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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Konsentrasi hambat minimum dan konsentrasi bunuh minimum ekstrak etanol dan nanopartikel ekstrak etanol daun matoa (Pometia pinnata) terhadap Cutibacterium acnes Safira , Liyuza; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.786

Abstract

Infectious diseases are caused by the entry and proliferation of microorganisms, including bacteria, fungi, parasites, and viruses. These diseases occur when microbial interactions lead to host tissue damage, resulting in various clinical symptoms and signs. This study aimed to formulate nanoparticles of ethanol extract from matoa leaves and compare the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, as well as evaluate the antibacterial activity of both the extract and its nanoparticles against Cutibacterium acnes. This research was conducted experimentally. The independent variables were the concentrations of matoa leaf extract (6.25%, 12.5%, 25%, and 50%) and matoa leaf extract nanoparticles (0.625%, 1.25%, 2.5%, and 5%). The dependent variable was the antibacterial activity of both formulations against Escherichia coli and Cutibacterium acnes. Nanoparticle size characterization was performed using a Particle Size Analyzer (PSA), yielding an average size of 528.95 nm. The MIC values for C. acnes were 12.5% for the extract and 1.25% for the nanoparticles, while the MBC values were 50% and 5%, respectively. The highest antibacterial activity of matoa leaf ethanol extract against C. acnes was observed at a concentration of 50% (inhibition zone: 27.86 mm), whereas the nanoparticles exhibited a maximum inhibition zone of 26.53 mm at a 5% concentration. These findings indicate that matoa leaf extract nanoparticles exhibit strong antibacterial activity against C. acnes at lower concentrations compared to the crude extract, suggesting their potential as an effective antibacterial agent. 
Uji aktivitas antioksidan dan toksisitas dari ekstrak kayu kuning (Arcangelisia flava (L.Merr)) Shilvia, Fatin; Daulay, Anny Sartika; Ridwanto, Ridwanto; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.776

Abstract

Currently, people are beginning to shift towards traditional medicine using natural ingredients. One of the medicinal plants is Yellow Wood (Arcangelisia flava (L.) Merr). Yellow wood has been proven to have antioxidant, antimalarial, antidepressant, antidiabetic, and anticancer activities. The purpose of this study is to determine the antioxidant activity of yellow wood by analyzing its IC50 value and to evaluate the toxicity of yellow wood extract by determining its LC50 value. In this study, the antioxidant activity of the extract was tested using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, while the toxicity of yellow wood extract was assessed using the brine shrimp lethality test (BSLT) method with several concentration variants. The analysis of antioxidant activity in yellow wood using the 1,1-diphenyl-2-picrylhydrazyl method resulted in an IC50 value of 9.65 µg/ml, while vitamin C had an IC50 value of 3.96 µg/ml. Based on these results, both yellow wood and vitamin C fall into the category of very strong antioxidant activity. The probit analysis of the toxicity test of yellow wood extract using the brine shrimp lethality test method showed an LC50 value of 287.872 µg/ml, which is categorized as toxic.
Analisis Kepatuhan Pengguanaan Obat Tuberkulosis Pada Penderita TB Paru Di UPT RS Paru Sumatera Utara Tahun 2023 Tinambunan, Sarma; Manurung, Kesaktian; Sipayung, Rosetty; Nababan, Donal; Gultom, Rumondang
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.782

Abstract

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a pressing global health issue, with high incidence and mortality rates. Treatment adherence is a key factor in the success of TB therapy. This study analyzes the factors influencing adherence to TB medication among pulmonary TB patients at UPT Lung Hospital of North Sumatra. The study employed a cross-sectional design with an analytical survey approach. The research sample consisted of 120 pulmonary TB patients undergoing treatment. Data were collected through questionnaires, medical records, and secondary sources and analyzed using the Chi-Square test and logistic regression. The results showed that education level (p-value = 0.03), employment status (p-value = 0.03), knowledge level (p-value = 0.00), and family support (p-value = 0.05) had a significant relationship with adherence to TB medication. Meanwhile, age (p-value = 0.91) and gender (p-value = 0.59) did not show a meaningful relationship. Multivariate analysis identified knowledge and family support as the dominant factors influencing adherence. These findings suggest that education-based interventions and enhanced family support can improve TB treatment adherence. This study recommends developing public health programs to empower patients and their families in TB control efforts.
Determinan Kepatuhan Minum Obat Tuberkulosis Di UPT Puskesmas Garoga Kecamatan Garoga Kabupaten Tapanuli Utara Tahun 2023 Hutauruk, Ricardo; Manurung, Kesaktian; Hutajulu, Johansen; Nababan, Donal; E Sitorus, Mido
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.783

Abstract

Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis, primarily affecting the lungs and transmitted through airborne droplets. As a global health concern, TB requires long-term treatment adherence to ensure successful outcomes. This study aimed to identify determinants of medication compliance among TB patients at the UPT Garoga Community Health Center, North Tapanuli Regency, in 2023. Using a cross-sectional design, data were collected from 42 patients through interviews and medical records. Variables analyzed included age, gender, education, occupation, knowledge, the role of health workers, and medication supervisors (PMO). Univariate, bivariate, and multivariate analyses were conducted to assess relationships between these factors and medication compliance. Results indicated significant associations between compliance and age (p = 0.001), gender (p = 0.006), education (p = 0.001), knowledge (p = 0.002), the role of health workers (p = 0.001), and PMO support (p = 0.002). However, no significant relationship was found between occupation and compliance (p = 0.036). These findings highlight the importance of patient education, health worker involvement, and family support in improving TB treatment adherence. The study underscores the need for targeted interventions to address these determinants and enhance treatment outcomes in TB patients.
Faktor-Faktor Yang Mempengaruhi Kejadian Stunting Di Upt Puskesmas Lumban Sinaga Kecamatan Pangaribuan Kabupaten Tapanuli Utara Tahun 2023 Pakpahan, Leonardo; Manurung, Kesaktian; E Sitorus, Mido; Ketaren, Otniel; Lina Tarigan, Frida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.784

Abstract

Stunting is one of the chronic nutritional problems that remains a global concern, especially in developing countries such as Indonesia. This study aims to identify factors associated with the incidence of stunting in the Puskesmas Lumban Sinaga Pangaribuan District, North Tapanuli Regency. This study is an onservational analytic study with a Case Control approach. This research was conducted from October 2023 to February 2024. The sample in this study were all mothers who had stunting toddlers as many as 75 cases(total population) control samples as many as 75 toddlers who did not suffer from stunting. Data collection using questionnaires and analyzed using logistic regression tests. The results showed that exclusive breastfeeding history (p 0.000), family income (p 0.013), maternal education (p 0.007), parity (0.000) and maternal height (p 0.000) had a significant relationship with the incidence of stunting. It is concluded that the factors associated with the incidence of stunting at the Lumban Sinaga Health Center are exclusive breastfeeding history, family income, maternal education, parity and maternal height with the dominant factor being maternal height. It is recommended for mothers to provide exclusive breastfeeding to babies for the first 6 months of life and continue breastfeeding with complementary foods until the age of 2 years to meet nutritional and immunity needs that are important for optimal growth.
Potensi Aktivitas Antibakteri Ekstrak Etanol Kombinasi Tanaman Herba Ziziphus mauritiana L., Ocimum basilicum Linn. dan Peperomia pellucida L. Kunth Terhadap Staphylococcus Aureus Fadiya , Faras; Fadila, Safira; Safrina, Safrina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.569

Abstract

The study of the combination of herbal plant extracts has become the subject of intensive research to increase the effectiveness of antibacterials in the application of traditional medicine utilization. The study of the combination of herbal plant extracts has become the subject of intensive research to increase the effectiveness of antibacterials in the application of traditional medicine utilization. This study aims to determine the inhibitory power of the combination of medicinal plant ethanol extracts, namely the combination of bidara leaves (Ziziphus mauritiana L.): suruhan herb (Peperomia pellucida L. Kunth); and basil leaves (Ocimum basilicum Linn.):suruhan herb (Peperomia pellucida L. Kunth) against the growth of Staphylococcus aureus. This study is an experimental laboratory study with phytochemical testing, microbiological testing using the disc diffusion method, and analysis of variance (ANOVA) on the inhibitory power of the combination of medicinal plant ethanol extracts, namely the combination of bidara leaves:suruhan herb and basil leaves:suruhan herb, against the growth of Staphylococcus aureus. The results of the phytochemical test showed that the extracts of bidara leaves, basil leaves, and suruhan herbs contain secondary metabolite compounds, namely alkaloids, steroids, saponins, flavonoids, and phenolics. The combination of suruhan herb:bidara leaves (HS:DB) and suruhan herb: basil leaves (HS:DK) extracts has antibacterial activity against Staphylococcus aureus, as indicated by the formation of an inhibition zone in each comparison. The mix of HS:DB and HS:DK extracts is the most effective at killing Staphylococcus aureus bacteria, with an inhibition zone diameter of 16.07 mm for HS:DB and 15.5 mm for HS:DK. The average area of the inhibition zone is half the area of the inhibition zone in the positive control (ciprofloxacin), with an average of 32.70 mm. The results of the one-way ANOVA test continued with the Duncan test, which stated that each single treatment and combination of extracts were able to inhibit the growth of Staphylococcus aureus, which showed a P value of 0.05.
Analisis efektivitas antibiotik levofloxacin dan ceftriaxon pada pasien pneumonia di instalasi rawat inap RSD X Kota Cirebon Tahun 2023 Efriani, Like; Putra , Teguh Adiyas; Fitriyani, Fifit
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.594

Abstract

Pneumonia is inflammation caused by microorganisms such as bacteria, viruses, fungi, and foreign substances that enter the lungs. The therapeutic management of pneumonia is given antibiotics to eliminate the causative bacteria and overall healing. Conceptually, levofloxacin antibiotics are considered better for pneumonia therapy than ceftriaxone. This study aimed to determine the effectiveness of comparing levofloxacin and ceftriaxone antibiotics in pneumonia patients in the inpatient installation of RSD X Cirebon City. Parameters to determine the effectiveness of antibiotics based on body temperature and length of stay (LOS). This study used a retrospective cross-sectional research design. Patient data from medical records were 91 samples that met the inclusion criteria. Data analysis included patient characteristics, antibiotic use, and therapy effectiveness data. Data were tested statistically using Mann-Whitney. The results showed that the comparison of levofloxacin and ceftriaxon had different effectiveness as antibiotic therapy in pneumonia patients hospitalized in RSD X Cirebon City, except based on length of stay.
Formulasi,dan Karakteristik Mutu Fisik serta Evaluasi Nilai Sun Protection Factor Sabun Transparan Ekstrak Daun Sirih Merah Yuniarti, Rafita; Nasution, Haris Munandar; Dachban, Syarifa Mayly B.; Putri, Nadya Iwani; Luthfianida, Arifna; Wahdaniati , Tri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.705

Abstract

The sun emits ultraviolet radiation and can produce free radicals. If these free radicals continue to come into contact with the skin excessively, they can damage cells and eventually cause cancer. Sun Protection Factor (SPF) is a substance that protects the skin from ultraviolet rays. The capacity of a product to shield the skin is indicated by its SPF rating. Soap is a type of formulation that individuals frequently utilize. Red betel leaf extract can protect the skin from the harmful effects of free radicals and is expected to increase the soap's ability to protect the skin from exposure to sunlight and maintain skin health. The methods include making transparent soap, testing physical quality, and determining the sun protection coefficient at various red betel leaf ethanol extract concentrations. The result is a transparent black-green soap with a pH of 9, a foam height of 57-65 mm, and a water content of <15%. At a concentration of ethanol extract of 0%, the SPF value is 3, and the SPF values are 7.5 (10%), 12.28 (30 and 50%), 18.2 (70%), and 25 (90%). From this information, it can be inferred that clear soap created with red betel leaf extract possesses excellent physical attributes and effectively protects against sun exposure.
Kajian mikrobiologi ekstrak terpartisi Annona muricata Lim. Folium terhadap Propionibacterium acnes dan Staphylococcus aureus Gemantari, Baiq Maylinda
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.745

Abstract

Annona muricata is a plant broadly reported to have various medicinal benefits and has been widely used around the world. The leaves are a part reported to have antimicrobial activity. This study aimed to determine the antimicrobial properties of A.muricata leaves partitioned extract against Propionibacterium acnes and Staphylococcus aureus. The partitioned extract was obtained by liquid-liquid partition of ethanolic extract using N-hexane, ethyl acetate, and ethanol. An antimicrobial study was conducted using the Kirby-Bauer method. The result showed that at the highest concentration model used, antimicrobial activity was shown in N-hexane partitioned extract and ethyl acetate partitioned extract. Those properties were known to correlate with some groups of secondary metabolites, including flavonoid, steroid, phenolic, and saponin.
Perbandingan metode ekstraksi maserasi dan sokletasi terhadap kadar fenolik total ekstrak etanol daun sirih (Piper betle L.) secara spektrofotometri visibel. Priyadi, Agus; Harun , Fatur Rahman; Daulay , Anny Sartika; Ridwanto, Ridwanto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.818

Abstract

Betel leaf (Piper betle L) is a plant widely used as a traditional medicine capable of treating various diseases without causing side effects due to bioactive compounds, one of which is phenolic. This research aims to identify the chemical compounds present in the ethanol extract and determine the total phenolic content of the ethanol extract of betel leaf (Piper betle L). The research method employed is an experimental approach, which includes plant material processing, ethanol extract preparation through maceration and Soxhlet extraction, characterization analysis, phytochemical screening, and determination of the total phenolic content of the ethanol extract of betel leaf using UV-Vis spectrophotometry. The betel leaf extract was prepared using maceration and Soxhlet extraction. The obtained extract was concentrated using a rotary evaporator. Subsequently, the total phenolic content was determined using Visible Spectrophotometry. The phytochemical screening of the ethanol extract of betel leaf revealed the presence of chemical compound groups such as alkaloids, flavonoids, saponins, tannins, steroids or triterpenoids, and glycosides. Total phenolic content was determined by determining the wavelength of gallic acid and operating time, measuring the gallic acid calibration curve, and calculating the total phenolic content using visible spectrophotometry. The results of the total phenolic content determination for the maceration extract were 19.61 ± 0.19716 mg GAE/g, and for the Soxhlet extraction, it was 29.79 ± 1.91040 mg GAE/g.

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