cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
 32   33   34   35   36 
Efek topikal gel ekstrak daun kayu manis (Cinnamomum burmannii) sebagai penyembuh luka insisi pada kelinci putih jantan (Oryctolagus cuniculus) Kasmadi, Fathnur Sani; Anggia, Sonia; Yuliawati, Yuliawati; Efendi, M. Rifqi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.466

Abstract

Cinnamon leaves (Cinnamomum burmannii) are plants that have many pharmacological effects. One of them is as a wound healer. The gel formulation becomes a convenient therapeutic solution for use. This study aimed to determine the impact of gel preparations on the healing of incision wounds in male white rabbits. The research method uses experimental methods. The test animal was injured on its back using a tool with a diameter of 2.5cm. There are five treatment groups used, namely: positive control (Bioplasenton), negative control (gel base), Formula 1 (extract 2.5%), Formula 2 (extract 5%), and Formula 3 (extract 7.5%). The results of wound healing observations were analysed using one-way ANOVA with a confidence level of 95%.  The results showed that the best formula for wound healing is formula 2. Then, formula three and formula 1 had a significance value between groups of 0.05.
Formulasi sediaan pasta gigi herbal ekstrak etanol bunga telang (Clitoria ternatea L.) dan uji aktivitas antibakteri terhadap bakteri Streptococcus mutans Rati , Yuliandini; Dalimunthe , Gabena Indrayani; Lubis, Minda Sari; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.479

Abstract

Dental and oral disease is a disease experienced by almost half of the world's population (3.58 billion people). Gum (periodontal) disease is the 11th most common disease in the world. One of the dental and oral diseases that has a fairly high prevalence in Indonesia is dental caries. The aim of this research was to evaluate the physical quality of toothpaste preparations with various concentrations (10%, 30% and 50%) and to determine the antibacterial activity of ethanol extract toothpaste preparations from butterfly pea flowers (Clitoria ternatea L.) against the growth of Streptococcus mutans bacteria.The stages of this research included processing plant materials, making ethanol extract of butterfly pea with ethanol 96% solvent, characterization examination, screening of phytochemicals, making herbal toothpaste preparations of butterfly pea extract, preparation evaluation, and testing the antibacterial activity of butterfly pea toothpaste against Streptococcus mutans using the well-diffusion method. Based on the research results, it can be seen that the antibacterial activity of the formula with the greatest zones of bacterial inhibition is F1 and F2, namely 21.85 mm and 21.15 mm with very strong inhibition criteria. The conclusion of this study is that herbal toothpaste with butterfly pea extract can prevent and treat dental caries caused by Streptococcus mutans bacteria.
Pembuatan lip balm nanoekstrak umbi bit (Beta vulgaris L.) dan bunga rosella (Hibiscus sabdariffa L.) sebagai pelembab alami Jannah, Miftahul; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.480

Abstract

One of the most sensitive parts of the outer skin on the face is the lips, as they are prone to extreme weather conditions such as heat and cold, which can cause dryness and chapping. To address this condition, it is essential to use a lip balm. One of the plants used as an active ingredient in lip balm formulations is beetroot and rosella flower. Nanoparticle-based cosmetics have advantages over micro-scale cosmetics. The objective of this research was to determine whether nano extracts of beetroot and rosella flower can be formulated into a lip balm preparation, whether beetroot and rosella flower extracts meet the characteristic requirements as nano extracts, and whether lip balm formulations from beetroot and rosella flower can be used as moisturizers. This research method is true experimental with a post-test control group design, where the results were observed after the treatment. The study uses samples of beetroot and rosella flowers. The stages of this research include sample preparation, characterization of simplicia, phytochemical screening, extraction and nano-extraction, lip balm formulation, physical quality evaluation, and moisture testing. The research results show that beetroot and rosella flower contain alkaloids, flavonoids, saponins, tannins, and anthocyanins. The beetroot and rosella flower extracts meet the characteristics of nanoextracts, with particle sizes of 261.64 nm for beetroot and 143.86 nm for rosella flowers. Beetroot and rosella flower formulated into a lip balm preparation can moisturize the lips, as evidenced by increased moisture and oil content on the lip skin before and after the preparation.
Uji Efektivitas Ekstrak Daun Tapak Dara Terhadap Penyembuhan Luka Sayat Pada Kulit Punggung Kelinci Samodra, Galih; Kaaffah , Silma
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.486

Abstract

Incision wounds are a form of damage to body tissues caused by sharp objects and can cause bleeding by involving the role of hemostasis so that inflammation occurs. One medicinal plant with potential as traditional medicine is the Catharanthus roseus leaf because it contains secondary metabolites such as alkaloids, flavonoids, saponins, and steroids. This study aims to determine the effect of Catharanthus roseus leaf extract on the healing of wounds on the skin of rabbit backs. Observations were made for 14 days on three rabbits whose backs were divided into six areas. In certain areas, it is wound along 2 cm with a depth of 0.1 cm to apply Catharanthus roseus leaf test ointment 2 times a day. Rabbits were tested with five treatment groups: extract concentration of 25%, 50%, and 75%, and positive control and negative control. The results showed that the wounds were positive by days 8 and 9, 75% concentration had closed, and all rabbits had no scabs. The results of statistical tests showed that blood tread leaf extract affected the parameter of wound length in rabbits, which was 0.000 (p˂0.05). It can be concluded that the preparation of Catharanthus roseus leaf extract with concentrations of 25%, 50%, and 75% provides the effectiveness of healing incision wounds in rabbits.
Potensi Beta-Hydroxybutyrate (BHB) dalam Penanganan Diabetes Tipe 2 dan Risiko Ketoasidosis pada Pasien Diabetes Balapadang, Rachel Noveriachristie; Sudarjat, Hadi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.520

Abstract

Diabetes mellitus (DM) is a metabolic disease with an increasing prevalence every year, especially type 2 DM. Before insulin as a DM therapy, the ketogenic diet was known as the main nonpharmacological therapy, which is a high-fat, adequate-protein, and low-carbohydrate intake diet. A ketogenic diet causes the ketogenesis process and produces ketone bodies, one of which is beta-hydroxybutyrate (BHB) which has various therapeutic effects such as lowering blood sugar levels. This study is a narrative review compiled by searching the literature on Google Scholar and PubMed databases with keywords related to the research topic. Bibliometric analysis was also carried out with VOSviewer software to determine the keywords relevant to the research topic. The results of the reviews that have been carried out show that BHB has the potential as a therapeutic agent in patients with DM2 with various mechanisms of action in lowering blood sugar levels including increased insulin secretion, suppression of lipolysis, and decreased Ala release. BHB as a supplement has been widely studied for its therapeutic effects but it is necessary to pay attention to the side effects that can occur such as ketoacidosis.
Formulasi sediaan pasta daging lidah buaya (Aloe vera (L.)Burm.f.) dan uji aktivitas antibakteri terhadap bakteri Streptococcus mutans Meutia, Cut; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.524

Abstract

Introduction: Aloe vera (Aloe vera (L.) Burm.f.) is a plant that contains 95% water. The rest is in the form of other active ingredients (essential oils, amino acids, minerals, vitamins, enzymes, and glycoproteins). The type of aloe vera used to make herbal aloe vera is the Barbadensis type, which contains substances for human needs, such as Vitamins A, B1, B2, B6, B12, Vitamin E, and Vitamin C. This plant can also cure diabetes, heart disease, and other diseases.  Aloe vera can be formulated into toothpaste preparations because it can improve hygiene and reduce plaque in the mouth. Objective: This study aimed to make a new formulation of (aloe vera (L.) Burm.f.) as a toothpaste preparation and evaluate its antibacterial activity against Streptococcus mutans bacteria. Methods: This study uses an experimental method. In this study, aloe vera was formulated as toothpaste. The physical evaluation carried out included tests for water content, total ash content, water-soluble extract content, ethanol-soluble extract content, acid-insoluble extract content, organoleptic test, oh test, homogeneity test, spreadability test, adhesion test, test viscosity, and foam formation test. Results: Based on the research results, it can be seen that aloe vera flesh has antibacterial activity against Streptococcus mutans bacteria. Conclusion: This research concludes to make a new formulation of (aloe vera (L.) Burm.f.) as a toothpaste preparation and evaluate its antibacterial activity against Streptococcus mutans bacteria.
Hubungan human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) dengan kejadian penyakit kardiovaskular: konsistenkah bukti yang ada? Fitriani, Indah; Dharmasaputra, Alan; Marshella, Sally; Rosiana, Safira; Pramesuari, Florentina Dewi; Umar, Tungki Pratama
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.546

Abstract

Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) pose ongoing global health challenges. This literature review evaluates the relationship between HIV infection and increased cardiovascular diseases, outlining findings from sixteen observational studies. Key findings involve an elevated risk of hypertension, coronary artery disease, sudden cardiac death, and cardiovascular risk factors among HIV patients. Additionally, antiretroviral therapy (ART) side effects are highlighted, including specific impacts of certain drugs. The gender of HIV/AIDS patients also plays a role in cardiovascular risk profiles. The study details the pathophysiological mechanisms, such as immune activation and inflammation, involved in the heightened cardiovascular risk in individuals with HIV/AIDS. This study underscores the importance of a comprehensive understanding of cardiovascular health impacts on the HIV/AIDS population to guide informed therapeutic choices for preventing cardiovascular status deterioration.  
Validasi Metode Penetapan Kadar Kurkumin pada Tablet Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dengan KCKT Choliq, Ramadhan Idam; Hardani , Prisma Trida; Sinulingga, Amanda Safithri
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.565

Abstract

Curcuma rhizome contains antioxidants, where the compound that acts as an antioxidant is curcumin. Temulawak rhizome extract tablets as a supporting supplement for the treatment process of diseases such as liver function disorders, ulcers, coughs, diarrhea, and constipation. This study was conducted to obtain a valid method in determining curcumin levels in temulawak rhizome extract tablet preparations by HPLC. The stages carried out in this study were the preparation of the mobile phase, standard preparation, HPLC optimization, sample preparation, and method validation. Validation consists of several parameters, namely linearity, LOD and LOQ, selectivity, precision, and accuracy. In the curcumin standard all parameters have met the requirements, linearity (r = 0.9975), LOD (6.5420 mg/L) and LOQ (21.8067 mg/L), selectivity (Rs = 1.7139). In brand A curcumin tablets, precision (RSD < 5.7%), while for accuracy (recovery 90-107%). The selected method can be used for the determination of curcumin content in temulawak rhizome extract tablet preparations.
Optimasi metode ekstraksi air umbi talas Jepang (Colocasia esculenta (L) Schott)): analisis aktivitas antioksidan, kandungan flavonoid, dan kadar luteolin Desmiaty, Yesi; Sandhiutami, Ni Made Dwi; Okta , Fauzia Noprima; Marvel, Nadya Sekar; Sumiyati , Yati
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.574

Abstract

Japanese taro (Colocasia esculenta (L) Schott)) is one of the edible plants that contain phytochemicals such as flavonoids, phenolics, triterpenoids, tannins, and vitamin C which are beneficial to the health of the human body. The compound is also known to have antioxidant activity. Proper extraction can produce quality extracts. This study aims to optimize the extraction method on Japanese taro tubers. Taro tuber was extracted using water with three different temperatures (room temperature, 40℃, and 60℃). The ABTS (2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) method was used to determine the antioxidant activity of the aqueous extract, in addition to determining the total flavonoid content by colorimetric test, and also analyzing the luteolin content by Thin Layer Chromatography (TLC) Densitometry. The total flavonoid content of Taro extracts at room temperature (TERT), 40℃ (TE 40), and 60℃ (TE 60) were 13.97±3.52 mg QE/gr extract; 7.99±2.10 mg QE/gr extract; and 5.98±0.49 mg QE/gr extract, respectively. Luteolin content of TERT, TE40, and TE60 were 0.27%±0.08; 0.25%±0.06; and 0.31%±0.05, respectively. Antioxidant IC50 values of TERT, TE40, and TE60 were 120.32, 137.03, and 159.37 µg/mL, respectively. The study shows that the greater the temperature in the extraction process, the less flavonoid and antioxidant compounds content. While there is a slight difference in determining luteolin levels, optimum luteolin content is obtained at 60°C for 6 hours.
Pengaruh gel ekstrak induk kunyit (Curcuma longa linn) terhadap penyembuhan luka sayat pada tikus putih jantan (Rattus norvegicus) Kaban, Vera Estefania; Nasri, Nasri; Rani, Zulmai; Suci, Nurul; Karo Sekali, Elva Swandi; Sagala, Hasel Untung Bersinar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.590

Abstract

One plant that has been shown to aid wound healing is turmeric. Turmeric has been scientifically proven to have choleretic and anti-inflammatory properties. Turmeric contains curcumin, which has antibacterial and antioxidant qualities that can accelerate the migration and re-epithelialization of cells useful in wound healing, including myofibroblasts, fibroblasts, and macrophages. This study aimed to determine the effect of turmeric mother extract gel on wound healing in male white rats (Rattus norvegicus). This study was conducted using experimental tests. Turmeric extract was prepared using 96% ethanol solvent with a maceration process. A 2 cm long incision wound was made on the back of white rats. The test animals were then divided into five groups to receive different treatments. Groups 3, 4, and 5 received turmeric mother extract gel with concentrations of 1%, 5%, and 10%, while Group 1 was negative control and Group 2 was positive control. The results showed that the incision wounds in male white rats could heal faster - on average, about 7.10 days - when treated with 96% ethanol extract of turmeric mother with doses of 1%, 5%, and 10%. This study concludes that a 10% turmeric mother extract gel is the best method to accelerate wound healing.

Page 34 of 66 | Total Record : 654

 32   33   34   35   36 

Filter by Year

2018 2026


Reset
Filter By Issues
All Issue JPS Volume 9 Nomor 1 (2026) JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue