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Jurnal MedScientiae
Published by Universitas Kristen Krida Wacana
ISSN : -     EISSN : 28291166     DOI : https://doi.org/10.36452/jmedscientiae
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal MedScientiae adalah jurnal yang dikelola oleh Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana. Jurnal ini mempublikasikan artikel-artikel secara open access dalam lingkup bidang kedokteran dan kesehatan seperti kedokteran dasar, bioetika kedokteran, biologi sel, biologi molekuler, genetika, fisiologi, biokimia, bioinformatika, anatomi, farmakologi, kesehatan masyarakat, dan ilmu biomedik lainnya. Tim editorial menerima naskah berupa artikel penelitian, literature dan systematic review, dan laporan kasus. Naskah yang dikirimkan hendaknya belum pernah diterbitkan sebelumnya di jurnal maupun media yang lain dan disiapkan sesuai dengan template atau format yang telah ditentukan. Setiap naskah yang memenuhi kriteria jurnal akan direview oleh pakar yang sesuai (peer reviewer). Jurnal MedScientiae tidak mengenakan biaya selama proses mulai dari penerimaan naskah hingga publikasi. Jurnal MedScientiae terbit 3 kali dalam satu tahun, yaitu pada bulan April, Agustus dan Desember dengan cakupan keilmuan yang telah disebutkan di atas. Edisi pertama jurnal akan diterbikan di bulan Mei tahun 2022 dengan nomor ISSN 2829-1166.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 220 Documents
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Dilema Etik bagi Tenaga Kesehatan dalam Menentukan Pilihan Tindakan Medis Berdasarkan Prinsip Berbuat Baik (Beneficence) atau Prinsip Otonomi (Autonomy) Saputra, Warren; Djai Yen, Liauw
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3212

Abstract

The primary goal of the medical profession is to alleviate suffering and restore health to patients through medical practice. This practice is based on ethics and morals. The principle of beneficence requires doctors to act for the good of the patient, while the principle of autonomy emphasizes the individual's right to make their own decisions. These principles are prima facie obligations that in situations of conflict, must be assessed for their respective weight based on context to determine the best course of action for the patient. The literature review was conducted from the reference source, PubMed. The articles obtained were selected according to the inclusion criteria, and the final result obtained 10 articles. Beneficence and autonomy are key moral duties in bioethics, and the interaction between the two requires careful consideration in determining the best way to act.  In some cases, such as the practice of allergy, ethical dilemmas may arise. Deepening the science of ethics and using appropriate communication with soft paternalism are options in the solution of such problems. In medical practice, the principles of beneficence and autonomy often pose dilemmas, especially when the doctor's preference to do good conflicts with the patient's medical decisions, such as in cases of physical restraints, plastic surgery, pediatric patients, and mental patients. Persuasive conversations can help achieve care that meets the patient's goals, without compromising the principles of beneficence and autonomy.
Gene Therapy Revolution: Recent Advances and Modern Biomedical Laboratory Techniques Antoni, Marcel; Susilowati, Rina Priastini
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3258

Abstract

Genetic therapy is a revolutionary innovation in the medical world that aims to treat or prevent diseases through the modification of the patient's genetic material. This literature review examines the latest advances in genetic therapy, including the biomedical laboratory techniques used. Techniques such as Polymerase Chain Reaction (PCR), DNA sequencing, CRISPR-Cas9, and Prime Editing have provided the ability to modify genes with high precision. Genetic therapy has shown success in various diseases, including monogenic genetic diseases such as hemophilia and Duchenne Muscular Dystrophy, as well as cancer through Chimeric Antigen Receptor T-cell (CAR-T) therapy. Additionally, research shows the potential of genetic therapy in addressing complex diseases such as cardiovascular disease and diabetes, as well as in regenerative treatment for degenerative diseases like Parkinson's. Despite being promising, challenges related to ethics, safety, and accessibility still need to be addressed. Case studies indicate that although there are many successes, there are still obstacles to be overcome to improve the effectiveness and safety of this therapy. This literature review concludes that genetic therapy has great potential to become an important pillar of modern treatment in the future, provided that further research and development are needed to overcome the various existing barriers.
Hubungan Antara Kelainan Refraksi Dengan Perilaku Membaca Pada Siswa Anggota Jemaat Gereja Kristen Nafiri Sion Fajar Kemuliaan Tahun 2023 Indrajanti, Mirza; Wijaya, Esther; Nila, Seri; Sinaga, Natasya Advelin; Gosali, Vincentio Owen; Kencana, Billy Gadi
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3332

Abstract

Myopia is an eye disorder in which parallel rays coming from an infinite distance are refracted in front of the retina. Astigmatism is an optical condition of the eye, in which parallel rays are not refracted at a single focal point, so that the focus is unclear, vision is blurred and often dizzy. Anisometropia is a difference in refractive error between the two eyes of 1-2 Diopters (D) in one or more meridians. This can cause aniseikonia, namely a difference in shadow both in shape and size that causes difficulty in fusion. Hypermetropia / Hyperopia / farsightedness is a condition of not being able to see close objects clearly, this condition is the opposite of farsightedness (myopia). The symptoms of hypermetropia are similar to presbyopia in the elderly. Research objective is to educate students about visual health. Method is data collection was conducted through anamnesis, visual acuity examination using refraction instruments and distributing questionnaires to students of the Nafiri Sion Fajar Kemuliaan Christian Church aged 12-22 years, totaling 62 people, then diagnosed with refractive disorders. There is a relationship between refractive disorders and students' reading behavior.
Kecemasan Preoperasi pada Pasien yang Akan Menjalani Operasi Appendiktomi: Kecemasan Preoperasi pada Pasien yang Akan Menjalani Operasi Appendiktomi Ramba, Erni; Tania, Elly; Citraningtyas, Theresia
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3351

Abstract

Anxiety is an individual's reaction to unexpected situations that everyone often experiences in life, providing warnings and directing someone to try to protect themselves. The process of surgery or surgery can cause anxiety reactions. This literature review aims to determine the description of anxiety in preoperative appendicitis patients and the factors that can influence the patient's preoperative anxiety level. Research articles in the form of clinical trials and randomized control trials were reviewed using the Google Scholar search engine, using specific keywords such as anxiety AND "preoperative" AND appendectomy AND comparison. A total of five relevant journals based on the purpose of the literature review. The conclusion from this literature review is that methods that can be implemented and are effective in reducing anxiety in pre-appendectomy patients include communication and education, implementation of the finger grip technique. Knowledge of surgical procedures can reduce anxiety. It should be noted in this literature review that the number of responses from each journal is still considered insufficient.
Trabekuloplasti pada Glaukoma: Sebuah Tinjauan Pustaka Terkini Lily, Lia Listya; Kalangi, Geraldi Marcelino; Manufandu, Gracea Sintike; Anugrahsari, Santi
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3360

Abstract

Glaucoma is a progressive optic neuropathy that can lead to irreversible blindness, where intraocular pressure (IOP) serves as the only modifiable risk factor for disease control. Among the various treatment modalities, laser trabeculoplasty, especially Selective Laser Trabeculoplasty (SLT), has gained popularity as it improves aqueous humor outflow and reduces IOP. This review combines recent studies comparing SLT with other modalities such as Micropulse Laser Trabeculoplasty (MLT) and their clinical outcomes. The purpose of thisliterature review is to highlight the efficacy of Selective Laser Trabeculoplasty (SLT) in managing intraocular pressure (IOP)in glaucoma patients, especially primary open angle glaucoma (POAG), both as first-line therapy and as adjunctive therapy. Literature sources were selected through an internet search using articles in research journal databases on Google Scholar and Pubmed and 30 literatures were selected from these methods. The literature revealed that SLT, as a first-line therapy or adjunct to medical treatment, effectively lowers IOP and can be repeated safely with continued efficacy. In addition, SLT offers an alternative for patients who are unresponsive to topical treatment, providing a non-invasive optionthat may eliminate the need for surgery. This review also examines the role of SLT in long-term glaucoma management, its comparison with newer techniques, and the effectiveness of repeated treatments in maintaining IOP control. Further studies are recommended to validate the long-term outcomes of SLT, especially for various applications and its comparison with newer laser therapies.
Tinjauan Etik Rumah Sakit Berkontribusi Dalam Limbah Makanan Yen, Liauw Djai; Wea, Brigitta Yuliana; Tholib, Clemarie Natasha; Mai, Roy; Rasyiqah, Fajrina Rizki; Yurike, Vony; Ongga, Leonardo
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3456

Abstract

About a third of the food produced per year is thrown away and becomes food waste, affecting various fields on a global scale. According to Williams and Walton, food waste generated by hospitals is two to three times greater than in other service areas. If this food waste is processed and recycled, it will produce methane and CO2 emissions which will also worsen global warming. The purpose is to review the ethics of hospitals that contribute to food waste. This is a literature study that was carried out using the Pubmed and Google Scholar databases from 2014-2024 with the main keywords "food waste", "hospital", and "ethic", and obtained 17 journals in Indonesian and English. The results showed that vegetables were often the type of food left most in hospitals. Strategies to reduce food waste include attractive presentation, room service systems, and bioconversion innovations with BSF larvae. Indonesia itself has several policies to reduce food waste, but more focused management is still needed. It can be concluded that the main strategies for reducing food waste include improving food presentation, flexible services such as room service, bioconversion with BSF larvae, and recycling. More specific regulations for hospitals are needed in Indonesia
Effect of The Addition of Lime (Citrus aurantifolia) on Total Phenolic and Antioxidant of Turmeric Infusion (Curcuma domestica Val.) Rukmana, Dewi Samudra Putri Aliffa; Rumiati, Flora; Sudrajat, Susana Elya
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3459

Abstract

Turmeric is a traditional drink that has been known since ancient times in Indonesia. Turmeric is an herbal ingredient that is efficacious as an antioxidant and is usually combined with tamarind. The added tamarind serves to add to the efficacy of turmeric. In this study, the role of tamarind from sour turmeric drink was replaced with lime fruit. The purpose of this study was to determine the effect of lime powder on pH, antioxidant activity and total phenol of turmeric infusion. Lime turmeric infusion is made by adding water at 900C for 15 minutes. The lime turmeric infusion solution was then tested for pH, total phenol, and antioxidant levels using the DPPH method. Turmeric infusion without the addition of lime fruit powder has a pH of 4.8, total phenol content of 1.324 ± 0.013 mgGAE/g, and antioxidant of 312.55 ± 0.62 ppm. While the turmeric infusion with the addition of lime has a pH of 3.4, a total phenol content of 1.852 ± 0.004 mgGAE/g, and an antioxidant value of 31.80 ± 1.22 ppm. The addition of lime fruit to turmeric infusion resulted in a decrease in pH, an increase in total phenol levels, and antioxidant levels.
Prevalensi dan Hubungan Infeksi Protozoa Usus dengan Kejadian Diare di RSUD Kemayoran Tahun 2020-2021 Sari, Monica Puspa; Pandapotan, Roy Akur; Agustina, Nurul Fitria
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3464

Abstract

Infeksi protozoa usus masih menjadi permasalahan di dunia, terutama di negara berkembang seperti Indonesia dengan angka prevalensi 10-18%. Infeksi protozoa usus dapat menyebabkan diare pada anak. Tujuan penelitian adalah ingin mengetahui prevalensi dan hubungan protozoa usus pada penderita diare yang dirawat di RSUD Kemayoran Jakarta. Metode penelitian yaitu analitik deskriptif dengan pendekatan cross sectional menggunakan data rekam medik penderita diare pada tahun 2020-2021 di RSUD Kemayoran. Hasil penelitian ini menunjukkan dari 76 responden didapatkan bahwa kejadian diare di RSUD Kemayoran pada tahun 2020 sampai 2021 paling banyak terjadi pada anak laki laki dengan prevalensi protozoa usus (10,5%). Entamoeba histolytica merupakan protozoa usus yang paling sering menyebabkan diare pada anak. Gejala mual ditemukan sebanyak 5,3%, tanpa dehidrasi sebanyak 6,6% dengan lama rawat 3 hari (9,2%). Hasil uji Fisher menunjukkan bahwa terdapat hubungan yang bermakna antara infeksi protozoa usus dengan gejala mual yang timbulkan (p=0,044), terdapat hubungan antara infeksi protozoa usus dengan karakteristik tinja yang cair (p=0,048) dan berlendir (p=0,045). Hasil uji Mann Whitney menunjukkan bahwa terdapat hubungan antara infeksi protozoa usus dengan usia, pekerjaan dan tingkat pendidikan (p=0,000) serta kadar hemoglobin (p=0,013). Kesimpulan terdapat hubungan antara infeksi protozoa usus dengan gejala mual, konsistensi tinja, usia, pekerjaan, tingkat pendidikan dan kadar hemoglobin.
Faktor yang Mempengaruhi Tingkat Kelelahan pada Perawat Rumah Sakit Pemerintah Provinsi DKI Jakarta Winata, Susanty Dewi; Ingkiriwang, Elly; Sutanti, Yosephin Sri; Purnamawati, Purnamawati; Winaktu, Gracia JMT; Berliana, Adisa
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v313.3466

Abstract

The issue of the quality of work of nurses in hospitals is something that needs attention, especially regarding the level of work fatigue by nurses. Work fatigue is a symptom related to work efficiency, skills and increased anxiety. Research shows that work fatigue has a significant impact on work accidents. This study aims to determine the factors that influence the level of fatigue in nurses in government hospitals. This research is a descriptive analytical research with a cross sectional approach. The population in this study were nurses at government hospitals. In this research, fatigue factors are divided into 3, namely age, gender and length of service. Sampling was carried out using the simple random sampling method. Data collection uses a questionnaire in the form of a Google form. Based on the results, it was found that there was a relationship between factors that influence fatigue and the level of fatigue, p - value <0.005 (0.000).
Caenorhabditis elegans sebagai Model Hewan Penelitian Biologi dan Biomedis Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3467

Abstract

Caenorhabditis elegans is a microscopic nematode, with a transparent body, short life span, self-fertilization ability. C. elegans is easy to be cultured and has been used as an animal model for molecular research, medicine, pharmacology, and toxicology. In addition, C. elegans was the first animal to have its genome completely sequenced and has played a major role in understanding apoptosis and RNA interference. The use of C. elegans as a biological model in environmental toxicology assessments has allowed for the determination of several endpoints. Some of these utilize effects on the biological functions of the nematode and others use molecular markers. Furthermore, C. elegans has enabled the assessment of neurotoxic effects for pesticides and heavy metals, since this nematode has a very well-defined nervous system. Overall, almost every known toxin has been tested in this animal model. In the near future, the knowledge available about the life cycle of C. elegans will allow for more studies on reproduction, transgenerational toxicity for newly developed chemicals and materials, and detailing the signaling pathways involved in the mechanisms of toxicity. C. elegans is an important animal model for research into the identification and understanding of the machinery of nuclear transport. This has helped elucidate biochemical pathways involved in diseases such as obesity, diabetes, and Alzheimer's disease. C. elegans is an excellent animal model for studying aging because of its short lifespan, susceptibility to oxidative stress, and similarity to the human aging process.

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