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Program Studi Farmasi, Fakultas Ilmu Kesehatan UIN Syarif Hidayatullah Jakarta Jl. Kertamukti No. 5, Pisangan, Ciputat 15412 Tangerang Selatan, Banten, Indonesia Telp: (62-21)74716718 Fax: (62-21) 7404985
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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 140 Documents
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Relationship between Prescription Services and Patient Satisfaction Level at the Outpatient Installation of X Hospital, South Tangerang City Novitri, Suci Ahda; Sholehah, Alsyah; Yaenap, Siti; Shavira, Rurynta Ferly
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.46238

Abstract

Prescription service is one of the pharmaceutical services that aims to improve the quality of life of patients. Good service will increase patient satisfaction so that it will affect the quality of life of patients. Patient satisfaction can be assessed by measuring elements of responsiveness, assurance, tangible, empathy, and reliability. The purpose of this study was to determine the relationship between prescription services (waiting time) and the level of patient satisfaction at the South Tangerang City X Hospital. This study was an observational quantitative study with a cross sectional approach using a survey. The number of samples used was 382 respondents through purposive sampling method. The data obtained were analyzed by univariate and bivariate analysis using SPSS version 22. The results showed that the level of patient satisfaction with the elements of responsiveness was 76.65%, assurance was 76.64%, tangibles was 75.28%, empathy was 76.60%, and reliability was 76.21%. Based on the results of the analysis using chi-square, there is a relationship between prescription services and the level of patient satisfaction at the South Tangerang City X Hospital with a p value of 0.000 (p-value <0.05). This study can be concluded that there is a significant relationship between prescription services (waiting time) and the level of patient satisfaction in the outpatient installation of South Tangerang City X Hospital.
Extraction of Polyphenol From Turmeric (Curcuma longa), Red Ginger (Zingiber officinale), and Aromatic Ginger (Kaempfeiria galanga l) Using Natural Deep Eutectic Solvent Based On Choline Chloride and Sugar Maulia, Gina; Maimulyanti, Askal; Nurhidayati, Isna; Mellisani, Bella; Nurhasanah, Nurhasanah
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.45812

Abstract

Indonesia is a tropical country rich in biodiversity, including a wide variety of herbal plants. Herbs and spices are abundant in Indonesia and have been used in local customs since ancient times. Turmeric, ginger, and curcuma are rhizomes used as spices in Indonesian cooking and natural medicine. This study investigates the efficiency of natural deep eutectic solvents (NADES) synthesized from choline chloride and various sugars—fructose, glucose, maltose, and xylose in extracting polyphenolic compounds from Indonesian rhizomes: turmeric (Curcuma longa), red ginger (Zingiber officinale), and aromatic ginger (Kaempferia galanga L). The NADES were prepared using choline chloride as hydrogen bond acceptor (HBA). The hydrogen bond donor (HBD) is a sugar such as fructose, xylose, maltose, and glucose. The total phenolic content (TPC) was quantified and reported in mg gallic acid equivalent (GAE)/g extract.  Kaempferia galanga exhibited the highest TPC among the rhizomes, reaching 32.21 mg GAE/g when extracted with ChCl–Fructose NADES.  Curcuma longa and Zingiber officinale yield 20.05 mg GAE/g and 25.84 mg GAE/g under the same solvent conditions, respectively. When comparing the performance of the solvents, the following order was observed: ChCl–Fr > ChCl–Xyl > ChCl–Mal > ChCl–Glu. These findings suggest that solvent polarity and hydrogen bonding capacity significantly influence polyphenol solubility and extraction efficiency. NADES based on ChCl–Fructose showed the greatest potential for eco-friendly extraction of bioactive phenolics from medicinal rhizomes.
Identification Asthma Control Level And Its Factor Among Patient in A Tertiary Hospitals In Jakarta, Indonesia: A Cross-Sectional Study Wiyati, Tuti Wiyati
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.42069

Abstract

Poor asthma control level can result in mortality and morbidity in asthma patients. Therefore, it is important to detect it early and identify related factors. This was a cross-sectional study with data collection carried out in outpatient asthma patients in a tertiary hospital in Jakarta. The level of asthma control was measured using the Asthma Control TestTM (ACTTM) questionnaire. SPSS version 25 using Chi-Square Test was applied to determine risk factors that potentially associate with the level of asthma control. Forty-four patients met the criteria enrolled in this study. The results showed 43.2% of asthma patients were very uncontrolled, 27.4% of asthma patients were poorly controlled, and well-controlled asthma patients were 29.5%. There were not potential factor found to be associated with asthma control level of the patients.Keywords: Asthma, Asthma Control Level, Risk factors.
The Effect of Gelatin and Propylene Glycol on the Penetration Rate of Asiaticoside from Centella asiatica (L.) Urb Leaf Extract Gel Dahlizar, Sabrina; Anggraeni, Yuni; Munfarikhatin, Atina; Suryani, Nelly; Betha, Ofa Suzanti; Zilhadia, Zilhadia; Fajriah, Sofa; Septama, Abdi Wira; Handayani, Maulina; Herdini, Herdini
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.43891

Abstract

Centella asiatica (L.) Urb. is a plant known for its potential in scar treatment due to the presence of asiaticoside, a compound capable of promoting skin cell tissue repair. However, the large molecular size of asiaticoside hinders its penetration through the skin. This study aims to evaluate the effect of gelatin and propylene glycol on the transdermal penetration of asiaticoside from a gel formulation containing Centella asiatica leaf extract. Four different formulations were tested: a control (F1, without gelatin or propylene glycol); one with 15% propylene glycol (F2); one with 4% gelatin (F3); and one with 4% gelatin and 15% propylene glycol (F4). The physical characteristics of the formulations were assessed using several parameters: organoleptic properties, pH, homogeneity, centrifugation, spreadability, viscosity, and rheological behaviour. Penetration studies were performed using a Franz Diffusion Cell with a Whatman No. 1 membrane (pre-coated with Spangler solution) for 360 minutes. The penetration data were analyzed using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS) with a C18 BEH column (2.1 × 50 mm; 1.8 μm particle size). The results showed that each formulation exhibited distinct characteristics. The study findings indicated that both gelatin and propylene glycol, as well as their combination, significantly influenced the penetration of asiaticoside in the gel formulation. Propylene glycol, functioning as a penetration enhancer, was found to increase the penetration of asiaticoside in both gelatin-based and liquid formulations.
The Effect of Administration Platycerium bifurcatum (Cav.) C.Chr.) Extract On Total Bilirubin Levels and Hepatosomatic Index Values of Ethanol-Induced Rats Saputra, Hendri; Pertiwi, Reza; Komala Sari, Delia; Wulandari, Septi; Rahmawati, Reza
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.46829

Abstract

Hati merupakan organ vital yang memiliki peran utama sebagai pusat metabolisme. Kerusakan hati berkaitan dengan proses inflamasi yang memicu peningkatan indeks hepatosomatik (IHS). Salah satu indikator kerusakan hati adalah kadar bilirubin total (hiperbilirubinemia). Hingga saat ini penanganan hiperbilirubinemia masih terbatas pada terapi radiasi dan transfusi tukar, karena belum ada pengobatan farmakologis yang spesifik terhadap kondisi ini. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun pakis tanduk ( Platycerium bifurcatum (Cav.) C.Chr) terhadap kadar bilirubin total dan indeks hepatosomatik tikus putih jantan. Penelitian ini merupakan penelitian eksperimen laboratorium dengan rancangan Post Test Control Group Only dengan jumlah tikus 35 ekor yang dibagi menjadi 7 kelompok (normal, negatif, positif (aktif sakatonik), pelarut (Na CMC), ekstrak etanol pakis tanduk rusa dosis 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Perlakuan dilakukan selama 14 hari, pada hari terakhir tikus diinduksi dengan etanol absolut 2 mL/200 gBB kemudian setelah 12 jam dilakukan pembedahan untuk mengambil organ hati dan sampel darah untuk memeriksa kadar bilirubin total. Data dianalisis menggunakan One Way ANOVA dilanjutkan dengan Post Hoc LSD. Hasil penelitian ini, ekstrak etanol pakis tanduk rusa selama 14 hari dapat menurunkan bilirubin total dan HSI tikus putih jantan, analisis data ekstrak dengan dosis 50 mg/kgBB dan 100 mg/kgBB terdapat perbedaan yang bermakna dengan kontrol negatif (p<0,05). Hal ini menunjukkan bahwa pemberian ekstrak etanol pakis tanduk rusa selama 14 hari dapat menurunkan kadar bilirubin total dan HSI tikus putih jantan, analisis data ekstrak dengan dosis 50 mg/kgBB dan 100 mg/kgBB terdapat perbedaan yang bermakna dengan kontrol negatif (p<0,05). Hal ini menunjukkan bahwa pemberian ekstrak etanol pakis tanduk rusa selama 14 hari dapat menurunkan kadar bilirubin total dan HSI tikus putih jantan. Ekstrak etanol pakis tanduk rusa mempunyai pengaruh terhadap penurunan kadar bilirubin total dan HSI
Profil Asam Lemak Minyak Ikan Belanak (Chelon planiceps) Sebagai Sumber Omega-3 Asal Desa Lembo Kabupaten Konawe Utara Hikmah, Nurull -; Irnawati, Irnawati; Trinovitasari, Nita; A.Sida, Nurramadhani; Anwar, Irvan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.41029

Abstract

Ikan Belanak (Mullet) is a small pelagic fish that lives in shallow coastal waters. This type of fish lives in the coastal area of Lembo Village, North Konawe Regency. The objective of this study was to characterize physicochemicals and determine the fatty acid profile of mullet oil, which is a source of fish oil that contains unsaturated fatty acids that are beneficial to health. The reflux process is used to remove mullet flesh, which yields fish oil. The findings demonstrated that the physicochemical properties of mullet oil varied. These properties included the acid number, peroxide number, iodine number, and saponification number, which were, respectively, 0.81 mg KOH/g, 8.30 meqO2/kg, 50.98 I2/100 g, and 109.07 mg KOH/g. The fatty acid profile of mullet oil is dominated by palmitic acid, cis-9-oleic acid and DHA. Based on the test results, mullet oil can be used as edible oil according to SNI and IFOS standards. 
Analisis Pola Peresepan Obat Berdasarkan Perbedaan Status Penjamin (BPJS dan Non-BPJS) Rahayu, Retno Tri; Marvel, Marvel; Nurmeilis, Nurmeilis; Dhilasari, Estu Mahanani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.39009

Abstract

Evaluasi penggunaan obat merupakan aspek krusial dalam pelayanan farmasi klinik di fasilitas kesehatan. Tujuan penelitian ini adalah menganalisis hubungan antara status penjamin (BPJS dan non-BPJS) dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kementerian Kesehatan Republik Indonesia (Kemenkes RI) di sebuah klinik di daerah Kroya (Provinsi Jawa Tengah) pada tahun 2020. Indikator peresepan yang digunakan mencakup rerata jumlah obat per lembar resep, persentase peresepan antibiotik untuk ISPA non-pneumonia (batuk-pilek) dan diare non-spesifik, serta peresepan injeksi untuk myalgia. Penelitian ini menggunakan desain cross-sectional dengan data diperoleh secara retrospektif dari resep dan buku rawat jalan pasien. Sampel dipilih menggunakan teknik total sampling, menghasilkan 2.206 sampel resep yang dianalisis. Hasil penelitian menunjukkan perbedaan yang bermakna secara statistik (p<0,05) antara penjamin BPJS dan non-BPJS dalam semua indikator peresepan yang dievaluasi. Perbedaan ini terlihat pada rerata jumlah obat yang diresepkan (BPJS: 2,91; non-BPJS; 3,42), persentase peresepan antibiotik pada ISPA non-pneumonia (BPJS: 41,5%; non-BPJS: 63,1%), persentase peresepan antibiotik pada diare non-spesifik (BPJS: 39,8%; non-BPJS: 68,1%), dan persentase peresepan injeksi pada myalgia (BPJS: 0,0%; non-BPJS: 4,1%). Terdapat hubungan yang signifikan antara status penjamin dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kemenkes RI.
Identification Asthma Control Level And Its Factor Among Patient in A Tertiary Hospitals In Jakarta, Indonesia: A Cross-Sectional Study Wiyati, Tuti Wiyati; Hasanah, Rizqa Putri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.42069

Abstract

Poor asthma control level can result in mortality and morbidity in asthma patients. Therefore, it is important to detect it early and identify related factors. This was a cross-sectional study with data collection carried out in outpatient asthma patients in a tertiary hospital in Jakarta. The level of asthma control was measured using the Asthma Control TestTM (ACTTM) questionnaire. SPSS version 25 using Chi-Square Test was applied to determine risk factors that potentially associate with the level of asthma control. Forty-four patients met the criteria enrolled in this study. The results showed 43.2% of asthma patients were very uncontrolled, 27.4% of asthma patients were poorly controlled, and well-controlled asthma patients were 29.5%. There were not potential factor found to be associated with asthma control level of the patients.Keywords: Asthma, Asthma Control Level, Risk factors.
The Effect of Gelatin and Propylene Glycol on the Penetration Rate of Asiaticoside from Centella asiatica (L.) Urb Leaf Extract Geleaf Extract Gel Dahlizar, Sabrina; Anggraeni, Yuni; Munfarikhatin, Atina; Suryani, Nelly; Betha, Ofa Suzanti; Zilhadia; Fajriah, Sofa; Septama, Abdi Wira; Handayani, Maulina; Herdini
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/w7prk175

Abstract

Centella asiatica (L.) Urb. is a plant known for its potential in scar treatment due to the presence of asiaticoside, a compound capable of promoting skin cell tissue repair. However, the large molecular size of asiaticoside hinders its penetration through the skin. This study aims to evaluate the effect of gelatin and propylene glycol on the transdermal penetration of asiaticoside from a gel formulation containing Centella asiatica leaf extract. Four different formulations were tested: a control (F1, without gelatin or propylene glycol); one with 15% propylene glycol (F2); one with 4% gelatin (F3); and one with 4% gelatin and 15% propylene glycol (F4). The physical characteristics of the formulations were assessed using several parameters: organoleptic properties, pH, homogeneity, centrifugation, spreadability, viscosity, and rheological behaviour. Penetration studies were performed using a Franz Diffusion Cell with a Whatman No. 1 membrane (pre-coated with Spangler solution) for 360 minutes. The penetration data were analyzed using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS) with a C18 BEH column (2.1 × 50 mm; 1.8 μm particle size). The results showed that each formulation exhibited distinct characteristics. The study findings indicated that both gelatin and propylene glycol, as well as their combination, significantly influenced the penetration of asiaticoside in the gel formulation. Propylene glycol, functioning as a penetration enhancer, was found to increase the penetration of asiaticoside in both gelatin-based and liquid formulations.              
Melindungi Konsumen Melalui Regulasi: Studi Kasus Sosialisasi Peraturan BPOM Tentang Batas Cemaran Kosmetik Kashuri, Mohamad
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.45307

Abstract

This study evaluates the effectiveness of disseminating BPOM Regulation No. 16 of 2024 in enhancing stakeholder understanding and support for regulations designed to protect consumers from unsafe cosmetics. The regulation aims to align national standards with international ones; however, its implementation faces significant challenges. Using a descriptive quantitative approach, a survey was conducted with 528 participants in a hybrid-format dissemination program. The results indicate that the dissemination activities were effective, with an average evaluation score of 5.19 out of 6 for the regulation, and consumer protection aspects receiving the highest score (5.40). The implementation of the activities was rated as excellent (average score of 5.39), reflecting the organizers’ success in reaching a broad audience. However, challenges related to implementation costs were identified as barriers for MSMEs, which require technical guidance and operational support. The study concludes that the dissemination activities improved stakeholder preparedness, but successful implementation requires a collaborative approach involving technical assistance, adequate time allocation for discussions, and innovative delivery methods. These measures are crucial to support a safe and globally competitive Indonesian cosmetics industry.

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