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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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DETERMINASI KEPATUHAN MINUM OBAT PADA PASIEN DIABETES MELLITUS TIPE II DI PUSKESMAS TERARA: ANALISIS KORELASI FAKTOR-FAKTOR PENGARUH Sovia, Fitriwati; Anjani, Rizky Puji; Ramadhan, Leny
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2115

Abstract

Diabetes mellitus is a chronic disease that requires ongoing management because it cannot be permanently cured. Adherence to the treatment plan is crucial to prevent deterioration in physical condition. This study aims to analyze the correlation between factors affecting medication adherence in patients with type II diabetes mellitus at Terara Community Health Center. This research uses an observational analytic design with a cross-sectional approach. The study population consists of 151 patients with type II diabetes mellitus, with a sample of 35 individuals selected through purposive sampling. Data were collected using a questionnaire and analyzed with Fisher's test. The results indicate that factors such as gender (P=0.015), occupation (P=0.015), knowledge (P=0.006), attitude (P=0.001), motivation (P=0.021), and family support (P=0.004) have a significant correlation with medication adherence. Conversely, age, education, and healthcare support did not show a significant correlation with medication adherence. In conclusion, factors such as gender, occupation, knowledge, attitude, motivation, and family support significantly influence medication adherence in patients with type II diabetes mellitus at Terara Community Health Center.
AKTIVITAS ANTIBAKTERI NANOPARTIKEL KITOSAN DARI LIMBAH CANGKANG RAJUNGAN (Portunus pelagicus) TERHADAP BAKTERI Staphylococcus epidermidis Fauliya, Fauliya; Yusan, Liza Yudistira
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2125

Abstract

Staphylococcus epidermidis bacteria are commonly associated with causing acne, which is a type of Gram-positive bacteria. Chitosan nanoparticles have potential as antibacterials that can be developed into alternative therapies. The purpose of this study was to determine chitosan nanoparticles derived from crab shell waste (Portunus pelagicus) in inhibiting Staphylococcus epidermidis bacteria. Disc diffusion is the method used to test antibacterial activity. The concentrations of chitosan nanoparticles used were 400 ppm, 600 ppm and 800 ppm. Tetracycline was used as positive control and 1% acetic acid as negative control. The results showed that chitosan nanoparticles had stronger antibacterial activity with increasing concentration, the strongest inhibition at a concentration of 800 ppm (14.12 ± 3.72 mm). Chitosan nanoparticles have antibacterial activity against Saphylococcus epidemidis bacteria. The higher the concentration of chitosan nanoparticles can increase its ability to inhibit bacterial growth.
HUBUNGAN TINGKAT KEPATUHAN MINUM OBAT HIPERTENSI MENGGUNAKAN KUESIONER HILL-BONE TERHADAP KUALITAS HIDUP PASIEN DI PUSKESMAS PEKAUMAN BANJARMASIN SELATAN Safitri, Sri Desi; Hartanto, Dedi; Mulyani, Tuty
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2142

Abstract

Hypertension is a disease that is the number one cause of death in the world every year. Based on measurements at ages ≥18 years, the highest hypertension prevalence data according to the province is South Kalimantan at 44.13%. One of the causes of the high prevalence of hypertension is due to low compliance in taking medication. Compliance is very necessary while undergoing hypertension treatment to reduce the impact and thus provide a good quality of life. The purpose of this study was to determine the relationship between the level of compliance using the Hill-Bone questionnaire on the quality of life of hypertensive patients at the Puskesmas Pekauman. This study used an observational method with a cross-sectional design to determine the picture of the level of compliance with the quality of life of hypertensive patients at the Puskesmas Pekauman. Data collection using the Hill-Bone questionnaire to determine adherence level and EQ-5D-5L questionnaire to determine patient's quality of life. The results of this study showed that of the 68 respondents, 3 people (4.40%) with a moderate level of compliance had a moderate quality of life, 59 people (86.80%) with a moderate level of compliance had a high quality of life and 6 people (8.8 %) with a high level of compliance have a high quality of life, which is obtained from Kendall's tau-B test, p-value = 0.000 < 0,05. It can be concluded that there is a significant relationship between compliance and quality of life in hypertension sufferers at the Puskesmas Pekauman.
MEKANISME KO-KEMOTERAPI EKSTRAK ROSELLA (Hibiscus sabdariffa. L) DENGAN DOXORUBICIN PADA SEL KANKER SERVIKS (HeLa) SECARA IN VITRO Daud, Intan; Hayu Nurani, Laela; Bachri, Moch. Saiful; Ariani Edityaningrum, Citra; Ma’ruf, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2158

Abstract

Cervical cancer caused by exposure to Human Papilloma Virus (HPV) through sexual intercourse can be treated with Doxorubicin. Doxorubicin shows side effects so it needs to be combined with co-chemotherapy. Rosella (Hibiscus sabdariffa L.) The main content of anthocyanins is cytotoxic to HeLa cells.  The purpose of this study was to find co-chemotherapy combination of Doxorubicin and Rosella extract with apoptosis mechanism and Rosella antiproliferation.  The research method starts from the maceration process of Rosella petals using 96% ethanol. Cytotoxic test method, antiproliferation test, apoptosis, and combination test with MTT method using HeLa cells. The result of cytotoxic test showed IC50 of Rosella extract was 32.3 ± 2.15 µg/mL and IC50 of Doxorubicin was 2.68 ± 0.09 µg/mL. The antiproliferation test results in the control cell doubling time of 28.25 ± 0.21 hours while the concentration of Rosella extract at levels of 32.3; 16.15; and 8.08 µg/mL doubling time of 53.23 ± 0.20 hours, 39.02 ± 0.19 hours and 46.74 ± 0.23 hours so that it shows the inhibition of cell multiplication growth. The IC results show the combination of 4.04 µg/mL Rosella Flower Extract and 2.67 µg/mL Doxorubicin which is 0.0013 can be interpreted as a very strong synergistic effect (0.0013 ≤ 0.1). So it can be concluded the combination of ethanol extract Rosella flowers has antiproliferation properties through the mechanism of delaying the doubling time.
PENGEMBANGAN DAN VALIDASI KUESIONER BELIEF ABOUT MEDICINE (BMQ) UNTUK MENGUKUR PERSEPSI RISIKO MASYARAKAT TERHADAP OBAT SETELAN Walidah, Ziyana; Hermansyah, Andi; Wijaya, I Nyoman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2162

Abstract

Nowadays, the consumption of medicine suits is a problem of self-medication that occurs in the community. BPOM prohibits this medicine from being used, because the quality is not guaranteed and it can cause harm when consumed because it contains several classes of hard drugs. The high consumption of medicine suits indicates a lack of public understanding of the risks posed by medicine suits. Measuring people's perceptions of medicine suits needs to be done, one of which is by filling out a questionnaire. There is no questionnaire that measures a person's perception of suit medicine, so it is necessary to develop research instruments through validity and reliability tests of questionnaires related to measuring people's perceptions or beliefs about a treatment. This study was conducted using observational method and cross sectional time design. Where it involved 30 trial respondents while still paying attention to the inclusion criteria that had been set. The results of this study indicate that the questionnaire designed has met the minimum values of validity and reliability. Where there is only one invalid question item. While in general the resulting value of r count> r table. Regarding reliability, all items have achieved a Cronbach' alpha value of more than 0.6. This indicates that the questionnaire on community risk perception towards legitimate use of medicine suits can be used repeatedly.
AKTIVITAS ANTIBAKTERI DAN ANTIBIOFILM DARI EKSTRAK DAUN BANGUN-BANGUN (Coleus amboinicus L.) TERHADAP BAKTERI Staphylococcus aureus Fitra, Romadhonsyah; Romadhonsyah, Fitra; Aisha Nanda Caela Amry; Annisa Fitria; Arde Toga Nugraha; Arba Pramundita Ramadani; Nangim Khasanah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2173

Abstract

Biofilm formation by bacteria, especially the genus Staphylococcus, is a serious health problem. Various medicinal plants have been used to control the infection, but research related to the antibiofilm activity of Coleus amboinicus is still limited. Bangun-bangun leaves (C. amboinicus) are plants from the Lamiaceae family that contain secondary metabolites such as terpenoids, flavonoids, and phenolics that are thought to be responsible as antibacterial and antibiofilm. This study aims to examine the antibacterial and antibiofilm activity of C. amboinicus against S. aureus. C. amboinicus leaves were extracted using 96% ethanol. The ethanol extract was then screened for phytochemicals using Thin Layer Chromatography (TLC) using several spray reagents. Antibacterial activity was analyzed using microdilution technique to obtain the value of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Antibiofilm activity was analyzed using crystal violet method. The result showed that the ethanol extract of C. amboinicus leaves contained flavonoids, phenolic terpenoids, and tannins. Antibacterial assays were obtained for the MIC value of 8 mg/mL and MBC of 16 mg/mL. The ethanol extract showed biofilm inhibitory activity with an IC50 value of 2,40 mg/mL. Based on these results, C. amboinicus has potential antibacterial and antibiofilm activity to inhibit S. aureus.
LAPORAN KASUS: ANALISIS KOMBINASI PENGGUNAAN HEPATOPROTEKTOR PADA CEDERA HATI KARENA INFEKSI BAKTERI STREPTOCOCCUS VIRIDANS Muhammad Hasan Andryanto; Fauna Herawati; Umi Fatmawati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2179

Abstract

Streptococcus viridans is one of the bacteria that can cause Community-Acquired Pneumonia (CAP). CAP disease has a higher prevalence of non-alcohol-related fatty liver disease (NAFLD). Continuous increase in fat levels in the liver triggered by pneumonia can cause inflammation in the liver, it causes a rapid decline in liver function and results in increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin. The use of hepatoprotectors in conditions of impaired liver function is essential to improve liver cell regeneration and promote liver detoxification. One of the drugs and supplements that can act as a hepatoprotector is ursodeoxycholic acid (UDCA) and Curcuma. Here we report the use of hepatoprotector drugs in cases of Community-Acquired Pneumonia (CAP) disease due to Streptococcus viridans bacteria in patients without comorbidities with the results of liver function test examinations from the beginning of hospital admission, during treatment, until the patient is discharged. The purpose of our case report is to illustrate the effect of the combined use of UDCA and Curcuma drugs on liver injury due to Streptococcus viridans bacterial infection in order to prevent complications, morbidity, mortality and improve the quality of life of patients. Based on the case reports that we present, the combined use of UDCA and Curcuma drugs as hepatoprotectors can improve liver function with reduced parameters of AST, ALT, and total bilirubin levels.
HUBUNGAN TINGKAT KEPATUHAN MINUM OBAT TERHADAP KADAR GULA DARAH PASIEN DM TIPE 2 DI PUSKESMAS PEKAUMAN BANJARMASIN Hasniah; Kurnia, Ina; Ramadhani, Juwita
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2188

Abstract

One of the most important factors in the treatment of Type 2 diabetes mellitus (type 2 diabetes mellitus) is the degree of patient compliance with the rules of its treatment. The degree of adherence of Type 2 DM patients to treatment guidelines has a significant impact on the stability of blood sugar levels. The purpose of this study was to determine the relationship of drug adherence to blood sugar levels of patients with Type 2 diabetes in Pekauman Banjarmasin Health Center. This study was conducted using observational analytical methods with cross-sectional design, data collection was carried out prospectively in February-April 2024 with a sample of 76 respondents. Data obtained from interviews and questionnaires. The instrument used for medication adherence using the questionnaire Morisky Medication Adherence Scale (MMAS-8). The relationship between the level of compliance of patients with blood sugar levels was analyzed using a statistical chi-square test. The results showed that there was a significant relationship between the level of patient compliance with blood sugar levels with the value (P = 0.000). The conclusion of this study is that adherence to medication is an important role in the management of treatment in patients with Type 2 diabetes mellitus at the Pekauman Banjarmasin Health Center.
THE IMPACT OF PVA CONCENTRATION ON THE PHYSICAL QUALITY OF THE Eleutherine palmifolia (L.) Merr LEAVES PEEL-OFF GEL MASK Kumalasari, Eka; Prihandiwati, Erna; Ma'ruf, Muhammad; Ariani, Novia; Amelia, Senya Puteri; Fawwazi, Muhammad Hafizh Abiyyu Fathin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2277

Abstract

The natives of Central Kalimantan utilize Eleutherine palmifolia (l.) Merr as a traditional medicine to treat various diseases. Eleutherine palmifolia  leaves are rich in flavonoid substances. Eleutherine palmifolia  leaves extract has an IC50 value of 45.33 ppm, indicating significant antioxidant activity. Antioxidants are helpful in reducing the risk of UV radiation-induced skin damage. Eleutherine palmifolia leaves have antioxidant properties that can be used as a peel-off gel mask. Polyvinyl alcohol (PVA) bases come in various formulations for peel-off gel mask that F1 10%, F2 12%, and F3 14%. The concentration of PVA is the most significant element affecting how well peel-off gel masks create films. This study aims to determine the impact of PVA concentration on the physical of the Eleutherine palmifolia  leaves Peel-off gel mask. All formulas are tested for organoleptics, homogeneity, spreadability, pH value, and drying speed. The results showed that all peel-off gel mask compositions pass the physical properties test. A one-way ANOVA statistical analysis reveals a significant variation in the preparations drying speeds (p<0,05).
EFEK NEFROPROTEKTOR EKSTRAK TEMULAWAK (Curcuma xanthorrhiza roxb) TERHADAP KADAR KREATININ TIKUS (Rattus Norvegicus) YANG DIINDUKSI PARACETAMOL Putri, Jilan Fandini; Rizkawati, Muflihah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.1799

Abstract

Paracetamol is commonly used as an analgesic and antipyretic. The toxic doses of paracetamol-induced toxic effects such as renal tubular necrosis. Creatinine (Cr) is a biochemical function to assess kidney function. In Indonesia, ginger is one of the leading plants which has health benefits, as a hepatoprotector and nephroprotector because it contains curcumin and xanthorrhizol. This research was conducted to determine the effect of ginger extract on the creatinine levels of Wistar rats induced by paracetamol. The method used an experimental pre-post-test control group design. The research subjects divided into five groups consisting of 5 rats, K1 (negative control), K2 ( paracetamol 2 g/kgBW), P1, P2, and P3 given curcuma 800 mg/kgBW, 1.600 mg/kgBW, 3.200 mg/kgBW and a toxic dose of paracetamol of 2 g/kgBW on the last three days. The data was analyzed with the Paired T-test followed by a one-way ANOVA test to see differences between groups. The results showed a significant difference between the creatinine levels of Wistar rats before and after treatment (p=0.029). Administration of graded doses of ginger to the Wistar Rat group which was induced by paracetamol, showed a significant difference compared to the control group, between groups K2 and P1 (dose 800 mg/kgBB) with a p-value=0.031. Based on the results, it can be concluded that graded doses of Temulawak can minimize damage to the kidneys of Wistar Rats due to paracetamol induction as shown by the difference in creatinine levels in the 800 mg/kgBB treatment group compared to the control group.

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