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INDONESIA
Medical and Health Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 28073541     DOI : https://doi.org/10.20884/1.mhj.2023.2.2.8053
Core Subject : Health,
Medicine & Pharmacology
Medical and Health Journal (EISSN. 2807-3541) is containing various articles/ manuscripts in the forms of research article, systematic reviews, case reports in the field of medicine focusing on basic medicine, clinical medicine, biomedical sciences, medical biotechnology, and public health. This journal is published by Universitas Jenderal Soedirman, Purwokerto, Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 124 Documents
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VITAMIN D PADA PASIEN ACNE VULGARIS DAN KORELASI DENGAN LUARAN KLINIS: REVIEW SISTEMATIK Pratama, Radya Putra; Arjadi, Fitranto; Mulyanto, Joko
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11004

Abstract

Background: Vitamin D is thought to have a role in the pathogenesis of acne vulgaris through anti-inflammatory effects. Research regarding the relationship between vitamin D and the severity of acne vulgaris still shows mixed results. Objective: To determine the correlation between vitamin D levels and clinical severity in acne vulgaris patients. Method: This systematic review uses Pubmed, Google Scholar, and Science Direct databases. Of the 362 articles, 13 articles that met the inclusion criteria were analyzed narratively. Results: Of 13 studies, 4 showed significant differences in serum vitamin D levels between degrees of acne severity. Meanwhile, the other 9 did not show any significant differences. One study showed significant differences in tissue vitamin D levels with severity. Conclusion: Overall, results are still inconsistent. There is evidence of a higher risk of vitamin D deficiency and decreased tissue vitamin D levels in people with acne vulgaris as severity increases. It is suspected that this is related to the role of vitamin D in suppressing inflammation. Further studies considering confounding factors are needed to clarify this association.
ROLE OF HYDROGEN PEROXIDE (H2O2) IN YOGHURT (Lactobacillus bulgaricus and Streptococcus thermophilus) IN INHIBITING THE GROWTH OF Staphylococcus epidermidis CAUSES OF ACNE VULGARIS Peramiarti, Idsap; Setiawati, Setiawati; Williem, Williem
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11179

Abstract

Acne vulgaris (AV) is an inflammation of the pilosebaceous follicles caused by the bacterium Staphylococcus epidermidis (S. epidermidis). Yoghurt is the result of fermented milk with a mixture of Lactobacillus bulgaricus and Streptococcus thermophilus as Lactic Acid Bacteria (BAL) which produce several compounds like lactic acid, bacteriocin, hydrogen peroxide, and carbon dioxide. Hydrogen peroxide is effective in reducing inflammatory and non-inflammatory lesions in AV patients. This study aims to determine whether hydrogen peroxide produced by lactic acid bacteria in yoghurt affects inhibiting the growth of S. epidermidis. This research is an experimental study with the post-test only method with control group design which was conducted in vitro. Analysis of H2O2 levels in yoghurt using permanganometric titration. Bacterial growth inhibition test using macro delusion and colony counter. The samples used were 30 samples with two repetitions and divided into 10 concentration groups (0%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%) with 0 % as negative control. Differences in treatment group barriers were analyzed using the One Way ANOVA test. One Way Anova test showed p < 0.001 which indicated a significant difference between each concentration group. The results of the Post-Hoc LSD test were p<0.05 between the control group and all treatment groups. H2O2 in yoghurt has antibacterial activity against S. epidermidis. This study showed that there was an inhibition of the growth of S. epidermidis by yoghurt at concentration of 5% had a hydrogen peroxide content of 0.17 mg/mL and pH of 5.7 was the minimum inhibitory concentration of S. epidermidis growth.
THE POTENTIAL OF HERBAL PLANT EXTRACTS AS A COMPLEMENTARY THERAPY IN DIABETES MELLITUS: A LITERATURE REVIEW Prameswari, Shafira Audy; Afifah, Afifah; Pratiwi, Meidy; Rahmania, Firda; Fatah, Muhammad Riski; Ningsih, Elisa Fitria; Maulana, Krisna; Khaerunnisa, Ghina Eka Nur
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11344

Abstract

Diabetes mellitus (DM) is still a serious health problem that needs attention in Indonesia. Management of this disease can be done with conventional therapy that has been commonly practiced. However, advances in DM treatment approaches have side effects such as hypoglycemic coma, liver disorders, and kidney disorders. The way to overcome this is by combining medicinal plants and conventional therapy. However, the lack of scientific research or testing that illustrates the effectiveness of herbal plants is still a problem in the use of herbal plants. This literature study provides a scientific overview of the effectiveness of herbal extracts as complementary therapy for DM. The literature search was conducted through online data sites PubMed, Science Direct, Research Gate, and Google Scholar using the keywords (Antidiabetic) AND (Herbs) from 2013 to 2023. From the search results, 13 articles were obtained that met the eligibility criteria. Based on tests conducted in each article obtained, all herbal extracts studied have anti-diabetic properties that can reduce blood glucose levels depending on the dose given. This finding suggests that herbal extracts can be utilized as complementary therapy for people suffering from DM.
POTENTIAL OF RED ONION PEEL ETHANOL EXTRACT (Allium cepa L.) TO DEGRADATION OF Staphylococcus aureus BIOFILM Sari, Dwi Nur Indah; Rosyada, Alya Ghina; Laksitasari, Anindita; Djati, Fanni Kusuma; Andini, Restian Febi
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11371

Abstract

Dental biofilm is a bacterial colonization adhering to the tooth surface, enveloped by an extracellular matrix. This biofilm shields bacteria from the body's defense and antibacterial systems, potentially leading to various dental and oral diseases.Staphylococcus aureus is among the bacteria forming dental biofilm. Red onion peel is known to contain flavonoids, saponins, tannins, steroids and alkaloids which have antibacterial and anti-biofilm activity. This study aimed to determine the potential of shallot peel extract in degrading S. aureus biofilms. This study was conducted with a posttest-only control group design. Red onion peel extraction is carried out using the maceration method. A total of 5 groups of extracts (50%, 25%, 12.5%, 6.25%, and 3.12%), positive control (chlorhexidine gluconate 0.2%), and negative control (DMSO 1%) were tested for their activity in S. aureus biofilm degradation at 24 and 48 hours of incubation. The biofilm degradation was assessed using the microtiter plate assay method with crystal violet staining read at a wavelength of 595 nm. Percent biofilm degradation was statistically analyzed using Two way ANOVA and LSD. The results indicated significant differences based on treatment, incubation time, and the interaction between the two. The highest activity was observed at a concentration of 25%, although it was still lower than that of positive control. Conclusion: the ethanol extract of red onion peel has the potential to degrade S. aureus biofilms, with the highest activity at a concentration of 25% and an incubation time of 48 hours.
EFEKTIVITAS PEMBERIAN JAHE (Zingiber officinale) SEBAGAI ANTIEMETIK PADA IBU HAMIL Hasna, Annajmi; Nurunnisa, Shinta; Syami, Danial; Izzati, Olivia Nolisviani; Aristya, Davina Aqiilah; Wibowo, Arif Difan Satria; Anjani, Rr. Berliana Putri Dyah; Wahyudin, Wahyudin
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11372

Abstract

Nausea and vomiting during pregnancy are common occurrences in the first trimester. This can be attributed to an increase in estrogen and progesterone hormones produced by human chorionic gonadotropin (HCG) in the placenta. Various therapies can be employed as antiemetics in pregnant women, and one of them is traditional therapy involving the administration of ginger extract. This research design uses a literature review methodology, gathering data from international and national journals that meet the inclusion and exclusion criteria. The databases utilized include Google Scholar, PubMed, and Garuda. To understand the effectiveness of ginger extract administration as an antiemetic in pregnant women. The methodology employed is a literature review, utilizing the Google Scholar database to search for articles published between 2013 and 2023 in both Indonesian and English languages. Ginger can reduce nausea and vomiting by modulating gastrointestinal effects such as smooth muscle contractions and stimulating gastric motility. It inhibits 5-HT3 receptors in the central nervous system, hampers carminative effects, reduces cisplatin effects, and has effects similar to dimenhydrinate. Administering ginger infusion twice a day for 4-7 days has shown a decrease in the occurrence of nausea and vomiting in pregnant women. Additionally, ginger aromatherapy with 5 ml for four consecutive days can reduce the incidence of nausea and vomiting in pregnant women with hyperemesis gravidarum. Ginger extract can reduce nausea and vomiting in pregnant women.
PENGETAHUAN ORANG TUA TENTANG KECACINGAN DAN PENGOBATAN TERHADAP KEJADIAN INFEKSI SOIL TRANSMITTED HELMINTH DI SDN CIBEREM KECAMATAN SUMBANG KABUPATEN BANYUMAS: A CROSS SECTIONAL STUDY Susiawan, Lieza Dwianasari; Wahyudin, Wahyudin; Sari, Octavia Permata; Pramono, Wisnu Budi; Bahiyah, Fiona Annisa
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11388

Abstract

Soil Transmitted Helminths (STH) infection is a disease caused by nematodes and often occurs among elementary school age children. One factor that can influence the occurrence of recurrent infections is parents' lack of understanding about worm treatment. Errors in treating worms can be influenced by several factors, one of which is the level of parental knowledge. To determine the relationship between the level of parental knowledge about worms and treatment on the incidence of Soil Transmitted Helminth infections at SDN Ciberem, Sumbang District, Banyumas Regency. Analytical research is an observational study with a cross-sectional design on 96 Ciberem Elementary School students using purposive sampling techniques. Data collection was carried out by questionnaires on parental knowledge and fecal examination at the FK Unsoed Parasitology Laboratory using the floating method (qualitative). Hypothesis analysis uses Fisher's Exact test. Result: The prevalence of STH infection at SDN Ciberem was 5.2% with the worm type Trichuris trichiura. The results of the Fisher's Exact statistical test showed that parental knowledge about worms (p= 0.052) did not have a significant relationship with the incidence of STH infection. The level of parental knowledge about worm treatment (p=0.033) has a significant relationship with the incidence of STH infection. Conclusion: There was no relationship between the level of parental knowledge about worms and the incidence of STH infection. There is a relationship between the level of parental knowledge about worm treatment and the incidence of STH infection.
DRUG INTERACTIONS AND CONTRAINDICATIONS ANESTHESIA DRUGS IN PSYCHIATRIC PATIENTS Wardani, Henry Nur Kusuma; Pramono, Wisnu Budi
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11390

Abstract

Psychotropic drugs are used in the treatment of psychiatric and non-psychiatric conditions. Many patients taking psychotropic medications may present for procedures that require anesthesia. Psychotropic drugs can have dangerous interactions with drugs commonly used in anesthesia, some of which can be life-threatening. In this review, we describe current anesthetic considerations for patients undergoing psychotropic drug therapy, including antidepressants, antipsychotics, mood stabilizers, anxiolytics, and stimulants. The pharmacology, side effects, and potential drug interactions of commonly prescribed psychotropic drug therapy with anesthetic agents are described. Next, we highlight current recommendations regarding discontinuation and continuation of these medications during the perioperative period.
POTENSI PELARUT ETIL ASETAT PADA EKSTRAKSI FLAVANOID DARI TANAMAN CIPLUKAN (Physalis angulata L.) Sylviningrum, Thianti; Rianto, Bayu Dwi; Agamonanza, Freddy; Ardinas, Shinta Prima
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11407

Abstract

The ciplukan plant (Physalis flavonoi L.) is widely used as a traditional medicine because it contains various bioactive compounds such as flavonoids and physalin. The purpose of this study was to identify and measure the total flavonoid content of ciplukan extracts in various solvents. Ciplukan was extracted by maceration using ethanol, n-hexane and ethyl acetate solvents. Flavonoids were identified by UV-Vis spectrophotometry at 510 nm wavelength. Total flavonoid content was measured based on the calibration curve of quercetin as the standard of comparison. The highest yield of ciplukan extract was obtained from ethanol solvent (18.5%), followed by n-hexane and ethyl acetate. The highest absorbance and total flavonoid content were found in the ethyl acetate extract, which were 0.1162 and 3,709.01 μg/g. Flavonoids from Ciplukan extract were identified most optimally in the semipolar solvent ethyl acetate compared to the polar solvent ethanol and nonpolar n-hexanes. The conclusion of this study is that ethyl acetate extract has the potential to be developed as an herbal medicinal material.
PEMBERIAN ANTIBIOTIK PADA SEPSIS NEONATORUM Hapsari, Ariadne; Wijayana, Kamal Agung
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11437

Abstract

Neonatal sepsis is still an unsolved problem in newborn baby services and care. In developing countries, almost the majority of newborn baby treated are related to sepsis. The same thing was found in developed countries in babies treated in newborn baby intensive care units. In addition to morbidity. High mortality was also found in BBL sepsis sufferers. Neonatal sepsis is a clinical syndrome of systemic disease accompanied by bacteremia that occurs in the first 28 days of life. Bacterial, viral or fungal invasion into the blood before or after birth can spread to other organs/systems causing meningitis, pneumonia, osteomyelitis and pyelonephritis. Patient treatment usually involves giving a combination of antibiotics which aims to expand the range of pathogenic microorganisms that the patient may be suffering from. It is hoped that the combination of antibiotics will have good sensitivity to both Gram-positive and Gram-negative germs. Depending on the pattern and resistance of germs in each hospital, usually the antibiotics chosen are the ampicillin/ cloxacillin/ vancomycin group and the aminoglycoside/cephalosporin group. The length of treatment depends on the type of germ causing it. In patients with gram-positive bacteria, antibiotics are recommended for 10-14 days, while for patients with gram-negative bacteria, treatment can be continued for 2-3 weeks.
RELATIONSHIP BETWEEN MMP14 +7096 GENETIC VARIATION WITH CHILD TURCOTTE PUGH (CTP) SCORE IN HEPATIC CIRRHOSIS Wijayana, Kamal Agung; Siswandari, Wahyu; Hapsari, Ariadne; Yudha, Paskalis Bhaskara Unggul
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11438

Abstract

Background: Hepatic cirrhosis is chronic hepatic damage followed by structural change and decreased function of hepar. Child Turcotte Pugh (CTP) score is used to assess the severity of hepatic cirrhosis. Genetic variation of MMP14 has a role in the progressivity of liver diseases. Relationship between MMP14 +7096 genetic variation and Child Turcotte Pugh score in hepatic cirrhosis was not well known.Aim: To determine the relationship between MMP14 +7096 genetic variation with Child Turcotte Pugh score in hepatic cirrhosis patients in Prof. Dr. Margono Soekarjo General Hospital Purwokerto.Methods: Analytical observational study with cross-sectional design was conducted among 30 patients who were diagnosed hepatic cirrhosis in Prof. Dr. Margono Soekarjo General Hospital Purwokerto. Data collection was performed by total samping of blood laboratory test and PCR-RFLP. Data was analysed using Kruskal-Wallis test and Mann-Whitney post hoc test.Results: Kruskal-Wallis test shows relationship between genetic variation of MMP14 +7096 with Child Turcotte Pugh (CTP) score (p=0,024). Mann-Whitney post hoc test shows significant relationship between CC and TT genotype (p=0,02).Conclusions: There is a significant relationship between CC and TT genotype MMP14 +7096 genetic variation with Child Turcotte Pugh score in hepatic cirrhosis patients in Prof. Dr. Margono Soekarjo General Hospital Purwokerto.

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