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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Efektivitas krim ekstrak daun melinjo (Gnetum gnemon L.) terhadap jumlah sel fibroblas pada luka bakar derajat II dalam tikus putih (Rattus norvegicus) Sulaiman, Azhari Athaillah; Maslachah, Lilik; Utama, Suzanita; Yuniarti, Wiwik Misaco; Sukmanadi, Moh.; Hidajati, Nove
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.693

Abstract

Burn wound is an injury that causes tissue damage, typically due to contact with a heat source. Fibroblasts have an important role in wound healing, synthesizing collagen as the main constituent of the extracellular matrix which is important in wound integrity. The purpose of this study was to determine the effectiveness of cream of melinjo (Gnetum gnemon L.)  leaf extract on the number of fibroblast cells in deep partial thickness burn in white rats (Rattus novegicus). Twenty male white rats (Rattus norvegicus) were divided into five treatment groups, with four replications in each group, and were induced with in deep partial thickness burn. The negative control group (K-) was treated with cream base, the positive control group (K+) was treated with Silver Sulfadiazine, while P1, P2, and P3 group was treated with respectively 2.5, 5 and 10% melinjo (Gnetum gnemon L.) leaf extract cream. Therapy was given twice a day for 14 days. Oneway ANOVA showed significant differences between each treatment group (p <0.05) and continued with the Duncan test. The average number of fibroblasts in each treatment group showed that the K- were significantly different from the K+, P2, P3 groups but not P1. The lowest mean number of fibroblast cells was found in the K- group. The conclusion from the research that has been carried out was that melinjo (Gnetum gnemon L) leaf extract cream decrease the number of fibroblast cells in second-degree burns wounds in white rats (Rattus norvegicus).
Hubungan pengetahuan ibu dengan tindakan manajemen swamedikasi pada anak balita di Desa Ketapang Dua Aceh Timur. Shufyani, Fahma; Siregar, Syati Manaharawan; Dominica, Dwi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.727

Abstract

Introduction: Self-medication is something that is often practiced by the Indonesian community as a way to take care of themselves when they are sick. Taking and consuming medication without advice from a healthcare professional, whether for diagnosis, prescription, or health supervision, is called self-medication. Self-medication can provide significant benefits to the government in maintaining national health if done correctly. Self-medication can assist healthcare professionals, reduce the time spent waiting for a doctor's diagnosis, and save money, especially in developing countries, because healthcare professionals will be more focused on more serious and critical health conditions. Objective: This study aims to determine mothers' knowledge about self-medication for fever and to understand the self-medication actions taken by mothers, as well as to examine the relationship between mothers' knowledge and their self-medication actions for fever in toddlers in Ketapang Dua Village, East Aceh. Method: This study uses a quantitative method of a descriptive-analytical nature with a cross-sectional design. The sampling technique used purposive sampling. Data were analyzed using the Chi Square test. Data collection was conducted in July 2024. The research population is the knowledge of mothers regarding self-medication management for toddlers in Ketapang Dua Village, East Aceh. The sample of this study consists of 40 respondents. Results: from this study indicate that 35% of mothers have a fairly good level of knowledge about self-medication for fever. Self-medication for fever in toddlers shows that around 47.5% have taken appropriate actions. There is a significant relationship between maternal knowledge and self-medication actions for fever in toddlers in Ketapang Dua Village, East Aceh, with a p-value of 0.026 < 0.05. It can be concluded that the presence of maternal knowledge regarding self-medication for fever in toddlers in Ketapang Dua Village, East Aceh, is classified as quite good. The conclusion: of this study is that the frequency distribution of maternal knowledge shows that some have fairly good knowledge, with 14 respondents (35.0%) and respondents with less adequate knowledge amounting to 21 respondents (65.5%). The frequency distribution of fever self-medication actions shows that some mothers provided appropriate self-medication actions, with 19 respondents (47.5%) doing so, while 21 respondents (52.5%) provided less appropriate self-medication actions. There is a significant relationship between maternal knowledge and self-medication practices for fever in toddlers in Ketapang Dua village, East Aceh, with a p-value of 0.026 > 0.05.
Pengaruh penambahan ekstrak kental daun kelapa sawit (Elaeis Guineensis Jacq.) terhadap viskositas krim tabir surya antijerawat Dominica, Dwi; Putri , Yona Harianti; Versita , Riana; Shufyani , Fahma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.729

Abstract

Introduction: ROS due to sun exposure can damage the skin. Skin structures that are damaged or thinned cause the risk of acne on the skin, one of which is that the skin can be infected with acne-causing bacteria. Palm leaf (Elaeis guineensis Jacq.) is one of the plants that has good antioxidants and antibacterial. The aim: This study aims to determine the effect of the addition of extracts on the viscosity of anti-acne sunscreen creams. Methods: This study was experimental by conducting a viscosity test of sunscreen preparations using a brokfield viscometer. The results of this study show that Formula F1 (1.5%) has the highest viscosity of 8,970 cPs, followed by F2 (3%) at 7890 cPs, and F3 (4.5%) at 7090 cPs which is included in the good viscosity range. Sunscreen creams have pseudoplastic flow properties. Conclusion: the higher the concentration of the extract, the greater the viscosity of the preparation.
Formulasi salep sari batang daun talas (Colocasia esculenta L. ) schoot pada penyembuhan luka sayat pada tikus putih jantan (Rattus norvegicus) Ardiani, Rani; Shufyani, Fahma; Siregar, Syati Manaharawan; Silalahi , Ali Affan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.730

Abstract

Introduction: Taro contains several compounds that can accelerate wound healing, such as flavonoids, phenols, and saponins. These compounds act as natural antibiotics, cleansing wounds with their antibacterial and antifungal properties. Therefore, this plant can aid in the wound healing process. Tannins, on the other hand, have the ability to constrict blood vessels and reduce bleeding in the wound area, decrease infection, and aid in wound healing during the inflammatory phase. One of the wound healing factors, vitamin C helps strengthen the walls of blood vessels, especially in the injured area, to maintain blood supply there and assist in accelerating collagen synthesis during the wound healing process. Lectin, a substance that can accelerate wound closure by aiding better cell regeneration. Arecaceae plants have many benefits for society, such as being used as a food source by harvesting their tubers, or being used as ornamental plants that beautify yards. Taro is also used as medicine both internally and externally. Almost all parts of the taro plant are processed into medicines, and the tubers, stem bark, and roots are crushed and then applied to the skin to heal wounds or bruises. Objective: This study aims to determine the wound healing effects of the sap from the taro stem (Colocasia esculenta L) Schott on male rats (Rattus norvegicus). Method: This study uses an experimental method, which includes sampling, preparation of taro leaf stem extract with concentrations of 2%, 4%, 6%, ointment evaluation test, and incision wound healing activity test on white rats grouped into 5 groups, each consisting of 3 rats. Statistical analysis includes one-way ANOVA to see if there is a significant difference between concentrations in the healing of incisional wounds in male white rats. Result: The research conducted shows that F1 (2% concentration) can heal the rats on the 10th day. F2 (4% concentration) the rats healed on the 8th day, F3 (6% concentration) the cut wounds healed on the 7th day, positive control (Betadine ointment) all rats healed on the 7th day. Conclusion: The extract of taro leaf stems (Colocasia esculenta L) Schoot can be formulated into an ointment preparation for the healing of incised wounds in male white rats (Rattus norvegicus), with the most effective concentration being 6% because it can heal incised wounds the fastest among the other concentrations.
Uji efektivitas ekstrak etanol daun bayam hijau (Amaranthus hybridus L.) sebagai imunostimulan pada mencit putih jantan (Mus musculus) Tarigan, Rida Evalina; Sinaga, Arinda Agnes; Shufyani, Fahma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.735

Abstract

The immune system plays a critical role in defending the body against pathogens, and enhancing its activity through immunostimulants is essential for improving health. This study aims to evaluate the immunostimulatory potential of ethanol extract from green amaranth leaves (Amaranthus hybridus L.) in male white mice (Mus musculus). The ethanol extract green amaranth leaves was prepared from dried green amaranth leaves and tested for its effect on phagocytic activity using the carbon clearance method. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, and steroids. The animals were divided into five groups: negative control (0.5% Na CMC), positive control (Stimuno Forte®), and three experimental groups receiving varying doses of the ethanol extract (125 mg/kg, 250 mg/kg, and 500 mg/kg body weight). The results indicated that the ethanol extract significantly enhanced phagocytic activity, with the most optimal effect observed at 125 mg/kg body weight. The stimulation index increased with higher doses, demonstrating the dose-dependent immunostimulatory effect. The study concludes that the ethanol extract of green amaranth leaves can serve as an effective natural immunostimulant, with the 125 mg/kg body weight dose being the most effective in enhancing immune function in male white mice. These findings suggest the potential of green amaranth as a therapeutic agent for immune-related disorders.
Formulasi sediaan lip cream ekstrak etanol bunga kecombrang (Etlingera elatior (Jack) R. M. Sm.) dan bunga rosella (Hibiscus sabdariffa L.) sebagai zat pewarna alami Rumanti, Ruth Mayana; Sari , Rika Puspita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.744

Abstract

Introduction: The kecombrang flower and roselle flower are known as sources of natural antioxidants and have the potential to be used as natural dyes in lip cream products. Both types of flowers contain compounds such as tannins, flavonoids, and saponins. The aims of study to analyze the effect of varying concentrations of ethanol extract from the kecombrang flower (Etlingera elatior (Jack) R. M. Sm.) and the roselle flower (Hibiscus sabdariffa L.) on the color of lip cream formulations. The method of research was conducted through laboratory experiments that included sampling, extract preparation, product formulation, physical quality evaluation, and panelist preference testing. Data were analyzed descriptively by calculating the percentage of preference levels and presented in the form of tables and graphs. The results show that the preparation has a semi-solid texture, with colors ranging from light pink to dark pink in certain combinations, and a purplish pink for the 10% roselle extract formulation. The pH of the preparation is in the range of 5.1-5.4, without coarse grains, good spreadability, an average spread distance of 5.5 cm, an average adhesion time of 12.73 seconds, and no irritation. The cycling test indicates color instability, changing from light pink to dark brownish purple. Based on the hedonic test, formulation F5 has the highest preference level, which is 88.33%. The conclusion of this study is that the ethanol extract of kecombrang and rosella flowers produces a light pink lip cream that is suitable for formulation in lip cream preparations. The higher the concentration of the extract used, the darker the pink color produced, with a texture that tends to be more liquid and a decreasing pH.
Formulasi dan Evaluasi Tablet dengan Bahan Tambahan Tongkol Jagung (Zea mays L.) sebagai pengganti HPMC yang digunakan untuk Anti Diabetes Surbakti, Christica Ilsanna; Suryani , Monica; Nerdy, Nerdy
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.779

Abstract

Corn (Zea mays L) is a food crop that is known and cultivated in developing countries. So far, corn cobs have not been widely used as a value-added product. Corn cobs have 35.5% crude fiber, 2.5% protein, 0.12% calcium, 0.04% phosphorus and the remaining 38.16% of other substances. Corn cobs, which are biomass, contain phenolic phytochemicals which are very likely to be used as active antioxidant ingredients. The choice of method for making tablets is adjusted to the characteristics of the active substance used. In this research, the method used in making metformin HCl tablets was wet granulation. Wet granulation is the process of adding liquid to a powder or powder mixture in a container equipped with stirring which will produce agglomeration or granules. The evaluation results of corn cob additive granules as a substitute for HPMC showed the results of the flow time test (F1 1.5 seconds, F2 1.4 seconds F3 1.63 seconds), F1 angle of repose test (34.96 o, F2 41, 43 o, F3 41.92 o), humidity test (F1 1.794 %, F2 1.999 %, F3 2.331 %) and compressibility test (F1 11 %, F2 15%, F3 8%).  The results of the evaluation of antalgin tablets using corn cobs as a substitute for HPMC showed visual test results where the tablets were round and white in color, the weight uniformity test showed results (F1 A (5%) 708.7-783.3 and column B (10% ) 671.4-820.6, F2 A (5%) 562.775– 705.75 and column B (10%) 571.05-698.6, F3 688.75– 761.25 and column B (10%) 625.5-797.5), size uniformity test shows results (F1 diameter 1.3545 and thickness 0.4705, F2 diameter 1.359 and thickness 0.468, F3 diameter 1.36 and thickness 0.471), fragility test shows results (F1 0 .06978367 %, F2 0.53272451 %, F3 0.06978367 %) and tablet hardness showed results (F1 6.764, F2 4.984, F3 7.89) and disintegration time test showed results (F1 2 minutes, F2 2 minutes, F3 2 minute).
Drug Formulasi paper soap ekstrak etanol dedak padi (Oryza sativa L.) dan uji aktivitas antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus Zannah , Muhamad; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.229

Abstract

Paper soap is soap in the form of thin sheets resembling paper. Rice bran from rice milling waste contains antibacterial compounds. The aim of this research was to formulate paper soap from rice bran ethanol extract and to determine its antibacterial activity. This research is a type of experimental research carried out in a laboratory. Includes steps such as taking and identifying samples, preparing and making ethanol extract of rice bran (Oryza sativa L.), and testing antibacterial activity against Escherichia coli using the Disc Disc method, where the inhibition zone of the ethanol extract of rice bran and the paper soap preparation is containing rice bran extract (Oryza sativa L.) was observed and measured as a result of the antibacterial activity test. The results of this research show that the ethanol extract of rice bran contains chemical compounds, namely alkaloids, flavonoids, saponins, tannins, triterpenoids/steroids and glycosides. Rice bran ethanol extract has characteristics in accordance with the 1989 MMI requirements. The results of determining the antibacterial activity of rice bran ethanol extract produce an inhibition zone against Escherechia coli bacteria ranging from 5mm - 12.5mm and Staphylococcus aureus ranging from 5.5 mm-16.67 mm. The results of the paper soap evaluation test, organoleptic examination, thickness examination, weight uniformity test, stability test, foam power test met the requirements and in the irritation tests F0, F1, F2 and F3 did not irritate the skin, in the hedonic test the most preferred formula was F1. The results of determining the antibacterial activity of paper soap produced an inhibition zone for Escherechia coli bacteria ranging from 8.16mm - 12.5mm and Staphylococcus aureus ranging from 15mm-14.83mm. From the research results it can be concluded that rice bran ethanol extract can be formulated into paper soap and has antibacterial activity.
Evaluasi kesesuaian penyimpanan obat di gudang farmasi puskesmas Ngesrep berdasarkan standar kefarmasian dan Syariat Islam Rini , Tri Diana Puspita; Rochajati , Siti; Najmi , Tusti Naida Pavita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.239

Abstract

Pharmaceutical services are direct services and communication to patients related to pharmaceutical preparations to achieve definite results and improve patients' quality of life. Drug storage is the activity of storing and maintaining by placing received drugs in a place that is considered safe from theft and physical disturbances that can damage the quality of the drug. If there is an error in storing the drug, it will decrease the drug content and result in losses to the Health Center. This study was conducted to distribute the storage of pharmaceutical preparations in the Ngesrep Health Center pharmacy installation warehouse. This study is a type of non-experimental research, namely descriptive research conducted through observation and interviews related to storing pharmaceutical preparations through evaluation based on Permenkes Number 74 of 2016 and the Directorate General of Pharmacy and Medical Devices and analysis of drug storage indicators. Based on the results of the study, it was obtained that the suitability of the spatial storage requirements at the Ngesrep Health Center in 2024 was 90.74%, with excellent information.
Studi perbandingan profil asam lemak minyak ikan lele dan minyak ikan keting melalui pemurnian dengan bentonit Jannah, Nadia Miftahul; Ningrum, Karina Primatyas
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.378

Abstract

In general, fish have high omega-3 and omega-9 fatty acid content and are beneficial for health. This makes fish oil develop into a food supplement. Increasing the amount of free fatty acids in oil can potentially reduce the quality and damage of fish oil. Adsorbents have bleaching properties that can affect color changes in fish oil and fish oil content. This study aims to determine the effect of bentonite adsorbent treatment on the fatty acid profile of catfish oil and keting fish oil analyzed using the Gas Chromatography Mass Spectrometry (GC-MS) method. Catfish oil (CFO) and Keting fish oil (KFO) samples were extracted without using organic solvents and then treated with bentonite as an adsorbent. The extracted oil was derivatized and then injected into the GC-MS instrument system. There were 29 types of fatty acids detected in each sample, namely 12 types of saturated fatty acids (SFA), 8 types of monounsaturated fatty acids (MUFA), and 9 types of double unsaturated fatty acids (PUFA). The effect of purification with bentonite was analyzed using One-way ANOVA from Minitab19 software showing that there were differences in the content of fatty acid profiles of CFO and KFO that were purified and not purified with bentonite, shown in each category of fatty acids SFA, MUFA and PUFA which had a p value <0.05.

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