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Vita Widyasari
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INDONESIA
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 498 Documents
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In silico study of the bioactive compounds in Peronema canescens Jack (Sungkai) leaf infusion targeting VEGFR-2: Insights into anticancer potential rahayu, Ika; Sudrajat, Susana Elya; Timotius, Kris Herawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art6

Abstract

Background: Peronema canescens Jack, commonly known as sungkai, is a medicinal plant traditionally consumed as a herbal infusion. It has demonstrated potential anticancer properties attributed to its bioactive constituents, particularly clerodane-type diterpenoids known as peronemins. The anticancer potential of these compounds can be preliminarily explored using in silico approaches. Of particular interest are the reported the cytotoxic effects of sungkai leaves against cancer cell lines and their interactions with angiogenesis-related targets, including vascular endothelial growth factor receptor-2 (VEGFR-2). VEGFR-2 is a critical tyrosine kinase receptor that regulates angiogenesisa and Its aberrant activation contributes to tumor growth and metastasis. Consequently, VEGFR-2 represents a well-established target for anticancer therapy development. Objectives: This study aims to investigate the bioactive compounds present in sungkai leaf infusion using liquid chromatography-mass spectrometry (LC-MS), and to predict their interactions with VEGFR-2 through in silico molecular docking analysis. Methods: Phytochemical profiling of the leaf infusion was conducted using LC-MS. Molecular docking was performed using PyRx 0.8 integrated with AutoDock Vina to assess ligand-protein interactions between selected compounds and VEGFR-2 (PDB ID: 2QU5). The resulting interactions were visualized using Discovery Studio.Results: LC-MS analysis identified ten major compounds in the leaf infusion, consisting of one alkaloid (gentiatibetine) and nine flavonoids. Molecular docking analysis revealed that genkwanin and acacetin-7-galactoside exhibited strong binding affinities toward VEGFR-2 (−9.6 and −9.2 kcal/mol, respectively), approaching that of the referencesorafenib (−11.2 kcal/mol). Both compounds interacted with key catalytic residues, suggesting their potential to inhibit VEGFR-2 by stabilizing its inactive conformation.Conclusion: This study provides the first to report that sungkai leaf infusion is rich in flavonoid compounds two of which exhibit strong anti-VEGFR-2 activity. These findings suggest the potential of sungkai leaf infusion as a natural anticancer agent and support the needfor further in vitro and in vivo validation.
Erythroderma due to generalized pustular psoriasis in an infant: A case report of a rare condition Anggatama, Marcella; Rinonce, Hanggoro Tri; Wirohadidjojo, Yohanes Widodo; Danarti, Retno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art15

Abstract

Erythroderma is a widespread redness of the skin accompanied by exfoliation that affects over 90% of the body surface. Its presence in infants is clinically important because it can be life-threatening, making it essential for paediatricians and dermatologists to be vigilant. Various skin diseases can cause erythroderma. Timely, accurate identification of the underlying cause results in improved treatment and prognosis. Generalized pustular psoriasis is one of many causes for erythroderma. Nevertheless, this condition is rare in infants, making it challenging to diagnose and treat. The current medical evidence for treatment is primarily derived from case reports rather than clinical trials. Hence, this case report aims to share the authors’ experience in treating infants aged 6 months with erythroderma caused by generalized pustular psoriasis. In our case, the diagnosis was determined by completing the patient's medical history, performing a physical examination, and conducting a histopathological examination. The treatment involved the topical application of moisturizers containing ceramide as well as the systemic administration of steroids and vitamin D. Due to the restricted availability of systemic retinoids, the authors administered steroids in this particular case, resulting in an improved outcome.
Adolescent mental health and bullying Lusiyana, Novyan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art1

Abstract

Jejunal intussusception caused by metastatic scalp melanoma with synchronous gallbladder involvement: A case report Handaya, Adeodatus Yuda; Aditya, Azriel Farrel Kresna; Tianty, Belvia Adelaida Maia
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art14

Abstract

Adult jejunal intussusception due to metastatic melanoma originating from a scalp lesion represents an uncommon clinical entity. Despite being a relatively rare form of skin cancer, melanoma is known for its aggressive behaviour and high metastatic capacity. Although metastases to the gallbladder are infrequent, melanoma is considered the most prevalent source of secondary tumours in this organ. Gallbladder metastases often resemble asymptomatic polyps, solid lesions, or cholecystitis. These lesions are increasingly identified as incidental findings due to the advances in medical imaging. In this case, multislice computed tomography (MSCT) served as the primary diagnostic modality, identifying both the jejunal intussusception with an intraluminal lead point and multiple gallbladder polyps. We report a clinical course of a 65-year-old man with a history of scalp melanoma who presented with gastrointestinal symptoms. The patient underwent exploratory laparotomy, segmental resection of the jejunum with primary anastomosis, and cholecystectomy. Histopathological findings confirmed the diagnosis of metastatic melanoma involving the resected tissues. This report emphasizes an imperative of continuous monitoring and an early detection in melanoma survivors, as well as a critical role of timely surgical intervention in managing metastatic manifestations.
Adverse effects of cell phone radiation on Purkinje cells of the cerebellum of pregnant Balb/c mice Armalina, Desy; Susilaningsih , Neni; Sutanto, Heri; Sunarno, Sunarno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art4

Abstract

Background: Pregnant women often use mobile phones for communication and health-related information. The World Health Organization (WHO) recommends minimizing mobile phone use during pregnancy to reduce maternal and child health risks. Electromagnetic waves (EMW) from cell phones can be absorbed by the brain and may affect neuronal function.Objective: This study aimed to evaluate the size, histology, and number of Purkinje cells in the cerebellum of pregnant mice exposed to cell phone EMW compared to unexposed controls.Methods: Fourteen pregnant Balb/c mice were randomly divided into exposed (EG) and control (CG) groups. The EG was exposed to an electromagnetic wave with a specific absorption rate (SAR) of 1.74 W/kg for 24 hours per day from gestation day 0 to 19. On day 20, cerebellar tissues were harvested and processed with hematoxylin–eosin (HE) staining for histological assessment.Results: The mean Purkinje cell size in the EG (0.069 ± 0.009 mm) was slightly smaller than in the CG (0.070 ± 0.007 mm), but this difference was not statistically significant (p = 0.741). However, the Purkinje cell count was significantly lower in the EG (6.160 ± 0.746) than in the CG (7.800 ± 0.764; p < 0.001), indicating that EMW exposure reduced Purkinje cell numbers.Conclusion: Exposure to cell phone EMW during pregnancy led to a significant reduction in Purkinje cell numbers in the cerebellum, while cell size remained unchanged. These findings suggest that prenatal exposure to EMW may negatively affect fetal cerebellar development. This underscores the need for pregnant women to be cautious with mobile phone use and highlights the importance of further research to clarify the risks to maternal and fetal health.
Unveiling harlequin ichthyosis beyond the neonatal period: A case from North Sumatra, Indonesia Manurung, Widya Gabriella; Paramita, Deryne Anggia; Nababan, Kristo Alberto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art11

Abstract

Harlequin ichthyosis (HI) is a rare and life-threatening form of autosomal recessive congenital ichthyosis, typically diagnosed in the neonatal period due to its distinctive clinical features. We report a 7-year-old boy from North Sumatra, Indonesia, who survived well beyond infancy despite limited resources. He was born preterm at 35 weeks to consanguineous parents, with a history of a sibling who died in early infancy from a similar condition. The patient presented with ectropion, eclabium, underdeveloped ears, severe contractures, and generalized hyperkeratotic plaques with deep fissures. Clinical management focused on supportive dermatologic care, including twice-daily bathing, emollient application, topical antibiotics for erosions, and multidisciplinary referrals. Notably, the patient did not receive systemic retinoids or neonatal intensive care, yet the survival was achieved with minimal but consistent supportive measures. This case underscores the importance of early recognition of HI, the role of family history and consanguinity in clinical suspicion, and the potential for survival in resource-limited settings. It also highlights the profound psychosocial burden on affected families and emphasizes the need for genetic counselling to reduce recurrence in high-risk populations.
First bronchoscopy with cryobiopsy and argon plasma coagulation at Indonesia national referral hospital: Case series Maulidzy, Achmad Zaki; Marhana, Isnin Anang; Fatmawati, Farah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art10

Abstract

Cryobiopsy has emerged as a superior method for diagnostic endobronchial tissue sampling, offering more extensive and diagnostically valuable specimens than traditional techniques. Argon plasma coagulation (APC), a form of cryoablation, facilitates effective tumour resection and haemostasis with minimal complications. At Dr. Soetomo General Academic Hospital, conventional methods have predominantly been used for lung tumour sampling. These case reports introduced the novel application of cryobiopsy and APC in our institution, showcasing our expertise in advanced bronchoscopic techniques. We report on a 55-year-old male with a T3N1Mx stage IIIA left lung tumour and a 65-year-old male with a T4N2M1b stage IVA right lung cancer. Diagnoses were small-cell lung carcinoma and adenocarcinoma with wild-type EGFR mutation, respectively. Procedures were performed with minimal complications, demonstrating the effectiveness and safety of these techniques. These case reports underscored the potential of cryobiopsy and APC to enhance diagnostic accuracy and therapeutic outcomes, advancing pulmonary oncology care. These techniques provide superior diagnostic accuracy and therapeutic benefits with minimal complications. Our findings support the broader adoption of these advanced bronchoscopic interventions, particularly in settings where traditional methods may fall short.
Fulminant fournier's gangrene in a 39-year-old male sailor with poorly controlled diabetes mellitus: A case report Wibawa, Putu Chandra; Wiradana, Anak Agung Anom; Putra, Agung Ngurah Rai Kusuma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art12

Abstract

Fournier’s gangrene is an uncommon yet potentially fatal form of necrotising fasciitis that involves the genital, perineal, and perianal regions, with mortality rates approaching 40%. We describe a case involving a 39-year-old male sailor who presented after 10 days of progressive scrotal swelling that had extended to the buttocks, along with purulent discharge, intense pain, and fever. The patient had a background of poorly managed diabetes mellitus and chronic alcohol use. On physical examination, necrotic changes were noted in the scrotal and perianal areas. Laboratory findings revealed elevated white cell count, hyperglycemia, hyponatremia, hypokalemia, and hypoalbuminemia. Culture results identified Proteus mirabilis and Klebsiella pneumoniae subspecies pneumoniae. Emergency surgical debridement and necrotomy were performed, followed by antibiotic therapy (ceftriaxone and metronidazole), fluid replacement, pain management, and insulin administration. This case underscores the critical need for early recognition and timely surgical treatment in managing Fournier’s gangrene, especially in patients with risk factors such as diabetes and alcohol use. Occupational demands that delay medical consultation may worsen disease severity and complicate therapeutic efforts.
Predictors of clinical outcomes in traumatic intracerebral haemorrhage: Development of a prognostic scoring model Riza, Ainul; Syahrul, Syahrul; Zakaria, Iskandar; Hidayat, Imam; Musadir, Nasrul
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art2

Abstract

Background: Traumatic intracerebral haemorrhage (tICH) is frequently observed as a form of intracranial bleeding that follows traumatic brain injury (TBI).Objectives: This study aims to analyse the Glasgow Coma Scale (GCS) score, haemorrhage volume, leukocyte count, and sodium and potassium levels as predictors of clinical outcomes in patients with traumatic intracerebral haemorrhage and to develop a predictive scoring model based on these variables.Methods: This observational analytic study used a retrospective cohort design in the neurology inpatient room at RSUDZA Banda Aceh between January and March 2025. The study included 80 patients with tICH who met the inclusion criteria. The GCS score, bleeding volume, leukocyte count, and sodium and potassium levels were assessed as predictors. The Glasgow Outcome at Discharge Scale (GODS) was used to evaluate clinical outcomes. A multiple linear regression analysis was used to evaluate the effects of independent variables on clinical outcomes. The model was validated using the Hosmer and Lemeshow tests (p>0.05), showing a good fit between the predicted and observed values.Results: A bivariate analysis indicated significant associations between GCS score, bleeding volume, leukocyte count, sodium, potassium levels, and outcomes (p<0.05). A multivariate analysis identified only GCS score (p=0.010; OR=10.102) and bleeding volume (p=0.034; OR=0.129) as independent predictors. A predictive scoring model was developed from the regression coefficients, with scores ranging from 0 to 7. Higher scores indicate a greater probability of poor outcomes, with a score of 7 corresponding to a 98.7% probability. Conclusion: This study highlights the GCS score and bleeding volume as key predictors of clinical outcomes in patients with tICH, while leukocyte count and sodium and potassium levels remain relevant supportive factors in the clinical context. Further validation in larger, diverse populations is warranted to assess its applicability in various clinical settings.
Cosmetic application behaviours and their association with sensitive skin in young adult women Saraswati, Ni Wayan Citra Ayu; Sari, Dian Puspita; Hidajat, Dedianto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art3

Abstract

Background: Sensitive skin is an uncomfortable sensation on the skin that arises due to a response to stimuli that normally do not cause discomfort. Women more commonly experience it than men. Recent evidence indicates that cosmetic use is the predominant triggering factor compared to other factors, particularly in women, due to the extensive and varied use of products. Objective: This study examined the relationship between the number of cosmetic products used daily and weekly and the incidence of sensitive skin among young adult females.Methods: This cross-sectional study employed a stratified random sampling method. The study population involved young female adults who agreed to participate after completing the informed consent form. The exclusion criteria were facial inflammation and use of oral or topical medication containing corticosteroids. The cosmetic usage pattern was assessed through a questionnaire. Skin sensitivity assessment was conducted by utilizing the lactic acid stinging test (LAST), where 10% aqueous lactic acid solution was topically applied to the right nasolabial fold region. The mann-whitney test was employed to analyze the relationship between the number of cosmetic products used daily and weekly and the occurrence of sensitive skin. Results: Out of 136 subjects, 23.5% have sensitive skin based on the LAST. The most prevalent products used by the majority of respondents are facial wash, sunscreen, and moisturizer, with a percentage of >70%. No significant relationship is found between the number of products used daily and weekly and sensitive skin (p > 0.05). Conclusion: No significant differences regarding the number of products used among sensitive and non-sensitive skin groups. Therefore, future studies are needed to explore the ingredients in cosmetic products and their volume of usage, as well as to conduct prospective studies assessing the impact of cosmetic usage patterns on the occurrence of sensitive skin.

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