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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Uji efektivitas antidiare ekstrak etanol biji asam Jawa (Tamarindus indica L.) terhadap mencit jantan dengan metode transit intestinal Simanjuntak, Nerly Juli Pranita; Neswita, Elfia; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.458

Abstract

Tamarindus indica is a member of the Fabaceae plant family, often used as a food source and traditional medicine. For generations, tamarind has often been used in medicine. One part of this plant that is often used is the seeds, which treat various conditions such as asthma, bronchitis, leprosy, tuberculosis, wounds, stomach problems, diarrhea, dysentery, vertigo, and diabetes. The active components of tamarind seeds include tannin compounds, fatty acids, flavonoids, saponins, alkaloids, and glycosides. This study used the intestinal transit method to examine the antidiarrheal effect of ethanol extract from tamarind seeds on male mice. This research method uses the intestinal transit method, namely comparing the length of the intestine through which the marker passes. The results of the observation of the antidiarrheal effect of the ethanol extract of tamarind seeds at a dose of 50 mg/kg bw gave the weakest antidiarrheal effect. The 450 mg/kg bw dose gave the most substantial antidiarrheal effect. Increasing the tamarind seed ethanol extract dose increased the antidiarrheal effect. The results of statistical analysis showed that administration of 2% tamarind seed ethanol extract suspension at a dose of 150 mg/kg bw and 450 mg/kg bw to male mice showed a practical antidiarrheal effect because it was not significantly different from loperamide 0.52 mg/kg bw which showed an impact. Antidiarrheal in Duncan's mean difference test (P > 0.05). The conclusion is that the ethanol extract of tamarind seeds has an antidiarrheal effect when given to male mice induced with oleum ricini using the small intestine passage method.
Uji toksisitas akut ekstrak rotan sel (Daemonorop melanochaetes Bl.) terhadap larva udang (Artemia Salina Leach) dengan metode brine shrimp lethality test (BSLT) Athaillah, Athaillah; Maulida Lubis, Roqayyah; Chandra, Putra; Pangondian, Aswan; Rambe, Robiatun
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.463

Abstract

Cell rattan is very popular because it has properties in treating malaria, diabetes and also has appetite-stimulating properties. The chemical content of rattan consists of flavonoids, alcohol, triterpenoids, saponins and glycosides. Flavonoids consist of 15 carbon atoms with a C6-C3-C6 structure. In plants, flavonoids are bound to sugars in the form of flavonoid glycosides and aglycones. Research methods include making rattan extract using the maceration method, phytochemical screening, toxicity activity testing using the BSLT (Brine Shrimp Lethality Test) method and determining the LC50 value based on the probit value. The research results show that rattan extract contains secondary metabolite compounds, including steroids/triterpenoids, saponins, flavonoids, glycosides and alkaloids. The results of the toxicity activity test showed that the LC50 value was 322 ppm and was included in the toxic category.
Analisis Kandungan Nutrisi Nugget Ayam Terfortifikasi Daun Kelor (Moringa oleifera) Aris, Muhammad; Asmaq, Nur
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.464

Abstract

The aim of this research was to observe the nutritional value enhancement of nugget products after fortification with moringa leaf powder. The research method employed was an experimental approach through a Completely Randomized Design (CRD) non-factorial with 4 treatments and 4 replications for each treatment. The treatments included in this study were without moringa leaf powder (A0), 5% moringa leaf powder (A1), 10% moringa leaf powder (A2), and 15% moringa leaf powder (A3). The parameters observed were the protein content, fat content, and water content of the nugget samples. The research results indicate that fortification with moringa leaves significantly increased the water content (by 53.63%) and protein content (by 13.21%), while significantly reducing the fat content (by 9.90%). This effect was observed across various concentrations, with the optimal concentration found in treatment A3.
Studi in silico senyawa golongan flavonoid dari ranting dan akar dadap serep (Erythrina subumbrans) sebagai antipiretik Montero, Mahkota Alda Mora; Wardani, Arief Kusuma
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.483

Abstract

Studies in silico offer an exciting world where researchers use the power of computing to explore a variety of scientific phenomena. In silico allows researchers to virtually test thousands of potential compounds, including natural ingredients, interacting with biological targets. This can speed up drug discovery and reduce reliance on expensive laboratory trials. Erythrina subumbrans is a plant in the Papilonaceae family that has been phytochemically tested to contain flavonoids suspected of having antipyretic effects. The study aims to identify the most potentially antipyretic compounds among the eight flavonoid groups of the branches and roots of Dadap Serep (Erythrina subumbrans). The study uses the molecular docking method. Tests were conducted against eight flavonoids of the branches and roots of the Dadap serep, namely pinocembrin, 3,6,4’-trichydroxyflavone, 3,6-dihydroxylflavon, lupalbigenin, erysubin F, genistein, 5-hydroxyphoronone, and abyssinone V, as well as positive controls of paracetamol against target proteins with PDB code 1CX2. The data analysis compared the total binding energy and hydrogen binding scores on the emerging amino acid residues. The test results showed that the three most potentially antipyretic compounds were lupalbigenin, erysubin F, and abyssinone V, with consecutive total bending energy scores of -126.3 kcal/mol, -113.1 kcal/mol, and -111.8 kcal/mol.
Formulasi sabun mandi esensial minyak nilam dengan pewarna kopigmentasi biji kesumba keling (Bixa orellana L.) dengan angkak merah Indriana , Meutia; Sari, Nurmala; Julianty , Siti Muliani; Muzakkir, Muzakkir; Febriani , Yessi; Nurrahman, Taufik; Salman, Salman
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.342

Abstract

Background; The skin is the outermost layer of the body that serves as a protective barrier against exposure to sunlight and is also where sweat is produced. Sweat can make the skin appear dull and sticky. Soap is a cosmetic product that is used for body cleansing. Annatto and red mold rice are used as natural colorants formulated in soap preparations, where the color produced by annatto and red mold rice is not stable. Therefore, a copigmentation method is needed to stabilize the colorant annatto with red mold rice. Method; This research use an experimental approach that initially involves the extraction of annatto seeds and red mold rice using 96% ethanol. Subsequently, the extracted compounds are formulated into soap preparations with variations in ratios of 1:1, 1:2, 2:1, and 2:2. To evaluate the quality of the soap preparations, various tests have been conducted, including homogeneity testing, pH testing, foam height testing, water content testing, and irritation testing. Result; The results showed that the copigmentation of annatto seeds with red mold rice in the form of ethanol extract could be formulated into a soap dosage form at a ratio of 2:1 (F4) is the best preparation, is a homogeneous preparation, has a pH of 9.4 , has a foam height of 8.3 cm, has a water content of 6.25%. All copigmented soap with ethanol extract of annatto seeds with red mold rice does not irritate the skin of the hands.
Literature review: faktor-faktor yang berhubungan dengan health-seeking behavior dan quality of life pada pasien penderita asma Sulistiawati, Sulistiawati; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.368

Abstract

Background: Asthma affects approximately 335 million people worldwide and is the 14th most common disease globally in terms of disability, burden, and negative impact on individuals, society, and the economy. Asthma patients often experience a decline in condition due to sudden onset symptoms. Comorbid conditions such as depression and anxiety, changes in nighttime and early morning activities, and environmental factors such as cold air can affect the quality of life of asthma patients and influence their health-seeking behavior. Methods: This study used an observational design with a literature study approach. The databases used to obtain this article are PubMed and Scopus. Results: From the literature study results, 7 articles were analyzed that met the eligibility criteria according to the inclusion and exclusion criteria. The resulting factors are associated with health-seeking behavior and quality of life in asthma patients. Conclusion: This study states that factors associated with health-seeking behavior and quality of life in asthma patients include education, distance to health facilities, socio-economic factors, age, employment status, gender, obesity, and anxiety/depression.
Review artikel: analisis faktor yang mempengaruhi kejadian pneumonia pada bayi dan balita Sholih, Mally Ghinan; Mulki, Munir Alinu; Julianti, Nurlia; Jannah, Roudotul; Indriyani, Yuni Lili
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.386

Abstract

Pneumonia is an infection of the lower respiratory tract which is the main cause of death in toddlers and children. Although there is a lot of information about risk factors for pneumonia, there is information that is not presented in detail and specifically. The purpose of this review article is to provide insight into the risk factors that cause pneumonia in babies and toddlers, making us more alert and aware of the importance of preventing and treating pneumonia, especially in babies and toddlers. The review method for this article is a literature review. The database comes from national and international journals via Google Scholar and PubMed databases published in the years 2013-2023. The results and discussion of this review include information about pneumonia, risk factors for pneumonia, and factors causing pneumonia in infants and toddlers. Based on the articles that have been reviewed, it shows that the factors that influence the incidence of pneumonia are exposure to cigarette smoke, LBW, nutritional status, gender, and history of exclusive breastfeeding. 
Uji Aktivitas Antihiperlipidemia Ekstrak Etil Asetat Daun Jambu Air (Syzygium aqueum) terhadap Kadar Kolesterol Total pada Tikus Jantan Galur Wistar Setianingsih, Siti; Sumantri, Sumantri; ‘Afiah, Noni Faridatul
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.420

Abstract

The ethyl acetate extract of guava leaves contains secondary metabolites in the form of flavonoids and alcaloids which have been shown to have an antiperlipidemic. This study aims to determine the content and levels of the ethyl acetate extract of water guava leaves (EEADJA) and antihyperlipidemic activity in hyperlipidemic rats.This research was an experimental study with a randomized matched pre-test and post-test control group design . Hyperlipidemic rats were made by giving PTU 12.5 mg/kg/day orally for 14 days. Hyperlipidemic rats were divided into 5 groups with 5 rats each, namely group I (negative control) CMC-Na 0.5%, group II (positive control) simvastatin 0.18 mg/kgBW/day, groups III, IV and V given EEADJA (100, 200, and 400) mg/kgBW/day for 14 days orally. Differences in data on total cholesterol levels before and after treatment were tested statistically by testing the antihyperlipiemia effect using the paired t-test and One Way Anova test to determine differences in the reduction in total cholesterol levels with various dose variations. EEADJA with various doses of 100, 200, and 400 mg/kg/day has the ability to reduce total cholesterol levels in the blood of hyperlipidemic rats.
Prevalensi dan identifikasi cemaran bakteri patogen staphylococcus aureus pada ayam krispy Daerah Amplas Kota Medan menggunakan rabbit coagulase plasma with EDTA Rahayu, Yayuk Putri; Nasution, Haris Munandar; Supiyani, Supiyani
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.435

Abstract

Staphyococcus aureus bacteria is one of the bacteria that contaminates crispy chicken meat and can cause Extraordinary Events or Kejadian Luar Biasa (KLB) in Indonesia as a cause of diarrhea. This is due to lack of hygiene in processing, storing and serving crispy chicken. Poisoning can occur due to food contamination by S. aureus enterotoxin. The aim of the research was to analyze the prevalence and identify the presence of S. aureus bacteria found in crispy chicken meat in the Amplas area of Medan city using Rabbit Coagulase Plasma with EDTA. Method for identifying S. aureus using BPA (Baird Parker Agar Base) and Egg Yolk media. Specific identification testing using Gram staining, catalase test, and coagulase test using Rabbit Coagulase Plasma with EDTA. The value of S. aureus bacterial contamination using the TPC (Total Plate Count) method and analysis of the prevalence of S. aureus contamination. The results of research on roadside cart krispy chickens were found to be positive for S. aureus with characteristics of Gram positive, positive coagulase and positive catalase as well as contamination values above 1X102 CFU/ml exceeding the threshold so they do not meet SNI standards. Meanwhile, the local fast food crispy chicken value for the presence of S. aureus bacteria does not exceed the threshold of 1X102 CFU/ml so it meets SNI standards. The prevalence value of S. aureus contamination in roadside cart krispy chicken was 75.0% and local fast food was 8.3%.
Vegetables, Heavy metals, FAAS, Kajian Cemaran Logam Berat Timbal (Pb), Kadmium (Cd), Dan Merkuri (Hg) Pada Sayuran Di Daerah Pertambangan Aceh Jaya Secara Spektrofotometri Serapan Atom. Kurniaty , Rina; Adiyana, T.M. Dayan; Yusuf , Muhammad; Mahmudi , Mahmudi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.448

Abstract

Heavy metal contamination in vegetables poses a threat to humans, especially at predetermined thresholds. In this study, Pb, Cd, and Hg metals were analyzed using Flame - Atomic Absorption Spectrometry (F-AAS) and Vapor Generation Accesory - Atomic Absorption Spectrometry (VGA-AAS) methods at mining areas in Krueng Sabee Sub-District, Aceh Jaya District, Aceh Province. Method validation was conducted to obtain accurate heavy metal analysis results on the samples. The results showed that the highest Pb metal contamination was found in cassava leaf I sample with levels of 2.44 ± 1.33 mg/Kg and the lowest was found in spinach III sample with levels of 0.15 ± 0.07 mg/Kg. The high Pb content was also found in kale I and spinach I samples obtained in areas close to the mining area with levels of 1.07 ± 0.59 mg/Kg and 0.93 ± 0.50 mg/Kg, respectively. The highest Cd metal contamination content was found in kale II samples with levels of 0.11 ± 0.01 mg/Kg and the lowest Cd metal contamination with levels of 0.02 ± 0.01 mg/Kg was found in cassava leaf II samples. The highest Hg metal content of 0.58 ± 0.12 mg/Kg was found in cassava leaf I sample and the lowest level was 0.04 ± 0.02 mg/Kg owned by spinach III sample. Contamination of Hg metal in all vegetable samples showed levels that were above the established SNI 7387 (2009) quality standard of 0.03 mg/Kg. The quality standards for Pb and Cd metal contamination are 0.5 mg/Kg and 0.2 mg/Kg, respectively.  This study shows the need for government monitoring of heavy metal contamination in agricultural areas near mining activities to ensure safe food consumption.

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