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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 885 Documents
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Skrining Fitokimia, Analisis GC-MS, dan Aktivitas Antioksidan (Metode DPPH) Ekstrak Etanol Daun Sirih Cina (Peperomia Pellucida (L.) Kunth) Putri Nurjannah; Rahma Yulia; Syarifah Nadia
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1562

Abstract

Introduction: Peperomia pellucida (L.) Kunth, commonly known as Chinese betel leaf, is a medicinal plant widely used in traditional medicine for various ailments. The plant is reported to contain diverse secondary metabolites with potential pharmacological activities, including antioxidant properties. However, comprehensive information on its phytochemical constituents and antioxidant potential remains limited, particularly for extracts of Indonesian origin. Objective: This study aimed to determine the phytochemical profile, chemical constituents, and antioxidant activity of the ethanol extract of P. pellucida leaves. Methods: Dried leaf powder (100 g) was extracted by maceration using 96% ethanol (1:10 w/v) for 3 × 24 hours at room temperature. Phytochemical screening was conducted using standard qualitative tests for alkaloids, flavonoids, glycosides, saponins, steroids/terpenoids, and tannins. Chemical composition was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). Antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, with IC₅₀ values determined by linear regression analysis. Vitamin C served as the positive control. Results: The extraction yielded a concentrated ethanol extract of 11.8% (w/w). Phytochemical screening revealed the presence of flavonoids, glycosides, saponins, and terpenoids/steroids, while alkaloids and tannins were not detected. GC-MS analysis identified 14 chromatographic peaks, with major compounds including methyl hexadecanoate (14.12%), methyl 9-octadecenoate (13.61%), and triacontanoic acid. The ethanol extract exhibited very strong antioxidant activity with an IC₅₀ value of 41.47 µg/mL, compared to vitamin C (IC₅₀ = 4.083 µg/mL). The linear regression equation for the extract was y = 0.4291x + 32.2016 (R² = 0.9985). Conclusion: The ethanol extract of P. pellucida leaves contains various secondary metabolites and demonstrates very strong antioxidant activity. Although GC-MS analysis was predominantly characterized by fatty acid esters, the observed bioactivity likely results from synergistic contributions of multiple bioactive constituents. Further studies employing LC-MS/MS are recommended to identify specific compounds responsible for the antioxidant activity and to quantitatively determine total phenolic and flavonoid contents to establish their correlation with the observed bioactivity.
Eksplorasi Cemaran Mikroba Staphylococcus aureus dan Perhitungan Total Plate Count Pada Daging Ayam Broiler Dari Pasar Modern di Kota Surabaya Arsa Thalita Jazinda Putri; Isnawati Isnawati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1563

Abstract

Introduction: Broiler chicken meat is a widely consumed animal protein source; however, it is highly susceptible to microbial contamination that can compromise food quality and safety. Contamination of Staphylococcus aureus in animal-derived food products serves as a critical indicator of hygiene and sanitation practices and poses risks of various health disorders. Objective: This study aimed to determine the microbial contamination levels of Staphylococcus aureus and the Total Plate Count (TPC) values in broiler chicken meat obtained from several modern markets in Surabaya City, as well as to evaluate its safety level based on SNI 9159:2023 concerning Microbiological Criteria for Animal-Derived Food Products. Methods: This study employed a descriptive exploratory method with 10 broiler chicken carcass samples purposively collected from two different modern markets in Surabaya City. S. aureus testing was conducted using the spread plate method on Baird-Parker Agar media, followed by coagulase test and Gram staining for specific confirmation, while TPC testing utilized the pour plate method on Plate Count Agar media. Results: The results showed that 3 out of 10 samples were detected to contain S. aureus with contamination values ranging from 2.6 × 10⁴ CFU/g to 3.0 × 10⁴ CFU/g, which exceeded the maximum limit of SNI requirement of 1 × 10⁴ CFU/g. All samples exhibited TPC values ranging from 1.5 × 10⁴ to 3.5 × 10⁴ CFU/g, which remained below the maximum SNI limit of 1 × 10⁶ CFU/g. Conclusion: Some broiler chicken meat samples from modern markets in Surabaya City remained contaminated with S. aureus above the permissible threshold, necessitating attention to handling practices, sanitation, and storage conditions. Chicken meat should be cooked at high temperatures and consumed in well-done condition to ensure food safety for public health.
Pola terapi antihipertensi dan luaran klinis pada preeklamsia Nela Puspa Tama; Dedy Almasdy; Yelly Oktavia Sari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1565

Abstract

Introduction: Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality worldwide, necessitating effective clinical management strategies to improve pregnancy outcomes. Despite established guidelines for antihypertensive therapy in pregnancy, data on real-world treatment patterns and their associated clinical outcomes in Indonesian healthcare settings remain limited. Objective: This study aimed to describe sociodemographic and clinical characteristics, antihypertensive therapy patterns, blood pressure changes, and maternal and neonatal outcomes among preeclampsia patients at a tertiary referral hospital in West Sumatra, Indonesia. Methods: A descriptive observational study was conducted involving 80 preeclampsia patients hospitalized at Dr. M. Djamil General Hospital, Padang, from January to December 2025. Data were collected retrospectively from medical records using total sampling based on predefined inclusion and exclusion criteria. The study evaluated sociodemographic characteristics, antihypertensive therapy regimens, blood pressure changes (pre- and post-therapy), and clinical outcomes including maternal symptom resolution and neonatal status. Data were analyzed using descriptive statistics and Wilcoxon signed-rank tests with SPSS version 25. Results: The majority of patients were aged 20–35 years (70%), housewives (72.5%), and had completed senior high school education (61.3%). Methyldopa was the most frequently used oral monotherapy (22.5%), while the combination of methyldopa and nifedipine was the predominant regimen (68.8%). Antihypertensive therapy significantly reduced systolic blood pressure from 168.94 ± 21.21 mmHg to 134.74 ± 13.32 mmHg and diastolic blood pressure from 104.84 ± 13.80 mmHg to 83.11 ± 7.11 mmHg (p < 0.001). Maternal symptoms including headache and blurred vision resolved completely following treatment. However, neonatal outcomes remained concerning, with 35.0% of newborns requiring NICU admission and 16.3% resulting in intrauterine fetal death. Fetal complications including oligohydramnios (12.5%) and absent end-diastolic flow (2.5%) indicated impaired uteroplacental perfusion. Conclusion: Antihypertensive therapy effectively reduced blood pressure and improved maternal symptoms in preeclampsia patients. However, the persistence of adverse neonatal outcomes despite maternal hemodynamic improvement underscores the need for comprehensive management approaches that include close maternal-fetal monitoring, early detection of placental insufficiency, and optimized referral systems. Further prospective studies with larger sample sizes and extended follow-up are warranted to evaluate long-term therapeutic outcomes.
Prevalensi Skabies dan Faktor Risiko Pada Pemilik Kucing yang Berkunjung ke RSH Provinsi Sumatera Selatan : Studi Potong Lintang Winda Wahyu Setya Rahmah; Hamzah Hasyim; Yuanita Windusari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1591

Abstract

Scabies is a skin disease caused by infection with the Sarcoptes scabiei mite, and its incidence has increased worldwide in recent years. In addition to personal hygiene factors associated with scabies prevalence, close contact with infected pets also increases the risk of scabies transmission. This study aims to identify risk factors associated with scabies among cat owners at Visiting South Sumatra Provincial Animal Hospital. This study was a quantitative analysis with a cross-sectional design conducted from August to October 2023 at the Animal House of South Sumatra. A total of 112 respondents were recruited using a simple random sampling technique. The independent variables in this study were the use of antiseptics or soap, cleanliness of clothes, cleanliness of towel, cleanliness of bed sheets, and methods of keeping cats, while the dependent variable was scabies. Data analysis was performed using univariate and bivariate methods using the chi-square test with a significance level of p < 0,05 and a 95% confidence interval (CI). Statistical analysis showed that 21,5% of respondents experienced scabies. Scabies was influenced by the use of antiseptics or soap (p-value = 0,0001), clothing cleanliness (p-value = 0,019), towel cleanliness (p-value = 0,001), and methods of keeping cats (p-value = 0,0001). There was no significant association between bed linen cleanliness (p-value = 0,222) and scabies incidence among cat owners visiting the South Sumatra Animal Husbandry Hospital (RSH). Based on the study results, it was concluded that scabies incidence in cat owners was significantly related to personal hygiene behaviors and pet care management. Therefore, pet owners are advised to improve personal hygiene and good pet care management as a preventative measure against scabies transmission.
Analisis Faktor-Faktor yang Mempengaruhi Perilaku Pembelian Konsumen terhadap Produk Farmasi pada Platform E-Commerce: Tinjauan Sistematis Rifai Arfan; Anna Wahyuni Widayanti; Suci Paramitasari Syahlani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1595

Abstract

As digital technology advances, consumers increasingly purchase pharmaceutical products through e-commerce due to easier access, competitive prices and product variety. However, studies examining the determinants of online purchases of prescription and over-the-counter (OTC) medicines remain limited. This study seeks to determine the elements that influence customers' decisions to purchase pharmaceuticals through e-commerce platforms. A systematic review was performed utilizing databases including PubMed, Scopus, ScienceDirect, Google Scholar, and Garuda. This study is limited to publications from 2012 to 2025. The data were analyzed using the TDF and COM-B frameworks. Results showed that eleven overarching themes influence consumers' decisions to purchase medicines through e-commerce platforms. These themes include price and cost savings, medicine and service quality, data security and privacy, risks and limitations, accessibility and convenience, product availability, logistics and delivery services, insurance policies and integration, user experience, customer service, and social or habitual factors. Preliminary evidence suggests that price may be a more influential factor in studies conducted in Asian developing countries, whereas quality, data security, and regulatory considerations were more frequently reported in the limited number of studies from developed countries.
Identifikasi dan Kuantifikasi Kadar Fenol Total Jahe (Zingiber officinale) Ekstrak sebagai Tahap Pendahuluan untuk Pengembangan Salep Topikal Putri Jati Utami; Triasari Oktavriana; Prasetyadi Mawardi; Utiya Nur Laili; Larisa Sabrina Rahadiyanti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1597

Abstract

Ginger (Zingiber officinale) is traditionally used for inflammatory conditions and is currently being developed as a topical agent for psoriasis, with therapeutic effects largely attributed to phenolic constituents such as gingerols and shogaols. Prior to formulating ginger extract into 5% and 10% salves, qualitative confirmation and quantitative determination of phenolic content are essential to ensure adequate active marker levels. This study aimed to identify and quantify the total phenolic content of ginger extract intended for topical salve development. Qualitative identification used the ferric chloride (FeCl3) 1% test. Quantitative determination employed the Folin–Ciocalteu method with gallic acid as reference standard. Approximately 0.2 g of extract was dissolved in methanol p.a., reacted with 7.5% Folin–Ciocalteu reagent and 1% NaOH, and absorbance measured at λmax in triplicate. Total phenolic content was expressed as % gallic acid equivalents (GAE). The FeCl3 test produced a distinct color change confirming phenolic compounds. λmax was 733 nm with operating time 44–46 minutes. The calibration curve was linear (Y = 0.0652 + 0.00706X; r = 0.9991). Mean total phenolic content was 7.47 ± 0.36% GAE (74.70 ± 3.63 mg GAE/g extract; CV = 4.86%, meeting the < 5% precision criterion). The value measured by the Folin–Ciocalteu method reflects the total reducing capacity of the extract, which is primarily attributable to phenolic constituents such as gingerols and shogaols, although contributions from other reducing substances cannot be excluded. This batch-specific value provides a baseline reference qualifying the extract as the candidate active ingredient for subsequent 5% and 10% topical salve formulation, with confirmatory chromatographic identification recommended prior to scale-up.
Karakteristik dan pelepasan asam salisilat dari sediaan nanogel secara in vitro Nurul Arafah; Minda Sari Lubis; Rafita Yuniarti; Zulmai Rani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1598

Abstract

Salicylic acid is a beta-hydroxy acid (BHA) widely used in dermatology due to its keratolytic, comedolytic, and anti-inflammatory properties. Aim: This study aims to determine the amount of salicylic acid active ingredient incorporated into the nanogel formulation and to assess whether the salicylic acid active ingredient in the nanogel formulation can enhance the rate of release through the skin barrier. Methods: formulation of a nanogel preparation containing 1% salicylic acid. Subsequently, particle size measurements, determination of salicylic acid concentration, absorption efficiency testing, and release testing were conducted in vitro using a Franz diffusion cell, thereby allowing the determination of the cumulative amount of salicylic acid released and its flux. Results: The salicylic acid nanogel formulation has a particle size of 46.8 nm, indicating successful nanogel formation. The average adsorption efficiency value from six replicates was 92.8%, indicating that most of the salicylic acid was successfully adsorbed into the nanogel system. In vitro release tests showed an increase in cumulative release as samples were taken from minute 15 to minute 480, yielding an average Q value of 17.9 ± 0.08 µg/cm² and continuing to rise to 86.4 ± 0.08 µg/cm². Conclusion: A salicylic acid nanogel formulation has the potential to enhance the effectiveness of topical salicylic acid delivery.
Efektivitas Analgesik Ekstrak Etanol Daun Pegagan (Centella asiatica) Terhadap Mencit Putih (Mus musculus) Siti Rahmadani; Lukman Hardia; Angga Bayu Budiyanto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1602

Abstract

Background: Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, representing a major health problem that requires effective management. Although synthetic analgesics are widely used, their long-term administration is often associated with adverse effects, particularly gastrointestinal disturbances, thus driving the search for safer alternatives from natural sources. Centella asiatica (pegagan) is a medicinal plant traditionally used for various ailments, containing bioactive compounds with potential analgesic properties. Objective: This study aimed to evaluate the analgesic activity of ethanol extract of Centella asiatica leaves in male white mice (Mus musculus) and to determine the most effective dose. Methods: A true experimental study with pretest-posttest control group design was conducted involving 25 male mice randomly assigned into five groups (n=5 each): positive control (paracetamol 65 mg/kgBW), negative control (1% Na-CMC), and three treatment groups receiving ethanol extract at doses of 100, 150, and 200 mg/kgBW. The extract was prepared by maceration using 70% ethanol and subjected to phytochemical screening. Analgesic activity was evaluated using the tail flick method, with latency time measured at 30, 60, 90, and 120 minutes post-administration. Data were analyzed using Wilcoxon signed-rank test and Mann-Whitney U test at 95% confidence level. Results: Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins, and tannins in the extract, while steroids were not detected. The 100 mg/kgBW dose demonstrated the most consistent and significant analgesic activity, with statistically significant differences (p < 0.05) observed at 60, 90, and 120 minutes compared to pre-test values. This dose achieved the highest percentage of analgesia (63.09%) at 120 minutes, which was significantly superior to the positive control group. The 150 mg/kgBW dose showed inconsistent effects, while the 200 mg/kgBW dose exhibited comparable activity but with less consistency. Conclusion: The ethanol extract of Centella asiatica leaves possesses significant analgesic activity in mice, with the optimal dose of 100 mg/kgBW. The analgesic effect is likely mediated through the inhibition of cyclooxygenase enzymes and subsequent reduction of prostaglandin synthesis, supported by the presence of flavonoids, alkaloids, and triterpenoid compounds. These findings support the potential development of Centella asiatica as a standardized herbal analgesic agent.
Gambaran Imunohistokimia pada Pasien Infeksi Herpes Simplex Virus 1 dengan Karsinoma Tiroid: Sebuah Serial Kasus Putri Jati Utami; Prasetyadi Mawardi; Triasari Oltavriana; Utiya Nur Laili; Larisa Sabrina Rahadiyanti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1603

Abstract

Thyroid carcinoma is one of the most common endocrine cancers with a multi-factorial etiology. The role of HSV-1 in the pathogenesis of thyroid cancer remains an area of ongoing investigation. HSV-1 may be present in thyroid tissue raising questions about its potential role in thyroid carcinogenesis. The first case involves a 65-year-old male diagnosed with thyroid carcinoma, presenting with a history of oral discomfort and pain two weeks before evaluation. The second case is a 73-year-old male, also diagnosed with thyroid carcinoma with no history of herpes simplex virus (HSV). Both patients underwent thyroidectomy, and histopathological examination confirmed the presence of papillary carcinoma in thyroid tissue. Immunohistochemical analysis further identified HSV-1 in both cases. A study has reported a higher frequency of HSV DNA detection in thyroid carcinoma, with a significant correlation between oncogenic mutations and HSV presence. The upregulation of nectin-1 expression in thyroid carcinoma facilitates HSV occurrence, thereby increasing the susceptibility of cancer cells to viral infection. Moreover, thyroid hormone levels may play a role in HSV reactivation, highlighting the intricate interplay between thyroid function, viral activity, and cancer progression. Histopathological examination, including immunohistochemical (IHC) staining, identified HSV 1 in two patients diagnosed with thyroid carcinoma. These findings underscore the need for further research involving a larger cohort to elucidate the potential role of HSV in thyroid carcinogenesis.
Tren Penelitian Bioetika, Genetika, dan Pendidikan dalam Konteks Muslim: Analisis Bibliometrik (2016–Mei 2026) Ridha Aulia; Muhammad Rizki Fadil; Achmad Luthfi Chakim; Sazkia Nazilla; Dewi Wulandari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1606

Abstract

Rapid advancements in genomics, genetics, and biotechnology have generated ethical challenges that require scholarly engagement, including in Muslim contexts. This study maps global publication trends on bioethics, genetics, biotechnology, and education in Muslim contexts from 2016 to May 13, 2026. Data were retrieved from the Scopus database using a predefined search string and screened through a PRISMA-based selection procedure. Of the 343 records initially identified, 130 documents met the inclusion criteria. Bibliometric data were analyzed descriptively and visualized using VOSviewer to examine publication trends, source productivity, keyword co-occurrence, and collaboration networks. The findings show growing scholarly attention to bioethics and health-related issues, particularly since 2022, with bioethics and Islam serving as central thematic nodes. However, education-related terms, especially those connected to Islamic education beyond medical education, are relatively underrepresented in the analyzed dataset compared with health-oriented bioethics themes. This pattern indicates that existing Scopus-indexed literature has more strongly developed clinical, biomedical, and normative-religious discussions than curriculum- or pedagogy-focused studies. As a descriptive bibliometric study, this article does not evaluate curriculum quality or the actual implementation of bioethics education. Instead, it identifies a thematic gap that should be examined further through qualitative, curriculum-focused, and institution-based research in Islamic educational settings.

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