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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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PERAMALAN KEBUTUHAN PERSEDIAAN OBAT PADA UPT. PUSKESMAS TANJUNG HABULU Assiva, Isri; Noor Hayatie, Marliza; Hirdianti Bandi, Maulida; Suasri, Eni
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2154

Abstract

The Tanjung Habulu Community Health Center (UPT Puskesmas Tanjung Habulu), located in Tanjung village, Bajuin District, faces challenges in drug supply, having experienced shortages in the past. Therefore, a study was conducted comparing the weighted moving average method and the single exponential smoothing method to forecast the inventory of Amlodipine 10 mg, Glimipiride 2 mg, and Piroxicam 10 mg capsules for the upcoming period. To assess the accuracy of these methods in forecasting drug inventory on a quarterly basis, the Mean Absolute Percentage Error (MAPE) was utilized. Based on the research findings, it can be concluded that the weighted moving average method outperforms the single exponential smoothing method due to its smaller MAPE value. Forecasting results using the Weighted Moving Average method are Amlodipine 10 mg totaling 9,898 tablets and a MAPE value of 10%, Glimpiride 2 mg totaling 4,650 tablets and a MAPE value of 15%, and Piroxicam capsules 10 mg totaling 3,460 tablets and a MAPE value of 9%.
ANALISIS PREDIKSI EFEK ANTIINFLAMASI PADA PIPER PORPHYROPHYLLUM SECARA IN SILICO Prayoga, Tria; Rahmat, Deni; Sandhiutami, Ni Made Dwi; Desmiaty, Yesi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2352

Abstract

This study aims to predict the anti-inflammatory effects of compounds in Piper porphyrophyllum using in silico methods. The compounds were analyzed using AutoDock software to evaluate their binding potential with the target protein and Lipinski's rule of five to assess their drug-likeness based on pharmacokinetic properties. Qualitative results show that compounds such as 4'-hydroxy-3',5,7-trimethoxyflavone, 4',5-dihydroxy-3',7-dimethoxyflavone, and 5-hydroxy-3',4',7-trimethoxyflavone form significant interactions with key residues on the target protein. Quantitatively, these compounds exhibit more negative binding free energy compared to the natural ligand (-7.34 kcal/mol), with values of -8.35 kcal/mol, -8.13 kcal/mol, and -8.20 kcal/mol, respectively, indicating stronger binding affinity. Evaluation using Lipinski's rule shows that these compounds meet the criteria as potential drug candidates. In conclusion, this in silico method can predict the potential of Piper porphyrophyllum compounds as anti-inflammatory agents, supporting further research for experimental validation.
FORMULASI DAN UJI MUTU FISIK KRIM MASKER WAJAH ANTI-AGING FRAKSI DAUN MIANA (Coleus scutellarioides (L) Benth) Silaban Erllin Tirza Stevany; Muh. Taufiqurrahman; Nurillahi Febria Leswana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2204

Abstract

One of the natural ingredients that can be used as a cosmetic ingredient is miana leaf (Coleus scutelleroides (L) Benth) which contains flavonoid compounds with antioxidant activity that can be used for skin care. These compounds can prevent free radicals that can cause premature aging. The extraction method was used in this study with 96% ethanol solvent and continued with the fractionation process. The determination of antioxidant activity was determined by calculating the IC50 value where the IC50 value of the ethyl acetate fraction of miana leaves obtained was 27.90 ppm. In the study, a formulation of face mask cream preparations with a variety of active ingredients (0,6; 1,2; 2,4). Evaluation of the preparation was carried out on the physical quality of face mask cream using the cycling test method. Based on the results of stability tests on the four preparations, formula 2 with 1.2 g of active ingredients shows the best formula. Antioxidant testing from F1, F2 and F3 obtained IC50 values of 96.33 ppm, 82.73 ppm, 72.71 ppm. The statistical test of antioxidant activity showed a p<0.05 result which indicates that there is a significant difference between the three formulas. Cycling test showed that the facial mask cream preparation was physically and chemically stable. There was no significant change in color, odor, texture, phase separation, or pH change. Viscosity also remained stable, indicating good shelf life during normal storage.
EKSTRAK DAUN ECENG GONDOK (Eichhornia crassipes) SEBAGAI ALTERNATIF ANTIBAKTERI ALAMI TERHADAP KARIES GIGI Rahimah, Asri; Darsono, Putri Vidiasari; Noval; Nastiti, Kunti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2223

Abstract

Dental caries is a major problem of dental and oral health. One of the bacteria that causes dental caries is Streptococcus mutans. Water hyacinth leaves contain flavonoids, tannins, alkaloids, and terpenoids that can be used as antibacterials. Objective for identifying the antibacterial activity of water hyacinth leaf extract (Eichhornia crassipes) against Streptococcus mutans bacteria. Type of research used True Experimental with a Posttest-only Control Group. Antibacterial activity using well-diffusion method and determination of MIC and MBC using liquid dilution method analyzed non-parametric statistics Kruskal-Wallis and Mann Whitney. Results from this water hyacinth leaves contain secondary metabolites, namely flavonoids, tannins, alkaloids and terpenoids. The antibacterial activity test of water hyacinth leaf extract has an inhibition zone diameter of 15.41 mm. The MIC value at a concentration of 50% and does not have a MBC. Research results show that hyacinth extract is bacteriostatic against Streptococcus mutans bacteria that cause tooth decay.
AKTIVIITAS ANTIOKSIDAN ANTIHIPERLIPIDEMIA DAN ANTIHIPERTENSI DARI EKSTRAK ETANOL DAUN KEDABU (Sonneratia ovata. Backer) Raharjo, Danang; Fitriawati, Anna; Aminnulloh, Muhhamad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2245

Abstract

Kedabu (Sonneratia ovata. Backer) is one type of mangrove from the genus Sonneratia with high flavonoid content that has the potential as an antioxidant. The flavonoid content in the kedabu plant includes sonnerphenolic, vanillin, (-)-(R)-nyasol, (-)-(R)-4’-O-methylnyasol, maslinic acid, lingueresinol and gallic acid. Flavonoids as antioxidants can improve blood lipid profiles by lowering total cholesterol, triglycerides, and LDL, and increasing HDL. In addition, flavonoids can inhibit the activity of Angiotensin-converting enzyme (ACE) so that it has the potential as an antihypertensive. This study aims to examine the potential of kedabu leaf extract as an antioxidant, antihypertensive and antihyperlipidemic agent tested in vitro. Antioxidant testing was carried out using the ABTS (2,2-azinobis-3-ethylbenzothiazoline-6sulfonate) method, antihypertension testing was carried out by inhibiting Angiotensin converting enzyme and antihyperlipidemia testing was carried out by inhibiting the lipase enzyme. The results of the study showed that the total flavonoid content was 38.248 ± 0.142 mgQE / g with an antioxidant capacity with an IC50 value of 28.30 ± 0.558 ppm. From the Angiotensin converting enzyme inhibition and lipase enzyme inhibition tests, the IC50 values ​​were 44.851 ± 0.130 ppm and 39.133 ± 0.889 ppm, respectively. Based on these results, the kedabu leaf extract showed antihypertensive and antihyperlipidemia activities by inhibiting the activity of Angiotensin converting enzyme and lipase enzymes.
EFEKTIVITAS GEL EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH YANG DIINFEKSI Staphylococcus aureus riski dwi utami; olvaria misfa; alfiza rahmanita; mahendra
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2263

Abstract

The World Health Organization (WHO) estimates that around 180,000 deaths occur due to burns.  The healing process of burn wounds is influenced by several factors, such as the area, depth of the burn and infection. One of the bacteria that causes infection in burn wounds is Staphylococcus aureus. Starfruit leaf extract, used in gel form, is a natural remedy that offers benefits for burn treatment. This study aimed to analyze the effectiveness of starfruit leaf extract gel in healing burn wounds infected with Staphylococcus aureus in white rats. This research method was true experimental with a randomized posttest only control group design with 20 rats divided into four groups, namely the positive control group using bioplacenton (C1), the negative control group using gel base (C2), treatment group 1 with starfruit leaf extract gel with a concentration of 6% (P1) and group treatment 2 with starfruit leaf extract gel with a concentration of 12% (P2). The study found the smallest burn area on day 3 and day 7 was group C1 with an average of 2,799 cm2 and 2,324 cm2. On the 14th day it was group P2 with an average of 1,134 cm2. On the 21st day it was groups C1 and P2 with a mean of 0.163 cm2 and 0.164 cm2. The One-Way Anova test revealed significant differences in burn wound healing on days 3, 7, 14, and 21 (p < 0.05). Starfruit leaf extract gel effectively heals burns in white mice infected with S. aureus, with 12% concentration 
FORMULASI NANOHIDROGEL EKSTRAK DAUN KELOR (Moringa oleifera) DENGAN VARIASI KONSENTRASI CARBOPOL 980 SEBAGAI PERAWATAN LUKA SAYAT Kristiana, Isha Desty; Noval, Noval; Budi, Setia; Audina, Mia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2275

Abstract

A cut wound is the damage or loss of body tissue due to a sharp object, which can cause bleeding, as well as cause inflammation. Hydrogel is an ideal preparation for wound closure. Nanohydrogel are a development of nanotechnology that has a particle size of 10-1000 nm. Making nanohydrogel preparations requires a gelling agent to obtain a qualified preparation, for example Carbopol 980. Nanohydrogel was made using Moringa leaf extract (Moringa oleifera) as an active substance and made with variations in Carbopol 980 concentration. To evaluate the results of nanohydrogel preparation and determine the effect of variation in Carbopol 980 concentration on moringa leaf extract (Moringa oleifera) nanohydrogel preparation. The method used was experimental with Quasi Experimental design. Simplisia is made into extracts and formulated into nanohydrogel preparations and continued with evaluation. Data were analyzed using One Way Anova. The particle size of moringa leaf extract nanohydrogel preparation was found to be 338 nm. The results of the preparation evaluation showed that moringa leaf extract nanohydrogel with varying concentrations of Carbopol 980 had an effect on the pH, viscosity, and spreadability tests shown in the One Way Anova statistical test (p<0.05). From the evaluation results, the ideal formulation for nanohydrogel preparation is obtained in formula 4 with a concentration of Carbopol 980 of 1%.
ANALISIS KORELASI NILAI SPF DAN KANDUNGAN SENYAWA POLIFENOL TOTAL EKSTRAK BUNGA ROSELLA (Hibiscuss sabdariffa L.) DAN TELANG (Clitoria ternatea L.) Fitri, Hidayah Anisa; Shafiyatun, Arina Nur Nida; Utami, Pri Iswati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2300

Abstract

Excessive and persistent sun exposure containin UV B radiation to the skin causes both acute and chronic sunburn. Polyphenol compounds contained in red rosella extract (ER1), purple rosella extract (ER2) and telang (ET) extracst have photoprotective activity toward UV including UV B. This study aimed to determine their SPF value, total phenolic content (TPC) and their total flavonoids content (TFC) in vitro and to analyze the correlation between the three parameters. In vitro test was performed by UV-Vis spectrophotometry method and correlation was analyzed statistically using two-tailed pearson, graphic plotting and r-value analysis. Results showed that in 0,8% concentration, ER1 and ER2 having maximum SPF values, while ET having ultra SPF value. There was a very strong relationship between SPF, TPC and TFC in the extracts and all of them dependent in concentration. The higher concentration of extract used, the higher the number of TPC, TFC and SPF value. The photoprotective mechanism towards UV B light of ER1 and ER2 were likely contributed by their TPC, but it was both TPC and TFC for ET.
QUALITY CHARACTERIZATION AND ANTIOXIDANT PROPERTIES OF ROSE PERIWINKLE CRUDE DRUGS Hartanti, Dwi; Charisma, Shintia Lintang; Rinawati, Jeri; Hamad, Alwani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2320

Abstract

Leaves and flowers of rose periwinkle (Catharanthus roseus (L.) G. Don) are used for traditional diabetes management in Banyumas, Indonesia. This study evaluated the selected quality characters, total flavonoid content (TFC), total phenolic content (TPC), and the antioxidant activities of rose periwinkle crude drugs. Plant materials were collected from three locations in the Baturraden and Sumbang subdistricts and dried using an artificial heat drying rack to obtain crude drugs. The crude drugs' quality characters, TFC, TPC, and antioxidant activities were evaluated using standard methods. The quality characters of the crude drugs were specified as follows: loss on drying (9.12±0.50%), total ash (8.20±0.71%), acid-insoluble ash (0.24±0.06%), water extractable (28.82±6.77%), and ethanol extractable (35.17±1.79%). The chromatographic profile was generated from chloroform-methanol (8:2) separation over silica GF254. The TFC and TPC were 7.66±0.48 mg Quercetin equivalent (QE)/g and 7.27±1.07 mg Gallic acid equivalent (GAE)/g, respectively. The antioxidant activities were 148.95±12.00 Trolox equivalent (TE)/g for DPPH radical scavenging activity and 651.14±77.91 mM TE/g for FRAP. The DPPH radical scavenging activity and FRAP were weakly to moderately correlated to TPC and TFC. The phenolic compound and flavonoid contents of physicochemically-characterized rose periwinkle were not significantly correlated to their antioxidant activities.
AKTIVITAS ANTIINFLAMASI DAN ANTIOKSIDAN KOMBINASI EKSTRAK ETANOL BUNGA ROSELA (Hibiscus sabdariffa) DAN DAUN PEGAGAN (Centella asiatica) PADA TIKUS WISTAR JANTAN DENGAN OBESITAS Kaniawati, Marita; Sulaeman, Agus; Susilawati, Elis; Zinan, Daula Zahra; Irviansyah, Cepy Okta
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2323

Abstract

One of the triggers for obesity is high fat and high carbohydrates foods which increase Free Fatty Acid (FFA) and Reactive Oxygen Species (ROS), that trigger oxidative stress and chronic inflammation, which play a role in various degenerative diseases. This study aims to determine the potency and effective dose of ethanol extract of roselle flowers (Hibiscus sabdariffa) and gotu kola leaves (Centella asiatica) combination on oxidative stress (represented by Malondialdehyde or MDA) and its effect on inflammation (represented by Tumor Necrosis Factor-α or TNF-α). This research used in vivo experimental preventive method using 35 mice which were divided into normal group, induction group, comparison group curcumin 1.8 mg/kgBW, test group 1 EDP 200 mg/kgBW, test group 2 EBR 250 mg/kgBW, test group 3 EBRDP 125:200 mg/kgBW and test group 4 EBRDP 250:100 mg/kgBW. MDA levels were measured using UV-Vis spectrophotometry at 532 nm and TNF-α levels were measured using an ELISA kit on the 60th day. The results showed a decrease in blood MDA levels in EDP 200 mg/kgBW, EBR 250 mg/kgBW and EBRDP 250: 100 mg/kgBW and in liver MDA levels in EDP 200 mg/kgBW and EBRDP 250:100 mg/kgBW. The study also showed decreasing TNF-α levels in EDP 200 mg/kg BW, EBR 250 mg/kgBW, and the combination of EBRDP dose 125:200 mg/kgBW. In conclusion, the combination of EBRDP dose 250:100 mg/kgBW is the most effective dose in reducing MDA levels. The combination of EBRDP dose 125:200 mg/kgBW is the most effective dose in suppressing TNF-α levels.

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