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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Studi in silico senyawa Echinochrome-A, Spinochrome-A, and Echinamine-A pada Echinometra mathaei dalam menghambat enzim maltase-glucoamylase sebagai antidiabetes Prasetyanti, Intan; Kresnamurti, Angelica
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.476

Abstract

DM can be caused by the release and absorption of glucose in the small intestine by digestive enzymes. Inhibition of this enzyme can help manage DM. Human Maltase-glucoamylase (MGA) is an enzyme in the small intestine that is responsible for catalyzing the release of glucose from carbohydrate digestion. By inhibiting this enzyme, it is hoped that glucose in type 2 diabetes patients can be controlled. Analyze the potential of Echinochrome-A, Spinochrome-A, and Echinamine-A in Echinometra mathaei extract as an antidiabetic using molecular docking. Molecular docking using Echinochrome-A, Spinochrome-A, Echinamine-A as a compound test and Miglitol as standard for the Human Maltase-glucoamylase receptor. Echinochrome-A, Spinochrome-A, and Echinamine-A has an affinity and hidrogen bonds with amino acid residues that are not significantly different from Miglitol, so that Echinochrome-A, Spinochrome-A, and Echinamine-A has potential as an antidiabetic.
Uji aktivitas afrodisiak ekstrak etanol daun cengkeh (Syzygium aromaticum L.) pada tikus putih jantan (Rattus norvegicus) Patala, Recky; Risnawati, Risnawati; Wulandari , Ayu; Yanuarty , Rezky; Handayani , Tien Wahyu
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.485

Abstract

Sex drive is what everyone needs to have a beautiful and harmonious sex life. Decreased sex drive is one of the factors that cause discord in relationships between men and women, and sexual dysfunction is a major concern. In Indonesia, this sexual disorder is most prevalent in men with a prevalence rate of 10% (all ages combined) and more than 50% occurs in the age group 50-70 years. The aim of this study was to determine the aphrodisiac effect of the extract by looking at several parameters, namely mount latency (ML), intromission frequency (IL), ejaculation latency (EL), mount frequency (MF), intromission frequency (IF), and ejaculation frequency (EF). This study used an experimental method with a post-test modified randomized control group design with 15 male white rats and 30 female white rats divided into 3 treatment groups with a ratio of (1: 2), each group consisting of 5 male rats and 10 female rats. Normal control group (NaCMC 0.5%), positive control group (X-Gra 52.5 mg/kgBB), and control test clove leaf extract sample at a dose of 250 mg/kgBB. Administration of extracts and comparators was only given to male white rats for 30 days. The results of this study indicate that clove leaf extract contains secondary metabolites of flavonoids, saponins, alkaloids, tannins, and strong antioxidants. The administration of clove leaf of extract at a dose of 250 mg/kg body weight showed a significant difference between the positive group and clove leaf of extract with a value of P < 0.05, this indicates that clove leaf of extract has aphrodisiac activity.
Analisis kadar parasetamol dan kafein dalam sediaan tablet menggunakan metode spektrofotometri derivatif zero crossing Pulungan, Ainil Fithri; Rosaldi, Hikmah; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.489

Abstract

The development of drugs in the form of combination tablets at this time has increased a lot; combining drugs in a tablet preparation can provide an increasing reaction and ability. This makes combining drugs such as Paracetamol and caffeine an effective combination in the pharmaceutical field. Paracetamol is an antipyretic analgesic drug that can be combined with caffeine which can be used in therapy with a combination of these drugs. The objective of this research was to ascertain the concentration of a combination of paracetamol and caffeine in a tablet formulation by employing a zero cross-derivative spectrophotometric method. In this study, solvent optimization was carried out with 17 categories of solvent selection, and acetate: methanol (30:70) was selected using the zero cross-derivative methods with a dA / d plot utilizing the maximum wavelength of paracetamol 258 nm and caffeine 288 nm, because there was an actual wavelength shift in this analysis. To validate the determination of the level of the zero cross-derivative method using the second absorption in the ace solvent (30:70 acetate: methanol). Spectrophotometric analysis of zero crossing derivatives of a mixture of paracetamol and caffeine found that paracetamol levels in tablet A were 95.24 8.47%, in tablet B of 92.86 0%, and in tablet C of 96.5 0%, while the caffeine content was 104.89 0%, 102.09 0%, and 91.6 0%. According to USP 30 NF 25 (2007), it can be concluded that the test results of the composition of paracetamol and caffeine in tablets meet the requirements.
Analisis kadar amilosa pada pati jagung manis (Zea Mays L. Var. Saccharata) secara spektrofotometri UV-Vis Fadjria, Neri; Arfiandi, Arfiandi; Auliyah, Nabila Dhiyaul
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.494

Abstract

Sweet Corn Starch (Zea mays L. var. saccharata) is composed of two fractions: amylose and amylopectin. The determination of amylose content in Sweet Corn Starch is carried out using the spectrophotometric method. This method employs a 2% iodine solution as a reagent, which reacts with starch to generate a coloured solution that can be measured using a spectrophotometer. The amylose content is quantified through visible spectrophotometry, resulting in a regression equation of y ̂ = 0.006 + 25.2x, with a coefficient of determination (R2) = 0.998 and a correlation coefficient (r) = 0.9989. The amylose content in Sweet Corn Starch is determined to be 28.65%, whereas the amylopectin content is found to be 71.35%. Furthermore, the analysis provides additional parameters: Standard Deviation (SD) = ± 0.0044, Detection Limit (BD) = 0.0005 mg/ml, and Quantity Limit (BK) = 0.0018 mg/ml. These parameters offer valuable insights into the quality and properties of the sweet corn starch sample.
Uji Efektivitas Antihiperurisemia Ekstrak Etanol Kencur (Kaempferia galanga L.) dan Jahe Hitam (Kaempferia parviflora) terhadap Tikus yang Diinduksi Jus Hati Ayam dan Potassium Oxonate Wikantyasning, Erindyah Retno; Wahyuni, Arifah Sri; Julianti, Tri Budi; Putri, Nastity Zhahwa Amalia; Astuti, Devi Dwi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.497

Abstract

Hyperuricemia is caused by excessive production and/or poor elimination of uric acid. Kencur (Kaempferia galanga L.) and black ginger (Kaemperia parviflora) can be utilised as antihyperurisemic alternatives because their flavonoids block xanthin oxidase (XO). The study determine the efficacy of black ginger ethanol extract (EEJH) as an in vivo antihyperuricemic agent. This research was conducted to determine the effectiveness of kencur ethanol extract (EK) dan black ginger ethanol extract (EEJH) as an antihyperuricemia in vivo. A complete random design used involving 32 mice in 8 groups. Negative control (CMC Na 0.5%); positive control (Allopurinol 10 mg/kgBW); EK and EEJH respectively 12.5; 25; and 50 mg/kgBW. Hyperurisemia was induced by chicken liver juice 4 mL/200 gBB p.o. and potassium oxonate 250 mg/kgBB i.p. UA monitoring was carried out before induction, 0, 7, and 14 days after treatment. Tukey post hoc tests and ANOVA were used to evaluate the data. The results indicate that both of EK and EEJH can reduced UA (p<0.05) however the reduction is significant with Allopurinol (P<0.05). Thus, it can be inferred that the EK and EEJH have potential for enhanced antihyperurysemic in decreasing the UA.
Faktor-Faktor yang Mempengaruhi Stunting di Indonesia : Studi PRISMA (Preferred Reporting Items for Systematic Review & Meta Analysis). Masdalena, Masdalena
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.504

Abstract

Stunting, a long-term nutritional problem that arises from insufficient food intake and is caused by vitamin deficiencies, has a broad and complex impact on children's health. Stunting can appear when the child is still in the womb and can occur until the child is two years old. This study explores the factors that influence stunting in Indonesia. Using the PRISMA (Preferred Reporting Items for Systematic Review & Meta-Analysis) method. Through a literature review from various sources such as Google Scholar and PubMed, this research aims to identify crucial factors related to stunting in toddlers by defining the keywords "stunting" and "stunting factors". In the identification, screening, eligibility, and analysis stages, 20 articles were selected that met the criteria for this research. Twenty (20) articles from 2019-2024 have been analysed using the PRISMA diagram. Articles from various journals were found to originate from Indonesia. Research studies show that the factors that influence stunting in Indonesia are 27.27 times compared to mothers with a higher level of education (aOR = 27.27; 95% CI = 4.37 to 170.11), with statistical significance (p = 0.00001). Internal factors influence stunting in Indonesia.
Hubungan suhu rumah dan kontak penderita dengan kejadian penularan tuberkulosis di Kecamatan Manonjaya Kabupaten Tasikmalaya Dewi, Candrawati Puspita; Raharjo , Mursid; Adi , Mateus Sakundarno
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.505

Abstract

Based on data from the Global Tuberculosis Report, the World Health Organization (WHO) in 2021 states that from 7.1 million in 2019 to 5.8 million in 2020, a 17% decrease, around 16 countries contributing to this decrease, namely India, Indonesia, the Philippines, were affected. worst. Reduced access to TB diagnosis and treatment has resulted in an increase in TB deaths, estimated at 1.3 million TB deaths in 2020. TB cases in Tasikmalaya Regency are still 45% and there are 36% RO TB cases (43 people) and the discovery of TB suspects has also not yet reached the target, which is only 40%. The aim of the research was to determine the relationship between house temperature and patient contact with the incidence of tuberculosis in Manonjaya District, Tasikmalaya Regency. The research design used case control. The research was conducted in March 2024 in Manonjaya District, Tasikmalaya Regency. The research sample was 128 respondents. The independent variables are the temperature of the house and the patient's contact. The dependent variable is the incidence of pulmonary tuberculosis transmission. The instrument is an observation sheet. Data were analyzed by chi square test using SPSS. This research applies the principles of confidentiality, useful information and scientific development. The results of the study showed that there was a relationship between house temperature (OR=2.15; 95% CI; 1.05-4.37) and patient contact (OR=4.31; 95% CI; 2.04-9.11) with the incidence of transmission of tuberculosis in the home. The conclusion is that there is a relationship between house temperature and patient contact with the incidence of tuberculosis in Manonjaya District, Tasikmalaya Regency. Tuberculosis sufferers and the patient's family can take preventive measures to prevent transmission of tuberculosis.
Pengaruh konseling obat terhadap pengetahuan dan tingkat kepatuhan pasien hipertensi Tahun 2023 Nainggolan , Intan; Nurasni, Nurasni; Simanjuntak, Nerly Juli Pranita; Novriani , Erida; Piska , Finna; Meutia , Rena; Neswita, Elfia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.507

Abstract

Hypertension is when blood pressure exceeds normal limits, and it is generally a lifelong condition that requires maintaining stable blood pressure. Every year, the relationship between hypertension and death from heart and blood vessel disease stabilizes. Every year, the link between hypertension and death from heart and blood vessel disease is proven. This research took place from July to September 2023 at H. Adam Malik Hospital, Medan, with 53 patients who met the inclusion criteria. The study aims to assess the level of adherence of hypertensive patients to the use of their medication using the Morisky Medication Adherence Scale questionnaire and to see whether counseling can increase the level of patient compliance. The results of the analysis show that providing counseling has a significant impact on increasing compliance in hypertensive patients at H.Adam Malik General Hospital, Medan, as demonstrated by the Wilcoxon test with p-value < 0.05.
Formulasi dan uji aktivitas repellent lilin aromaterapi dari minyak atsiri serai wangi (Cymbopogon Nardus L.) dengan cengkeh (Syzygium Aromaticum L.) Ginting , Indra; Rudang , Singgar Ni; Andry, Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.515

Abstract

Background: Aromatherapy candles are an alternative to inhalation therapy applications, namely the inhalation of aroma vapors produced from essential oils. Fragrant Lemongrass (Cymbopogon nardus L.) and Clove (Syzygium aromaticum L.) contain essential oil compounds that have the potential as natural pesticides. This study aims to formulate aromatherapy candles from essential oils of citronella and clove flowers as mosquito repellents with various concentrations, namely negative control, F1:1%:3%, F2: 2%:2%, and F3: 3%:1 %. The research was done experimentally by making preparations of aromatherapy candles, with preparation evaluation tests including organoleptic tests, air bubble tests, burn time tests, and melting point tests. The candle quality test includes a scent preference test, a candle effectiveness test against mosquitoes, and a therapeutic test on sleep quality using the Mi Band 5 Smartwatch. The results of the preparation evaluation test met the requirements. The most preferred scent was F2 (2%:2%). The effectiveness of wax as a repellent was very optimal in killing mosquitoes, with the best value affecting mosquito mortality shown by F3 treatment (3%:1%). The effectiveness of candles as a therapy for sleep quality showed that there was a change in the quality of sleep that was getting better, with the best value affecting sleep quality shown by the F2 treatment (2%:2%). The conclusion from the researchers of the study is that aromatherapy candle formulations from citronella and cloves can be used as mosquito repellents and also improve sleep quality.
Formulasi gel ekstrak daun kelor (Moringa oleifera Lam.) serta uji karakteristik sediaan dan uji cemaran mikrobiologi Dewi, Asiska Permata; Fadila, Sarah; Darmadi, Darmadi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.550

Abstract

Moringa leaves are a type of medicinal plant that contains flavonoids, polyphenols, saponins, and tannins. The objective of this research is to make a Moringa leaf extract gel formulation and test the characteristics of the preparation's and test for microbial contamination.  The characteristics are tested using organoleptic tests, pH, homogeneity, spreadability, and dosage form consistency. Meanwhile, the microbiological contamination testing included the Total Plate Count and Yeast Mold Count tests. The results of testing the characteristics of the preparation on Moringa leaf extract gel, in the organoleptic test revealed that the dosage form was semi-solid, the color was white to brownish yellow, and the odor of the extract, the pH of the preparation ranged between 6-6.2, spreadability ranged from 6.2-6.4 cm, consistency of the preparation was homogeneous, and no phase separation occurred. Furthermore, the ALT test at concentrations of 2%, 4%, 6%, 8%, positive control, and negative control obtained a colony count of 9.5x106 CFU/mL. 3.8x105 CFU/mL, 6.7x106 CFU/mL, 6.8x105 CFU/mL, 1.47x104 CFU/mL and 1x101 CFU/mL. Meanwhile, the AKK test obtained colony counts of 1.35x105 CFU/mL, 9.7x102 CFU/mL, 1.1x102 CFU/mL, 7.8x103 CFU/mL, 1x101 CFU/mL, and 1x101 CFU/mL. According to the findings of the ALT test, the number of bacterial colonies still surpasses the threshold standards stipulated by BPOM number 32 of 2019. Meanwhile, the AKK test showed that the concentration of 2% exceeds the limit for yeast mold contamination

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