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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 140 Documents
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Hubungan Sosiodemografi Pasien dengan Pengetahuan Pasien tentang Pelayanan Informasi Obat menggunakan Telefarmasi (E-Pharmacy) Restinia, Mita; Mustafidah, Mabrurotul; Adhamira, Rania; Kinanti, Annisa Putri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.31900

Abstract

E-pharmacy or telepharmacy is a form of ICT-based health service that facilitates consultation with medical practitioners. Telepharmaceutical services in Indonesia have not been implemented widely. This is because ICT access has not been perfectly spread throughout Indonesia. There is also still little socialization related to telepharmaceuticals, so that the understanding of telepharmaceuticals cannot reach the public, which causes telepharmaceuticals to not being implemented properly. This study aims to determine the relationship between the sociodemographic characteristics of respondents and the level of patient knowledge of drug information services using telepharmacy. This research is a descriptive quantitative correlation research. Respondents in this study amounted to 401 people. Statistical test using Chi Square test obtained p value < 0.05 for age and education test with telepharmaceutical knowledge, which can be concluded that there is a relationship between respondent's age and education with telepharmaceutical knowledge; and p value > 0.05 for the test of gender, occupation, frequency of application use with telepharmaceutical knowledge, which can be concluded that there is no relationship between gender, occupation, frequency of application use and telepharmaceutical knowledge.
The Impact of EG and DEG Cases on Sales of Over-The-Counter Syrup Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana; Siada, Nyoman Budiartha; Marwati, I Gusti Ayu
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32013

Abstract

The Indonesian Food and Drug Authority (BPOM) investigated and listed safe and unsafe syrup products in response to the contamination of Ethylene Glycol (EG) and Diethylene Glycol (DEG), causing Acute Kidney Injury in pediatric patients. Unsafe products were recalled and removed from distribution, leading to uncertainty and panic among the public and significantly impacting over-the-counter syrup sales in several pharmacies. This retrospective observational study assessed the impact of EG and DEG contamination on the sales of over-the-counter syrup in Pharmacy X in South Denpasar. Data from three months before (August to October 18th, 2022) and three months following the official instruction was published (October 19th, 2022 to December 2022) were analyzed using Wilcoxon test. The findings reveal a staggering decline in the sales of over-the-counter syrup by 35,03% (p-value of 0.03). Moreover, there was a notable increase of prescriptions in powder forms. The contamination cases caused panic, resulting in changes in behavior and consumption patterns. Despite the availability of safety information on an official website, public hesitance toward syrup products persists, indicating the need to implement a more effective strategy to address misinformation and restore public trust. Each individual must be responsible for educating the public during crises to prevent the spread of misinformation, ultimately restoring trust and normal consumer behavior. Furthermore, efficient stock management should be implemented to anticipate potential health crises in the future proactively.
Penggunaan Obat Herbal pada Responden COVID-19 yang Menjalani Isolasi Mandiri Restinia, Mita; Aldrat, Hendri; Pangestuti, Alia Dening; Musir, Ahmad
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32294

Abstract

COVID-19 is an infectious disease caused by spreading the coronavirus worldwide. In Indonesia, COVID-19 patients with mild symptoms can undergo independent isolation at home. The public widely uses herbal medicines in the treatment of COVID-19. A non-experimental cross-sectional study was performed to identify the profile of the use of herbal medicines by COVID-19 respondents during independent isolation in South Tangerang. The sampling technique conducted purposive sampling on 96 respondents who met the inclusion criteria. The instrument used is a questionnaire with close-formatted and open-ended questions. Questionnaires were distributed online from March to May 2022. The most used herbal medicines were honey (85.4%), ginger (52.1%), propolis (35.4%), turmeric (32.3%) and garlic (26%). The reason respondents used herbs because they were made from natural ingredients (84.4%), the method of use was boiled or brewed (58.3%), information on the use of herbal medicines was obtained from the family (63.5%), the source of obtaining herbal medicines was sent by relatives/family/friends (69.8%), the duration of using herbal medicines is 1-7 days (39.6%), the time to use herbal medicines was generally in the morning (49%), and the cost of herbal medicines is IDR 100,000 - 500,000 (44.8%). Through this research, it can be concluded that South Tangerang City's people still use herbal medicines as an alternative treatment while infected with COVID-19. Therefore, further education on the safety and maximum use of herbal medicines is required.
Penggunaan Tumbuhan Obat Sebagai Penunjang Kesehatan pada Masyarakat Betawi Aldrat, Hendri; Wulandari, Winda Trya; Restinia, Mita
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 1 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32588

Abstract

Changes in land use from rice fields and plantations to residential areas, offices, and trading complexes will certainly result in changes in the biodiversity of the environment of the inhabitants of the capital city of Jakarta, including the Betawi community. The scarcity of certain species due to land conversion also affects people’s ethnobotanical knowledge. This study aimed to explore how the Betawi people, with the rapid flow of urbanization, use medicinal plants around them. A total of 25 respondents of the selected Betawi ethnicity were interviewed about the use of medicinal plants. Purposive sampling and snowball sampling were used. The data obtained from the respondents were collected and compared using triangulation techniques with previously published ethnobotanical reports. The results showed that as many as 61 species from 36 families were used by the Betawi people to support their health. Ginger, lemongrass, and jatropha are the most widely used plants. The most widely used species belong to the Zingiberaceae family. The most commonly used part is the leaves (55%), the most common processing method is boiling (48%), the most common way to administer the medicine is by drinking (49%), and as much as 61% of medicinal plants are used in the home. In conclusion, the Betawi people still maintain the tradition of using herbal medicine amidst the high rate of urbanization in the capital city of Jakarta. Furthermore, it is necessary to conduct further experiments in the laboratory to validate the safety, efficacy, and identification of the active ingredients in these plants. 
Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Rudiana, Tarso; Simanjuntak, Partomuan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
Aktivitas Antibakteri Sediaan Masker Gel Peel Off Ekstrak Mentimun (Cucumis Sativus) Dan Tomat (Solanum Lycopersicum) Terhadap Staphylococcus Epidermidis Rahasasti, Indri Dwi; Luviriani, Eva; Calyptranti, Rosellynia; Kurniawati, Triani; Rahayu, Lia Handayani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.35117

Abstract

Acne is a disease that can be caused by bacteria, one of which is Staphylococcus epidermidis. Acne can be treated with active compounds derived from natural ingredients such as cucumbers and tomatoes. Gel masks peel off. This study aims to determine the average diameter of the inhibition zone, the difference in the average diameter of the inhibition zone, and the antibacterial activity of the peel-off from a mixture of cucumber (Cucumis sativus) and tomato  (Solanum lycopersicum) with a concentration of 5%, 10 %, 15%, 20% against  Staphylococcus epidermidis. This experimental study uses a Completely Randomized Design (CRD) consisting of one factor and 6 levels. The results showed that the average diameter of the inhibition zone of the anti-acne peel-off gel mask preparation of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10%, 15% and 20% were 16.38 mm, respectively. ; 24.88 mm; 29.88 mm and 34.88 mm. There was a significant difference in the average diameter of the inhibition zone of the peel off mixture of cucumber and tomato extracts with a concentration of 5%, 10%, 15%, and 20%; against Staphylococcus epidermidis. gel mask preparation peels off from a mixture of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10% concentration, 15% concentration and 20% concentration, namely strong, very strong, very strong and very strong.  
Profil Pelayanan Informasi Obat pada Pelayanan Swamedikasi Obat Allopurinol di Apotek Kabupaten Bekasi Putri, Clarisya Pramirusanti; Wulandari, Ainun; Siregar, Tahoma
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.35167

Abstract

Tenaga kefarmasian merupakan tenaga kesehatan yang memberikan pelayanan kefarmasian kepada masyarakat, salah satunya Pelayanan Informasi Obat khususnya dalam memberikan pelayanan pengobatan mandiri. Peran apoteker di apotek dapat dikatakan belum maksimal, baik dalam penggalian informasi maupun teknis pelayanan informasi obat. Penelitian ini bertujuan untuk mengetahui layanan informasi obat pada layanan pengobatan mandiri allopurinol di apotek di Kabupaten Bekasi. Jenis penelitian ini menggunakan penelitian deskriptif. Penelitian ini dilakukan secara observasional dengan menggunakan metode simulasi pasien, yaitu simulasi pasien yang telah dilatih. Pemilihan sampel apotek menggunakan metode Probability Sampling dan Cluster Random Sampling dengan jumlah apotek yang ada di Kabupaten Bekasi sebanyak 76 buah yang terbagi dalam 21 kecamatan. Subyek penelitian dalam penelitian ini adalah petugas di bagian apotek yaitu apoteker, asisten apoteker, dan petugas non apotek. Instrumen penelitian yang digunakan adalah checklist yang berisi kriteria informasi yang harus disediakan oleh tenaga farmasi dalam pelayanan informasi obat sesuai Peraturan Menteri Kesehatan Republik Indonesia Nomor 73 Tahun 2016 tentang Standar Pelayanan Kefarmasian di Apotek. Hasil penelitian menunjukkan bahwa penggalian informasi dari pasien dikategorikan buruk dengan nilai 0,16% (≤70%), pemberian informasi obat allopurinol dikategorikan buruk dengan nilai 14,11% (≤70%), sehingga kualitas pelayanan kesehatan baik. pelayanan informasi obat yang dilakukan oleh apoteker (7,57%), oleh asisten apoteker (7,18%), dan oleh petugas non apotek (6,56%), dimana ketiganya termasuk dalam kategori buruk (≤70%). Dari penelitian ini disimpulkan bahwa peran petugas apotek dalam memberikan pelayanan informasi obat allopurinol masih rendah dan perlu ditingkatkan.
In Silico Assessment of Chemical Constituents of Zingiber officinale Rosc. For Anti-diabetic Activity: Molecular Docking with α-Glucosidase Receptor Normi, Normi; Supandi, Supandi; Komala, Ismiarni
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.36161

Abstract

Diabetes Mellitus (DM) is a disease in which blood sugar (glucose) levels are elevated because the body cannot release or utilize insulin adequately. Rhizome of Zingiber officinale Rosc. (ginger) has been reported to possess anti-diabetic properties. This study aimed to provide information on the chemical components of ginger that have potential in silico antidiabetic activity against the α-glucosidase receptor. Twenty chemical components of ginger (quercetin, catechin, humulene, β-sesquiphellandrene, camphene, farnesene, β-sitosterol, stigmasterol, curcumin, 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, 8-shogaol, 10-shogaol, 6-paradol, 8-paradol, 10-paradol, methyl-6-gingerol, and methyl-8-gingerol) were used as ligands. An in silico study was conducted using the molecular docking technique with the AutoDock Vina software, which was then displayed using PyMOL and Biovia Discovery Studio. The grid box settings obtained in this study were as follows: center_x = -20.209, center_y = -6.763, center_z = 9.393, size_x = 12, size_y = 10, size_z = 12, and spacing (angstrom) = 1. The results indicated that the native ligand acarbose exhibited a binding energy of -6.9 kcal/mol. In contrast, four test ligands, quercetin (-7.3 kcal/mol), catechin (-7.1 kcal/mol), curcumin (-7.0 kcal/mol), and 6-gingerol (-7.0 kcal/mol) - demonstrated lower binding energies than acarbose, suggesting more stable conformations and more potent pharmacological effects. Lipinski analysis revealed that these four test ligands met all five Lipinski rule criteria. The study calculated the Root Mean Square Deviation (RMSD) value for the Docking of acarbose with the α-glucosidase macromolecule, resulting in a value of 0.384 Å. Interaction analysis conducted using Biovia Discovery Studio software revealed various interaction types, including hydrogen bonding, hydrophobic, electrostatic, and unfavorable interactions. In conclusion, this study provides valuable insights into potential therapeutic compounds derived from ginger and offers a foundation for further research and development in pharmaceutical and medicinal chemistry.
Measuring Compliance Therapy in Type 2 Diabetes Mellitus Patients using Proportion of Days Covered (PDC) Method and Its Effect on Clinical Outcomes Anwar, Irvan -; Sabarudin, Sabarudin; Malina, Rachma; Widaningsih, Ayu Dewi; Wijaya, Aurelia Arbaleta; Nurawaliah, Lilis
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.37761

Abstract

Diabetes Mellitus (DM) is a chronic disease that occurs when blood glucose levels rise beyond normal limits because the body is unable to produce or use insulin effectively. Therapeutic adherence is one of the causes of normal blood glucose levels and the success of patient therapy. Measurement of therapeutic adherence of dm type 2 patients needs to be carried out to monitor the success of their therapy. This study aims to determine the adherence of antidiabetic therapy using the Proportion of Days Covered (PDC) method and its effect on the clinical outcomes of type 2 DM patients at Sulawesi Tenggara. The research method used is observational research with a descriptive design approach. The sample of this study was 186 people obtained using the Slovin formula. Patients are said to be adherence if their PDC value ≥ 80% and are said to be non-adherence if their PDC value < 80%. The data were analyzed using the chi square test. The results showed that patients adhering to treatment amounted to 130 people (69.9%), while patients who did not comply with treatment amounted to 56 people (30,1%) and there was a significant influence between adherence to antidiabetic therapy on the success of therapy  (clinical outcome) with p value = 0.000 in type 2 DM patients at Sulawesi Tenggara. It was be concluded that most of the patients in this study were adherent to the treatment and there was a significant influence between the adherence of antidiabetic therapy to the success of the therapy (clinical outcomes)
Study of Consumer Satisfaction Levels with E-Pharmacy Services Using the Customer Satisfaction Index (CSI) and Importance Performance Analysis (IPA) Mustafidah, Mabrurotul; Shavira, Rurynta Ferly; Adhamira, Rania; Kinanti, Annisa Putri; Citraningsih, Kinanti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.37922

Abstract

E-pharmacy is one of the efforts to improve pharmaceutical services to make them easier and more efficient. Customer Satisfaction Index (CSI) is a scale that can describe consumer satisfaction with a product or service. Customer satisfaction with e-pharmacy services can be assessed by the value of customer expectations for service quality and the reality of the service performance received. This study aims to examine the level of consumer satisfaction, expectations, and priorities for attribute improvement in the dimensions of e-pharmacy services so that service providers can evaluate and improve their services. Furthermore, the analytical method in this study uses an analysis of the results of the gap based on the Service Quality (Servqual), Customer Satisfaction Index (CSI), and Importance Performance Analysis (IPA). The results of this study indicate that attributes' performance on the dimensions of e-pharmacy services is not satisfactory. Customer satisfaction in e-pharmacy service is 86.11% or in the 'very satisfied' category. Meanwhile, the service attribute prioritized for service providers is to improve the guarantee that the drugs given are in good condition (by showing the drug's expiration date).

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