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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Formulasi liniment kombinasi jahe merah (Zingiber officinale var. rubrum Theilade) dan atsiri daun peppermint (Menthae piperitae L.) sebagai aromaterapi Limbong, Yulia Safitri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.728

Abstract

Pendahuluan: Minyak atsiri dapat digunakan dalam penggunaan obat luar, seperti lulur, minyak pijat, lotion, pengharum ruangan dan sebagainya. Minyak atsiri dapat digunakan secara langsung. Tujuan: Penelitian ini bertujuan untuk mengetahui kombinasi minyak atsiri Jahe Merah (Zingiber officinale var. rubrum Theilade) dan daun peppermint (Mentha piperita L.) dapat diformulasikan menjadi sediaan liniment sebagai aromaterapi. Metode: Penelitian ini dilakukan secara eksperimental yaitu untuk mengetahui suatu gejala atau pengaruh yang timbul sebagai akibat dari adanya perlakuan tertentu, meliputi penyiapan sampel, formulasi sediaan, evaluasi terhadap mutu fisik sediaan seperti uji organoleptis, uji homogenitas, uji pH, uji iritasi dan uji kesukaan (hedonik). Hasil: dari penelitian ini menunjukkan Pemeriksaan organoleptis sediaan liniment dari minyak atsiri jahe Merah dan daun Peppermint berbentuk cairan jernih, beraroma jahe merah dan mint, berwarna kuning. Sediaan homogen dan sesuai syarat pH yang baik. Tidak menimbulkan iritasi. Konsentrasi terbaik yang digunakan dalam pembuatan formulasi sediaan liniment kombinasi minyak atsiri Jahe Merah dan minyak atsiri daun peppermint aromaterapi adalah (20% : 20%) kerena memiliki aroma dan rasa yang nyaman terhadap panelis.. Kesimpulan: menunjukkan Minyak atsiri Jahe Merah kombinasi daun peppermint dapat diformulasikan menjadi sediaan liniment sebagai aromaterapi dengan Konsentrasi terbaik yaitu F3 (20% : 20%).
Analisis docking tanaman meniran (Phyllanthus niruri L.) terhadap penghambatan asetilkolinesterase penyakit alzheimer Silalahi , Ali Affan; Shufyani , Fahma; Siregar , Syati Manaharawan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.731

Abstract

Meniran plants (Phyllanthus niruri L.) are plants of the Phyllanthus genus. It is known that Phyllanthus genus plants contain astragaline, phyllanthine, hypopyllanthin compounds. Which is a flavonoid derivative that can function as an inhibitor of acetylcholinesterase enzyme against Alzheimer's disease. Based on the results of molecular docking, astragaline compounds have the best binding affinity compared to other compounds, namely -8.4 kcal/mol while the nativ ligand is -5.8 or in other words astragaline compounds derived from meniran plants (Phyllanthus niruri L.) can react when the drug binds to the target receptor in Alzheimer's disease. This type of research aims to determine the potential of compounds from the meniran plant (Phylanthus niruri L.) by inhibiting acetylcholinesterase in Alzheimer's disease. This study used molecular docking method with autodock vina program and visualized with discovery studio program. The conclusion of the study can be seen from the results of docking visualization which shows the form of hydrogen conventional that dominates the hydropobic bond. The interaction that occurs on the active side of the protein indicates that the compound has the ability. In other words, the compound can react as a drug when it binds to the target receptor in Alzheimer's disease.
Gambaran budaya keselamatan pasien di rumah sakit Izza Karawang Tahun 2024 Dewi, Marhindayani; Damayanti, Rita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.737

Abstract

This study was conducted to describe the patient safety environment developed by Izza Hospital, Karawang, using the Hospital Survey on Patient Safety Culture (HSOPSC) instrument developed by the Agency for Healthcare Research and Quality (AHRQ). The research method used a quantitative descriptive design with a survey approach, involving 326 respondents from medical and non-medical personnel who were directly related to patient care. The sampling technique was accidental sampling, and data were analyzed using univariate analysis for the frequency distribution of the 12 dimensions of patient safety culture. The findings showed that most respondents were nurses (62.9%) with 1-5 years of service (38%) and working hours >40 hours per week (64%). The assessment of the work unit showed the majority in the “good” category (56%), while the most patient safety reports were 1-2 reports per year (35%). Most indicators of patient safety culture showed positive responses, such as teamwork (97%) and open communication (66-81%). However, there were challenges in indicators such as response to errors and staff courage to ask critical questions. In conclusion, the patient safety culture at Izza Hospital is in the “good” category but needs specific improvements in certain dimensions to support more optimal patient safety. These results provide insights for the hospital in formulating strategies for continuous improvement of patient safety culture.
Efektivitas sediaan spray ekstrak etanol Gracilaria sp. sebagai penolak nyamuk Aedes aegypti Puspita, Wana; Pratami, Gina Dania; Setyaningrum, Endah; Nurcahyani, Nuning
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.753

Abstract

Dengue Hemorrhagic Fever or commonly known as DHF is a disease that is transmitted through the bite of female Aedes aegypti mosquitoes which carry the Dengue virus so that it can cause Extraordinary Events (KLB). Prevention of dengue fever is generally carried out using refills containing the chemical DEET (N,N-diethyl-meta-toluamide) which is dangerous for the skin. Gracilaria sp. It is known to contain compounds that are toxic to mosquitoes, such as alkaloids, flavonoids, steroids, saponins, tannins and triterpenoids. This research aims to see the effectiveness of the ethanol extract of Gracilaria sp. as a repellent for Ae. aegypti, Effective Concentration 50% (EC50), irritating effects, and physical properties of the ethanol extract spray preparation of Gracilaria sp. The research was carried out with methodology in accordance with the recommendations of the World Health Organization Pesticides Evaluation (WHOPES) using a Completely Randomized Design (RAL). The protective power provided by the ethanol extract of Gracilaria sp. analyzed using Oneway ANOVA, followed by the Least Significant Difference (LSD) test. Probit analysis was carried out to determine the effectiveness of the ethanol extract concentration of Gracilaria sp. as a repellent. The research results show that concentration levels of 5%, 10%, 15%, and 20% provide protective power capabilities of 14.40%, 31.81%, 47.76%, and 61.17% respectively with an EC50 value of 18.86%. The spray is homogeneous and does not cause skin irritation. Conclusion, spray preparations containing ethanol extract of Gracilaria sp. potential as a repellent for Ae. aegypti. Using this repellent can help reduce the risk of dengue fever which is transmitted by mosquitoes. Further research is needed on the effectiveness of Gracilaria sp. as a repellent with a concentration above 20% and an irritation test was carried out on > 10 probands for > 15 minutes by spraying the preparation repeatedly.
Formulasi orally disintegrating tablet dari serbuk kembang kol (Brassica oleracea var. botrytis L.) dengan variasi konsentrasi sari tapai sebagai disintegrant Lestari, Sri Indah; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.773

Abstract

Cauliflower (Brassica oleracea var. botrytis L.) has a nutritional content consisting of calcium, magnesium, potassium, phosphorus, and low saturated fat. It has vitamin C, which helps increase body immunity. Orally Disintegrating Tablet preparations can dissolve quickly when placed on the tongue, formulated for ease of use of drugs for patients who have difficulty swallowing. Therefore, disintegrants are very important in ODT preparations. Tapai extract has a sweet, slightly sour taste and disintegrates immediately when placed on the tongue. This research aimed to determine whether cauliflower powder with tapai extract disintegrants can be formulated into ODT preparations and which formulation is the best.  This research included characterization of simplicia, making pre-formulation by mixing all ingredients, evaluating pre-formulation, and tablet printing by direct compression method. Then, the tablet evaluation was carried out. The disintegrant was tapai extract with 5%, 7.5%, and 10% concentrations. Data were analyzed using the One Way ANOVA method. The results of the formulation evaluation, the flow time test obtained <10 seconds, which is easy to flow; the angle of repose test obtained 26˚, the category is very good; and the compressibility test obtained 18-20%, which is quite good. The results of the tablet evaluation in the organoleptic test obtained round tablets, sweet taste, brownish-white color, and distinctive odor. The weight uniformity test on all formulas did not have any deviating weights; the size uniformity test met the requirements, the hardness test obtained 1-3 kg, the friability test obtained 0.4-0.7%, the petri dish disintegration time test obtained 44.07-52.48 seconds, and the mouth disintegration time test obtained 53.07-57.78 seconds and the wetting time test obtained 53.21-54.87 seconds. The best formula is formula 3, with a 10% tapai extract concentration.
Studi pemanfaatan ekstrak kulit batang jamblang (Syzygium cumini L.) sebagai alternatif pewarna rambut berbasis herbal Muzakkir , Muzakkir; Sembiring, Fanny Rizki; Indriana , Meutia; Salman, Salman
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.795

Abstract

Hair dye is a cosmetic product used to restore or alter hair colour. Research on herbal-based hair dyes has expanded with the growing interest in natural ingredients. The bark of the jamblang tree (Syzygium cumini L.), which produces a black pigment, has long been utilised in various crafts. This potential makes it a candidate for natural hair dye. This study examines the use of ethanol extract from jamblang bark in the formulation of herbal hair dye and its effectiveness in producing a black colour. The research aims to investigate the utilization of ethanol extract from jamblang bark (Syzygium cumini L.) as an herbal hair dye. The focus is on evaluating the extract's effectiveness in a formulation with pyrogallol, copper (II) sulfate, and xanthan gum, as well as determining the optimal concentration to achieve black hair colour. The method for preparing the hair dye formulation involved the use of ethanol extract from jamblang bark in varying concentrations of 5%, 7.5%, 9.5%, and 11.5%, with the addition of 2% each of pyrogallol, copper (II) sulfate, and xanthan gum. Distilled water was used as the solvent. The dyeing process was conducted by immersing 200 strands of grey hair in preparation for 4 hours, followed by visual observation of colour changes. Colour stability was tested through 15 wash cycles and exposure to sunlight for 5 hours. An irritation test was also conducted on volunteers to evaluate the safety of the hair dye preparation. The study's results indicate that increasing the concentration of ethanol extract from jamblang bark affects the effectiveness of hair dyeing. The optimal formulation was achieved at a 7.5% extract concentration with the addition of 2% pyrogallol, 2% copper (II) sulfate, and 2% xanthan gum, which resulted in black colour. Stability tests showed that the colour remained unchanged after 15 wash cycles and 5 hours of sunlight exposure. Furthermore, the irritation test on volunteers demonstrated that the preparation did not cause skin irritation reactions. Thus, the ethanol extract of jamblang bark has the potential to serve as a safe natural hair dye, offering good colour stability and effectiveness in darkening grey hair.
Penetapan kadar flavonoid total dan aktivitas antioksidan ekstrak etanol, fraksi n-heksan, etil asetat daun senggani (Melastoma candidum D.Don) secara spektrofotometri visibel Apmarja, Sarah Utami; Nasution, Muhammad Amin; Nasution , Haris Munandar; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.797

Abstract

Medicinal plants are natural sources that have antioxidant activity, characterized by the content of phenolic and flavonoid components in reducing free radicals which depends on the number of hydroxyl groups in their molecular structure. One of the plants that contain flavonoid compounds which have antioxidant activity is senggani leaves (Melastoma candidum D.Don). This research aimed to determine the chemical compounds contained in the ethanol extract, to determine the total flavonoid value of the ethanol extract, the ethyl acetate fraction and the n-hexane fraction and to determine the antioxidant activity of the ethanol extract, the ethyl acetate fraction and n-hexane fraction. The stages of this research include processing plant materials, making ethanol extract, making ethyl acetate fraction and n-hexane fraction, characterization examination, phytochemical screening, and determining the total flavonoid content of ethanol extract, ethyl acetate fraction and n-hexane fraction of senggani leaves using Visible and Spectrophotometric methods. Determination of the antioxidant activity of ethanol extract, ethyl acetate fraction, and n-hexane fraction using different techniques, namely DPPH with ABTS. The results of phytochemical screening on simplicia powder and ethanol extract contained chemical compound groups such as alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. The results of determining the total flavonoid content in the ethanol extract of senggani leaves were 44.7805 ± 0.176606439 mgQE/g; In the ethyl acetate fraction, it was 48.421 ± 0 mgQE/g, and in the n-hexane fraction it was 31.491 ± 0.091844121 mgQE/g. The results of antioxidant activity using the DPPH method obtained an IC₅₀ value for the ethanol extract of 12.51 (μg/ml); in the ethyl acetate fraction of 9.42 (μg/ml); in the n-hexane fraction, it was 40.45 (μg/ml), and in the vitamin C standard it was 4.32 (μg/ml). Antioxidant results using the ABTS method obtained an IC₅₀ value for the ethanol extract of 8.21(μg/ml); in the ethyl acetate fraction of 5.93(μg/ml); in the n-hexane fraction, it was 23.35(μg/ml), and in the vitamin C odor it was 2.65(μg/ml).
Penetapan kadar flavonoid ekstrak metanol kulit kayu raru (Cotylelobium lanceolatum Craib) pada variasi konsentrasi pelarut menggunakan metode spektrofotometri UV-Vis Nasution, Kartika Zsaskia; Daulay, Anny Sartika; Ridwanto, Ridwanto; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.724

Abstract

The use of plant-based traditional medicine remains a common practice in developing countries, with more than 80% of the population relying on it for healthcare and treatment. In Indonesia, natural medicines continue to be a primary choice for public health, aligning with local traditions and cultural practices. One such medicinal plant is raru bark, which possesses various pharmacological activities, including antidiabetic, astringent, antilaxative, antibacterial, antiseptic, antidiarrheal, and blood-clotting properties. This study aims to characterize the methanol extract of raru bark and determine its flavonoid content using UV-Vis spectrophotometry. The research stages included plant material processing, methanol extraction, characterization tests, macroscopic and microscopic examinations, phytochemical screening, and flavonoid quantification. Phytochemical analysis revealed that the methanol extract of raru bark contains flavonoids, tannins, saponins, and triterpenoids. Characterization tests showed that all evaluated parameters met the required standards. Flavonoid quantification was performed by determining the maximum wavelength of quercetin using UV-Vis spectrophotometry at different solvent concentrations. The results indicated that the total flavonoid content at a 96% solvent concentration was 1.625 ± 0.153 mgQE/g, at 70% was 1.318 ± 0.003 mgQE/g, and at 50% was 1.146 ± 0.006 mgQE/g.
Analisa Waktu Tunggu Dalam Pelayanan Resep pada Pasien Rawat Jalan di Instalasi Farmasi RSUD dr. Hadrianus Sinaga Pangururan Tahun 2023 Dewi Ginting, Fitri; Manurung, Kesaktian; E Sitorus, Mido; Nababan, Donal; Lina Tarigan, Frida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.780

Abstract

Quality of health services is one approach or effort that is fundamental in providing health services to patients. As a professional person in the field of health services, both individually and in groups, you must always try to provide good quality health services to all patients, Without exception. One of the most essential parts of a hospital is the pharmacy installation. Pharmacy installations are an inseparable part of a complete hospital health service system. The pharmacy installation is responsible for procuring and presenting drug information to all parties in the hospital and developing extensive and well-coordinated pharmaceutical services to meet and provide good service to patients. Servicing old prescriptions to outpatients in the pharmacy installation can cause patient dissatisfaction, impacting the quality of service and hospital. This makes researchers interested in analyzing the waiting time in prescription services for outpatients in the pharmacy installation at RSUD dr. Hadrianus Sinaga Pangururan in 2023. Research Focus on Waiting Times for Prescription Services for Outpatients at the Pharmacy Installation at RSUD dr. Hadrianus Sinaga Pangururan in 2023. The research subfocus is: What is the flow of patient prescription services, what causes the lengthening of waiting times for patient prescription services, and what is the impact of extending waiting times for outpatient prescription services at the pharmacy installation at RSUD Dr. Hadrianus Sinaga Pangururan? Type of Research: This research is survey research using a qualitative approach and an in-depth interview method. Research Location: This research was carried out at RSUD dr. Hadrianus Sinaga Pangururan. Based on the research results on analyzing waiting times for outpatient services at the pharmacy installation at RSU dr. Hadrianus Sinaga In 2023, the results can be taken: The lengthening of waiting times that occurs in Outpatient Pharmacy Installations due to the availability of medicines that often happen in vacancies. The extended waiting time occurs in the Outpatient Pharmacy Installation because writing labels takes a long time. The extended waiting time at the Outpatient Pharmacy Installation is due to taking one month's prescription, which must go through the verification stage. The impact of extending the waiting time in the Outpatient Pharmacy Installation is that patients' dissatisfaction is indicated by protesting and getting angry. The effect of lengthening waiting times in Outpatient Pharmacy Installations due to the unavailability of medicines causes patient management to be hampered.
Evaluasi Hubungan Kualitas Pelayanan Kesehatan Terhadap Kepuasan Pasien di Instalasi Rawat Jalan Rumah Sakit Umum Daerah Tarutung Tahun 2023 Hutabarat, Andrian; Manurung, Kesaktian; Lina Tarigan, Frida; Nababan, Donal; Sipayung, Rosetty
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.781

Abstract

This study aims to evaluate the relationship between the quality of healthcare services and patient satisfaction at the Outpatient Installation of Tarutung Regional General Hospital in 2023. The research employed a cross-sectional design, focusing on five dimensions of service quality: tangible (facilities), reliability, responsiveness, assurance (quality assurance), and empathy. Data were collected through questionnaires administered to 96 outpatients from September 2023 to February 2024. The results indicate excellent overall service quality at the Outpatient Installation of Tarutung Regional General Hospital. However, certain dimensions require improvement, such as responsiveness (10.5% rated as poor), assurance (6.10%), tangible (6.30%), empathy (5.20%), and reliability (9.40%). While 72.9% of patients expressed satisfaction, 27.1% reported dissatisfaction. Statistical analysis revealed a significant relationship between healthcare service quality and patient satisfaction (p < 0.05). These findings underscore the importance of enhancing service quality, particularly in the underperforming dimensions, to improve patient satisfaction. This study provides practical contributions for hospital management in designing strategies to improve the quality of service.

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