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Hang Tuah Medical Journal
Published by Universitas Hang Tuah
ISSN : 16931238     EISSN : 25984861     DOI : https://doi.org/10.30649/htmj.v19i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Hang Tuah Medical Journal: is published by Faculty of medicine, Universitas Hang Tuah with p-ISSN: 1693-1238 e-ISSN: 2598-4861. Its disciplinary focus is medical science and speciality in bio marine science. Hang Tuah Medical Journal is published in English and Indonesia for May and November. Each 90-100 page edition contains between nine and eleven scientific articles on research, case reports and study literature. Contributors of Hang Tuah Medical Journal included: medical researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. Hang Tuah Medical Journal as the open-access journal has been indexed by SINTA-Science and Technology Index, Garuda, Google scholar Hang Tuah Medical journal has been certificated as a Scientific Journal by Sinta (Science and Technology Index) S5 . valid until Volume 17 No.1, 2017.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 161 Documents
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Karakteristik Determinan Preeklamsia di RSUD dr. Soedono Madiun periode 1 Januari 2020 sampai dengan 31 Desember 2020 HARIATI, FADILAMUNA; O. H. PRASETYADI, FRANS; PRANITASARI, NITA; EDY SUDIARTA, KETUT
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.317

Abstract

Abstract Background : Preeclampsia become one of the cases that causes maternal and perinatal morbidity and mortality. Morbidity and mortality occurs due to disorders in pregnancy (preeclampsia and eclampsia) by 14%. Preeclampsia is gestational hypertension characterized with increased blood pressure(2140/90mmHg), proteinuria(>300mg/24 hours), increased creatinine(>1.02mg/dL), and edema that can occur with age gestation >20 weeks. The purpose of this study is to determine the determinants which can cause preeclampsia in RSUD dr. Soedono Madiun, From January 1st2020 to December 31st2020. Methods : This type of research is descriptive research using a documentation study of patient medical record sheets at RSUD dr. Soedono Madiun from January 1st2020 to December 31st2020. The techniques sampling in this study is a purposive sampling technique. Univariate analysis is used to describe the characteristics of the variables that have been studied. Results : The case of preeclampsia in RSUD dr. Soedono as many as 67 cases. Most occurred in multigravida as many as 39cases (58.2%), at maternal age 20-35 as many as 48cases (71.6%), with the highest body mass index were obese or BMI more equal to 30 as many as 33cases (49.3%), hypertension as the most happened of maternal disease with 9cases (13.43%) and pregnancy disorders in 18cases (26.87%) with a long gestation interval. Conclusion : Preeclampsia is more common in multigravida pregnancies (2-4 weeks) at the age of the mother are 20-35 years with BMI more than 30 or obesity and mothers who have hypertension and long gestation interval. Keywords : Preeclampsia, Determinants
Hubungan BBLR dengan Kejadian Stunting pada Anak Usia 24-60 Bulan di Wilayah Kerja Puskesmas Tabanan I Tahun 2018-2019 WIDHIDEWI, NI WAYAN; PRIYANKA HERMAWAN, PUTU; ELMY SANIATHI, NI KADEK
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.470

Abstract

Stunting is caused by a lack of nutritional intake for a long time so that it can cause disturbances in physical development and cognitive function that can cause death. One of the factors that influence the occurrence of stunting in toddlers is the history of low birth weight. This study aims to examine the relationship between low birth weight (LBW) and the incidence of stunting in children aged 24-60 months in the Tabanan I Health Center Working Area in 2018-2019 using analytical research methods and case control study designs and using secondary data collection methods derived from the nutrition sections. The study sample was a total of 190 toddlers recorded in the stunting and LBW report at Tabanan I Health Center, during 2018-2019 who met the inclusion and exclusion criteria obtained using consecutive sampling technique. Data analysis was performed univariately and bivariately using SPSS version 25.0 with the Spearman correlation test. The results of the chi square test showed that the p value was less than the significant level (p < 0.05), it can be stated that there is an association between low birth weight and the incidence of stunting in children aged 24-60 months in the Tabanan I Health Center Working Area. The result of Levene's test is 0,184 (>0.05) which means that the variance of data between stunting and normal groups is homogeneous or the same. Conclusion toddlers who suffer from LBW have a 2,17 greater risk of experiencing stunting than toddlers who do not experience LBW.
Aktivitas Antibakteri Gel Hand Sanitizer Minyak Biji Pala (Myristica fragrans Houtt.) dengan Variasi Gelling Agent RACHMAWATI DWI AGUSTIN; YUNIASIH MULYANI JUBELIENE TAIHUTTU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.479

Abstract

Hand hygiene is important because hands are one of the intermediary pathways for the entry of microbes into the body. Efforts to maintain cleanliness by diligently washing hands and using a practical way of using hand sanitizer. The alcohol content in hand sanitizers can have a long-term impact on skin health, for that alternative alcohol substitutes can use natural ingredients as the basic ingredients of antiseptic hand sanitizers. Nutmeg seed oil contains active compounds as antibacterial ingredients. This study aims to determine the correct formulation of nutmeg oil hand sanitizer gel preparation and test its effectiveness in inhibiting the growth of pathogenic bacteria, namely Escherichia coli and Pseudomonas aeruginosa. Gel preparations were made with variations of the gelling agent Carbopol and CMC-Na. The stability test of the physical properties of the gel preparation includes organoleptic test, homogeneity test, and pH test. Antibacterial activity test by disc diffusion method. The results showed that the gel preparation had a characteristic nutmeg odor, with a clear color for the CMC-Na base and white for the Carbopol base. The pH values obtained for all preparations ranged from 5.7-6.2. The results of the antibacterial activity test showed that the nutmeg oil hand sanitizer gel based on CMC-Na and Carbopol had the ability to inhibit Escherichia coli and Pseudomonas aeruginosa bacteria quite well. The conclusion of this study is that the formulation of CMC-Na-based nutmeg seed oil gel formulation is considered to be the optimal formulation in inhibiting the growth of pathogenic bacteria and has a consistent physical form.
Analisis Pemberian Ekstrak Rumput Kebar (Biophytum Petersianum Klotzsch) Terhadap Kadar MDA Mencit Model Diabetes Melitus : Analisis Pengaruh Pemberian EKstrak Rumput Kebar (Biophytum petersianum Klotzsch) terhadap kadar MDA mencit model diabetes melitus DJURUMANA, YOHANA; MINNALIA SOAKAKONE; YOWAN EMBUAI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.482

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and abnormalities in the metabolism of carbohydrates, fats, and proteins. The mechanisms of diabetes mellitus can affect infertility starting with an increase in free radicals due to hyperglycemic conditions, leading to glucose auto-oxidation, protein glycation, and activation of the polyol pathway metabolism, which further accelerates the formation of reactive oxygen species. Oxidative stress increases the amount of Reactive Oxygen Species (ROS), oxidizes unsaturated fatty acids in spermatozoa membranes, leading to a chain reaction in cell membranes and the formation of toxic lipid peroxides. Lipid peroxides generate aldehyde compounds due to the disruption of the fatty acid chain, such as Malondialdehyde (MDA). Malondialdehyde (MDA) is a marker of oxidative stress. This study aims to evaluate the effect of Kebar Grass extract on the level of MDA (malondialdehyde), which is one of the indicators of oxidative stress, in a diabetic mouse model. The mice in this study were divided into two groups: a diabetes control group and a treatment group receiving Kebar Grass extract. The results of the study indicate that the administration of Kebar Grass extract did not have a significant effect on the MDA levels in the diabetic mouse model. Although there was a trend of decreased MDA levels in the treatment group, the difference did not reach a statistically significant level. This research indicates that although Elephant Grass has the potential as a traditional remedy for diabetes management, its effect on reducing oxidative stress, measured by MDA levels, may not be very strong. Further research is needed to better understand the mechanisms of action of Elephant Grass in diabetes management and its impact on oxidative stress.
Penatalaksanaan Pasien Penyakit Jantung Koroner Di RSPAL dr. Ramelan Surabaya ZULVINA, NADIFA FAULIZA; M. FATHUDDIN AL-ISLAMI; NABELLA CHOLIDATUN NIKMAH; NADHIFA NURIZZAH DHIYANISA; NADIFA SALMA SARI; ROOSTANTIA INDRAWATI; INTAN KOMALASARI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.503

Abstract

Background: World Health Organization (WHO) data shows that coronary heart disease is the highest mortality and morbidity throughout the world among other heart and vascular diseases, namely around 43%. The pharmacological therapy is evaluated based on the rationality of drug use including the right indication, the right drug, the right patient and the right dose. The aim of evaluating rational drug use is to ensure that patients receive treatment that suits their needs and at an affordable price. The rational use of drugs is important in the success of disease and improving the quality of health. Methode: The method in research uses an observational analytical method with a retrospective cross-sectional approach, with a purposive sampling technique. Data obtained from the patient's medical record status. The population in this study were all outpatients with a diagnosis of coronary heart disease in The Polyclinic Cardiology Department at RSPAL dr. Ramelan Surabaya period of January – March 2023. Result : The most patient characteristics based on range of age were in the 56 until 65 years old, namely 113 patients (33.43%). Characteristics of patients based on gender, the highest number of coronary heart medication users were men, 240 patients (71%). Characteristics of patients based on comorbidities (with comorbidities) were mostly with comorbidities, 296 patients (88%). The percentage of rational drugs of use includes the right indication (78.70%), the right drug (82.25%), the right dose (100%), and the right patient (99.11%). Conclusion: The rationale for using coronary heart medication in coronary heart patients in the outpatient installation at RSPAL dr. Ramelan Surabaya is 94.30% rational. Keywords: Coronary Heart Disease, Evaluation of Drug Use, Drug Evaluation, Outpatient.
Efek Teripang Terung (Phyllophorus Sp.) Terhadap Kadar HDL Dan LDL Tikus Dengan Diet Tinggi Lemak ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI; LESTARI DEWI; SOEDARSONO; INDRI NGESTI RAHAYU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.576

Abstract

Cholesterol is divided into two different forms, including HDL (high-density lipoprotein, also referred to as "good fat". LDL (low-density lipoprotein), sometimes known as "bad fat". A buildup of cholesterol levels in the blood that can lead to cardiovascular disease. Sea cucumbers contain flavonoids which are a class of phenolic compounds. Flavonoids have properties as antioxidants. This study was conducted to determine the effect of ethanol extract of sea cucumber (Phyllophorus sp.) on HDL and LDL levels in wistar strain white rats induced by high fat diet. This study was conducted in the biochemistry laboratory of the Faculty of Medicine, Hang Tuah University using 30 white rats (Rattus norvegicus) male wistar strain. The rats were divided into 5 groups, namely, groups of animals that did not receive treatment, groups of animals fed a high-fat diet, groups of animals fed a high-fat diet and sea cucumber ethanol extract 8.5mg/kgBB, groups of animals fed a high-fat diet and sea cucumber ethanol extract at a dose of 17mg/kgBB, groups of animals fed a high-fat diet and simvastatin. On the 35th day, HDL and LDL levels were examined in all groups. The conclusion of the results of this study is that the administration of sea cucumber ethanol extract can increase HDL levels even though it is not significant, and can significantly reduce LDL levels. Keywords: Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet
Analisis Sitogenetika Pada Pasien Dengan Amenore Primer ODILIA YULIANI SISTRI; EVA DIAH SETIJOWATI; HERNI SUPRAPTI; RETNO DWI WULANDARI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.650

Abstract

Abstract Amenorrhea is defined as the absence of menstruation in women of reproductive age. It is called primary amenorrhea if a person has not menstruated until the age of 16 years with normal secondary sexual characteristics or until the age of 14 years but there are no signs of secondary sexual development. There are many factors that cause primary amenorrhea, such as pituitary/hypothalamic disorders, dysfunction and abnormalities of the vaginal and uterine outlets. These abnormalities are caused by abnormalities in the endocrine glands, genetic (genes and chromosomes), psychological, environmental and structural abnormalities. This study aims to determine chromosome analysis in patients with primary amenorrhea at the Medical Genetics Laboratory, Faculty of Medicine, Wijaya Kusuma University Surabaya. The study was an observational descriptive study. The population in this study were all medical records of primary amenorrhea patients and the samples in this study were medical records of patients with primary amenorrhea at the Medical Genetics Laboratory of the Faculty of Medicine, Wijaya Kusuma University Surabaya in 2018-2023 and met the inclusion and exclusion criteria. The inclusion criteria are as follows: patients with a history of primary amenorrhea and exclusion criteria are secondary amenorrhea (POF) Premature Ovarian Failure. From 75 samples of primary amenorrhea patients, 39 patients (52%) had normal karyotypes and 36 patients (48%) had abnormal karyotypes. The 36 patients with abnormal karyotypes can be classified into number abnormalities, structural abnormalities, and primary amenorrhea patients with 46.XY DSD karyotypes. The chromosome number abnormalities in the patients were 45.X (Turner syndrome) and Turner mosaicism. Structural abnormalities were chromosomal deletions, isochromosomes, and translocations.
Efektivitas Ekstrak Etanol Rimpang Temulawak Sebagai Antibiofilm Terhadap Candida Albicans Penyebab Kandidiasis WASILATUN NAJAHAH; MASFUFATUN
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.693

Abstract

Curcuma (Curcuma xanthorrhiza Roxb) is a type of herbal plant that can be used to control infections from C. albicans, because it contains alkaloids, flavonoids, phenolics, saponins, triterpennoids, and glycosides. The purpose of this study is to analyze the effectiveness of temulawak rhizome ethanol extract as an antibiofilm against Candida alibicans, which causes candidiasis. The research design used is purely experimental with a post test control group only design approach. The extraction method used is maceration with 96% ethanol solvent, the antibiofilm activity test uses the microtiter plate biofilm assay method. The measurement of Optical Density (OD) of the antibiofilm activity test results was carried out with a microplate reader at a wavelength of 595nm. The data was analyzed using SPSS for Windows V29.02. The results showed that Temulawak ethanol extract (Curcuma xanthorrhiza Roxb) had a significant effect on the formation of C. albicans biofilm (p<0.05) with the highest inhibition at a concentration of 1.56%, and the smallest value at a concentration of 50%. The MBIC50 value was determined by probit analysis, so that the concentration of Temulawak ethanol extract (Curcuma xanthorrhiza Roxb) which can inhibit 50% of the formation of C. albicans biofilm is located at a concentration of 0.031%. Thus, it can be concluded that Temulawak rhizome ethanol extract has antibiofilm effectiveness against C. albicans, which causes candidiasis at the stage of biofilm formation. Thus, ethanol extract of temulawak rhizome has the potential to be used as an herbal medicine for the treatment of infectious diseases caused by C. albicans biofilm.
Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Abstract

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin
Karakteristik Pasien Dengan Penyakit Ginjal Kronis Stadium V Yang Menjalani Hemodialisis Reguler Di Rumah Sakit Tabanan MASYENI, SRI; MADE , SUHITA GIANI; PUTU, ARYA SURYANDITHA
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.810

Abstract

Abstract Chronic Kidney Disease (CKD) significantly impacts global health, contributing to both morbidity and mortality. This condition is characterized by severe kidney damage, which results in increased blood urea levels and can lead to serious complications. Reports indicate that the number of CKD cases is on the rise. This study is descriptive and employs a cross-sectional design, analyzing the medical records of CKD patients. The focus is on individuals who underwent examinations at Tabanan Hospital between January 1, 2019, and May 31, 2024. A total of 101 subjects were selected for the analysis. The results revealed that the majority of patients with stage V chronic kidney failure were over 60 years old (38.6%). The highest incidence of CKD was observed in men, accounting for 53.5% of the cases. Most patients had hypertension that was managed with medication (67.3%), and approximately 50.5% of the subjects experienced severe anemia

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