cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Siska Musiam
Contact Email
siska@stikes-isfi.ac.id
Phone
+62511-3301610
Journal Mail Official
jiis@stikes-isfi.ac.id
Editorial Address
Jl. Flamboyan III/7c Kayu Tangi 70123 Banjarmasin Kalimantan Selatan
Location
Kota banjarmasin,
Kalimantan selatan
INDONESIA
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
 36   37   38   39   40 
FORMULASI DAN UJI AKTIVITAS SEDIAAN TRANSDERMAL PATCH EKSTRAK BIJI RAMBUTAN (Nephelium lappaceum L) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus strain wistar) SEBAGAI ANALGETIK Srie Rezeki Nur Endah; Ali Nofriyaldi; Elin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1582

Abstract

The rambutan plant has anti-pain characteristics based on empirical evidence.  Flavonoids, tannins, and saponins, which are known to have analgesic effect, are found in rambutan seeds. The purpose of this study was to assess the analgesic effectiveness of rambutan seed extract transdermal patch formulation and the most effective dose for male white rats. The maceration process with 70% ethanol is used to extract rambutan seeds for the research. Analgesic activity testing was performed on 25 male white mice divided into five groups, with group 1 serving as a negative control and receiving a 1% Na-CMC patch. Group II, as a positive control or comparison, was applied with Salonpas Pain Relief Patch 10%. Group III: As a test dose, I was attached to a patch of rambutan seed extract with a concentration of 1%. Group IV, as test dose II, had a patch of rambutan seed extract with a concentration of 2% applied to it. Group V, as test dose III, had a patch of rambutan seed extract with a concentration of 4% applied to it. The test preparation was administered transdermally, while 1% acetic acid was administered intraperitoneally 15 minutes after administration of the test preparation. Observe the stretching process every 5 minutes for 60 minutes. The research results on the analgesic activity of the test doses were 83.50%, 93.81%, and 42.26%, respectively. These results show that the most effective dose is dose II with a concentration of 2%.
POTENSI ANDROGRAFOLID, DEOKSIANDROGRAFOLID, NEOANDROGRAFOLID SEBAGAI ANTIATEROSKLEROSIS PADA CASPASE-1: STUDI IN SILICO Ugrasena, Putu Yudha; Puspita Sari, Dyah Ratna Ayu; Indraswari, Putu Ika Indah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1625

Abstract

Atherosclerosis is a vascular pathological condition characterized by active, chronic, progressive inflammation and plaque formation in the arterial walls Interleukin 1-beta (IL-1β) cytokine influences every stage of atherosclerosis, from destroying monocytes and other immune cells to forming plaques. Caspase-1 protein plays a role in activating the inflammatory cytokine Pro-Interleukin-1 Beta (Pro IL-1β) to IL-1β. One of the plants that has the potential to treat atherosclerosis is Andrographis paniculata. Andrographolide and its analogs, such as neoandrographolide and deoxyandrographolide, are the main bioactive compounds with various pharmacological activities. This study aimed to screen the activity of the compounds through the description of the stability of the compounds in protein caspase-1. This type of research was an in-silico exploratory study of the caspase-1 protein (PDB ID: 1RWK), with compound preparations, protein preparations, validating the molecular docking method to docking andrographolide neoandrografolid and deoksiandrografolid compounds on the target protein. The compounds has an affinity for the target protein with binding energy values ​​of -5.95 kcal/mol, -6.02 kcal/mol, and -6.81 kcal/mol respectively, which are smaller than the native ligand -4.77 kcal/mol. Docking results show that andrographolide, neoandrografolid, and deoxyandrografolid can potentially inhibit caspase-1, which activates the pro-inflammatory cytokine IL-1β in atherosclerosis.
ANALISIS LC-MS/MS SENYAWA METABOLITE EKSTRAK DAUN PUTAT (Planchonia valida) DAN PREDIKSI POTENSINYA SEBAGAI KANDIDAT OBAT ANTIKANKER Dewi, Tribuana Tungga; Bela, Anisa; Prabawa, Satria; Latief, Madyawati; Tarigan, Indra Lasmana
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1629

Abstract

Secondary metabolite compounds contained in plants are bioactive substances related to the chemical content in plants, so that some plants can be used as medicinal materials. Putat (Planchonia valida) is a medicinal plant that has bioactive compounds that have potential as anticancer. Compound analysis of LC-MS test results has been carried out which shows several metabolite compounds contained in putat. The method used is analyzing compounds obtained from LC-MS results, screening compounds using pchembl and chemspider websites. And using the pChEMBL webserver to find out the bioactivity of these compounds. The purpose of this study is to determine and predict the potential bioactivity of the compounds contained therein as new drug candidates. The results obtained from this study are metabolite compounds in putat have the potential as anticancer based on the screening results carried out using the pChEMBL webserver by looking at the highest pIC50 value, obtained the highest pIC50 value of 8.18 with target proteins namely Serine/threonin mTOR and Cholinesterase which are target proteins that have anticancer activity.
PREVALENSI DAN POLA SENSITIVITAS Klebsiella pneumoniae DAN Escherichia coli  PENGHASIL EXTENDED SPECTRUM BETALAKTAMASE DI RSPAD GATOT SOEBROTO TAHUN 2021 Yusmaini, Hany; Bahar, Meiskha; Harfiani, Erna; Ufi Dewintera
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1670

Abstract

ESBL-producing K. pneumoniae and E. coli are the Enterobacteriaceae that most commonly cause bacteriemia and nosocomial infections in the world. It is important to be aware of these bacteria to prevent an increase in infections with these resistant bacteria in hospitals. This research is a retrospective descriptive study, aiming to determine the prevalence of ESBL produced by K. Pneumoniae and E. coli and their sensitivity patterns. The data comes from clinical specimens that were examined for bacterial culture and antibiotic sensitivity tests in the Clinical Pathology Microbiology Lab in 2021. ESBL test using VITEK 2 compact tool. The results of the research were that E. coli was the most ESBL producing bacteria (50.9%) while K. pneumoniae was 20.9%. The highest prevalence of positive ESBL came from the ICU (41.4%) and the surgical ward (40.8%). Almost all rooms from which specimens were sent had a higher prevalence of positive ESBL E.coli, while for K.pneumoniae negative ESBL was higher. The most common types of positive specimens were bronchial lavage (67.4%) and wound swab (47.1%). Antibiotics that have high sensitivity to ESBL positive bacteria are Amikacin, Tigecycline and Meropenem.This research shows an increase in the prevalence of ESBL-producing K. pneumoniae and E. coli at the Gatot Soebroto Army Hospital, although it is still lower than several other national referral hospitals. Infection control, rational use of antimicrobials and prevention of transmission must continue to be pursued to reduce its prevalence.
PENELUSURAN AKTIVITAS ANTIBIOFILM DAN FORMULASI SPONS Petrosia sp. SEBAGAI NANOGEL PENYEMBUH LUKA ULKUS DIABETIKUM AKIBAT INFEKSI BIOFILM Staphylococcus aureus Arifin Nur Fahdianto; Virgiawan Yoga Pratama; Hasyrul Hamzah; Indra Yudhawan; Nur Atika Astriani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1804

Abstract

Diabetic ulcers are known to be one of the most feared complications and account for 80% of hospital admissions in patients with Diabetes Mellitus (DM). Diabetic ulcers occur due to bacterial infections, exacerbated by the formation of biofilm in the wounds. Nanotechnology presents a new alternative strategy for inhibiting biofilm formation, one of which is nanogel. The richness of marine biota that has the potential as an anti-biofilm candidate includes Petrosia sp. This study aims to extract and test the anti-biofilm activity of the Petrosia sp. formulation as a nanogel for healing diabetic ulcers caused by biofilm infection of Staphylococcus aureus. The extraction method used is maceration with 96% ethanol as a solvent, and biofilm activity is determined using the microtiter broth method. The procedure for creating incisional wounds on male mice induced with diabetes by alloxan is performed after shaving the fur in the area to be incised, followed by the application of 2% lidocaine cream as a local anesthetic. Subsequently, a preclinical trial on male mice is conducted by monitoring the stages of S. aureus biofilm wounds in both the test group and the positive control group. The results show that the nanogel formula from Petrosia sp. can inhibit up to 78.04% ± 0.01 on diabetic ulcer wounds with S. aureus biofilm over a period of 10 days and is highly potential to be developed as a new anti-biofilm candidate for diabetic ulcers caused by S. aureus biofilm.
AKTIVITAS ANTIBAKTERI DAN KOMPONEN KIMIA MINYAK ATSIRI TEMU KUNCI (Boesenbergia rotunda L. Mansf) TERHADAP BAKTERI PENYEBAB JERAWAT Mulyaningsih, Sri; Anastasya, Yolanda; Darmawan, Endang
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1924

Abstract

Essential oil of fingerroot (Boesenbergia rotunda L. (Mansf)) have antibacterial activity against Staphylococcus but was not specific against acne-causing bacteria. The aim of this study was to determine its chemical content and antibacterial activity of the fingerroot oil against S. aureus, S. epidermidis, and Propionibacterium acnes that cause acne. The essential oil was isolated by steam and water distillation. The organoleptic, yield, and refractive index were observed. Gas chromatography-mass spectrometry (GC-MS) carried out the identification of essential oil components. Antibacterial activity of the oil was determined with the diffusion method. Broth microdilution methods was used for determination of the minimum inhibitory concentration (MIC) and minimum bactericide concentration (MBC). Fingerroot essential oil was clear in color, aromatic odor, chelate taste, and slightly bitter with a yield of 1.19%. The refractive index was 1.4785 ± 0.0001. GC-MS identification showed 5 main components of fingerroot oil were camphor (28.70%), ocimene (24.71%), eucalyptol (16.26%), geraniol (14.81%), and methyl cinnamate (4.16%). The diameter of the zone of inhibition of bacterial growth was greatest at 20% concentration of fingerroot oil, followed by 10%, 5%, and 2.5%. MIC value of fingerroot oil against S. aureus and S. epidermidis was 0.625% and against P. acnes was 1.25%. The MBC value of fingerroot oil was doubled as the MIC value. The great antibacterial activity of fingerroot essential oil makes it potential to be developed into anti-acne preparations.
PENGARUH EDUKASI TERHADAP PENGETAHUAN MASYARAKAT DALAM MENYIMPAN DAN MEMBUANG OBAT DI RUMAH TANGGA Hastuti, Sri; Rahem, Abdul; Hermansyah, Andi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1941

Abstract

Improper storage and disposal of medicines at households is a public health issue which may lead to poor quality of medicines, damage the medicines, misuse of medicines and environmental pollution. Proper storage and disposal are influenced by the knowledge, attitudes and practices of the general public. This research aims to determine the effect of education on people’s knowledge in storing and disposing of medicines in Tambakrejo, Sidoarjo, Indonesia. A one group pretest - posttest design was conducted involving 120 housewife as respondents in Tambakrejo, Sidoarjo, Indonesia. The respondent was recruited using purposive sampling. A questionnaire was used to measure knowledge level before and after the intervention. The intervention was in the form of community counseling and leaflet distribution. Data were subsequently analyzed using Wilcoxon Signed Ranks Test. Of 120 respondents, the majority was older than 45 years (60.80%), unemployed (72.50%), stored up to 5 medicines at home (75.80%) and obtained medicines from community pharmacy (78.30%). There was an increase in the knowledge level before and after the intervention, from the average score of 44.4 to 70.8. Community education can increase people’s knowledge in storing and disposing of medicines.
HUBUNGAN KOMORBIDITAS DAN PERILAKU TERHADAP TITER ANTIBODI DAN TERPAPAR COVID-19 PASCA VAKSIN ASTRAZENECA DOSIS LENGKAP DI UTA 45 JAKARTA Lukas, Stefanus; Diana Laila Ramatillah; Aldi, Yufri; Fatma Sri Wahyuni
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2028

Abstract

AstraZeneca vaccine has become one of the efforts to overcome the COVID-19 pandemic. This study aims to determine the relationship between the AstraZeneca vaccine and antibody titers and its association with exposure to COVID-19 infection. This study used a retrospective and prospective cohort design with convenience sampling. A total of 102 respondents who had received a complete dose of the AstraZeneca vaccine and were willing to be followed up for 18 months were involved in this study. Sociodemographic data, comorbidity history, lifestyle, and antibody titers were measured at two times: before the first dose and after the second dose of vaccinations. This study found that there was no significant relationship between comorbidities and respondent behavior (smoking and alcohol consumption) with COVID-19 antibody titers. Physical activity (exercise) showed a positive relationship with COVID-19 antibody titers. Respondents who exercised regularly had higher antibody titers than those who did not. There was a positive relationship between comorbidities, smoking, and alcohol consumption with the risk of exposure to COVID-19 infection after vaccination. This study found that physical activity (exercise) can increase COVID-19 antibody titers and provide protection against COVID-19 infection after vaccination.
TOXICITY TEST OF LIME PEEL EXTRACT (Citrus aurantifolia) USING THE BRINE SHRIMP LETHALITY TEST (BSLT) METHOD FOR DETECTION OF ANTI CANCER ACTIVITY Khairunnisa, Indah; Widiastuti, Endang Linirin; Nurcahyani, Nuning
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2083

Abstract

Cancer is one of the major problems affecting the people of Indonesia and the world. Lack of public awareness for early detection causes a delay in diagnosis. One of the medicinal plants that are commonly found in Indonesia is lime (C. aurantifolia). In lime peel extract, there is essential oil composed of D-Limonene (38.94%), β-pinen (26.66%), α-terpineol (8.29%), and terpinen-4-ol (4.32%). These compounds are known to have strong effects as anti-cancer. This study used a completely randomized design (CRD) with 5 treatments and 5 repetitions, namely 0, 125, 150, 250, and 1000 ppm. The research methods used were phytochemical test, FTIR (Fourier-Transform Infrared Spectroscopy) analysis, and BSLT test. The probit value was analyzed using SPSS to obtain the LC50 value. Lime peel extract (C. aurantifolia) has an LC50 value of 331.533 ppm including the toxic category and has potential as an anti-cancer agent. Based on phytochemical and FTIR tests, lime peel (C. aurantifolia) contains alkaloid, flavonoid, and tannin compounds which are known to have antioxidant properties and can disrupt the balance of Reactive Oxygen Species (ROS) so as to trigger apoptosis of cancer cells.
UJI IN VITRO NILAI SUN PROTECTING FACTOR (SPF) EKSTRAK ETANOL DAN EKSTRAK HEKSANA DAUN KENIKIR (Cosmos caudatus Kunth.) Rahmi, Lisa Amelia; Emelda, Emelda; Solikah, Wahyu Yuliana; Rais, Ichwan Ridwan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2106

Abstract

Bioactive substances found in kenikir leaves may be used as sunscreens. The purpose of the study is to evaluate the kenikir leaf ethanol extract (EEDK) and hexane extract (EHDK) as potential sunscreens. The maceration method is used for extraction, and 70% ethanol and n-hexane are used as each solvent. employing the UV-Vis spectrophotometric method at a wavelength of 290–400 nm and concentration series of 200, 400, 600, and 800 ppm to measure the SPF value of EEDK and EHDK. With SPF values of 1.3896 ± 0.0343, 1.7936 ± 0.0144, 2.2282 ± 0.0580, and 3.2575 ± 0.2257 obtained at concentrations of 200 ppm, 400 ppm, 600 ppm, and 800 ppm, respectively, the results demonstrate the potential of EEDK as a sunscreen. 1.1454 ± 0.0204; 1.3193 ± 0.0048; 1.4993 ± 0.0169 are the EHDK SPF values.

Page 38 of 43 | Total Record : 429

 36   37   38   39   40 

Filter by Year

2016 2025


Reset
Filter By Issues
All Issue Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina Vol 9 No 2 (2024): JIIS Vol 9 No 1 (2024): JIIS Vol 8 No 2 (2023): JIIS Vol 8 No 1 (2023): JIIS 2023: Webinar Nasional & Call For Paper Vol 7 No 2 (2022): JIIS Vol 7 No 1 (2022): JIIS Vol 6 No 2 (2021): JIIS Vol 6 No 1 (2021): JIIS Vol 5 No 2 (2020): JIIS Vol 5 No 1 (2020): JIIS Vol 4 No 2 (2019): JIIS Vol 4 No 1 (2019): JIIS Vol 3 No 2 (2018): JIIS Vol 3 No 1 (2018): JIIS Vol 2 No 2 (2017): JIIS Vol 2 No 1 (2017): JIIS Vol 1 No 2 (2016): JIIS Vol 1 No 1 (2016): JIIS More Issue