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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 62 Documents
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Search results for , issue "JPS Volume 9 Nomor 1 (2026)" : 62 Documents clear
Formulasi dan Evaluasi Gel Pengharum Serai Wangi dengan Kombinasi Basis Karagenan, Xanthan Gum, dan HPMC Anggraini, Windi; Salman, Salman; Febriani , Yessi; Indriana , Meutia; Muzakkir, Muzakkir
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1459

Abstract

Background: Unpleasant odors in bathroom areas are a common hygiene problem that requires practical and environmentally friendly solutions. Citronella oil (Cymbopogon nardus L. Randle) is known to contain active compounds with a distinctive aroma that has potential as a natural fragrance agent. However, an appropriate gel base is needed to maintain the stability and aroma retention of the preparation. Objective: This study aims to formulate and evaluate a bathroom fragrance gel from citronella oil with a combination of carrageenan, xanthan gum, and hydroxypropyl methylcellulose (HPMC) bases and to determine the concentration of citronella oil that produces the preparation with the best physical stability and aroma retention. Methods: This research was an experimental laboratory study. Citronella oil was formulated into gel preparations with four concentration variations (2.5%; 5%; 7.5%; and 10%) using a combination of carrageenan, xanthan gum, and HPMC bases. Evaluation of the preparations included organoleptic test, syneresis, liquid evaporation, preference test (hedonic), and aroma retention test for 15 days of storage. Data were analyzed statistically with a 95% confidence level. Results: The results showed that all formulas produced gels with good organoleptic characteristics (cloudy white color, characteristic citronella aroma, and semi-solid texture). The formula with 10% citronella oil concentration (F4) showed the best results with the lowest syneresis value (0.62%), the lowest liquid evaporation percentage (21.69%), and the highest remaining gel weight (92.03%). The preference test showed that F4 had the highest average value (4.25) in the like category, and the best aroma retention with a score range of 4.19-4.70 until day 15. Conclusion: The combination of carrageenan, xanthan gum, and HPMC bases can produce physically stable bathroom fragrance gel preparations. The formula with 10% citronella oil concentration (F4) is the best formulation and has the most potential to be developed as a natural bathroom fragrance product.
An Pengaruh Perlakuan Dekolorisasi Karbon Aktif terhadap Intensitas Warna dan Kadar Fenolik Total dari Ekstrak Daun Okra (Abelmoschus esculentus L.) Saepudin, Syumillah; Hartono, Kusdi; Khoerunnisa, Annisa; Rahmayanti , Nurul; Febriani, Raihani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1156

Abstract

Background: Okra leaves (Abelmoschus esculentus L.) are a potential natural source of phenolic compounds with antioxidant activity and prospective applications in pharmaceutical and cosmetic formulations. However, the dark green color of the extract, mainly due to chlorophyll pigments, may negatively affect the aesthetic quality of the final product. Decolorization using activated carbon is therefore required to improve visual appearance without reducing bioactive compounds. Objective: This study aimed to evaluate the effect of activated carbon decolorization on color intensity and total phenolic content of okra leaf extract. Methods: Okra leaf extract was prepared by maceration using 70% ethanol. Decolorization was performed using activated carbon at various concentrations (0.5–8%) and contact times (2–72 hours). Color intensity was measured using a UV–Vis spectrophotometer at 663.50 nm. Total phenolic content was determined using the Folin–Ciocalteu method and expressed as mg gallic acid equivalent (GAE)/g extract. Statistical analysis was conducted using one-way ANOVA at a significance level of 0.05. Results: Activated carbon effectively reduced color intensity through adsorption mechanisms. Variation in activated carbon concentration did not significantly affect total phenolic content (p = 0.71), whereas contact time had a significant effect (p = 0.0014). The optimum condition was observed at 24 hours of contact time, showing reduced color intensity while maintaining phenolic content. No significant correlation was found between absorbance reduction and total phenolic content (ρ = 0.102; p = 0.555), indicating selective adsorption. Conclusion: Activated carbon decolorization effectively improves the visual appearance of okra leaf extract without significantly reducing its total phenolic content. The optimum contact time was 24 hours, suggesting its potential application in enhancing the quality of natural-based pharmaceutical and cosmetic preparations.
Perbandingan Aktivitas ekstrak Jahe Merah (Zingiber officinale var. rubrum) dan Kunyit (Curcuma longa L) Terhadap Respon Imun Pada Hewan Uji: Tinjauan Literatur Lismawan, Gita Novianti; Septiani, Dia; Ramadhani, Biandra Cinta; Ramadhany, Arifa Salsabilla
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1194

Abstract

The immune system plays a crucial role in protecting the body against various pathogenic agents; therefore, efforts to enhance immune function through natural approaches are essential. This study aims to systematically compare the immunomodulatory effects of red ginger (Zingiber officinale var. rubrum) and turmeric (Curcuma longa L.) based on a systematic literature review of preclinical experimental studies. Literature was systematically collected from two electronic databases, PubMed and Google Scholar, covering publications from 2010 to 2025, using keywords related to Zingiber officinale var. rubrum, “red ginger”, Curcuma longa, “turmeric”, “immune”, “immunity”, “cytokine”, “immune response”, and “immunomodulatory effect”. Of the 260 articles identified, only 10 studies met the inclusion criteria and were analyzed further. Based on reported immunological response patterns, red ginger predominantly influences innate immune parameters measurable during the early phase of immune activation, including increased macrophage phagocytic activity, enhanced production of proinflammatory cytokines (IL-1β and IFN-γ), and activation of natural killer (NK) cells. In contrast, turmeric demonstrates significant effects on adaptive immune parameters that are generally evaluated over longer intervention periods, mediated by curcumin through inhibition of the NF-κB signaling pathway, upregulation of anti-inflammatory cytokines (IL-10), and enhancement of regulatory T cell (Treg) function to maintain immunological homeostasis. Both red ginger and turmeric exhibit potential as natural immunomodulatory agents that support immune defense; however, their mechanisms and magnitude of effects differ. Red ginger tends to elicit more rapid immune responses, whereas turmeric exerts more sustained regulatory effects. In conclusion, the utilization of red ginger and turmeric may serve as preventive and therapeutic phytotherapeutic alternatives to enhance immune function. Nevertheless, as the available evidence is largely derived from animal experimental studies, further well-designed pharmacokinetic studies and controlled clinical trials are required to confirm efficacy, safety, and optimal formulations in humans.
Uji Aktivitas Antioksidan Kombucha Daun Kelakai (Stenochlaena palustris (Burm.F) Bedd) Dengan Metode DPPH Hidayatullah, Muhammad; Abdurrahman, Abdurrahman; Andina , Lisa; Astiati , Rini; Rina, Rina
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1256

Abstract

Degenerative diseases are often caused by exposure to free radicals, and antioxidants play an important role in maintaining body stability by counteracting them. Kelakai (Stenochlaena palustris), a typical plant of Kalimantan, contains bioactive compounds such as phenolics and flavonoids, making it a potential source of natural antioxidants. This study aims to determine the results of antioxidant activity tests on kelakai leaf kombucha. Kombucha was chosen because its antioxidant activity is influenced by the phenolic content formed during fermentation, potentially becoming an antioxidant-rich probiotic drink. The antioxidant activity test of kelakai leaf kombucha used the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results of determining the maximum absorption wavelength of 0.1 mM DPPH were at 515 nm with the highest absorption of 0.602. The antioxidant activity test using quercetin as a comparison resulted in an IC₅₀ value of 3.0892 ppm. This quercetin IC₅₀ value is included in the very strong category (<50 ppm). Meanwhile, the antioxidant activity test on kelakai leaf kombucha yielded an IC₅₀ value of 0.5845 ppm. This value also indicates that kelakai leaf kombucha has very strong antioxidant activity. Increasing sample concentration is directly proportional to the increase in antioxidant activity, as indicated by a decrease in the absorption value. Therefore, the development of kelakai leaf kombucha and testing its antioxidant activity are expected to produce innovative functional food products.
Hubungan Kualitas Pelayanan Kefarmasian Terhadap Kepuasan Pasien Rawat Jalan RS Bhayangkara TK. III Banjarmasin Lisdawati , Maulina; Su’aida , Nily; Fadillah , Aris
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1286

Abstract

Background: The quality of pharmaceutical services is a crucial factor in the success of treatment and patient satisfaction. Objective: This study aims to analyze the relationship between the quality of pharmaceutical services and the satisfaction of outpatients at RS Bhayangkara TK. III Banjarmasin. Methods: This study employs a descriptive quantitative method with a survey approach, where data is collected through questionnaires distributed to patients receiving services at the hospital’s pharmacy department. Results: The results indicate a significant relationship between the quality of pharmaceutical services and patient satisfaction (p–value = 0,000 ≤ 0,05) analyzed through five dimensions of service quality: tangibility, reliability, responsiveness, assurance, and empathy. The Chi-Square test analysis showed that all these dimensions positively contribute to patient satisfaction. Additionally, this study evaluated the waiting time for both compounded and non-compounded medications, revealing that the hospital’s pharmacy services comply with the time standards set by the Ministry of Health. Conclusions: This study confirms the significant relationship between the quality of pharmaceutical services and outpatient satisfaction at Bhayangkara level III Hospital. Higher service quality, greater outpatient satisfaction, highlighting the need for continuous improvement in pharmaceutical services.
Pengaruh Ekstrak Bunga Kecombrang (Etlingera elatior (Jack)) Terhadap Gambaran Histopatologi Lambung Pada Tikus Putih Jantan (Rattus norvegicus) Yang Diindukasi Streptozotocin Palipadang, Matra Novalia; Alaydrus , Syafika; Tandi , Joni; Islamiati , Utami; Toding, Ficanata Adhiguna; Managanta , Vianda
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1293

Abstract

Background: Hyperglycemia induced by streptozotocin (STZ) increases oxidative stress and inflammatory responses that may lead to gastric mucosal damage. Kecombrang flower (Etlingera elatior (Jack)) contains flavonoids and other secondary metabolites with antioxidant, anti-inflammatory, and antihyperglycemic properties that are potentially gastroprotective. Objective: This study aimed to evaluate the effect of ethanol extract of kecombrang flower on the histopathological profile of the stomach in male white rats (Rattus norvegicus) induced by streptozotocin and to determine the most effective dose. Methods: This experimental in vivo study employed a posttest-only control group design. Twenty-five male rats were divided into five groups (n=5): normal control, negative control (STZ-induced), positive control (STZ + glibenclamide), extract 50 mg/kg body weight (BW), and extract 100 mg/kg BW. Streptozotocin was administered intraperitoneally at 40 mg/kg BW. Gastric tissues were examined histopathologically using hematoxylin-eosin staining and assessed based on degeneration, necrosis, and inflammation scoring. Data were analyzed using Kruskal–Wallis followed by Mann–Whitney test with Bonferroni correction (p<0.05). Results: Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, and tannins in the extract. Statistical analysis showed significant differences among groups in degeneration (p=0.013) and inflammation (p=0.047), but not in necrosis (p=1.000). The 100 mg/kg BW dose demonstrated the most prominent protective effect, with lower degeneration and inflammation scores and an average gastric damage score of 1, comparable to the positive control group. Conclusion: Ethanol extract of kecombrang flower at a dose of 100 mg/kg BW effectively reduced gastric histopathological damage in streptozotocin-induced male rats, indicating its potential gastroprotective activity through antioxidant and anti-inflammatory mechanisms.
Studi Fitokimia Senyawa Aktif Ekstrak Batang Nelambo suon (Rubiaceae) Rossardy, Marzella Dea; Muslihin, A.M.; Watora, Wahyuni; Budiyanto, Angga Bayu; Hardia, Lukman; Irwandi, Irwandi; Aponno, Alyssa Mileta; Utami, Hikmahtul Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1333

Abstract

Background: Papua has high biodiversity with significant potential as a source of traditional medicinal plants, including Nelambo suon (Rubiaceae), which has been empirically used by local communities. However, scientific information regarding the active compounds in its stem bark remains limited. Objective: This study aimed to identify the secondary metabolite groups present in the ethanol extract of Nelambo suon stem bark through phytochemical screening. Methods: The research was conducted experimentally using the maceration method with 80% ethanol as the solvent. The stem bark simplicia was extracted and qualitatively screened for alkaloids, flavonoids, tannins, and saponins using specific reagents. Results: The results showed that the ethanol extract of Nelambo suon stem bark contained alkaloids, flavonoids, tannins, and saponins, indicated by characteristic color changes, precipitate formation, and foam production. Conclusion: These findings suggest that Nelambo suon stem bark is a potential source of bioactive compounds and may be further developed as a herbal medicinal material based on local wisdom.
Formulasi Dan Uji Aktivitas Gel Fraksi Aktif Biji Kopi Robusta (Coffea Canephora L.) terhadap Stapylococcus aureus sebagai Terapi Ulkus Diabetik Tarigan, Putri Diana Br; Sembiring , Novitaria Br; Yunus , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1334

Abstract

Introduction: Diabetes mellitus is one of the health problems that deserves attention worldwide. Diabetes mellitus causes complications in various organs of the body. One of the complications of diabetes mellitus for sufferers is the appearance of diabetic wounds or gangrene and ulcers that cause susceptibility to bacterial infections. One of the bacteria that causes diabetic wounds is Staphylococcus aureus, which can be found on the skin surface as normal flora. Objective: This study aims to formulate the active fraction of robusta coffee beans (Coffea Canephora L.) into a gel preparation and evaluate its antibacterial activity against Staphylococcus aureus. Methods: This experimental study involved the extraction of robusta coffee beans with 96% ethanol maceration, phytochemical screening, and fractionation using n-hexane, ethyl acetate, and water solvents. Furthermore, the fraction results were tested using the disk diffusion method to determine the active fraction in robusta coffee beans to be formulated into gel preparations with concentrations of 12.5%, 25%, and 50% and physical stability tests were conducted. Based on the results of the study, the water fraction and gel preparation of robusta coffee beans showed inhibition of antibacterial activity against Staphylococcus aureus, with the greatest inhibition at a concentration of 50%. Therefore, the active fraction gel of robusta coffee beans has the potential as a treatment for diabetic wounds. Organoleptic testing of the gel showed a distinctive honey smell, brown color, and a slightly acidic pH of formula 1.
Uji Total Flavonoid Dan Aktivitas Antioksidan Fraksi Aktif Biji Kopi Robusta (Coffea canephora L. ) Sebagai Diabetik Ulcer Perangin-Angin, Elpina Br; Sembiring , Novitaria Br; Kaban , Vera Estefania
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1342

Abstract

Diabetes mellitus is a chronic metabolic disease frequently accompanied by serious complications, including diabetic foot ulcers, which require comprehensive management and supportive therapies derived from natural sources. Robusta coffee beans (Coffea canephora L.) contain various bioactive compounds with potential antioxidant properties that may support wound healing. This study aimed to determine the total flavonoid content and evaluate the antioxidant activity of active fractions of robusta coffee beans. An experimental laboratory design was applied, involving maceration using 96% ethanol followed by solvent fractionation with n-hexane, ethyl acetate, and water. Total flavonoid content was determined using ultraviolet–visible spectrophotometry with quercetin as the reference standard, while antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl assay with vitamin C as a comparator. The results showed an extraction yield of 14.33%, and phytochemical screening confirmed the presence of alkaloids, flavonoids, phenolic or tannin compounds, saponins, and triterpenoids. All fractions exhibited very strong antioxidant activity, with the ethyl acetate fraction demonstrating the highest activity, comparable to vitamin C, whereas the highest total flavonoid content was observed in the n-hexane fraction. In conclusion, robusta coffee beans possess strong potential as a natural antioxidant source and may be developed as a supportive alternative therapy for diabetic wound management.
Genetika dan Farmakogenomika untuk Kinerja Atletik: Tren Terkini dan Arah Masa Depan di ASEAN Nugraha, Afif Tri; Malau , Jekmal; Kasasiah , Ahsanal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Siboro , Dewi Pratiwi Purba
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1375

Abstract

The integration of sport genomics and pharmacogenomics has become a central pillar of precision sports medicine, enabling individualized training, nutrition, and medication/supplement strategies for athletes. This structured narrative review synthesizes literature published between 2015 and 2025 from PubMed, ScienceDirect, and Google Scholar, with particular emphasis on implementation relevance in ASEAN, especially Indonesia. Findings are organized into three major themes: (1) genetic contributions to strength and endurance phenotypes, body composition, recovery, and injury susceptibility; (2) pharmacogenomic implications for drug selection, dose optimization, therapeutic safety, and potential exercise with drug interactions (e.g., NSAIDs, inhaled bronchodilators, caffeine, and creatine); and (3) ethical, privacy, equity, and gene-doping considerations. Athletic performance is inherently polygenic; variants in genes such as ACTN3, ACE, PPARGC1A, PPARA, and VEGF-A contribute to the power–endurance spectrum and vascular–metabolic adaptation, while pharmacogenes including CYP2C9, CYP1A2, ADORA2A, and ADRB2 may modulate therapeutic efficacy and adverse-effect risk. Moreover, physical activity itself may influence drug metabolism and pharmacodynamic responses, underscoring the limitations of one-size-fits-all protocols. Overall, genetic information should be positioned as a complementary decision-support layer rather than a deterministic predictor in sports medicine practice. Strengthening implementation in ASEAN requires larger, well-characterized athlete cohorts, standardized marker panels, longitudinal data integration, and robust ethical–regulatory frameworks to ensure safe and evidence-based genomic application.

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