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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "Vol 10 No 1 (2025)" : 26 Documents clear
COST MINIMIZATION ANALYSIS OF ANTIHYPERTENSIVE DRUG USE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS Utami, Indah Kurnia; Rakanita, Yasinta; Dewi, Niluh Puspita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1655

Abstract

Hypertension is the primary cause of Chronic Kidney Disease (CKD), as it damages blood vessels in the kidneys. The most commonly used management for hypertension as monotherapy includes Calcium Channel Blockers (CCB) such as Amlodipine and Angiotensin Receptor Blockers (ARB) such as candesartan. Patients with CKD undergoing hemodialysis depend on dialysis machines, which impacts their economic burden. Therefore, a cost analysis review of drugs with the same therapeutic goals is necessary. This was a non-experimental study with a descriptive design. Data were collected through retrospective purposive sampling from January to December 2023 using medical records and payment data for inpatient treatments with hemodialysis that met the inclusion criteria. Direct medical costs included antihypertensive, other medication, service and facility fees, and medical support costs. Of the 100 samples that met the inclusion criteria from January to December 2023, amlodipine was the most commonly used antihypertensive (56%), followed by candesartan (38%). The average direct medical costs were IDR 184.350 for Amlodipine and IDR 561,339 for candesartan. The patient characteristics by gender showed a higher percentage of males (52%) than of females (48%). By age, the majority were in the late adult group (67%), whereas the elderly accounted for (33%). The Amlodipine group achieved more significant cost minimization than the candesartan group. Future studies should examine the potential of amlodipine in reducing the economic burden of limited resources.  Keywords: antihypertensive, CMA, CKD
THE OPTIMATION OF FERMENTATION FOR METABOLITE PRODUCTION BY SYMBIONT Penicillium nalgiovense FROM THE SPONGE Gelliodes fibulata Rusmalina, Siska; Mahfur, Mahfur; Ermawati, Nur; Maliah, Nabilatun; Ananda, Luthfiah; Bintang Pratama, Kevin; Evi Ulfiani , Riska; Abdul Aziz, Danang; Husain, Khafidz; Ilma Faza, Febi; Hidayatullah, Adib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1682

Abstract

The fungi are sponge symbionts.  The fungus Penicillium nalgiovense acc MK087096  is a symbiont of the sponge Gelliodes fibulata. This symbiont has antibacterial activity, which supports the development of sponge-based drugs that are as effective as antibiotics. However, the primary challenge in developing marine resource-based medicine is the availability and sustainability of sponge raw materials. Fermentation biotechnology using sponge symbiont fumgi is an effective solution to address these challenges, as it allows the production of bioactive secondary metabolite compounds in large quantities, which can be used as raw materials for pharmaceutical preparation. The aim of this study was to determine the optimal medium and fermentation duration for producing secondary metabolites with antibiotic properties from the symbiotic fungus Penicillium nalgiovense, isolated from the sponge Gelliodes fibulata. This study was conducted naturally. The symbiotic fungus from the sponge Gelliodes fibulata was cultivated to facilitate growth. Fermentation was conducted with variations in secondary metabolite harvesting times of 2, 4, 6, 8, 10, and 12 days.  Secondary metabolites were obstained using liquid-liquid extraction with ethyl acetate. The optimal medium and fermentation time were determined based on the yield percentage for each medium across the six time variations. The fermentation biotechnology of the symbiotic fungus Penicillium nalgiovense acc MK087096 from the spone Gelliodes fibulata was carried out on SDB, PDB, also coconut flake-enriched PDB media.  The results showed the growth of the fungus and the production of bioactive secondary metabolites with antibiotic properties ...
A STUDY ON THE KNOWLEDGE AND ATTITUDES OF INDONESIAN WOMEN REGARDING MENSTRUAL CUPS AS ENVIRONMENTALLY FRIENDLY MENSTRUAL PRODUCTS Alfiani, Fitri; Yuniko Febby H Fauzia; Azkya, Fharelina N
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1338

Abstract

Inadequate menstrual hygiene can increase the risk of reproductive tract infections, including pelvic inflammatory disease, dysmenorrhea, and infertility. Therefore, the use of safe and effective menstrual products is essential. Currently, disposable pads are widely recognized products. Disposable pad waste is deemed environmentally detrimental, leading to an estimated annual production of 113,000 tons. Menstrual cups are a viable long-term alternative, since they can be reused for up to ten years, effectively prevent leaks, accommodate various activities, and diminish the risk of toxic shock syndrome. Examining Indonesian women's knowledge and attitudes about menstrual cups is crucial, as it substantially aids in advancing the attainment of Sustainable Development Goals (SDGs). Procedure. This was a quantitative study utilizing anonymous web-based questionnaires. Outcomes.  Of the Indonesian women, 75.97% possessed limited knowledge, while only 24.03%weree well-informed about menstruation cups as eco-friendly menstrual devices. 85.06% of Indonesian women were disinclined to utilize menstruation cups, while only 14.94% expressed a willingness to adopt these environmentally friendly menstrual devices. The ?-value was 0.514>0.05, which represents statistical insignificance; hence, knowledge was not associated with attitude.  Keywords: attitude; knowledge; menstrual_cup; menstruation; women_health  
COMPARISON OF TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF PURPLE LEAF EXTRACT (Graptophyllum pictum (L.) Griff.) USING MACERATION AND SOXHLETATION EXTRACTION METHODS Darotulmutmainnah, Azmi; Marini, Marini; Herliningsih, Herlingsih; Handayani, Hana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1608

Abstract

Purple leaves in Indonesia can be used as an anti-inflammatory medication and laxative to treat hemorrhoids, rheumatism, boils, and skin diseases. Purple leaves are also used as free-radical antidotes. This was due to the presence of secondary metabolite compounds in purple leaves. The right extraction method determines the amount of flavonoids that can be extracted and achieves a high flavonoid content. This study aimed to determine the total flavonoid content and antioxidant activity of purple leaves using different extraction methods, namely maceration and Soxhletation. This study employed an experimental method of testing total flavonoid levels using UV-Vis spectrophotometry and antioxidant activity using the DPPH method. The results showed that the maceration method yielded a total flavonoid level of 4,422 ± 0,047 ppm, which was higher than that obtained using the Soxhletation method (1,547 ± 0,027 ppm). In the antioxidant activity test, vitamin C was used as a comparator, with an IC50 of 2.263 ppm (very strong). The IC50 of purple leaf extract using the maceration method was 123,32 ppm (medium), while the soxhletation method yielded an IC50 of 104,42 ppm (medium). This shows that vitamin C has more potent antioxidant activity in counteracting free radicals than purple leaf extract, using maceration and Soxhletation methods. The  results showed a significant difference in total flavonoid levels using different extraction methods, while there was no significant difference in the antioxidant activity of purple leaf extract using maceration and  Soxhletation methods.   Keywords: antioxidant, extraction, flavonoid, maceration, purple leaf, soxhletation  
FORMULATION AND EFFECTIVENESS TEST OF THE WOUND HEALING GEL RED PIDADA FRUIT (Sonneratia Caseolaris) SKIN EXTRACT Rusdeni, Sofia; Rini Dwiastuti; Phebe Hendra; Hasyrul Hamzah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1633

Abstract

Red pidada fruit peel extract gel preparation can increase the efficiency and comfort of topical use because of its activity in the healing of open wounds. The aim of this research was to determine how variations in HPMC levels affect the physical quality and stability of red pidada fruit peel extract gel preparations, using the maceration method to obtain thick extracts and formulations with different HPMC concentrations (1% HPMC, 3% and HPMC 5% formula were tested for physical quality and stability, including the Storage Stability Test for 4 weeks. Effectiveness testing was also carried out in white mice using an incision wound method with a depth of 1.5 mm and macroscopic observation. The effectiveness test concentration was set to 5%. The results of data analysis using the Spss One Way ANOVA test showed that higher HPMC levels resulted in a thicker gel, viscosity, stickiness, spreadability, and higher pH. It can be concluded that the gel formulation that meets the requirements is that formula 2 provides organoleptic test results with a thick green color typical of red pidada, good homogeneity test, spreadability test 5.52 cm, adhesion test 2.61 minutes, viscosity test 2700cCps, pH test 4.92. During storage, the gel exhibited good consistency. The longer the storage time, the closer the pH changes to alkaline values. With the Anova value, there is a significant difference in the three formulas with a value of p=0.005 Keywords: red pidada (Sonneratia caseolaris) fruit peel, wound healing, HPMC, gel
ARTICLE REVIEW: POTENTIAL PHARMACOLOGICAL ACTIVITY OF LOBI-LOBI FRUIT (Flacourtia inermis, Roxb) Adiwinata, Much Cheril Wicaksono; Vitamia, Cszahreyloren
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1665

Abstract

The Lobi-lobi fruit is a tropical plant that is rich in secondary metabolites. Many studies have discussed the usefulness of secondary metabolites in this fruit. This study aimed to explore the secondary metabolites and pharmacological activities of lobi-lobi fruit (Flacourtia inermis, Roxb). The methods used included a literature review of various scientific journals discussing the health potential of fruits. The results showed that the lobi-lobi fruit extract had significant antioxidant activity with an IC50 value of 104.223 ?g/mL, and showed potential as an antidiabetic and antibacterial agent. This discussion highlights the importance of bioactive components, such as phenolics, for providing therapeutic effects. The conclusion shows that this fruit has potential as a source of natural medicine and requires further research. Keywords: secondary metabolites, flacourtia inermis, pharmacological activity
DRUG DOSE ADJUSTMENT IN CHRONIC KIDNEY FAILURE PATIENTS AT HOSPITAL X Nurdiansyah, Iid; Susilo, Rinto; Setyaningsih, Indah; Putri, Anisa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1669

Abstract

Chronic Kidney Disease (CKD) is a significant global health issue, with increasing incidence rates, high treatment costs, and poor prognosis. Adjusting drug dosages in patients with CKD is essential to prevent worsening conditions and ensure proper therapy. This study examines the drug adjustment practices at Hospital X. This research method uses a descriptive research uses secondary data from medical records (Jan-Dec 2021) of CKD patients at Hospital X. Data include patient demographics, comorbidities, medications, and dosage adjustments according to the Renal Pharmacotherapy Handbook. Results: Among the 52 patients, the majority were female (60%) and aged 46-65 years (57%). Ranitidine was the most prescribed drug (47.37%) for CKD patients, with 56.76% dosages aligning with renal dosing guidelines. This study concluded that ranitidine was the most common medication, and over half of the prescriptions were aligned with the renal dosing guidelines. Keywords: drug dose adjustment, chronic kidney failure,  renal pharmacotherapy
MICROBIAL CONTAMINATION IN MIXED SYRUP CONTAINING ERDOSTEIN AND CETIRIZIN STORED AT DIFFERENT STORAGE TEMPERATURE Cahyanti, Naomi Dwi; Purwaningsih, Hesti; Angelia, Inez; Deki, Yohanes Damasus Natanael; Ramadhan, Gilang
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1677

Abstract

Pharmaceutical services include drug dispensing activities, including drug compounding. Drug compounding is the process of mixing or changing ingredients to produce drugs that suit patient needs. Unmonitored storage conditions for compounded drugs in the community can affect the evaluation of the physical, chemical, and microbial contamination stability. The aim of this study was to determine the effect of storage temperature on the results of the evaluation of microbial contamination in compounding syrup pharmaceuticals, so it can provide education to the public about the storage patterns that have been carried out so far. Evaluation of microbial contamination in this study included contamination of the Total Yeast and  Mold Count (TYMC) and Total Plate Count (TPC). The objective of this study was a mixture of Erdostein syrup and cetirizine tablets. The research materials used for the microbial contamination test were mineral water, sterile water, Plate Count Agar (PCA) media, and Potato Dextrose Agar (PDA). The results of the study in the form of TYMC and TPC on day 0 were 0 cfu/mL. After 7 days of storage, microorganisms, namely TYMC, grew at room temperature (<30°C) 4.98x102 cfu/mL and cold temperature (2-8°C) 2.2x102 cfu/mL. The TPC results at room temperature storage (<30°C) were 8.33x102 cfu/mL and at cold temperatures (2-8°C) were 3.67x102 cfu/mL ...
FORMULATION AND EFFICACY TEST OF STICK-HEEL MOISTURIZER MADE FROM 96% ETHANOL EXTRACT OF PAPAYA (Carica papaya L.) LEAVES Marangyana, I Gede Bagus Indra; Listiani, Putu Ayu Ratih
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1649

Abstract

Papaya leaves contain phytochemicals including alkaloids, phenols, flavonoids, tannins, saponins, and steroids, which can function as natural moisturizers to maintain healthy heels. Papaya leaves were extracted using the maceration method with 96% ethanol solvent and evaporated on a rotary evaporator to obtain a thick extract. The yield was 10.2%. It was subsequently combined at concentrations of 5 %, 10 %, and 15% to create a moisturizing heel stick preparation. The physical quality of the stick heel moisturizer preparations was assessed using tests for homogeneity, spreadability, adhesion, pH, organoleptic properties, and moisturizing properties. The mixture produces a brownish-green stick, a semi-solid texture, a distinctive odor of papaya leaves, a pH of 6, good homogeneity, good adherence, and qualified spreadability. The moisturizing test results for FI 5%, FII 10%, and FIII 15% had average values of 2.23%, 1.56%, and 1.15%, respectively. The results of SPSS testing also showed various average values that were significant (p<0.05). From the obtained data, FIII was determined to be the most effective moisturizing formula. Keywords: Papaya leaf, stick heel, moisturizer.
IN VITRO ANTIBACTERIAL ACTIVITY OF CARICA PAPAYA LEAF EXTRACT-LOADED ACNE PATCHES AGAINST Propionibacterium acnes Indriaty, Sulistiorini; Rizikiyan, Yayan; Gianto, Vinie Regina Putri; Karlina, Nina; Hidayati, Nur Rahmi; Sulastri, Lela; Firmansyah, Deni
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1673

Abstract

Acne vulgaris is a prevalent skin condition that is characterized by inflammatory lesions. Propionibacterium acnes is a key bacterium implicated in its pathogenesis. This study aimed to investigate the antibacterial potential of Carica papaya leaf extract against P. acnes and its efficacy when formulated into acne patches. Ethanolic extracts of C. papaya leaves were prepared at concentrations of 20%, 25%, and 30%. These extracts were incorporated into acne patch formulations and evaluated for antibacterial activity using the paper disc diffusion method. Clindamycin 1% was used as a positive control and 70% ethanol was used as a negative control. The results demonstrated that all concentrations of the C. papaya leaf extract exhibited significant antibacterial activity against P. acnes. The 30% concentration demonstrated the largest zone of inhibition, which was comparable to that of the positive control. These findings suggest that C. papaya leaf extract-based acne patches are promising natural alternatives for the treatment of acne vulgaris. Keywords: Papaya leaves (Carica papaya L), Propionibacterium acne, Acne patch, Inhibitory power

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