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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 140 Documents
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Analysis of Escherichia coli Microbial Contamination and Total Coliform Bacteria in Refill Drinking Water in Pondok Cabe Ilir Village, South Tangerang City Puteri Amelia; Ummi Habibah; Ofa Suzanti Betha
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24699

Abstract

Water is an essential nutrient for human health. It is important to maintain adequate drinking water intake to prevent dehydration, which can cause hypothermia, dizziness, constipation, and kidney stones. Currently, water-filling stations are an alternative source of drinking water because of limited access to clean water at affordable prices. The purpose of this study was to determine bacterial contamination at a drinking water station in Pondok Cabe Ilir, South Tangerang, Banten, based on Permenkes RI No. 492/Menkes/Per/IV/2010. The study was conducted using the Most Probable Number (MPN) method and the IMViC test, Triple Sugar Iron test, H2S production test, and motility test to identify Escherichia coli. The results showed that one out of five refilled drinking water samples contained Coliform bacteria above the threshold according to Minister of Health Regulation No. 492/Menkes/Per/IV/2010.
Aplikasi FTIR sebagai Deteksi Cepat Bahan Non-Halal dalam Campuran Produk Olahan Mabrurotul Mustafidah; Arif Nur Ikhsan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24426

Abstract

The trend of Halal is not about label processed products, but also to become a necessity in products to gain public trust. Indonesia as the country with the most Muslims in Asia, has its own market for halal products. Consumer confidence increases for goods that have included halal in their products. The unknown material in this case is the material that makes the product non-halal, such as the presence of a mixture of pork. Many irresponsible producers use a mixture of non-halal ingredients to increase profits. To detect halal, various methods have been developed, one of which is FTIR. FTIR is a fast and easy to use instrument capable of analyzing mixtures in a product. Various studies for product authentication were analyzed using FTIR and showed results that FTIR was able to detect the presence of a mixture of unwanted ingredients in the product and could be used as a method to detect counterfeiters in processed products.
Comparative Anti-Inflammatory Effect of Aceclofenac with Saccharin and Aceclofenac in Carrageenan-Induced Granuloma Pouch Model in Mice Usman, Hendrizal; Umar, Salman; Aldi, Yufri; Rahmadevi, Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.48792

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Analisis Pola Peresepan Obat Berdasarkan Perbedaan Status Penjamin (BPJS dan Non-BPJS) Rahayu, Retno Tri; Marvel, Marvel; Nurmeilis, Nurmeilis; Dhilasari, Estu Mahanani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.39009

Abstract

Evaluasi penggunaan obat merupakan aspek krusial dalam pelayanan farmasi klinik di fasilitas kesehatan. Tujuan penelitian ini adalah menganalisis hubungan antara status penjamin (BPJS dan non-BPJS) dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kementerian Kesehatan Republik Indonesia (Kemenkes RI) di sebuah klinik di daerah Kroya (Provinsi Jawa Tengah) pada tahun 2020. Indikator peresepan yang digunakan mencakup rerata jumlah obat per lembar resep, persentase peresepan antibiotik untuk ISPA non-pneumonia (batuk-pilek) dan diare non-spesifik, serta peresepan injeksi untuk myalgia. Penelitian ini menggunakan desain cross-sectional dengan data diperoleh secara retrospektif dari resep dan buku rawat jalan pasien. Sampel dipilih menggunakan teknik total sampling, menghasilkan 2.206 sampel resep yang dianalisis. Hasil penelitian menunjukkan perbedaan yang bermakna secara statistik (p<0,05) antara penjamin BPJS dan non-BPJS dalam semua indikator peresepan yang dievaluasi. Perbedaan ini terlihat pada rerata jumlah obat yang diresepkan (BPJS: 2,91; non-BPJS; 3,42), persentase peresepan antibiotik pada ISPA non-pneumonia (BPJS: 41,5%; non-BPJS: 63,1%), persentase peresepan antibiotik pada diare non-spesifik (BPJS: 39,8%; non-BPJS: 68,1%), dan persentase peresepan injeksi pada myalgia (BPJS: 0,0%; non-BPJS: 4,1%). Terdapat hubungan yang signifikan antara status penjamin dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kemenkes RI.
Melindungi Konsumen Melalui Regulasi: Studi Kasus Sosialisasi Peraturan BPOM Tentang Batas Cemaran Kosmetik Kashuri, Mohamad
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.45307

Abstract

This study evaluates the effectiveness of disseminating BPOM Regulation No. 16 of 2024 in enhancing stakeholder understanding and support for regulations designed to protect consumers from unsafe cosmetics. The regulation aims to align national standards with international ones; however, its implementation faces significant challenges. Using a descriptive quantitative approach, a survey was conducted with 528 participants in a hybrid-format dissemination program. The results indicate that the dissemination activities were effective, with an average evaluation score of 5.19 out of 6 for the regulation, and consumer protection aspects receiving the highest score (5.40). The implementation of the activities was rated as excellent (average score of 5.39), reflecting the organizers’ success in reaching a broad audience. However, challenges related to implementation costs were identified as barriers, particularly for MSMEs. These businesses require technical guidance and operational support. The study concludes that the dissemination activities improved stakeholder preparedness, but successful implementation requires a collaborative approach involving technical assistance, adequate time allocation for discussions, and innovative delivery methods. These measures are crucial to support a safe and globally competitive Indonesian cosmetics industry.
Pengaruh Beberapa Jenis Praperlakuan Terhadap Peningkatan Rendemen Minyak Gaharu Hasil Hidrodistilasi Aldrat, Hendri; Supandi, Supandi; Musdja, M. Yanis
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.46701

Abstract

Minyak gaharu memiliki potensi untuk dikembangkan sebagai aromaterapi namun ketersediaannya di alam yang terbatas sehingga diperlukan upaya yang efektif untuk mendapatkan rendemen yang optimal. Berbagai pretreatment ekstraksi diketahui dapat meningkatkan rendemen minyak gaharu. Penelitian ini bertujuan untuk membandingkan rendemen dan profil senyawa minyak gaharu yang diperoleh dari pretreatment maserasi, microwave, ultrasonik, dan fermentasi. Penelitian dilakukan dengan melakukan pretreatment ekstraksi, distilasi serbuk kayu gaharu, identifikasi senyawa minyak atsiri melalui Gas Chromatography Mass Spectrometry (GCMS), serta uji hedonik. Hasil distilasi menunjukkan bahwa pretreatment fermentasi ragi tapai memiliki persentase rendemen minyak gaharu tertinggi sebesar 0,050% diikuti fermentasi Fusarium sp. (0,036%), ultrasonik (0,034%), microwave (0,030%), maserasi (0,024%) dan kontrol (0,018%). Ada sejumlah 6 senyawa yang konsisten dijumpai pada setiap sampel seperti α-agarofuran dan dihydrocolumellarin, dan asam heksadekanoat. Senyawa sesquiterpen terbanyak diperoleh dari pretreatment menggunakan ragi tempe. Berdasarkan hasil penelitian diketahui bahwa pretreatment maserasi, microwave, ultrasonik dan fermentasi dapat meningkatkan rendemen dan mempengaruhi profil senyawa minyak gaharu.
Studi awal: Identifikasi Keragaman Gen Bakteri Saliva pada Wanita Usia Lanjut Menggunakan Teknologi 16S Ribosome Sequencing Oxford Nanopore Adhiyanto, Chris; Hendarmin, Laifa A; Harriyati, Zeti; Suwarsono, Erike A. Suwarsono A; Suri, Auliyani Andam; Nugraha, Yudhi; Gunarti, Dwirini Retno
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.46752

Abstract

The elderly are a population particularly susceptible to diseases resulting from the decline in immune system function. The mouth is one of the areas of the body that is the entry point for microorganisms into the body. It is known that the oral microbiome greatly affects oral and systemic health. The oral bacterial profile is important to understand its role in maintaining health and causing disease. Therefore, maintaining oral health is very important, especially in our study of the elderly. Utilizing advanced sequencing techniques such as Oxford Nanopore Technology (ONT) offers the opportunity to reveal bacterial diversity comprehensively. This study aims to identify the oral microbiome in a group of elderly women. Knowledge of the oral microbiota profile could help spread awareness of the benefits of maintaining good dental hygiene, especially in older adults. Methods: Seven elderly housewives had their unstimulated saliva samples taken in the morning and kept at -80°C. The phenol-chloroform technique was used to isolate the DNA, and a Qubit Fluorometer was used to measure purity and concentration. By employing ONT for 16S rRNA sequencing and Epi2Me software for analysis, taxonomic mapping of the bacterial diversity was accomplished.  Results: According to the taxonomic analysis, Streptococcus and Veillonella were the most common genera in the samples. It was common to find species like Veillonella parvula, Veillonella atypica, Streptococcus mitis, and Streptococcus rubneri. These genera contributed to the dynamics of oral biofilms by exhibiting complex ecological interactions. With advanced sequencing technologies, this work highlights the diversity of oral bacteria in elderly women in Indonesia while providing a new perspective. Notwithstanding a few limitations, these findings provide insight into the ecological dynamics of the oral microbiota, potentially leading to clinical applications in the treatment and prevention of disease. 
HUBUNGAN PENGETAHUAN DAN PERILAKU SWAMEDIKASI PENGGUNAAN OBAT ANALGESIK PADA MASYARAKAT SEMPER BARAT JAKARTA UTARA Islam, Zainul; Sulistyaningsih, Endang; Luthfianti, Fanni
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.41623

Abstract

Swamedikasi adalah pemilihan dan penggunaan obat untuk melindungi diri dari penyakit dan gejalanya. Swamedikasi memiliki keuntungan termasuk penghematan biaya dan mengurangi beban pada layanan perawatan kesehatan. Namun, memiliki risiko yang dapat meningkatkan biaya pengeluaran dan bahaya kesehatan jika obat digunakan secara tidak tepat. Masyarakat membutuhkan pengetahuan untuk mendapatkan perilaku swamedikasi. Analgetika adalah obat yang digunakan untuk meringankan atau menekan rasa nyeri. Tujuan penelitian ini untuk mengetahui hubungan tingkat pengetahuan terhadap perilaku swamedikasi penggunaan obat analgesik. Penelitian ini menggunakan kuisioner yang telah diuji validitas dan reliabilitasnya. Analisis data menggunakan uji Chi-square dan Spearman-rho. Responden penelitian ini sebanyak 400 di 9 RW Kelurahan Semper Barat. Hasil penelitian menunjukkan mayoritas responden berpengetahuan cukup 64,3% dan berperilaku cukup 52,5%. Hasil uji Chi-Square menunjukkan mayoritas tidak ada hubungan karakteristik dengan pengetahuan dan perilaku. Kecuali, pendidikan dan pengetahuan. Hasil uji Spearman-rho menunjukkan adanya hubungan yang bermakna antara tingkat pengetahuan dengan perilaku swamedikasi. Korelasi Spearman-rho diperoleh (p 0,126) yang menunjukkan bahwa terdapat hubungan yang lemah antara pengetahuan terhadap perilaku swamedikasi obat analgesik.
Studi Farmakologi Ikan Zebra sebagai Model Obesitas dan Hiperglikemia: Pengembangan Induksi Diet-Induced Obesity Nurfakhrurajab, Irfan; Elfita, Lina; Fitriana, Narti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.45453

Abstract

Obesity and hyperglycemia are major risk factors for type 2 diabetes mellitus and various other metabolic disorders. The use of relevant animal models is essential to support pharmacological studies. The aim of this research was to develop an effective DIO (Diet-Induced Obesity) inducer for commercially available zebrafish as a model for obesity and hyperglycemia. Adult zebrafish were induced for obesity and hyperglycemia through administration of a high-fat diet for 4 weeks. The observed parameters included body weight, body length, body mass index (BMI), and blood glucose levels. The results showed that DIO induction significantly increased body weight, BMI, and blood glucose levels (P < 0.05) compared to the control group. In conclusion, zebrafish can be developed as a model for obesity and hyperglycemia through DIO induction, thus potentially serving as an alternative test animal for pharmacological studies of metabolic diseases.
Most Probable Number (MPN) Coliform of Jamu Gendong Kencur Rice in Traditional Markets in Sukoharjo Region Jamilatun, Makhabbah
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.40671

Abstract

One of the traditional medicines that is very popular with the public because it is affordable and easy to obtain in both traditional and modern markets is herbal medicine. Among the various types of herbal medicine circulating in the community, the one most frequently encountered is jamu carrying kencur rice. The safety of traditional medicinal products (herbal medicine) is a demand that has been put forward since the emergence of human health problems due to contamination by microorganisms, such as coliforms. Microbiological examination of water is very necessary to prevent contamination of water consumed by humans. This research aims to determine the contamination of coliform bacteria in the kencur rice herbal medicine in traditional markets in the Sukoharjo area. The method used in this research is the MPN (Most Probable Number) method which consists of two stages, namely the presumptive test and the confirmed test. The results showed that samples with codes 1, 2, 5, 6, 7, 8, 11, and 12 had an MPN value of 0/100 ml. Furthermore, samples with codes 3, 4, 9, and 10 show MPN values > 0/100 ml. Based on the research results, samples that meet good drinking water quality based on the Regulation of the Minister of Health of the Republic of Indonesia, are samples with codes 1, 2, 5, 6, 7, 8, 11, and 12, while samples with codes 3, 4, 9, 10 do not meet the requirements.

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