (Na-CMC) and one comparison group (Mefenamic acid). The results showed that starfruit can reduce the pain stretch index and have a pain protection ratio compared to the control group. A dose of 250 mg/kg has an analgesic protection ratio of 75.75%, and a dose of 500 mg/kg has a protection ratio of 85.14%. Thus, based on the results of this study, it can be seen that starfruit has the ability to act as an anti-pain.
Combination of Beetroot Juice, Honey and Green Apple on Hemoglobin Levels in Anemia Pregnant Women at Payung Sekaki Health Center, Pekanbaru Sari, Septi Indah Permata; Susilawati, Elly; Devi, Shinta; Pamudi, Berwi Fazri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.31539

Abstract

Anemia is a medical condition characterized by lower-than-normal hemoglobin (Hb) levels. In pregnant women, anemia can lead to prolonged delivery times, increased bleeding, and shock during contractions. The adverse effects of anemia on the fetus include premature birth, low birth weight (LBW), potential disabilities, and infant mortality. The recommended solution to overcoming anemia in pregnant women is to consume a combination of beetroot juice and green apples juice. Beets contain essential components that can elevate Hb levels, whereas green apples provide minerals and vitamin C, enhancing iron absorption (Fe). This study aimed to investigate the effect of a combination of beetroot juice and green apple juice on Hb levels in pregnant women with anemia. The study population was comprised of 200 normal pregnant women, with a sample size of 15 in trimester III (TM III) with anemia, selected through purposive sampling. The intervention involved administering the juice daily for seven days. Data were collected using observation sheets and easy-to-touch devices. The research design was pre-experimental, utilizing a one-group pre-test–post-test design. This study was conducted within the working area of the Payung Sekaki Public Health Center (PHC) from January to April 2022. Dependent T-test analysis was used for data evaluation. The average Hb level of TM III pregnant women before juice consumption was 9.7 g/dL, which increased to 10.6 g/dL after the intervention. The dependent t-test results, with a 95% confidence level (Cl), indicated a p-value of 0.000, signifying a significant impact of fruit juice on the Hb levels of TM III pregnant women experiencing anemia. These findings suggest that clinical midwives should educate pregnant women about the importance of Fe tablets and the positive influence of fruit juice on Hb levels.

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