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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 55 Documents
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Search results for , issue "JPS Volume 8 Nomor 1 (2025)" : 55 Documents clear
Analisis kuersetin pada ekstrak benalu teh (Scurrula oortiana Dans.) secara kuantitatif Silvyana, Annysa Ellycornia; Reubun, Yonathan Tri Atmodjo; Warti, Lia; Simangunsong, Lidia Octaviani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.575

Abstract

Indonesia has a variety of plants that are useful as medicine. One is the Tea Mistletoe plant (Scurrula oortiana Dans.). This plant contains flavonoid compounds that are effective as antioxidants, especially in the form of quercetin. Quercetin in the tea mistletoe plant can prevent cell damage caused by free radicals, where cells need this antioxidant to avoid the harmful effects of excessive reactive oxygen species (ROS) production and prevent damage to immune cells. This study aims to analyze the levels of quercetin in Tea Mistletoe extract using quantitative analysis methods such as thin-layer chromatography and UV-Vis spectrophotometry. Tea Mistletoe powder was extracted by maceration with 96% ethanol solvent and then concentrated using a rotary evaporator and water bath. The thick extract obtained was then tested for phytochemical screening and specific and non-specific parameters. Analysis of flavonoid quercetin compounds was carried out using a thin layer chromatography method using a mobile phase of a mixture of chloroform, ethyl acetate, and n-butanol with a ratio of 5:4:1 and a stationary phase of Silica Gel GF₂₅₄. Determination of flavonoid levels was carried out using UV-Vis spectrophotometry at a wavelength of 428 nm. The results of this study indicate that the Mistletoe Tea plant contains flavonoids, alkaloids, steroids, tannins, saponins, phenolics, and glycosides. All test parameters meet the specified requirements. The thin layer chromatography test showed the Rf value of the Mistletoe Tea extract of 0.78. The linearity test showed a correlation value (r) = 0.9988 with a total flavonoid compound content of 372.250 mg QE/g extract, or a percentage of 37.225%.
Analisis efektivitas biaya dan profil penurunan kadar glukosa darah penggunaan metformin dan glimepirid pasien diabetes melitus tipe 2 di RSUD R. Syamsudin, SH. Honifa, Honifa; Rokhmah , Nisa Najwa; Zunnita, Oktaviana; Elina, Elina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.600

Abstract

Hyperglycemia caused by abnormalities in insulin secretion and insulin function is a hallmark of a metabolic disorder known as diabetes mellitus (DM). The choice of alternative medications for DM varies significantly, making it essential to consider cost to ensure that the selected drug remains affordable while providing the best therapeutic effect. The purpose of this study is to examine the glucose-lowering profile and identify the most cost-effective antidiabetic drug for use in type 2 diabetes patients in the outpatient unit at RSUD R. Syamsudin, SH. Kota Sukabumi. This non-experimental study uses a descriptive design by reviewing the medical records of outpatients from the pharmacy department. Random blood glucose levels and medication costs are the parameters used. The results of the study showed that the use of the antidiabetic drug glimepiride, which is the most cost-effective drug for type 2 diabetes mellitus patients, demonstrated an average blood glucose reduction of 26.92% for patients using metformin and 22.97% for patients using glimepiride.
Formulasi dan uji sifat fisik granul effervescent ekstrak kunyit asam (Curcuma longa-Tamarindus indica). Kautsari, Farah Widya; Emha, Maulida Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.669

Abstract

Empirically, turmeric tamarind is used to relieve pain and inflammation and ease menstrual cramps. However, conventional herbal preparations are currently less popular, especially among teenagers. Effervescent turmeric tamarind formulations are an innovative, practical pharmaceutical preparation with the advantage of a pleasant taste, which helps disguise the bitter flavor of turmeric. This product also provides a refreshing effect due to the acid-base reaction that produces carbon dioxide (CO2). This study aims to evaluate the physical test of effervescent turmeric tamarind granules. This experimental study formulates three turmeric-tamarind effervescent granule formulas by varying the turmeric extract dosage (Curcuma longa) to 250 mg, 500 mg, and 750 mg. The evaluations performed include organoleptic tests, water content, flow properties and angle of repose, dissolving time, and pH testing. The results showed that turmeric extract (Curcuma longa) and tamarind (Tamarindus indica) can be formulated into effervescent granules—the three formulas with different variations of turmeric extract produced good physical quality test results. Variations in the concentration of turmeric extract did not affect the physical quality of the granules.
Formulasi masker wajah serbuk nano teh celup bekas dan aktivitas antibakteri terhadap Propionibacterium acnes dan Staphylococcus epidermidis Matondang , Fikriyah Hafni; Lubis, Minda Sari; Yuniarti , Rafita; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.685

Abstract

The increase in the cosmetic industry has caused a variety of facial mask products to circulate on the market, making it difficult for consumers to find one that suits their skin condition. Masks from well-known brands are easy to get, but some cause skin problems. Since ancient times, Indonesians have used plants as medicines and cosmetic ingredients for skin care. Tea can be processed into new active ingredients such as antioxidants, antibacterials, and anti-aging for cosmetics. Nanoparticle-based cosmetics are superior to micro-scale cosmetics. The objective of the research was to determine whether used tea bag powder meets the characteristic requirements as nanopowder, to determine whether used tea bag nanopowder in facial mask preparations meets the physical quality requirements, and to determine whether used tea bag nano powder facial mask preparations has antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis. This research method was true experimental with post test only control group design research design. The independent variables are tea bag powder and nanopowder and powder face mask formulation variations. The dependent variables are the characteristics of the simplicia, secondary metabolites, nanopowder characteristics, powder face mask formulation, and antibacterial activity test. The results showed that tea bag powder and nanopowder contained alkaloid, steroid, flavonoid, saponin, and tannin compounds. The inhibitory activity of the used tea bag nano powder mask on Propionibacterium acnes was 11.3 mm on Staphylococcus epidermidis, which was 11.2 mm. The tea bag powder used meets the characteristics of a nanopowder with a particle size of 684 nm. I used a tea bag nanopowder to prepare a face mask that meets the physical quality requirements.
Pembuatan nanoekstrak dari kulit buah jeruk kasturi (Citrus microcarpa) dan formulasinya sebagai pasta gigi Hasibuan , Fika Miah Sasmitha; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.694

Abstract

Dental caries is a common oral health problem among the Indonesian population, and its primary cause is the bacterium Streptococcus mutans. The peel of the Kasturi orange (Citrus microcarpa) fruit has been known to contain antibacterial properties, which may help prevent the occurrence of dental caries. This study aims to evaluate the toothpaste formulation with the active ingredient of nano-extract from kasturi orange peel (Citrus microcarpa). The extract of Kasturi orange peel was obtained through a maceration method, followed by phytochemical screening that identified the presence of flavonoids, steroids, alkaloids, saponins, glycosides, and essential oils. The extract was then processed into a nano-extract, and its particle size was measured using a Particle Size Analyzer (PSA) with a dynamic light scattering technique. The nano-extract was formulated into toothpaste at concentrations of 7.5%, 10%, and 12.5%, and its antibacterial activity was tested. Physical evaluations showed that the toothpaste maintained its shape, color, odor, and taste during storage, was homogeneous, had a pH within the acceptable range (4.5–10.5), viscosity within the required range (20,000–50,000 cps), and passed organoleptic testing (color, aroma, taste, and texture) on respondents.
Kandungan protein tempe kedelai yang berbeda bahan pengemas primer dan parameter penyimpanan Pujiastuti, Nurkholifah; Santoso, Broto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.718

Abstract

Soybean tempeh products are in great demand by most Indonesian people. The most of producers use plastic as packaging material, but some of them use natural materials such as banana leaves and teak. Soybean tempeh packaged with leaves is more popular with the public than plastic because it has a distinctive aroma and a savory taste. This study aims to determine the differences in protein content in soybean tempeh with different primary packaging materials with raw soybeans as a comparison. The three tempeh packages were produced using raw soybeans and under the same conditions. The protein content of the samples was determined by the Lowry reaction at a wavelength of 748.5 nm. This method has been determined for its validity through repeatability, linearity, and accuracy tests. Together with raw soybeans, samples that had been stored in the freezer were measured for their protein content at two different times. The Lowry method used is valid because all parameters have met the acceptance requirements where r2 linearity = 0.9954-0.9972 (> 0.9950); %RSD repeatability = 0.291-0.768 (<2%); and %recovery accuracy = 98.769-101.118% (80-120%). The average results of the protein content of raw soybeans, plastic-packaged soybean tempeh, banana leaves, and teak leaves on the 11th day were 5.531-7.967% while on the 35th day it was 5.881-7.972%. The results of the One-Way ANOVA statistical test with sig = 0.0001 (p <0.05) so it can be said that there is a significant difference between soybean tempeh with different primary packaging materials.
Penentuan konsentrasi hambat minimum dan konsentrasi bunuh minimum ekstrak dan nanopartikel ekstrak daun pepaya (Carica Papaya L.) terhadap Bakteri Cutibacterium acnes Khofifah , Nur; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.720

Abstract

One of the skin diseases that often occurs is acne (Acne vulgaris). Acne is caused by the activity of the Cutibacterium acnes bacteria. Current acne treatment still depends on the use of antibiotics, but long-term use of antibiotics can cause bacterial resistance. Therefore, it is necessary to develop alternative treatments for acne that are effective and safe, one of which is by using medicinal plants. One plant that has potential is papaya leaves (Carica papaya L.). This research aims to determine the minimum inhibitory concentration (MIC) and minimum killing concentration (KBM) of ethanol extract and papaya leaf extract nanoparticles as well as testing antibacterial activity against Cutibacterium acnes bacteria. The research was carried out experimentally. The independent variables are the concentration of papaya leaf extract (6.25% concentration, 12.5% ​​concentration, 25% concentration and 50% concentration), and the concentration of papaya leaf extract nanoparticles (0.625% concentration, 1.25% concentration, 2.5% concentration % and Concentration 5%). The dependent variable is the antibacterial activity of papaya leaf ethanol extract and nanoparticles extract against Cutibacterium acnes. Characterization of the size of the extracted nanoparticles using a Particle Size Analyzer (PSA). The characteristic results for the extract size were 2,203.45 nm while the size of the extract nanoparticles was 330.27 nm. The minimum inhibitory concentration (MIC) value of 1.25% papaya leaf ethanol extract nanoparticles is better than 12.5% ​​papaya leaf ethanol extract, and the minimum lethal concentration (KBM) value of 5% papaya leaf ethanol extract nanoparticles is better than papaya leaf ethanol extract 50% against Cutibacterium acnes bacteria. 5% papaya leaf ethanol extract nanoparticles have the same antibacterial ability as 50% papaya leaf ethanol extract and are sensitive to Cutibacterium acnes bacteria, so it can be said that 5% papaya leaf ethanol extract nanoparticles can reduce the dose concentration of antibacterial compounds up to one-tenth of the time compared to ethanol extract papaya leaves 50% (1:10)
Evaluation of the Implementation of Clinical Pharmacy Services at Kupang City Pharmacy Based on PERMENKES RI Number 73 of 2016 Patty, Yohana Febriani Putri Peu; Parwati, Dian
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.692

Abstract

Clinical pharmacy services in pharmacies are one of the responsibilities that pharmacists must perform. Some of the clinical pharmacy service activities contained in the applicable pharmaceutical service standards are prescription service assessment, dispensing, Drug Information Services (PIO), Counseling, Drug Therapy Monitoring (PTO), Monitoring Drug Side Effects (MESO). The purpose of this study was to determine the suitability of the implementation of clinical pharmacy services in the Kupang City Pharmacy area against the Regulation of the Minister of Health of the Republic of Indonesia Number 73 of 2016. This research method was carried out descriptively with a cross-sectional method. Sample selection was carried out by purposive sampling involving 10 pharmacies that met the inclusion criteria. Data collection was carried out using the interview method using an interview guideline sheet. The results showed that the implementation of clinical pharmacy services in 10 pharmacies in the aspect of reviewing prescription services was 100% (in accordance with the SPKA), the dispensing aspect was 100% (in accordance with the SPKA), the Drug Information Service (PIO) aspect was 100% (in accordance with the SPKA), the counseling aspect was 60% (not in accordance with SPKA). The home pharmacy care aspect, the Drug Therapy Monitoring (PTO) aspect and the Monitoring of Drug Side Effects (MESO) aspect was 100% not implemented by all pharmacy. Conclusion pharmacies in Kupang City have not fully implemented clinical pharmacy services based on the Regulation of the Minister of Health of the Republic of Indonesia Number 73 of 2016.
Formulasi sediaan patch dari ekstrak etanol daun laban (Vitex pinnata L.) sebagai antiinflamasi Rahmi , Ulfa; Dalimunthe, Gabena Indrayani; Yuniarti , Rafita; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.749

Abstract

Laban leaves (Vitex pinnata L.) contain flavonoids, saponins, tannins, and steroids, which have anti-inflammatory potential. This research aims to formulate laban leaves into an anti-inflammatory patch preparation for the back skin of mice induced by 3% carrageenan. Laban leaf simplicia was extracted using the maceration method using 96% ethanol, and patch preparations were made with varying extract concentrations of 5, 7.5, and 10%. The patch preparation is tested organoleptic, pH, weight uniformity, patch thickness, patch moisture, patch crease resistance, and irritation. The anti-inflammatory activity of the patch preparation was analyzed using the inflammatory associate edema method, namely measuring the anti-inflammatory effect using a caliper and 25 test animals, which were divided into 5 groups, namely negative control, positive control, and treatment group with a concentration of 5; 7.5; and 10% with 5 individuals each. The results of several tests that have been carried out are analyzed using the one-way ANOVA program. The results show the anti-inflammatory activity of laban leaves. There was no difference in the percentage of edema inhibition data on the back skin of mice between treatment groups. This shows that the anti-inflammatory patch preparation of Laban leaf extract (Vitex pinnata L.) has anti-inflammatory activity. The formula that provides the most potent anti-inflammatory activity is a patch preparation with an extract concentration of 10%. With an edema inhibition percentage of 59%. 
Penetapan kadar flavonoid total ekstrak etanol 70% dan ekstrak etil asetat daun sambung nyawa (Gynura procumbens (Lour)Merr.) secara spektrofotometri UV-Vis Rahmadani , Adevika; Ridwanto, Ridwanto; Daulay , Anny Sartika; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.751

Abstract

Sambung nyawa leaves (Gynura procumbens L.) are a simplicia with various medicinal properties. One of the chemical compounds in sambung nyawa leaves that plays a crucial role in treatment is flavonoids. Flavonoids in sambung nyawa leaves have benefits as antihypertensive, antioxidant, antihyperglycemic, and anti-inflammatory agents. Different drying methods for simplicia affect the total flavonoid content in the extract.The stages of this research included plant material processing, the preparation of ethanol and ethyl acetate extracts, characterization tests, phytochemical screening, and the determination of total flavonoid content in the ethanol extract and ethyl acetate extract of sambung nyawa leaves using visible spectrophotometry. The extracts of sambung nyawa leaves were made using the maceration method with 70% ethanol and ethyl acetate, and the obtained extracts were concentrated using a rotary evaporator. Total flavonoid content was then determined using visible spectrophotometry. Phytochemical screening of the ethanol and ethyl acetate extracts of sambung nyawa leaves revealed the presence of chemical compounds such as alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The total flavonoid content in the ethanol extract was found to be 6.5149 ± 0.0314 mcg/g of sample, while the ethyl acetate extract had a total flavonoid content of 77.6695 ± 0.1199 mcg/g of sample.

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