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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Analisi manajemen pengetahuan terhadap kepatuhan minum obat pada pasien hipertensi di apotek Medan central care pharmacy Shufyani, Fahma; Siregar , Syati Manaharawan; Yulia , Rahma
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.572

Abstract

Introduction: Hypertension is one of the most dangerous health problems in the world, because hypertension is the main risk factor that leads to cardiovascular disease such as heart attack, heart failure, stroke and kidney disease. The aim of this study was to determine the relationship between level of knowledge and adherence to taking medication in hypertensive patients at the Medan Central Care Pharmacy.. This Method This research method uses quantitative descriptive analytical methods using a cross-sectional design. The sampling technique uses purposive sampling technique. Data were analyzed using the Chi Square test. Data collection was carried out in June 2023. The research population was hypertension sufferers at the Medan Central Care Pharmacy. The sample for this research was 97 respondent. The results of this study showed that the frequency distribution of high knowledge was 45 respondents (46.4%), medium was 36 respondents (37.1%) and low was 16 respondents (16.5%). The frequency distribution of medication adherence was 19 respondents (19.6%) high, 45 respondents (46.4%) medium and 33 respondents (34%) low. The results of the chi-square test of knowledge with medication adherence showed a p-value of 0.000<0.05. The conclusion in this study is that the respondent's level of knowledge about hypertension is in the high category, the respondent's level of medication adherence is in the medium category and there is a relationship between the level of knowledge and medication adherence in hypertension patients at the Medan Central Care Pharmacy.
Tingkat pengetahuan dan sikap mahasiswa Fakultas Farmasi Universitas Muhammadiyah Surakarta tentang beyond use date obat Alinda, Oevita Nur; Karuniawati, Hidayah
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.490

Abstract

Beyond Use Date (BUD) is the expiry time of a drug after it is opened from its primary packaging. The aim is to determine the level of knowledge and attitudes regarding BUD, to analyze whether there are differences between sociodemographics and BUD knowledge and attitudes, as well as whether there is a relationship between knowledge and attitudes of students in the Muhammadiyah University of Surakarta Pharmacy study program regarding BUD. This research is descriptive analytical research with observational methods. The data collection method was cross-sectional. Analysis (using Mann-Whitney and Kurskall-Wallis analysis) was carried out to assess differences in mean knowledge and attitude scores. Linear regression analysis was carried out to identify factors related to knowledge and attitudes about BUD. Spearman Rank analysis was used to test the correlation between knowledge and attitudes. The research results showed that respondents had a sufficient level of knowledge at 53,0% and attitude about BUD were classified as good at 68,8%. Statistical analysis shows that knowledge and attitudes about BUD are significantly related to age and generation (p<0,001). The research results also stated that men, respondents aged 17 and 18 years and the class of 2023 had a lower understanding of knowledges and attitude about BUD. Apart from that, there is a correlation between knowledge and attitude (p=0,000).
Review artikel : pemanfaatan bahan alam pada sediaan face mist Rahmadasmi, Nola; Wulandari , Desti; AH , Ahdi Dinil Haq.
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.492

Abstract

This article review aims to review several journals that formulate face mist preparations by utilizing natural ingredients. Some of the natural ingredients used have a variety of beneficial properties for the skin, especially the face such as facial moisturizers, antioxidants and antibacterials. Face mist is included in cosmetics that are efficacious as skin refreshers, especially to refresh facial skin and can remove residual oil from the skin that may still exist. Refreshers are made according to the type of cleanser that refers to the type of skin on the face. Face mist preparations have advantages when compared to other preparations including easy to use and carry anywhere, and more quickly absorbed into the skin. The formula used is a variation of the concentration of the active substance (sample) with additional substances such as glycerin as a moisturizer and PVP (polyvinyl pyrrolidone) as a dispersing agent and preservatives in the form of nipagin, nipasol, DMDM Hydantoin and sodium benzoate and distilled water as a carrier (solvent).
Uji aktivitas antibakteri fraksi n-heksana dan etil asetat daun bandotan (Ageratum conyzoides L.) terhadap bakteri Staphylococcus epidermidis Rafliza , Rista; Nasution , Haris Munandar; Dalimunthe , Gabena Indrayani; Mambang , D.Elysa Putri
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.500

Abstract

Bandotan (Ageratum conyzoides L) is a wild plant that is easy to find in Indonesia, known to have medicinal properties and has antibacterial properties. The purpose of this study was to determine the antibacterial activity of the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum Conyzoides L) against Staphylococcus epidermidis bacteria.This research was conducted using an experimental method including sample collection, macroscopic examination, microscopic examination, simplicia manufacture, characteristic examination, phytochemical screening, preparation of ethanol extract, then fractionation, then testing of antibacterial activity against Staphylococcus epidermidis bacteria using the agar diffusion method. Data obtained from the diameter of inhibition were statistically analyzed using the Anova test, then followed by the Kruskal-Wallis test and the Ducan test. The results of macroscopic examination, with dark color, egg-shaped, two pointed, obtuse leaf base, serrated leaf margins, hairy veins on the upper and lower surfaces, slightly hairy young leaves, white hair color and pinnate veins. The results of microscopic examination, xylem, covering hair, mesophyll and anomocytic type of stomata. The simplicia characteristic results obtained water content of 7.3%, water-soluble essence content of 32.72%, 42.5% ethanol-soluble extract content, total ash content of 3 .3% and acid insoluble ash content of 1.8%. Phytochemical screening of simplicia powders and extracts showed the presence of alkaloids, glycosides, flavonoids, tannins, saponins and steroids. The results of the antibacterial activity test of the n-hexan fraction on Staphylococcus Epidermidis bacteria at concentrations of 10%, 30%, 50% and 70% were included in the resistant category. Meanwhile, the ethyl acetate fraction at a concentration of 10%, 30% and 50% is in the resistant category, at a concentration of 70% it is in the intermediate category. So it can be concluded that the n-hexane and ethyl acetate fractions of bandotan leaves (Ageratum conyziodes L) have activity against Staphylococcus epidermidis bacteria.. 
Evaluasi kualitas fisik dan mikrobiologi daging kambing yang dimarinasi dengan jus buah andaliman Amali, M. Rizky; Sinaga , Kurniawan
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.502

Abstract

The ain of this research was to determine the effect of using andaliman fruit juice on pH, cooking loss, water holding capacity and microbiology in goat meat.The study used a non-factorial Completely Randomized Design (CRD) with 4 treatments and 5 replications, as well as descriptive methods.The data from the research will be processed statistically using analysis of variance and if there is a significant effect, it will be continued with the Duncan further test. Goat meat has become the main choice among the population because of its good nutritional profile. Data analysis showed that marination with andaliman fruit extract had no significant effect on the pH value, cooking shrinkage, and water binding capacity of goat meat. While microbiology research describes the characteristics of a population or a phenomenon that becomes the object of research that is trial and error. From the observation data analyzed by descriptive method as many as 4 samples of goat meat obtained from the traditional market of kampung lalang, it was found that marinated goat meat with andaliman fruit extract had an effect on P2 with a total of 162 colonies, and increased in P3 with 235 colonies.
Metabolit Bioaktif Bakteri: Tinjauan tentang Potensi Antimikroba dan Aplikasinya Nova, Bastian; Supri Wardi, Epi; Sartika, Diza
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.514

Abstract

Bacteria are a promising source of bioactive compounds. This review provides a concise overview of existing research on antimicrobial molecules from bacteria. Additionally, it briefly summarizes bacteriocins, non-ribosomal peptides, polyketides, and lipopeptides targeting pathogens resistant to several drugs, considering next-generation antibiotics. The review highlights the potential use of bacteria as a source of antimicrobials for biotechnological, nutraceutical, and pharmaceutical applications. However, further investigation is needed to isolate, separate, purify, and characterize these bioactive compounds, as well as to formulate them into clinically approved antibiotics.
Preliminary Kandungan Glibenclamide dan Metabolitnya 4-trans-hidroksiglibenklamid menggunakan Metode spektrofotometri Uv-Vis Apriani, Aida; Muna, Tajul; Azhari, Saiful a
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.545

Abstract

Glibenclamide, another name for glyburide, is one of the antidiabetic drugs oral (ADO) which works by closing the K+-ATP channels in pancreatic beta cells thereby increasing insulin release. 4-trans-hydroxyglibenclamide is the main metabolite of glibenclamide which also has hypoglycemic effects. This study aims to determine the maximum wavelength of glibenclamide and its metabolite 4-trans-hydroxyglibenclamide. The results showed that the maximum wavelength of glibenclamide was at 300.60 nm, while 4-trans-hydroxyglibenclamide was at 299.50 nm and the glibenclamide calibration curve was obtained using the regression equation Y= Y=0.010x+0.001 with a correlation coefficient of 0.998, while 4 -trans-hydroxyglibenclamide Y= 0.0102x-0.0098 with a correlation coefficient of 0.99
Evaluasi aktivitas analgesik dan antidiare ekstrak etanol bunga telang (Clitoria ternatea Linn.) Ananda, RA Dewinta Sukma; Kusumawardani , Nurul; Fauzi , Rizal; Estiningsih , Daru; Emelda, Emelda; Solikah , Wahyu Yuliana; Nurinda , Eva; Gunawan , Adhi; Ramandani , Wulan; Stiawati , Rika
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.558

Abstract

The analgesic and antidiarrheal effects of Clitoria ternatea Linn. flower extract were tested in mice. A significant analgesic response (p<0.05) was observed in acetic acid-induced pain models in a dose-dependent manner. The percent protection of analgesic properties was calculated from the reduction of writhing by butterfly pea ethanol extract. The Butterfly pea extract doses at 100, 200, and 400 mg/ kg showed analgesic protection by 76.6% (9.4  ± 3.65), 93.9% (2.4 ± 1.95), and 97.5% (1.0 ± 0.71), respectively. The antidiarrheal properties of Clitoria ternatea Linn. flower extract were assessed using the castor oil-induced diarrhea method. Clitoria ternatea Linn. flower extract delayed the onset of castor oil-induced diarrhea in a dose-dependent manner and reduced the frequency of defecation. There was no significant difference (p>0.05) between the effects of 400 mg/kg of Clitoria ternatea Linn. flower extract and loperamide in protecting mice against castor oil-induced diarrhea. Based on the study results, it is suggested that the Clitoria ternatea Linn. flower extract has strong analgesic and antidiarrheal properties. 
Penentuan kadar flavonoid total ekstrak etanol kayu kuning (Arcangelisia flava (L.) Merr. ) dan uji antibakteri Staphylococcus aureus . Nuraida, Nuraida; Ridwanto, Ridwanto; Daulay , Anny Sartika; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.598

Abstract

Indonesia has a diversity of plant species used as traditional medicine, one of which is yellow wood (Arcangelisia flava (L.) Merr.), this yellow wood is antibacterial, anti-inflammatory, antiseptic and antipyretic. It is known that yellow wood contains saponins, flavonoids, alkaloids, tannins, and steroids that can treat malaria, fever, rheumatism and itching. This study aims to determine the value of total flavonoid content contained in yellow wood extract in various ethanol concentrations (50%, 70% and 96%) and to determine the antibacterial inhibition zone in yellow wood extract. The stages of this study include processing plant materials, making ethanol extracts of yellow wood with ethanol concentrations of 50%, 70% and 96% using the maceration method then the extract obtained is concentrated with a rotary evaporator, examining characteristics, phytochemical screening, determining the total flavonoid content of yellow wood extract concentrations (50%, 70% and 96%) by UV-Vis spectrophotometric method and antibacterial test of Staphylococcus aureus  by diffusion method. The results showed that ethanol extract of yellow wood contains alkaloid, flavonoid, tannin, saponin, and steroid/terpenoid compounds. The results of the determination of total flavonoid content in yellow wood extract at 50% concentration amounted to 0.815200888 ± 0.02445546 mg QE/g, 70% concentration amounted to 1.0660462967 ± 0.03265799 mg QE/g and at 96% concentration amounted to 1.6781149 ± 0.0085 mg QE/g. Antibacterial test on 96% yellow wood extract obtained an inhibition zone of 18.05 mm with a strong category.
Skrining fitokimia dan aktivitas antioksidan ekstrak etanol daging buah pala (Myristica fragrans) kawasan Aceh Selatan, Indonesia. Azhari , Saiful; Kurniaty , Rina; Yusuf, Muhammad; Zulyani , Riza; Mahmudi , Mahmudi; Rani, Wahyu Mustika; Farida , Mutia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.421

Abstract

The nutmeg fruit (Myristica fragrans) shows the presence of secondary metabolite compounds and has antioxidant activity. The nutmeg examined in this study is the flesh of the fruit and dried for seven days to obtain simplisia. The extraction process is by maceration method using 96% ethanol solvent. Based on the results of phytochemical screening of ethanol extracts of nutmeg flesh showed the presence of secondary metabolite compounds, which are groups of alkaloids, steroids, saponins and flavonoids. The results of antioxidant activity of ethanol extract of nutmeg flesh have an IC50 value of 22.88 ppm. In this study using vitamin C as a positive control for comparison with the IC50 value obtained is 3.82 ppm. The more secondary metabolite compounds in an extract, the higher the antioxidant activity.

Page 33 of 66 | Total Record : 654

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