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Medical and Health Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 28073541     DOI : https://doi.org/10.20884/1.mhj.2023.2.2.8053
Core Subject : Health,
Medicine & Pharmacology
Medical and Health Journal (EISSN. 2807-3541) is containing various articles/ manuscripts in the forms of research article, systematic reviews, case reports in the field of medicine focusing on basic medicine, clinical medicine, biomedical sciences, medical biotechnology, and public health. This journal is published by Universitas Jenderal Soedirman, Purwokerto, Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 124 Documents
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AKTIVITAS ANTIBAKTERI EKSTRAK TANGKAI Begonia multangula Blume TERHADAP PERTUMBUHAN Aggregatibacter actinomycetemcomitans Sari, Dwi Nur Indah; Prihastuti, Christiana Cahyani; Andini, Restian Febi; Gusri, Aldina; Ghani, Muhammad Hisyam; Nabila, Haidy Lailatun
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8594

Abstract

Periodontitis adalah penyakit gigi dan mulut yang paling sering ditemukan pada masyarakat dan dapat menyebabkan tanggalnya gigi. Salah satu bakteri penyebab periodontitis adalah Aggregatibacter actinomycetemcomitans. Perawatan periodontitis dilakukan dengan terapi mekanik (scaling and root planning) disertai terapi kimiawi (antibiotik dan obat kumur). Penggunaan terapi kimiawi yang berkepanjangan dapat menyebabkan resistensi bakteri, gangguan pengecapan dan perubahan warna gigi. Alternatifnya dapat digunakan bahan herbal yang memiliki daya antibakteri Tangkai Begonia multangula Blume di beberapa wilayah digunakan sebagai tanaman obat serta memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak tangkai Begonia multangula Blume terhadap pertumbuhan A. actinomycetemcomitans secara in vitro. Penelitian dilakukan secara eksperimental laboratoris dengan sampel A. actinomycetemcomitans ATCC 43718. Tangkai Begonia multangula Blume diekstraksi menggunakan metode maserasi dan dibuat 5 seri konsentrasi (3,12%, 6,25%, 12,5%, 25%, dan 50%). Uji antibakteri dilakukan metode difusi kertas cakram dengan kontrol positif Chlorhexidine gluconate 2% serta kontrol negatif DMSO 1%. Diameter zona hambat selanjutnya dianalisis statistic. Hasil penelitian menunjukkan bahwa aktivitas antibakteri ekstrak tangkai Begonia multangula Blume meningkat seiring peningkatan konsentrasi dengan aktivitas tertinggi pada konsentrasi 50% dengan zona hambat sebesar 20,33 mm (p<0,05). Simpulan dalam penelitian ini bahwa ekstrak etanol tangkai Begonia multangula Blume memiliki aktivitas sebagai antibakteri A. actinomycetemcomitans.
PREVALENSI Candida albicans PADA PASIEN OTOMIKOSIS DI RSUD MARGONO SOEKARJO Wijaya, Helmi Aditya; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah; Krisniawati, Nia; Rujito, Lantip
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8643

Abstract

Background: Otomycosis is an infection of the ear caused by various fungi. One of the most common fungi that cause Otomycosis is Candida albicans. Otomycosis is a challenge for the medical world and patients because it requires long-term treatment and has a high recurrence rate. It causes the importance of an overview of the prevalence in a place as planning health services, description of cases, and eradication programs. Banyumas Regency has a climate that supports the growth of mushrooms. One of the major hospitals in Banyumas is RSUD Margono Soekarjo. Objective: Knew the prevalence of Candida albicans on Otomycosis at Margono Soekarjo Hospital. Method: This research is a descriptive observational study on the target population of patients at the ENT clinic at RSUD Margono Soekarjo—sampling technique using a total sampling of as many as 42 subjects with 46 samples. Data analysis techniques use univariate analysis to describe the characteristics of each variable. Results: The results of otomycosis sufferers at Margono Soekarjo Hospital were male compared to female by 50:50, namely 21 of 42 subjects (50.00%), respectively. The age group that suffered the most from Otomycosis was the 26-35 age group, with 12 out of 42 subjects (28.57%). The prevalence of Candida albicans in Otomycosis of 2.17% or 1 of 46 patient samples with a clinical diagnosis of Otomycosis at Margono Soekarjo Hospital was caused by a fungus Candida albicans. Conclusion: Prevalence Candida albicans as a cause of Otomycosis in patients at the ENT polyclinic at Margono Soekarjo Hospital in the Januari-February 2023 period of 2.17%, namely 1 out of 46 samples, with 26 years of age included in the 26-35 years age group and female.
HUBUNGAN USIA DAN JUMLAH PARITAS DENGAN TIPE KARSINOMA ENDOMETRIUM DI RSUD PROF. DR. MARGONO SOEKARJO Nusa, Arifah Pelangi; Nawangtantrini, Gita; Aditiyono, Aditiyono; Novrial, Dody; Yamsum, M
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8741

Abstract

Background: Endometrial cancer ranks 15th with the highest number of new cases in 2020 in the world. There are still differences in research results regarding the relationship between age and number of parities with endometrial carcinome. Aim: To determine the relationship between age and parity with type of endometrial carcinoma at RSUD Prof. Dr. Margono Soekarjo. Method: This research is an observational analytic study with a cross sectional study. The sampling technique uses total sampling. Total subjects were 129 endometrial carcinoma patients at RSUD Prof. Dr. Margono Soekarjo in 2017-2022. The data taken is secondary data from the medical records. The variable age and number of parities are the data listed in the medical record document. Data were analyzed using the chi-square statistical test. Result: The total sample obtained was 129 patients. The most common age was found at the age of 51-60 years (41.1%) and the least at the age of <40 years (7.8%). The highest number of parities found was parity ≥2 (55.8%) and the least was parity 1 (15.5%). The results of the chi-square statistical test for age with endometrial carcinoma type showed a value of p = 0.159 (p>0.05). Based on the results of the analysis, there was no significant relationship between age and the type of endometrial cancer. The results of the chi-square statistical test for the number of endometrial carcinoma types showed a value of p = 0.02 (p <0.05). Based on the results of the analysis, it showed that there was a significant relationship between the number of parities and the type of endometrial cancer. Conclusion: There was no significant relationship between age and the type of endometrial carcinome and there was a significant relationship between the number of parities and the type of endometrial carcinome at RSUD Prof. Dr. Margono Soekarjo.
MANIFESTASI ORAL PADA PASIEN DIABETES MELLITUS Prakosa, Aditya Priagung; Aliyyu, Wienda Cinta; Rosyadah, Nada Janardita; Nur, Saniyya; Amalia, Rahma Ika
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8891

Abstract

Diabetes melitus termasuk dalam penyakit tidak menular yang kronis disebabkan oleh gangguan metabolisme di organ pankreas ditandai dengan peningkatan kadar gula darah melebihi normal. Wilayah Asia Tenggara yang didalamnya temasuk negara Indonesia menempati peringkat ke-3 di dunia dengan prevalensi penderita diabetes melitus mencapai 11.3%. Sementara itu, Indonesia menempati peringkat ke-7 di antara 10 negara dengan penderita diabetes melitus terbanyak mencapai 10,7 jiwa. Diabetes melitus dapat bermanifestasi menjadi penyakit lain salah satunya kelainan-kelainan di rongga mulut. Bentuk manifestasi diabetes melitus di rongga mulut yang umum ditemui antara lain, Oral Infection (Candidiasis), Xerostomia, Penyakit Periodontal, Recurrent Dental Caries, Burning mouth sensation (berkaitandengan xerostomia), Taste Dysfunction, Oral Mucosa Alteration (Lichen Planus), Poor Oral Wound Healing. Dalam tinjauan literatur ini menjelaskan mengenai penyakit sistemik diabetes melitus, pemeriksaan penunjang diagnosis dan tatalaksana manifestasi oral diabetes melitus. Tatalaksana manifestasi oral diabetes melitus tidak hanya berfokus pada penanganan penyakit yang ada di rongga mulut, namun lebih diutamakan untuk menghilangkan faktor etiologi serta menghindari faktor predisposisi.
BEETROOT (Beta vulgaris L.) AND ITS POTENTIAL AS AN ANEMIA TREATMENT IN PREGNANCY Fadlilah, Synta Haqqul; Suhartomo, Dalri Muhammad; Yusan, Rizak Tiara; Yudhawan, Indra
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9070

Abstract

Anemia is one of the most common nutritional problems in pregnant women. It is defined as a condition in which the hemoglobin (Hb) level is lower than normal. The main cause of anemia in obstetrics is iron deficiency. To prevent this condition, the Government of Indonesia through the Ministry of Health made a rule by giving iron tablets to pregnant women at least 90 tablets during pregnancy (Kemenkes RI, 2022). However, some people are often bored with this pharmacological therapy due to the nausea and vomiting effect of the iron smell. Therefore, the development of alternative anemia therapy has been done to minimize those problems. One of the herbal ingredients that are being studied for its potential as anti-anemia in pregnancy is beetroot (Beta vulgaris L.). This research is included in the type of literature review. The selected literature is research articles published in the last 10 years (2013 to 2023). There are 10 articles that match the topic of study. A total of 7 publications demonstrated the effect of beetroot on anemia in pregnant women during the pregnancy period, and 2 articles in the post-partum period. A study performed in vivo experiments on pregnant female rats. Almost all of the studies did intervention by giving subjects beetroot juice. Only one study used beets as an intervention as ice cream. The results show that beetroot has the potential to prevent and treat anemia in pregnancy by increasing hemoglobin levels and the amounts of hematocrit. It contains a high level of folic acid which is important for normal cell and tissue growth. The iron content of beetroot also plays an essential role in the human body transporting oxygen to red blood cells, so it helps to cure anemia.
HUBUNGAN FUNGSI PARU DENGAN TINGKAT KESANGGUPAN KARDIOVASKULER PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS JENDERAL SOEDIRMAN Fatchurohmah, Wiwiek; Muflikhah, Khusnul; Mustofa, Mustofa; Candrawati, Susiana; Madani, Arya Indra
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9196

Abstract

Kesanggupan kardiovaskuler merupakan salah satu indikator kebugaran seseorang dan prediktor penyakit kardiometabolik seperti diabetes melitus, penyakit jantung koroner, dan stroke. Salah satu organ yang berperan dalam kesanggupan kardiovaskuler adalah paru. Sehingga, fungsi paru berpotensi untuk menjadi prediktor tingkat kesanggupan kardiovaskuler. Penelitian ini bertujuan untuk mengetahui hubungan fungsi paru terhadap tingkat kesanggupan kardiovaskuler pada mahasiswa Fakultas Kedokteran Universitas Jenderal Soedirman. sebanyak 29 subyek laki-laki berusia 18-25 tahun menjadi subyek penelitian. Pengambilan sampel menggunakan teknik consecutive sampling. Fungsi paru diukur dengan pemeriksaan spirometri untuk mengetahui nilai Forced Vital Capacity (FVC), Force Expiratory Volume in 1 second (FEV1), dan rasio FEV1/FVC. Didapatkan rerata nilai persen prediksi FVC, nilai persen prediksi FEV1, rasio FEV1/FVC, dan rerata indeks kesanggupan kardiovaskuler pada subjek berturut-turut adalah 80,82±2,72%; 87,17±2,71%; 94,87±0,63%; 65,88±3,575. Uji korelasi Pearson menunjukkan tidak terdapat hubungan antara FVC, FEV1, dan rasio FEV1/FVC terhadap kesanggupan kardiovaskuler, dengan nilai p berturut-turut adalah 0,324; 0,284; dan 0,231 (p>0,05). Sebagai kesimpulan, tidak terdapat hubungan antara fungsi paru dengan tingkat kesanggupan kardiovaskuler pada mahasiswa Fakultas Kedokteran Universitas Jenderal Soedirman.
HERPES ZOSTER DENGAN MANIFESTASI KLINIS MENYERUPAI ILEUS PARALITIK: LAPORAN KASUS Sylviningrum, Thianti; Putranti, Ismiralda Oke; Ardianto, Ferdi Wiweko
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9424

Abstract

Latar Belakang: Herpes zoster (HZ) adalah penyakit erupsi vesikuler yang mengenai kulit dan saraf tepi akibat reaktivasi dari Varicella Zoster Virus (VZV). Reaktivasi VZV dapat menyebabkan neuropati dan lesi kulit vesikular yang terdistribusi sesuai dengan dermatom saraf. Neuropati pada sistem saraf enterik yang jarang dijumpai dapat berupa pseudo-obstruksi intestinal dengan gambaran klinis Ileus paralitik. Kami melaporkan kasus HZ dengan gambaran klinis menyerupai Ileus paralitik yang apabila terlambat ditangani akan meningkatkan morbiditas dan mortalitas penderitanya. Presentasi Kasus: Seorang laki-laki berusia 59 tahun datang ke Instalasi Gawat Darurat Rumah Sakit dengan keluhan perut teraba keras, dinding tegang, nyeri, tidak bisa kentut dan defekasi diikuti plenting isi air dari perut sampai punggung kanan. Hasil pemeriksaan fisik menunjukkan penurunan bising usus, dan erupsi lesi vesikuler dengan dasar kulit eritem terdistribusi dermatomal T8-10 dekstra. Pemeriksaan darah menunjukkan peningkatan monosit dan gula darah sewaktu, sedangkan hasil pemeriksaan radiologi abdomen tampak pelebaran usus besar dan distribusi udara normal di kolon. Hasil tes Tzanck dijumpai sel datia berinti banyak. Penderita didiagnosis HZ dan menunjukkan perbaikan setelah diberi asiklovir dan gabapentin. Simpulan: Neuropati pada sistem saraf enterik karena VZV perlu dipertimbangkan pada gambaran klinis Ileus paralitik disertai lesi kulit vesikuler yang patognomonik untuk HZ
KINERJA PELAYANAN DI RUMAH SAKIT UMUM DAERAH SYEKH YUSUF KABUPATEN GOWA Nurjaman, Rahmat; Saad, Nursan
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.9439

Abstract

Masyarakat merupakan pelanggan dari pelayanan publik memiliki kebutuhan dan harapan pada kinerja penyelenggara pelayanan publik yang professional.Tugas Pemerintah Pusat maupun Pemerintahan Daerah memberikan pelayanan publik yang mampu memuaskan masyarakat tertuang dalam Undang-Undang Republik Indonesia Nomor 25 Tahun 2009.Penelitian ini bertujuaan untuk menganalisis dan menggambarkan kinerja pelayanan di Rumah Sakit Umum Daerah Syekh Yusuf Kabupaten Gowa, dan mengetahui faktor faktor yang mempengaruhinya. Penelitian menggunakan desain deskriptif kualitatif. Informan diambil dari penentu kebijakan dan stakeholders dirumah sakit. Instrumen terdiri dari pendekatan wawancara dan dokumentasi. Hasil menunjukkan bahwa kinerja pelayanan dirumah sakit umum daerah Syekh Yusuf Kabupaten Gowa dilihat dari aspek dimensi responsivitas, responsibilitas, dan akuntabilitas secara umum belum mencapai tingkat yang optimal. Faktor faktor yang mempengaruhi belum maksimalnya kinerja pelayanan pada rumah sakit Umum Daerah Syekh Yusuf Kabupaten Gowa meliputi faktor internal organisasi (sumber daya aparatur, kepemimpinan, fasilitas organisasi, dan prosedur kerja) dan Faktor eksternal organisasi (Keuangan Daerah, kemampuan ekonomi masyarakat, dan nilai nilai sosial) tersebut belum memberikan dukungan Yang Optimal karena masih cenderung menampakkan diri sebagai kendala atau tantangan.
POTENTIAL OF PLANT-DERIVED ANTIMICROBIAL COMPOUND AGAINS MULTI-DRUG RESISTANT TUBERCULOSIS (MDR-TB): A LITERATUR REVIEW Pauzi, Rizqi Yanuar; Ihtiaringtyas, Suci; Wahyudin, Wahyudin
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.10459

Abstract

Antibiotic resistance is currently a global challenge, especially in the healthcare. Tuberculosis is a disease caused by Mycobacterium tuberculosis that has developed to resistant strains against antibiotic. Multi-drug resistant tuberculosis (MDR-TB) is a Mycobacterium strain that is resistant to first-line TB drugs such as isoniazid and rifampicin. More than 10 million people suffer from TB every year, while MDR-TB sufferers in 2022 about 410,000 people. Treatment for MDR-TB patients has side effects in the form of toxicity. Plant-derived antimicrobial compounds have the potential to inhibit the growth of MDR-TB so they can be used as alternative treatments. Recent studies discuss several potential plant compounds against MDR-TB in a country. This article presents several antimicrobial compounds from various plant species from various countries against MDR-TB. The results of the study showed that around 20 compounds from various plant species had the potential to inhibit MDR-TB. These compounds can be developed further, especially by examining their side effects on the body so that they can be used as an alternative treatment for MDR-TB.
KAJIAN LITERATUR: BIOPROSPEKSI TANAMAN DLINGO (Acorus calamus L) SEBAGAI ANTINYAMUK Ihtiaringtyas, Suci; Pauzi, Rizqi Yanuar
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.10961

Abstract

Acorus calamus, also known as sweet flag or calamus, is a water-loving shrub that grows in swampy areas and along the edges of water bodies in various parts of the world. This plant is renowned for its rhizomes, which are used in various traditional medicinal practices. Additionally, the plant contains secondary metabolites that have the potential to act as mosquito repellents. This research aims to explore the prospects of Acorus calamus L. as an anti-mosquito agent. The methodology employed is a Systematic Literature Review design. The literature review involved searching for articles using the Google Scholar database, including both national and international journal articles. The research findings suggest promising biological prospects as an anti-mosquito agent. This includes inducing mortality in larval stages as well as acting as a repellent for adult mosquitoes. These effects are attributed to the presence of bioactive compounds such as asarone, colamenole, calamin, colameon, and methyl eugenol. The most abundant chemical component is asarone (82%), an active compound with antifeedant properties that inhibit insect growth. Furthermore, Acorus calamus contains other secondary metabolites like alkaloids, saponins, flavonoids, phenols, tannins, steroids, and terpenoids. These compounds can enter the mosquito through respiratory contact and digestive toxicity, leading to mosquito mortality. Additionally, these compounds obstruct the chemical receptors (chemoreceptors) found in mosquito palps and antennae, causing mosquitoes to avoid feeding on blood. This review article aims to provide insights into the potential of Acorus calamus L as an anti-mosquito agent.

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