cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Zahratul Aini
Contact Email
dr.zahratulaini@unsyiah.ac.id
Phone
+62812388847262018
Journal Mail Official
m.zainudin@uii.ac.id
Editorial Address
Jl. Kaliurang Km 14,5 Yogyakarta, Indonesia
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 483 Documents
 45   46   47   48   49 
In silico study of the bioactive compounds in Peronema canescens Jack (Sungkai) leaf infusion targeting VEGFR-2: Insights into anticancer potential rahayu, Ika; Sudrajat, Susana Elya; Timotius, Kris Herawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art6

Abstract

Background: Peronema canescens Jack, commonly known as sungkai, is a medicinal plant traditionally consumed as a herbal infusion. It has demonstrated potential anticancer properties attributed to its bioactive constituents, particularly clerodane-type diterpenoids known as peronemins. The anticancer potential of these compounds can be preliminarily explored using in silico approaches. Of particular interest are the reported the cytotoxic effects of sungkai leaves against cancer cell lines and their interactions with angiogenesis-related targets, including vascular endothelial growth factor receptor-2 (VEGFR-2). VEGFR-2 is a critical tyrosine kinase receptor that regulates angiogenesisa and Its aberrant activation contributes to tumor growth and metastasis. Consequently, VEGFR-2 represents a well-established target for anticancer therapy development. Objectives: This study aims to investigate the bioactive compounds present in sungkai leaf infusion using liquid chromatography-mass spectrometry (LC-MS), and to predict their interactions with VEGFR-2 through in silico molecular docking analysis. Methods: Phytochemical profiling of the leaf infusion was conducted using LC-MS. Molecular docking was performed using PyRx 0.8 integrated with AutoDock Vina to assess ligand-protein interactions between selected compounds and VEGFR-2 (PDB ID: 2QU5). The resulting interactions were visualized using Discovery Studio.Results: LC-MS analysis identified ten major compounds in the leaf infusion, consisting of one alkaloid (gentiatibetine) and nine flavonoids. Molecular docking analysis revealed that genkwanin and acacetin-7-galactoside exhibited strong binding affinities toward VEGFR-2 (−9.6 and −9.2 kcal/mol, respectively), approaching that of the referencesorafenib (−11.2 kcal/mol). Both compounds interacted with key catalytic residues, suggesting their potential to inhibit VEGFR-2 by stabilizing its inactive conformation.Conclusion: This study provides the first to report that sungkai leaf infusion is rich in flavonoid compounds two of which exhibit strong anti-VEGFR-2 activity. These findings suggest the potential of sungkai leaf infusion as a natural anticancer agent and support the needfor further in vitro and in vivo validation.
Erythroderma due to generalized pustular psoriasis in an infant: A case report of a rare condition Anggatama, Marcella; Rinonce, Hanggoro Tri; Wirohadidjojo, Yohanes Widodo; Danarti, Retno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art15

Abstract

Erythroderma is a widespread redness of the skin accompanied by exfoliation that affects over 90% of the body surface. Its presence in infants is clinically important because it can be life-threatening, making it essential for paediatricians and dermatologists to be vigilant. Various skin diseases can cause erythroderma. Timely, accurate identification of the underlying cause results in improved treatment and prognosis. Generalized pustular psoriasis is one of many causes for erythroderma. Nevertheless, this condition is rare in infants, making it challenging to diagnose and treat. The current medical evidence for treatment is primarily derived from case reports rather than clinical trials. Hence, this case report aims to share the authors’ experience in treating infants aged 6 months with erythroderma caused by generalized pustular psoriasis. In our case, the diagnosis was determined by completing the patient's medical history, performing a physical examination, and conducting a histopathological examination. The treatment involved the topical application of moisturizers containing ceramide as well as the systemic administration of steroids and vitamin D. Due to the restricted availability of systemic retinoids, the authors administered steroids in this particular case, resulting in an improved outcome.
Adolescent mental health and bullying Lusiyana, Novyan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art1

Abstract

Page 49 of 49 | Total Record : 483

 45   46   47   48   49 

Filter by Year

2009 2025


Reset
Filter By Issues
All Issue JKKI, Vol 16, No 3, (2025) JKKI, Vol 16, No 2, (2025) JKKI, Vol 16, No 1, (2025) JKKI, Vol 15, No 3, (2024) JKKI, Vol 15, No 2, (2024) JKKI, Vol 15, No 1, (2024) JKKI, Vol 14, No 3, (2023) JKKI, Vol 14, No 2, (2023) JKKI, Vol 14, No 1, (2023) JKKI, Vol 13, No 3, (2022) JKKI, Vol 13, No 2, (2022) JKKI, Vol 13, No 1, (2022) JKKI, Vol 12, No 3, (2021) JKKI, Vol 12, No 2, (2021) JKKI, Vol 12, No 1, (2021) JKKI, Vol 11, No 3, (2020) JKKI, Vol 11, No 2, (2020) JKKI, Vol 11, No 1, (2020) JKKI, Vol 10, No 3, (2019) JKKI, Vol 10, No 2, (2019) JKKI, Vol 10, No 1, (2019) JKKI, Vol 9, No 3, (2018) JKKI, Vol 9, No 2, (2018) JKKI, Vol 9, No 1, (2018) JKKI, Vol 8, No 3, (2017) JKKI, Vol 8, No 2, (2017) JKKI, Vol 8, No 1, (2017) JKKI, Vol 7, No 5, (2016) JKKI, Vol 7, No 4, (2016) JKKI, Vol 7, No 3, (2016) JKKI, Vol 7, No 2, (2015) JKKI, Vol 7, No 1, (2015) JKKI, Vol 6, No 4, (2015) JKKI, Vol 6, No 3, (2014) JKKI, Vol 6, No 2, (2014) JKKI, Vol 6, No 1, (2014) JKKI, Vol 5, No 2, (2013) JKKI, Vol 5, No 1, (2013) JKKI, Vol 3, No 8, (2011) JKKI, Vol 2, No 6, (2010) JKKI, Vol 2, No 5, (2010) JKKI, Vol 1, No 3, (2009) JKKI, Vol1, No 1, (2009) More Issue