cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
 48   49   50   51   52 
Uji Aktivitas Antibakteri Formulasi Sediaan Obat Kumur Ekstrak Etanol Daun Senduduk (Melastoma malabathricum L.) Terhadap Pertumbuhan Streptococcus mutans Ayu , Tri Indah Pagar; Nasution , Haris Munandar; Rahayu, Yayuk Putri; Nasution , Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1002

Abstract

Background: Dental caries is a common oral health problem caused by Streptococcus mutans. Antiseptic mouthwash containing natural ingredients like senduduk leaves (Melastoma malabathricum L.) shows potential as an alternative, as it contains antimicrobial compounds (alkaloids, flavonoids, saponins, and tannins). Objective: To determine the antibacterial activity of senduduk leaf ethanol extract mouthwash against S. mutans and evaluate its physical characteristics. Methods: This experimental study included: (1) ethanol extraction of senduduk leaves using 96% ethanol maceration, (2) simplicia characterization and phytochemical screening, (3) formulation of three mouthwash concentrations (2.5%, 5%, 7.5%), (4) preparation evaluation (organoleptic properties, pH, viscosity), and (5) antibacterial activity testing using the well diffusion method. Results: The mouthwash preparation met physical criteria as a light-to-dark brown liquid with pH 6.33-6.43 and viscosity of 4.833-5.726 cps. Antibacterial tests showed dose-dependent effects, with the highest inhibition zone in the 7.5% formula (18.53 mm; strong category). Conclusion: Senduduk leaf extract shows potential as an antibacterial active ingredient in herbal mouthwash against S. mutans in vitro, though further testing (in vivo/clinical trials) is needed to validate therapeutic claims.
Penetapan Kadar Nikotin Tembakau Gayo (Nicotiana tabacum L) Menggunakan Metode Titrasi Asidimetri dan GC-MS. Rezky , Deswita Ina; Supiyani, Supiyani; Daulay, Anny Sartika; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.909

Abstract

Background: Gayo tobacco (Nicotiana tabacum L.) is known for its distinctive quality and is highly sought after, particularly among young adults. This tobacco contains nicotine, a compound that plays a significant role in influencing human behavior, acting both as a stimulant and as a raw material for cigarette production. Understanding the nicotine content in Gayo tobacco is crucial for assessing its potential industrial applications and its impact on health. Objective: This study aimed to determine the nicotine content in Gayo tobacco leaves and analyze it using acidimetric titration and GC-MS methods to obtain more accurate results. Methods: This research employed two analytical methods: acidimetric titration for quantitative nicotine determination and Gas Chromatography-Mass Spectrometry (GC-MS) for qualitative analysis of other chemical compounds in the Gayo tobacco leaf extract. The tobacco leaf samples were obtained from the Gayo region of Aceh and extracted using 96% ethanol. Results: The study revealed that the nicotine content in Gayo tobacco leaves was 1,3% based on acidimetric titration, while the ethanol extract showed a higher nicotine concentration of 2.5%. GC-MS analysis identified various other compounds, including piperidine derivatives, terpenoids, and aromatic compounds, which have potential pharmaceutical and industrial applications. Conclusion: This study successfully determined the nicotine content in Gayo tobacco leaves using acidimetric titration and GC-MS. The findings provide a comprehensive overview of the chemical composition of Gayo tobacco, serving as a foundation for further research into its applications in pharmaceuticals and other industries.
Hubungan Lingkungan, Petugas Kesehatan dan Pola Asuh Ibu yang Bekerja dengan Tumbuh Kembang Bayi di Klinik Pratama Sunggal Aulia , Marshanda Putri; Sephira, Intan Nadya; Sinaga , Jesika Kristin; Sembiring , Juni Kristiani Br; Sidabutar , Liontin; Paninsari, Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.974

Abstract

Background: Infant growth and development during the first 0-12 months represents a crucial phase with long-term impacts on quality of life. Environmental factors, working mothers' childcare practices, and healthcare providers' roles serve as key determinants influencing this process. The risk of developmental delays significantly increases for infants in less supportive environments or those receiving inadequate stimulation. Objective: To analyze the influence of environmental conditions, working mothers' childcare practices, and healthcare providers' roles on the growth and development of infants aged 0-12 months at Sunggal Primary Clinic. Methods: This observational analytical study employed a cross-sectional design involving 35 subjects selected through total sampling. Data collection utilized structured questionnaires and was analyzed using chi-square tests. Results: Statistical analysis revealed significant relationships between environmental conditions and child development (p=0.000, with 62.9% supportive environments), between healthcare providers' roles and development (p=0.000, with 60% adequate services), and between working mothers' childcare practices and development (p=0.000, with 57.1% optimal practices). Conclusion: All three variables significantly influence infant growth and development, indicating the need for an integrated approach to optimize these contributing factors.
The Perbandingan Kualitas Hidup Peserta Prolanis Diabetes Melitus Tipe 2 yang Memperoleh Monoterapi dan Politerapi di Puskesmas Prambanan Sleman Umsipyat , Annis Syafitri; Ananda, Raden Ajeng Dewinta Sukma; Nurinda , Eva; Wulandari, Ari Susiana
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.588

Abstract

Diabetes mellitus (DM) cases in the Yogyakarta Special Region in 2022 reached 42,050 patients (53.9%), with Sleman Regency having the highest prevalence. The therapy received by patients affects their clinical condition and quality of life. This study aims to determine the difference in the average quality of life of Prolanis DMT2 participants receiving monotherapy and polytherapy at Prambanan Public Health Center in Sleman. This research used an observational analytic study with a cross-sectional approach. The sample consists of 34 Prolanis participants at Prambanan Health Center, selected through total sampling. The instrument used is a quality-of-life questionnaire with a reverse Likert scale. The data analysis to measure quality of life is the Mann-Whitney statistics, using independent variables of monotherapy and polytherapy, and the dependent variable of quality of life scores. The majority of respondents are female (22 people, 66.7%), aged 56–65 years (16 people, 47.1%), and have a high school education level (15 people, 44.1%). Most are unemployed (21 people, 61.8%), have had diabetes for ≤ 5 years (26 people, 76.5%), and do not have complications (26 people, 76.5%). The average quality of life score for monotherapy is 28.88, and for polytherapy, it was 41.70. The quality of life for monotherapy is higher than for polytherapy, with a p-value of 0.001 (<0.05). This study aims to determine the difference in the average quality of life between Prolanis DMT2 participants receiving monotherapy and polytherapy at Prambanan Health Center in Sleman. Based on the research results, it was concluded that there is a difference in the average quality of life between Prolanis DMT2 participants at Puskesmas Prambanan Sleman who received monotherapy and those who received polytherapy, with a p-value of 0.001 (<0.05)
Formulasi Dan Uji Aktivitas Antibakteri Sabun Kertas Virgin Coconut Oil (VCO) Dengan Variasi Gliserin Sebagai Plasticizer Terhadap Staphylococcus Aureus Apriani, Aida; Dewi, Resmila; Sidiq, Teuku Sultan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.688

Abstract

Background: Virgin Coconut Oil (VCO) contains medium-chain saturated fatty acids (MCFA), particularly lauric acid, which is known for its antibacterial properties. VCO has the potential to be formulated into a practical and hygienic paper soap dosage form. In paper soap formulation, glycerin acts as a plasticizer that affects the physical properties of the preparation, but its effect on antibacterial activity has not been widely explored. Objective: This study aimed to formulate VCO paper soap with variations in glycerin concentration and to analyze its antibacterial activity against Staphylococcus aureus. Methods: This experimental research formulated four paper soap formulas with variations in glycerin concentration: 0% (F1), 10% (F2), 15% (F3), and 20% (F4). The preparations were evaluated through organoleptic tests, pH tests, foam height tests, and free alkali tests. Antibacterial activity was tested against Staphylococcus aureus using the disk diffusion method (Kirby-Bauer) with a positive control (commercial paper soap) and a negative control (aquadest). Results: The evaluation results showed that all formulas met the physico-chemical quality standards for soap. Formula 3 (15% glycerin) was the best preparation based on overall evaluation. The antibacterial test showed that all four VCO paper soap formulas (F1-F4) had moderate antibacterial activity against Staphylococcus aureus with inhibition zone diameters that were not statistically significantly different. The negative control showed no activity, while the positive control showed strong antibacterial activity. Conclusion: It was concluded that VCO paper soap was successfully formulated and exhibited moderate antibacterial activity against Staphylococcus aureus. Variations in glycerin concentration (0-20%) did not significantly affect the antibacterial activity, which is presumed to be more influenced by the lauric acid content in VCO.
Eksplorasi Aktivitas Antimikroba Bakteri Endofit Daun Betadine (Jatropha multifida L.) terhadap Patogen Staphylococcus aureus Arfiandi, Arfiandi; Fadjria , Neri; Nofita, Dewi; Rahmadini, Mutia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.899

Abstract

Background: Antibiotic resistance has spurred the exploration of novel antibacterial agents, including endophytic bacteria from medicinal plants like Jatropha multifida L. (Betadine leaves), traditionally used as antiseptics. Objective: To assess the antibacterial activity of endophytic bacterial isolates from Betadine leaves against Staphylococcus aureus. Methods: A laboratory-based experimental study employing the paper disc diffusion method. Endophytic isolates were cultured in Nutrient Broth, and centrifuged supernatants were tested for inhibition zones compared to positive (chloramphenicol) and negative (Na.CMC) controls. Results: The endophytic isolate produced a 16.11 mm inhibition zone (moderate activity), while chloramphenicol showed 27.63 mm (strong activity). No inhibition was observed in the negative control. Conclusion: Endophytic bacteria from Betadine leaves exhibit potential as natural antibacterial agents, though their efficacy is lower than standard antibiotics. Further development requires active compound characterization and toxicity studies.
Aktivitas Antijamur Kitosan Dari Cangkang Kerang Bambu (Solen corneus) Pada Pembuatan Hidrogel Terhadap Trichophyton mentagrophytes Hasibuan , Nabila Hasim; Ridwanto, Ridwanto; Nasution , Haris Munandar; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.906

Abstract

Background: Hydrogels are topical preparations applied to the skin surface. Chitosan, a compound derived from the deacetylation of chitin, has various benefits, including antifungal activity. Utilizing waste from bamboo clam shells (Solen courneus) collected in Belawan waters as a source of chitosan could provide a sustainable solution for developing antifungal hydrogel formulations. Objective: This study aimed to produce chitosan from bamboo clam shells, formulate it into a stable hydrogel, and evaluate its antifungal activity against Trichophyton mentagrophytes. Methods: This experimental study involved isolating chitosan through deproteinization, demineralization, depigmentation, and deacetylation steps. The resulting chitosan was characterized by moisture content, ash content, yield, solubility, and functional group identification using FTIR spectroscopy. Subsequently, chitosan was formulated into four hydrogel variations (0%, 2%, 4%, and 6%). The hydrogel formulations were evaluated for organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, and antifungal activity. Results: The produced chitosan exhibited functional groups similar to standard chitosan and a degree of deacetylation of 77.5%. Hydrogel evaluation over three weeks showed good stability, with pH values of 4–6.5, spreadability of 5–7 cm, adhesiveness greater than 1 second, and viscosity ranging from 3,000–50,000 cps, all meeting the required standards. The antifungal test demonstrated that the 6% chitosan hydrogel had the highest inhibition zone (11.5 mm) against Trichophyton mentagrophytes. Conclusion: Chitosan derived from bamboo clam shells was successfully formulated into a stable hydrogel with effective antifungal activity. The 6% concentration exhibited the strongest antifungal effect, indicating its potential as a topical preparation for treating skin fungal infections.
Pengaruh Konseling terhadap Kepatuhan pada Pasien Diabetes Melitus Tipe 2 di Poliklinik Penyakit Dalam Rumah Sakit Umum dr. Ferdinand Lumbantobing Sibolga Panjaitan , Riza Zul Syahri; Nasif , Hansen; Sari , Yelly Octavia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.912

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a global health threat with a steadily increasing prevalence. Its treatment is lifelong and requires optimal patient adherence to achieve therapeutic success. Pharmacist counseling is one of the interventions believed to improve such adherence. Objective: This study aimed to analyze the effect of pharmacist counseling and patient characteristics (age, gender, education, occupation, and access to hospital care) on medication adherence among T2DM patients. Methods: This study employed a one-group pretest-posttest design conducted at the Internal Medicine Polyclinic of dr. Ferdinand Lumbantobing Regional Hospital, Sibolga. A total of 75 respondents meeting the inclusion criteria were recruited. Adherence was measured using the MARS-10 (Medication Adherence Rating Scale 10 items) questionnaire before and after the counseling intervention. The Mann-Whitney and Kruskal-Wallis tests were used to analyze the influence of patient characteristics, while the Wilcoxon test was used to analyze the effect of counseling. Results: Analysis of demographic variables such as age, gender, education, occupation, and hospital access showed no significant relationship with adherence either before or after counseling (p>0.05). However, pharmacist counseling was proven to significantly improve adherence. The mean adherence score increased from 6.49 (pretest) to 8.08 (posttest) (p<0.05). The proportion of adherent patients rose from 52% to 94.67% following counseling. Conclusion: Patient characteristics had no significant effect on adherence. Pharmacist counseling was shown to be effective in significantly improving medication adherence among Type 2 Diabetes Mellitus patients.
pill box Pengaruh Tingkat Kepatuhan Menggunakan Pill Box Terhadap Keberhasilan Terapi Pasien Hipertensi Di Puskesmas Alalak Tengah Wahyunita , Sari; Rosyadi , Muhammad Ihsan; Fakhrani , Erwin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.962

Abstract

Background: Medication adherence is a crucial factor in the management of hypertension. Non-adherence is a common problem that can hinder therapeutic success. The use of a pill box as a reminder tool is considered to improve adherence; however, its impact on therapeutic outcomes requires further investigation, particularly at Alalak Tengah Primary Health Center, which has a high burden of hypertension cases. Objective: This study aimed to analyze the effect of pill box education on medication adherence and therapeutic success, as well as to examine the relationship between adherence and therapeutic outcomes among hypertensive patients at Alalak Tengah Primary Health Center. Methods: This experimental study with a cross-sectional design employed purposive sampling of 100 uncontrolled hypertensive patients. Data were collected from medical records and pill count observations to measure adherence. Therapeutic success was determined based on achieving target blood pressure. Data analysis was conducted using the Wilcoxon test to compare outcomes before and after the intervention, and the Spearman test to assess the correlation between adherence and therapeutic success. Results: The majority of respondents were female (76%), aged 51–60 years (36.5%), and housewives (71%). The pill box intervention significantly improved therapeutic success, with the proportion of patients achieving target blood pressure increasing from 0% to 79% (p-value = 0.001). Post-intervention medication adherence was very high (97%). However, statistically, there was no significant correlation between adherence and therapeutic success (p-value = 0.636 > 0.05). Conclusion: Education on pill box use was proven effective in significantly improving blood pressure control. However, high medication adherence was not directly correlated with therapeutic success. This indicates that hypertension treatment outcomes are influenced by other multifactorial factors beyond adherence, such as diet, physical activity, and individual responses to medication.
Unintended Medication Discrepancies (UMD) Pada Saat Rekonsiliasi Transfer dalam Konteks Negara Berpenghasilan Rendah dan Menengah : Tinjauan Naratif Husain, Aprilia; Khairinisa , Miski Aghnia; Insani , Widya Norma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.983

Abstract

Unintended medication discrepancies (UMD) frequently occur during transitions of care, particularly in low- and middle-income countries (LMICs), where the healthcare system often lacks standardized protocols, integrated information systems, and trained clinical pharmacists. This narrative review aims to explore the prevalence, characteristics, and contributing factors of UMD across LMICs based on analysis of 10 selected studies. Omission was the most frequently reported type of discrepancy, especially among elderly patients with complex therapy regimens. Factors influencing the occurrence of UMD include polypharmacy, inadequate documentation, absence of medication reconciliation protocols, limited pharmacist involvement, and poor inter-facility communication. Despite systemic limitations, studies demonstrate that pharmacist-led interventions can significantly reduce the incidence of UMD, even in resource-limited settings. Comparative analysis with studies from developed countries reveals that digital tools, standardized policies, and integrated pharmacist roles greatly enhance medication safety during transitions of care. The review concludes that addressing UMD in LMICs requires a multi-faceted approach, including national policy development, pharmacist integration into clinical teams, implementation of context-appropriate digital systems, and strengthening pharmacy education. These strategies are crucial for improving patient safety and reducing preventable adverse drug events related to medication discrepancies.

Page 50 of 66 | Total Record : 654

 48   49   50   51   52 

Filter by Year

2018 2026


Reset
Filter By Issues
All Issue JPS Volume 9 Nomor 1 (2026) JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue