Medical Sains : Jurnal Ilmiah Kefarmasian
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
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<![CDATA[POST-CHEMOTHERAPY TREATMENT IN NATIONAL HEALTH INSURANCE BREAST CANCER PATIENTS AT YOGYAKARTA CITY HOSPITAL ]]>
<![CDATA[Anggraeni, Dita Putri]]>;
<![CDATA[Yuliastuti, Fitriana]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.939
<![CDATA[Breast cancer accounts for approximately 16.6% of 396,914 cases of cancer and is one of the most fatal and common diseases among women. Treatment of breast cancer mostly has side effects, but the incidence of drug side effects does not always appear because the target drug does not selectively act on the target action. The aim of this study was to find a picture of post-chemotherapy treatment in breast cancer chemotherapy patients participating in the National Health Insurance at RSUD Yogyakarta. Observational method: Retrospective collection of data obtained from patients’ medical records. The subjects included patients with breast cancer at RSUD Yogyakarta who met the inclusion criteria for the primary diagnosis of breast cancer and received chemotherapy medication during the period of 2020. The univariate analysis showed the distribution of frequency and percentage of respondent characteristics, including age, gender, number of patients, single and combination chemotherapy drugs, generic and commercial drugs, and single or combination post-chemotherapy medications. The results were obtained from 72 patients who underwent 4 periods of chemotherapy. The most frequently used chemotherapy regimens for each period were the period 1 combination of Brexel, Epirubicin, Carboplatin. Period 2 combination of the Brexel and Zometa regimes. Periode 3 combination brexel, epirubicine, and carboplatin. The most widely used combination of post-chemotherapy drugs in periods 1-4 was the combination of Ranitidine and Ondansetron. Keywords: Ca Mamae, Chemotherapy, Regimen, Drugs]]>
<![CDATA[ANALYSIS OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY ETANOL EXTRACT OF BUTTERFLY PEA FLOWER (Clitoria ternatea) IN YOGYAKARTA ]]>
<![CDATA[Kusuma, Nyoman Rudi]]>;
<![CDATA[Sulistyani, Nanik]]>;
<![CDATA[Sugihartini, Nining]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1118
<![CDATA[Butterfly Pea Flower is one of the plants that has antioxidant activity. However, based on previous studies, the antioxidant content is highly dependent on the location and place of the BPF itself. Therefore, this study aims to measure the concentration of total flavonoids, phenolics, antioxidant and antibacterial activity in BPF so that this research can be further developed into certain products. Extraction using maceration method with 96% ethanol solvent (1:10). DPPH method for measuring antioxidant activity and the disc paper diffusion method for testing antibacterial activity. BPF contain flavonoids and total phenolics of 19.44 ± 0.060 mg Quercetin Equivalent (QE)/g and 36.37 ± 0.47 mg Gallic Acid Equivalent (GAE)/g, respectively. BPF also contains antioxidants with an IC50 index of 49.47 µg/mL and BPF extract has no antibacterial activity using the paper disc diffusion method. This antioxidant-rich BPF extract has a lot of promise for development into a cosmetic preparation with more research. Keywords: Butterfly Pea Flower, Antioxidant, Antibacterial, Flavonoid, Phenolic.]]>
<![CDATA[REAL WORLD DATA : ANTIVIRUS SELECTION IN COVID-19 PATIENTS AT PKU MUHAMMADIYAH GAMPING HOSPITAL ]]>
<![CDATA[Damayanti, Hazena Misgi]]>;
<![CDATA[Perwitasari, Dyah Aryani]]>;
<![CDATA[Risdiana, Irma]]>;
<![CDATA[Kuluq, Muhammad Husnul]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1125
<![CDATA[COVID-19 is a disease that requires antivirals, such as favipiravir and remdesivir, which have been recommended in Indonesia. Choosing the right antiviral agent can affect the length and total cost of hospitalization. The impact of COVID-19 can cause a decline in health and the economy, if not treated effectively. This study aimed to determine the average length of hospitalization and total cost of hospitalization for COVID-19 patients based on the selection of favipiravir and remdesivir antivirals at the PKU Muhammadiyah Gamping Hospital from August 2022-August to 2023 based on real world data. The research method was Observational research with a descriptive research design and retrospective data collection was used. During this period, 306 patients were diagnosed with COVID-19. A total of 171 patients met the inclusion criteria, including 130 patients using favipiravir antivirus and 41 patients using remdesivir antivirus. The results of this study are the average length of hospitalization of the patient group with antiviral favipiravir was 4.1 days and the patient group with antiviral remdesivir was 5 days and the average total cost of hospitalization of the patient group with antiviral favipiravir was IDR 12,377,415 and the average total cost of the patient group with antiviral remdesivir was IDR 14,428,132. The conclusion of this study is that the use of favipiravir antiviral therapy is more effective when viewed from the perspective of length of hospitalization and total cost of hospitalization; therefore, these results can be applied under the same conditions in the treatment of COVID-19.]]>
<![CDATA[AN OVERVIEW OF THE COMMUNITY KNOWLEDGE LEVEL TOWARDS THE USE OF GENERIC DRUGS IN TUPA VILLAGE, NORTH BULANGO DISTRICT, BONE BOLANGO REGENCY, GORONTALO PROVINCE, IN 2022 ]]>
<![CDATA[Abubakar, Fadlun]]>;
<![CDATA[Yunus, Fitriah Ayu Magfirah]]>;
<![CDATA[Hasili, Abdul Sulhadi]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1195
<![CDATA[Generic drugs are medications with generic names, as defined by the Indonesian Pharmacopoeia and International Non-proprietary Names (INN) from the WHO, and they do not use trade names or manufacturer logos. Examples of these include amoxicillin and metformin. The public often perceives generic drugs to be inferior to patented drugs because of their relatively lower prices. The purpose of this study is to describe the knowledge level of the community about the use of generic drugs in Desa Tupa, Kecamatan Bulango Utara, Kabupaten Bone Bolango in 2022. This study employs a descriptive method using a quantitative approach. Data were collected through questionnaires that were distributed to 30 randomly selected respondents. A univariate analysis was conducted by creating frequency distributions to determine the community's awareness level regarding generic drugs. The survey results indicated that most residents of Desa Tupa have limited information about the use of generic drugs. The study concluded that, in terms of knowledge level about generic drugs, 30% of respondents had heard of generic drugs, 22% knew that generic drugs were named according to INN (International Non-proprietary Names), 11% understood that generic drugs are those that have expired patents, 9% recognize that generic drugs do not use brand names, and 28% are aware that generic drugs are more affordable than branded drugs.]]>
<![CDATA[ANTIOXIDANT ACTIVITY, TOTAL PHENOL, AND FLAVONOID CONTENT EXTRACTS AND FRACTIONS MANGO SEEDS (Mangifera indica L.) ]]>
<![CDATA[Anjani, Ratna]]>;
<![CDATA[Kasmawati, Henny]]>;
<![CDATA[Yamin]]>;
<![CDATA[Salamah, Nina]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1196
<![CDATA[Antioxidants can either stop or slow down the excessive oxidation of a compound. This study aimed to determine the secondary metabolite compounds, antioxidant activity, total flavonoid and phenolic levels, and the correlation between the levels of flavonoid and phenolic compounds in inhibiting free radicals. The DPPH (1,1-diphenyl-2-picrylhydrazyl) method was used to evaluate antioxidant activity. Determination of total flavonoid levels using a UV-Vis spectrophotometer and the aluminum chloride method. The total phenolic content was determined using the Folin-Ciocalteu method. Based on the results of phytochemical screening, mango seed extract (Mangifera indica L.) contains secondary metabolites such as alkaloids, flavonoids, terpenoids, phenolics, and tannins. The relationship between the antioxidant activity of the DPPH method and total flavonoid levels was 91.31%, respectively. The relationship between the antioxidant activity of the DPPH method and the total phenolic content was 99.64%. Keywords: Mangifera indica L, secondary metabolites, antioxidant activity, DPPH, total flavonoids, total phenolics.]]>
<![CDATA[REVIEW ARTICLE: NANOHERBAL AS A NATURAL SOLUTION FOR BACTERIAL DIARRHEA PROBLEMS ]]>
<![CDATA[Embas Saraswati, Dewa Ayu]]>;
<![CDATA[Jafar, Garnadi]]>;
<![CDATA[Sulaeman, Agus]]>;
<![CDATA[Mulyani, Yani]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1248
<![CDATA[Diarrhea is a global health problem that is often caused by bacterial infections, including Escherichia coli and Staphylococcus aureus. The use of conventional antibiotics in treating diarrhea often faces challenges, such as drug resistance and adverse side effects. As an alternative, current research interest is focused on the use of nanoparticles from herbal ingredients as potential antibacterial agents in the treatment of diarrhea. This review article aims to present the latest developments in the use of herbal nanoparticles as an anti-bacterial therapy for diarrhea. The literature search method was carried out via PubMed, Science Direct, and Google Scholar using relevant keywords. Selected articles must meet inclusion criteria, such as originality, language, period, and availability of full text. After the selection process, articles that meet the criteria will be reviewed to identify findings related to the use of herbal nanoparticles in treating diarrhea. Data analysis was conducted to compare the findings of each article and draw appropriate conclusions. Therefore, this review article aims to provide a comprehensive understanding of the potential use of nanoparticles from herbal ingredients as an effective and safe solution to treat diarrhea problems, while also highlighting interesting research possibilities to be carried out in the future. effectiveness and bioavailability in the treatment of diarrhea. By increasing absorption and penetration into bacterial cells, this therapy can serve as an effective and sustainable antibacterial agent ...]]>
<![CDATA[POTENTIAL ANTIOXIDANT ACTIVITY OF SURUHAN LEAF AND STEM EXTRACT (Peperomia pellucida L. Kunth) USING THE DPPH METHOD AND DETERMINATION OF PHENOLIC AND FLAVONOID LEVELS ]]>
<![CDATA[Sodik, Jajang Japar]]>;
<![CDATA[Budiana, Wempi]]>;
<![CDATA[Roni, Asep]]>;
<![CDATA[Wahyudin]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1264
<![CDATA[Antioxidants are compounds that are capable of neutralizing free radicals. One plant with potential antioxidant properties is Peperomia pellucida. Objective: This study aimed to determine the antioxidant activity, total phenolic content, and total flavonoid content of extracts of the leaves and stems of Peperomia pellucida. Methods: Antioxidant activity was tested using the DPPH method, while the total phenolic and flavonoid contents were measured using UV-Vis spectrophotometry. Extraction was performed via reflux using three different solvents: n-hexane, ethyl acetate, and ethanol. Results: The highest antioxidant activity was found in the ethanol extract of the leaves, with an IC50 value of 36.85 µg/mL, and in the stems, with an IC50 value of 71.28 µg/mL. The highest total phenolic content in the ethanol extract of the leaves was 14.46 mg GAE/g and that in the stems was 12.82 mg GAE/g. The highest total flavonoid content in the ethanol extract of the leaves was 12.12 mg QE/g and that in the stems was 10.49 mg QE/g. Conclusion: The results indicated that the ethanol extract of Peperomia pellucida leaves exhibited very strong antioxidant activity. Keywords: antioxidants, DPPH, phenolic, flavonoids, suruhan Plants]]>
<![CDATA[SYNTHESIS OF CHALCONE AND PYRAZOLINE DERIVATIVES WITH ACETOPHENONE AND VERATRALDEHYDE AS PRECURSORS ]]>
<![CDATA[Fatmayanti, Baiq Risma]]>;
<![CDATA[Habibie, Ahmad]]>;
<![CDATA[Dhey, Anselmania Kartini]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1274
<![CDATA[Chalcones and pyrazolines are heterocyclic compounds with promising biological and pharmaceutical activities. Chalcone and pyrazoline can be found in different sources, such as natural and synthetic compounds. This study aimed to explore the synthesis of chalcone and pyrazoline derivatives with acetophenone and veratraldehyde as precursors. Chalcone was successfully synthesized through the Claissen-Schmidt reaction between acetophenone and veratraldehyde at room temperature 25-30 ºC and mediated by KOH as a base catalyst for 20 hours. The corresponding substituted pyrazoline derivative was also successfully synthesized through a cyclocondensation reaction between the synthesized chalcone and phenylhydrazine as starting materials under reflux conditions at temperatures of 75-80 ºC for 4 hours. The Chalcone A derivative compound obtained was (E)-3-(3,4-dimethoxy phenyl)-1-phenyl prop-2-en-1-one (Chalcone A). The Pyrazoline A derivative compound was obtained as pyrazole compound 5-(3,4-dimethoxy phenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole (pyrazoline A). Chalcone A and Pyrazoline A obtained as yellowish and brownish-orange powders in 14.89 % and 66.57 % yields, respectively. The chastities of Chalcone A and Pyrazoline A was 98.55 % and 88.54 %, respectively. A qualitative identification for both synthesized compounds was performed using normal-phase thin-layer chromatography which revealed the Rf value for Chalcone A and Pyrazoline A was 0.43 (in mobile phase ethyl acetate:n-hexane 3:1 v/v) and 0.55 (in mobile phase DCM:n-hexane 3:1 v/v), respectively. Moreover, the elucidation structure of synthesized compounds using FTIR and GC-MS instruments revealed the structure of synthesized Chalcone A and Pyrazoline A agrees with the theoretical structure of Chalcone A and Pyrazoline A. Keywords: Synthesis, Chalcone, Pyrazoline, Acetophenone, Veratraldehyde]]>
<![CDATA[IN SILICO IDENTIFICATION OF BREADFRUIT PLAN COMPOUNDS (Artocarpus atilis) AGAINST ANGIOTENSIN-CONVERTING ENZYME 2 AS A CANDIDATE MODEL OF COVID-19 INHIBITORS ]]>
<![CDATA[Fauzi, Muhammad]]>;
<![CDATA[Soemarie, Yulistia Budianti]]>;
<![CDATA[Hasniah]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1275
<![CDATA[The spread of COVID-19 has continued to grow rapidly worldwide. This disease is characterized by the presence of severe respiratory syndrome disorders in humans. The ACE2 receptor is the gateway for the COVID-19 virus to target cells, where it is expressed in airway epithelial and vascular endothelial cells. Breadfruit (Artocarpus altilis) contains active flavonoids. Flavonoid derivatives found in breadfruit include artonin-E, cycloaltilisin-7, cycloaltilisin, isocyclomorusin, cyclomorusin, cyclomulberrin, isocyclomulberrin, cyclocommunal, morusin, quercetin and artocarpin. This study aimed to determine the flavonoid derivative of breadfruit (Artocarpus altilis), which has the most effective potential against the ACE2 receptor, as a candidate inhibitor of the COVID-19 virus in silico. The results showed that of the eleven flavonoid derivatives of breadfruit (Artocarpus altilis) tested, 3 compounds gave the lowest binding affinity value, namely cycloaltilisin -8.79 kcal/mol, cyclomulberrin -8.95 kcal/mol, and artocarpin -9.30. kcal/mol compared to Chloroquine -7.67 kcal/mol and Hydroxychloroquine -7.22 kcal/mol. The predicted results of the Lipinski Rule of Five showed that the 3 compounds and the comparison drug met the Ro5 rule. The compounds cycloaltilisin, cyclomulberin, and artocarpine have antiviral activity, as indicated by the Pa value in the range of 0.5<Pa<0.7. Cycloaltilisin, cyclomulberin and artocarpine are the most effective compounds to be developed as candidates for COVID-19 inhibitors. Keywords: Breadfruit, ACE-2, Covid-19, In Silico]]>
<![CDATA[ANALYSIS OF FACTORS AFFECTING THE QUALITY OF LIFE OF PROLANIS PATIENT WITH TYPE 2 DIABETES MELLITUS ]]>
<![CDATA[Handayani, Dian]]>;
<![CDATA[Salsabila, Jihan]]>;
<![CDATA[Versita, Riana]]>;
<![CDATA[Pranata, Meki]]>
<![CDATA[ Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024) ]]>
Publisher : <![CDATA[Sekolah Tinggi Farmasi Muhammadiyah Cirebon ]]>
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DOI: 10.37874/ms.v9i3.1277
<![CDATA[Diabetes mellitus is an infectious disease characterized by hyperglycemia due to abnormalities in insulin secretion action or both. The goals of diabetes mellitus therapy include reducing symptoms and complications, reducing mortality, and improving the quality of life of patients with diabetes mellitus. This study aimed to provide an overview of the quality of life and the correlation between the characteristics of respondents and the quality of life of patients with type 2 diabetes mellitus who received oral antidiabetics. This study used observational analytics with a cross sectional design of 84 respondents. Patients' quality of life was measured using the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ). Data analysis was performed using an Independent Sample T-test. The results of this study showed that the quality of life of patients with type 2 diabetes mellitus was classified as good (56%) and there were significant differences between the two groups in the domains of health pressure, personal satisfaction, and trial effects on the DQLCTQ questionnaire; there were significant differences in BMI, duration of DM, and treatment type on the quality of life of prolanis patients with type 2 diabetes mellitus. Keywords: type 2 diabetes mellitus, quality of life, DQLCTQ]]>
