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Hang Tuah Medical Journal
Published by Universitas Hang Tuah
ISSN : 16931238     EISSN : 25984861     DOI : https://doi.org/10.30649/htmj.v19i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Hang Tuah Medical Journal: is published by Faculty of medicine, Universitas Hang Tuah with p-ISSN: 1693-1238 e-ISSN: 2598-4861. Its disciplinary focus is medical science and speciality in bio marine science. Hang Tuah Medical Journal is published in English and Indonesia for May and November. Each 90-100 page edition contains between nine and eleven scientific articles on research, case reports and study literature. Contributors of Hang Tuah Medical Journal included: medical researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. Hang Tuah Medical Journal as the open-access journal has been indexed by SINTA-Science and Technology Index, Garuda, Google scholar Hang Tuah Medical journal has been certificated as a Scientific Journal by Sinta (Science and Technology Index) S5 . valid until Volume 17 No.1, 2017.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 249 Documents
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Analisis Sitogenetika Pada Pasien Dengan Amenore Primer ODILIA YULIANI SISTRI; EVA DIAH SETIJOWATI; HERNI SUPRAPTI; RETNO DWI WULANDARI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.650

Abstract

Abstract Amenorrhea is defined as the absence of menstruation in women of reproductive age. It is called primary amenorrhea if a person has not menstruated until the age of 16 years with normal secondary sexual characteristics or until the age of 14 years but there are no signs of secondary sexual development. There are many factors that cause primary amenorrhea, such as pituitary/hypothalamic disorders, dysfunction and abnormalities of the vaginal and uterine outlets. These abnormalities are caused by abnormalities in the endocrine glands, genetic (genes and chromosomes), psychological, environmental and structural abnormalities. This study aims to determine chromosome analysis in patients with primary amenorrhea at the Medical Genetics Laboratory, Faculty of Medicine, Wijaya Kusuma University Surabaya. The study was an observational descriptive study. The population in this study were all medical records of primary amenorrhea patients and the samples in this study were medical records of patients with primary amenorrhea at the Medical Genetics Laboratory of the Faculty of Medicine, Wijaya Kusuma University Surabaya in 2018-2023 and met the inclusion and exclusion criteria. The inclusion criteria are as follows: patients with a history of primary amenorrhea and exclusion criteria are secondary amenorrhea (POF) Premature Ovarian Failure. From 75 samples of primary amenorrhea patients, 39 patients (52%) had normal karyotypes and 36 patients (48%) had abnormal karyotypes. The 36 patients with abnormal karyotypes can be classified into number abnormalities, structural abnormalities, and primary amenorrhea patients with 46.XY DSD karyotypes. The chromosome number abnormalities in the patients were 45.X (Turner syndrome) and Turner mosaicism. Structural abnormalities were chromosomal deletions, isochromosomes, and translocations.
Karakteristik Pasien Penderita Apendisitis Akut di RSUD Sanjwiani, Gianyar: Apendisitis akut MASYENI, SRI; SANJAYA LIE, MIRACLE NYOMAN; WIJAYA, INDRA
Hang Tuah Medical Journal Vol 22 No 1 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i1.661

Abstract

Acute appendicitis is one of the most common emergency surgical cases of lower right abdominal pain, a small proportion of cases in emergency units in the world which are often experienced by children and adults. This study aims to identify the characteristics of acute appendicitis in patients at Sanjiwani Hospital, Gianyar. This research is a descriptive study with a retrospective cross-sectional approach method that uses secondary data in the form of medical records of acute appendicitis patients who underwent examinations at Sanjiwani Regional Hospital, Gianyar in the period 1 January 2020–31 December 2022. The results showed that the highest number of acute appendicitis sufferers were aged 10–19 years (34.3%), with the highest incidence in males (60.6%), and the most symptoms found, namely lower right abdominal pain (100%), with the most positive examination of the Mc Burney Sign (89.9%) and increased white blood cells with an average of 12.8 x 10^3/uL.
Metaplasia Myelofibrosis WIJAYANINGRUM, LENA; I DEWA MADE WIDI HERSANA; I KETUT TIRKA NANDAKA
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.662

Abstract

Background: Myelofibrosis with myeloid metaplasia is a rare myeloproliferative disorder. Epidemiological data on the incidence of Myelofibrosis with myeloid metaplasia are still lacking. In Goteborg, Sweden, from 1983 to 1992, the incidence of the disease was retrospectively calculated at 0.4 per 100,000 population. In population- based leukemia data in the UK, the incidence of Myelofibrosis with myeloid metaplasia is estimated to be 0.73 per 100,000 person-years in men and 0.40 per 100,000 person-years in women. It is estimated that there are 230 new cases each year in England and Wales, 330 in Italy, and 1,600 in the United States. No medical therapies have been shown to be effective against the overall survival of patients. The prognosis of myelofibrosis with myeloid metaplasia varies widely. For this reason, it is necessary to report cases of Myelofibrosis Myeloid Metaplasia Methode: Descriptive research, in the form of case reports of patients with myelofibrosis metaplasia, with data obtained from primary data anamnesa and direct physical examination of patients and secondary data from medical records, the results of examinations of doctors at RSPAL Dr Ramelan Surabaya 2022-2024. Results: Since 13 December 2022 until this date 3 May 2024 (17 months).Patient with a diagnosis of Primary Myelofibrosis and high Uric Acid after undergoing therapy with jakavi 15 mg 1x1. Allopurinol 300mg 1x1 and Nabic 3x1. Experienced improvement in complaints of increased appetite. Resting at night there are no complaints. Activity such as walking is not easily tired, mass in the abdomen that does not cause pain. On physical examination, there was an increase in body weight from 50 kg to 55 kg and still found S IV splenomegaly, from the haematological examination there was a decrease in platelets 136.00 (10^3µL) which was previously 203.00 (10^3µL). Uric acid improved from 10.8 mg/dl to 7.7 mg/dl. Conclusion: Jakavi is a drug containing ruxolitinib that can treat splenomegaly or disease-related symptoms in adult patients with myelofibrosis. Keywords: Myelofibrosis Metaplasia.Splenomegaly.Jakavi
The Need For Marine Medicine Specialists for An Integrated Service Network Towards Advanced Indonesia 2045 BOY SUBIROSA SABARGUNA; HARMIN SARANA; KEES DE ROODE; DJATIWIDODO EDI PRATIKNYA; RISMA
Hang Tuah Medical Journal Vol 22 No 1 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i1.668

Abstract

Need for Marine Medicine Specialist Doctors: I. Hospital-Based Study Program, starting to run in 8 study programs, July 2024. II. Service Needs: 1) Regulations, 2) Development of Remote and Coastal Areas, 3) The existence of a Sea Highway, 4) The existence of marine tourism, 5) Fisheries, 6) Defense, 7) The existence of a New National Capital. III. Service Network: 1) Marine Medicine Service Center in the National Capital, 2) Frontline Areas, 3) Coastal Areas, 4) Hospital Ships. IV. Integrated Systems Network: 1) Defense System, 2) Transportation System, 3) Tourism System, 4) Fisheries System, 5) Telemedicine System, 6) Coastal Area Development, 7) Education, Research, Community Service and Innovation Systems. On August 25, 2023, the Marine Medicine Study Program was approved for a SCOR of 0.001/1,000 population, including efforts to accelerate the achievement of meeting needs. Calculation of Minimum Needs: calculated as 50% of the optimal value, 50% x 319 = 159.5 Rounded to 160, UNRAM and UHT Production Three more years: 3 +5 = 8, then it will only be achieved 20 to 40 years later. Proposed Solutions: 1) PRODI at UNRAM and UHT; There are 2 PRODIs with 3 classes: Regular, Parallel, and Scholarship, projected graduates 9+15 =24; 2) Immediately establish 10 Hospital Based PRODIs, this will meet the increasing needs, so produce 10 PRODIs, projected graduates 10 x 10 = 100; 3) Immediately form a Service Network and System Network, spread throughout Indonesia. 9 types, so there are 9 PRODI. Projection of graduates 9 x 10 = 90. Total projection: 24 + 100 + 90 = 214 per semester. Keywords: need for specialist doctors, study program, student class, graduate projections.
Efektivitas Ekstrak Etanol Rimpang Temulawak Sebagai Antibiofilm Terhadap Candida Albicans Penyebab Kandidiasis WASILATUN NAJAHAH; MASFUFATUN
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.693

Abstract

Curcuma (Curcuma xanthorrhiza Roxb) is a type of herbal plant that can be used to control infections from C. albicans, because it contains alkaloids, flavonoids, phenolics, saponins, triterpennoids, and glycosides. The purpose of this study is to analyze the effectiveness of temulawak rhizome ethanol extract as an antibiofilm against Candida alibicans, which causes candidiasis. The research design used is purely experimental with a post test control group only design approach. The extraction method used is maceration with 96% ethanol solvent, the antibiofilm activity test uses the microtiter plate biofilm assay method. The measurement of Optical Density (OD) of the antibiofilm activity test results was carried out with a microplate reader at a wavelength of 595nm. The data was analyzed using SPSS for Windows V29.02. The results showed that Temulawak ethanol extract (Curcuma xanthorrhiza Roxb) had a significant effect on the formation of C. albicans biofilm (p<0.05) with the highest inhibition at a concentration of 1.56%, and the smallest value at a concentration of 50%. The MBIC50 value was determined by probit analysis, so that the concentration of Temulawak ethanol extract (Curcuma xanthorrhiza Roxb) which can inhibit 50% of the formation of C. albicans biofilm is located at a concentration of 0.031%. Thus, it can be concluded that Temulawak rhizome ethanol extract has antibiofilm effectiveness against C. albicans, which causes candidiasis at the stage of biofilm formation. Thus, ethanol extract of temulawak rhizome has the potential to be used as an herbal medicine for the treatment of infectious diseases caused by C. albicans biofilm.
Efek Sinergis Vitamin C Dalam Meningkatkan Kinerja Antijamur Madu Apis dorsata Terhadap Biofilm Candida albicans Untuk Terapi Kandidiasis MASFUFATUN; ZAHRA, FATIMATUZ; AGUSTIN ANGRAENI, DWI PUTRI; NUZULA, FIRDAUSI
Hang Tuah Medical Journal Vol 22 No 1 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i1.698

Abstract

Honey is a natural ingredient produced by bees from flower nectar that has antimicrobial, antioxidant, anti-inflammatory, good wound healing effects, and bacteriostatic. This study aims to determine the synergistic effect of vitamin C in improving the antifungal performance of Apis dorsata honey against Candida albicans biofilm for candidiasis therapy. This research design is true experimental with a post-test only control group design approach using the microtiter plate assay method to measure the Optical Density (OD) value of the biofilm matrix. The test of the synergistic effect of Vitamin C on Honey was carried out by adding vitamin C to honey concentrations of 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, and 50%. Furthermore, the MBIC50 value between honey and the combination of honey and vitamin C was compared. The results showed that both honey and the combination of honey and vitamin C were each able to decrease the growth of C. albicans biofilm matrix against A. dorsata honey at various concentrations. The results of the Minimum Biofilm Inhibitory Concentration 50% (MBIC50) value in A. dorsata honey and the combination of A. dorsata honey and vitamin C were 84.27% and 63.56% respectively. Based on this study, it can be concluded that vitamin C can increase the antifungal performance of A. dorsata by lowering the MBIC50 value. Thus, the combination of vitamin C and honey can be used as an alternative therapy for candidiasis.
Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Abstract

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin
Karakteristik dan Faktor Risiko Pasien Kanker Kulit Di Rspal Dr. Ramelan Surabaya Periode Januari 2021-Desember 2023 HIBATULLAH, HISYAM; OCTAVIANDA, YOHANA; RAHAYU, INDRI NGESTI; MUTIADESI, WAHYU PRASASTI
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.771

Abstract

Skin cancer is one of the most common types of cancer diagnosed worldwide. The incidence and mortality rates of skin cancer have also continued to increase in recent decades. In Indonesia, skin cancer is the cancer with the third highest incidence after uterine cancer and breast cancer. The purpose of this study was to determine the characteristics and risk factors of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. Using a qualitative descriptive approach with variables in the form of secondary data that has been recorded in the medical records of skin cancer patients at RSPAL dr. Ramelan Surabaya for the period January 2021-December 2023. The data examined were the type of skin cancer, symptoms of skin cancer, location of skin cancer, patient age, and patient gender. The most characteristic type of skin cancer is Basal Cell Carcinoma in 51 cases. The most characteristic symptom of skin cancer was the formation of new moles/bumps in 67 cases. The characteristic of the location of skin cancer is mostly on the head in 69 cases. The age characteristics of cancer patients were most common in elderly patients at 56 cases. The sex characteristics of skin cancer patients were mostly female at 51 cases. The occupational characteristics of skin cancer patients were mostly indoor workers at 86 cases. Most cases were of the BCC type, with the most common symptom being the formation of new moles.
Hubungan antara Tingkat Pengetahuan tentang Kanker Serviks dan Hasil Pap Smear pada Wanita Dewasa DIGAMBIRO, REZA ADITYA; ILONA, FLORINDA; CHENDRASARI, JULIAN; SETYANINGRUM, DYAH AYU WORO; LESTARI, INDAH WIDYA
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.809

Abstract

Cervical cancer can arise from a persistent infection with Human Papillomavirus (HPV), which can be avoided through early detection by pap smear screening. Having adequate knowledge about cervical cancer is crucial for encouraging participation in pap smear tests, which can detect non-cancerous or precancerous changes before they progress. This cross-sectional descriptive-analytic study aimed to assess knowledge levels about cervical cancer and their correlation with pap smear results among women of reproductive age in Jakarta, Bogor, and Bekasi (23–50 years). A total of 133 participants underwent a structured questionnaire for assessing knowledge and a pap smear test for evaluating cervical health. The pap smear results showed that 80% were normal, 6% had atypical cells without malignancy, and 14% showed inflammatory lesions. A Chi-square test revealed a significant association between knowledge levels and pap smear outcomes. These findings provide valuable insights for healthcare stakeholders to develop effective health promotion strategies that increase pap smear coverage and encourage early detection of cervical cancer.
Karakteristik Pasien Dengan Penyakit Ginjal Kronis Stadium V Yang Menjalani Hemodialisis Reguler Di Rumah Sakit Tabanan MASYENI, SRI; MADE , SUHITA GIANI; PUTU, ARYA SURYANDITHA
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.810

Abstract

Abstract Chronic Kidney Disease (CKD) significantly impacts global health, contributing to both morbidity and mortality. This condition is characterized by severe kidney damage, which results in increased blood urea levels and can lead to serious complications. Reports indicate that the number of CKD cases is on the rise. This study is descriptive and employs a cross-sectional design, analyzing the medical records of CKD patients. The focus is on individuals who underwent examinations at Tabanan Hospital between January 1, 2019, and May 31, 2024. A total of 101 subjects were selected for the analysis. The results revealed that the majority of patients with stage V chronic kidney failure were over 60 years old (38.6%). The highest incidence of CKD was observed in men, accounting for 53.5% of the cases. Most patients had hypertension that was managed with medication (67.3%), and approximately 50.5% of the subjects experienced severe anemia

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