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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 523 Documents
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SYNTHESIS AND CHARACTERIZATION OF MOLECULAR IMPRINTED POLYMERS FOR PHENYLBUTAZONE EXTRACTION Dang Soni; Selvira Anandia Intan Maulida; Meilia Suherman; Aliqa Azqia Azzahra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.920

Abstract

Phenylbutazone is a pharmaceutical substance often added to rheumatic herbs. However, because of the complexity of the matrix caused by the presence of compounds in herbal medicines, the determination of phenylbutazone requires a time-consuming sample preparation process prior to analysis. This study was conducted to develop a specific sorbent that can be used to prepare phenylbutazone in herbal medicine. The performance of phenylbutazone Molecularly Imprinted Polymer (MIP) was evaluated using three distinct porogens (ethanol, methanol, and methanol-chloroform (1:1)) and two polymerization procedures (bulk and precipitation). According to the results of the polymer optimization, the polymer generated by precipitation in methanol-chloroform (1:1) has good sorbent characteristics. FTIR physical characterization revealed complete polymerization. The bulk procedure produces a more physically stable sorbent than the precipitation method does.  Keywords: MIP Performance Evaluation, Phenylbutazone Molecular Imprinted Polymer, Polymer Imprinting Factor
FORMULATION AND PHYSICAL EVALUATION OF EFFERVESCENT GRANULES OF MINT LEAF EXTRACT (Mentha x piperita L) AS STIMULANSIA Herliningsih; Angga Anugra Diputra; Haty Latifah; Melinda Fuji Rahayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.922

Abstract

Indonesia is a country with a diverse biodiversity spread across various regions. Several types of plants in Indonesia can be utilised as herbal medicines. One such plant suitable for medicinal purposes is mint leaves (Mentha x piperita L.). The chemical content found in mint leaves includes essential oils that serve as stimulants. This research aims to determine whether mint leaf extract can be used to create an effervescent granule formulation. Effervescent granules are produced using the wet granulation method, incorporating the active ingredient of mint leaf extract with different concentrations: F0: without the addition of mint leaf extract; F1: mint leaf extract added with a concentration of 15%; and F2: mint leaf extract added with a concentration of 17%. The effervescent granule formula is then evaluated based on its physical characteristics. Phytochemical screening of mint leaves yielded positive results, indicating the presence of essential oils. All mint leaf extract formulations tested for physical evaluation met the specified criteria. Flow properties and angle of repose testing resulted in values between 2-3 seconds for flow properties and 35°-36° for the angle of repose. Compressibility testing produced results ranging from 5% to 15%, pH testing yielded results between 5 and 6, and dissolution time results ranged from 40 to 41 seconds.  Keywords: Mint leaves, extraction, wet granulation, effervescent granules
EFFECTIVENESS TEST OF WOUND PATCH PREPARATIONS OF GOTU KOLA LEAF EXTRACT (Centella asiatica (L.) Urb.) ON INCISION WOUND IN RABBITS Marini Marini; Nur Azizah; Devin Nur Rohman; Angga Anugra Diputra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.923

Abstract

A wound patch is a dosage form that delivers drugs through the skin to produce systemic effects, with the advantage of controlled drug release. Centella asiatica (L.) Urb.) is widely used to heal incision wounds on the skin. The most important component was asiaticoside, which plays a major role in accelerating wound healing. This  study  was  conducted  to  test  the  effectiveness  of  transdermal  patches  from Centella asiatica (L.) Urb.) against incision  wounds was performed on 5 rabbits divided into different treatment groups, namely group I without treatment, group II wound patch base (negative control), group III plaster (positive control), and groups IV and V, comprising a wound patch of gotu kola leaf extract at concentrations of 16% and 32%, respectively. The data obtained were statistically tested for normality using the Shapiro-Wilk test.  The results showed that the wound patch preparation of 16% gotu kola leaf extract showed  a significant difference (p < 0.05) in wound length reduction compared to the negative and normal controls.  The wound healing time observed at concentrations of 16% and 32% provided wound healing effects. The best effect was observed at a concentration of 16%, with an average wound closure time of 12 days. It can be concluded that gotu kola leaf extract in the form of a wound patch preparation was effective in wound healing. Keywords: Gotu kola leaf extract; incision wound; Wound patch; Effectiveness test
FORMULATION AND STABILITY OF STERILE GEL OF AGARWOOD LEAVES EXTRACT (Gyrinops Versteeg (Gilg.) Domke) FOR DIABETIC WOUNDS Silvi Nurafni; Antonius Padua Ratu; Anisya Dwi Shakil; Siska Fitri Herdiyanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.924

Abstract

Agarwood leaves contain high levels of secondary metabolites due to increased metabolic processes in agarwood trees infected with fungi. Through this metabolic process, leaves contain secondary metabolites, flavonoids, and tannins. This causes agarwood leaves to have potential as an anti-inflammatory agent for treating diabetic wounds, aimed to formulate a sterile gel preparation of agarwood leaf extract and evaluate its quality, including sterility tests and stability tests (cycling tests) including organoleptic tests, homogeneity, spreadability, adhesive power, viscosity, and pH. A sterile gel formula was prepared with an extract concentration of 4% and variations of Carbopol 940 (gelling agent), namely 0.75%, 1.0%, and 1.25%. The results showed that F1, F2, and F3 were sterile and free of bacterial and fungal growth. The stability test before and after the cycling test in organoleptic tests F1, F2, and F3 were brown, had a distinctive odor of gaharu leaves, and had a soft texture. The homogeneity tests F1, F2, and F3 Homogeneous. The pH values before the cycling test were F1 5.63, F2 4.55, and F3 4.57, whereas after the cycling test, they were F1 5.05, F2 4.87, and F3 4.63. Adhesion time before cycling test F1 02.97 seconds, F2 03.15 seconds, F3 04.86 seconds while after cycling test F1 02.64 seconds, F2 03.04 seconds, F3 03.08 seconds. Spreadability test before cycling test F1 5.4 cm, F2 4.6 cm, F3 3.7 cm, while after cycling test F1 5.0 cm, F2 4.7 cm, F3 3.5 cm ...
FORMULATION AND ANTIBACTERIAL ACTIVITY OF HERBAL TOOTHPASTE BASED ON ACEH TRADITIONAL MEDICINE Rima Hayati; Amelia Sari; Rini Handayani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.925

Abstract

This research is based on Acehnese traditional medicine containing betel leaf, areca nut, kencur rhizome, gambier sap, and clove buds. Traditionally, all parts of the plant are wrapped in betel leaf folds and chewed to maintain oral health. This study aimed to incorporate these ingredients into an herbal toothpaste and test its efficacy against bacteria that cause tooth decay, such as S. mutans and E. faecalis. Extracts from betel leaf, areca nut, aromatic ginger, gambier sap, and clove buds were used in this study. Based on variations in extract concentrations, three formulations were developed: F1, F2, and F3. In addition, F0 was the toothpaste base. The herbal toothpaste was light brown in color, homogeneous, semisolid, and had a characteristic betel leaf aroma, according to the evaluation results. The final product had a pH of 7.52–8.59, viscosity of 238.9–242.3 cP, and a foam height of 20 mm (F0), 11 mm (F1), 9 mm (F2), and 6 mm (F3). These values meet the toothpaste quality standard (SNI 112-3524-1995). While F1 showed moderate inhibition against S. mutans and E. faecalis in the antibacterial test, F2 and F3, showed high inhibition against S. mutans and moderate inhibition against E. faecalis. Based on these results, the optimal formula is F3 which has a larger inhibition diameter of 12.23 mm for S. mutans and 9.10 mm for E. faecalis. This herbal toothpaste can be developed to prevent oral candidiasis and gingivitis.  Keywords: herbal toothpaste, antibacterial activity, Streptococcus mutans, Enterococcus faecalis
REVIEW : THE EFFECT OF MEDICATION REMINDER APPLICATIONS ON MEDICATION COMPLIANCE IN TYPE 2 DIABETES MELLITUS PATIENTS Deni Hendra Alamsyah; Yani Mulyani; Marita Kaniawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.926

Abstract

Diabetes Mellitus (DM) is a medical disorder that is characterized by elevated blood glucose levels. Its prevalence is increasing globally, with Indonesia projected to have 21.3 million type 2 DM patients by 2030. Medication compliance is crucial in managing diabetes, and medication reminder applications can effectively enhance patient adherence. We conducted a systematic review of 10 national and international journals from to 2013-2023 using PubMed, Google Scholar, and Science Direct, focusing on the following keywords: Diabetes, Medication Compliance, Medication Reminder Application. Our findings suggest that patient knowledge and compliance play a pivotal role in the success of therapy management and that medication reminder applications have a positive impact on enhancing medication adherence. Ensuring that patients with diabetes have access to these tools may improve treatment outcomes. Keywords: Diabetes Mellitus Type 2; Medication Compliance; Medication Reminder Application, Medication Adherence; Medication Reminder App
CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY TEST OF HONEY, LEMON, GINGER FERMENTATION AGAINST BACTERIA CAUSING ACUTE RESPIRATORY INFECTIONS (ARI) Andi Dian Astriani; Muhammad Iqbal
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.931

Abstract

Acute respiratory infection (ARI) is a disease that attacks one or more parts of the airway, from the nose to the alveoli. The most common bacteria found in the samples of patients with ARI were Streptococcus pneumonia, Staphylococcus aureus, and Klebisilia pneumonia. Honey contains flavonoids, amino acids and potassium as antibiotics that are bactericidal (kill bacteria) and bacteriostatic (inhibit bacterial growth). Gingerol in ginger (Zingiber officinale) and lemon (Citrus limon) has antibacterial activity. Honey fermentation is believed to have great potential as an antibacterial compound. This study aimed to determine the inhibitory activity and physical characteristics of fermented honey, lemons, and ginger against ARI bacteria. The test bacteria used were Streptococus pneumonia, Stahpylococcus aureus, and Klebsilia pneumonia. Fermentation of honey, lemon, and ginger was performed with variations in fermentation time (days 1, 3, 5, and 7) and honey without fermentation to determine the effect of fermentation time on inhibitory activity. The inhibition activity was tested using the agar diffusion method. Measurement of inhibition diameter using a caliper. Determination of ginger lemon fermented honey characteristics, including water content, sucrose content, and total sugar content, using gravimetric and titrimetric methods. Based on the activity test, honey fermented for 1 day had the greatest inhibitory activity of 9.71 mm; 9.20 mm; and 9.86 mm against Stahpylococcus aureus, Staphylococcus pneumonia, Klebsilia pneumonia compared to honey fermented for 3 days, 5 days, 7 days and honey without fermentation. ...
ANTIOXIDANT ACTIVITY OF ROASTED KEDAWUNG SEED (Parkia timoriana) USING SCAVENGER FREE RADICAL DPPH METHOD Ismanurrahman Hadi; Teguh Adiyas Putra; Reza Alrayan; Arif Setiawansyah; Dewi Luthfiana; Perdana Priya Haresmita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.932

Abstract

Kedawung seeds (Parkia timoriana) contain polyphenolics and flavonoids that can provide pharmacological activities, such as antioxidants. In several regions of Indonesia, kedawung seeds are preserved using the roasting method. This study aimed to analyze the effect of roasting on the content of phytochemical compounds and determine their antioxidant activity using the DPPH method. Roasted kedawung seeds were extracted using a maceration method in ethanol. Phytochemical screening was performed to qualitatively analyze the contents of several phytochemical compounds in the extract. The results showed that roasted kedawung seed extract contained alkaloids, flavonoids, saponins, and terpenoids. Antioxidant testing was performed using the DPPH method with ascorbic acid as a positive control. The IC50 value of ascorbic acid, P. timoriana seed and roasted seed of P. timoriana measured each 12.3 ppm; 20.6 ppm and 9.8 ppm; which categorized as strong antioxidant compounds. These results indicated an increase in the antioxidant effect after roasted seed processing. It concluded that the roasting process could enhance antioxidant effect of P. timoriana seed  Keywords: Kedawung seeds, roasted method, antioxidant, DPPH
FORMULATION AND IMMUNOMODULATORY BIOACTIVITY TEST OF NANOPARTICLE SYRUP OF ETHANOL EXTRACT OF SUNGKAI LEAVES (Peronema canescens Jack) Haflin; Agusriani; Kartika Mustofa; Ruri Putri Mariska; Rizky Yulion; Pitriani; Shafira Al Fadhilah; Barmi Hartesi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.936

Abstract

Sungkai plants are beneficial immunomodulators because of the presence of flavanoid compounds that increase oxygen radicals and antibody production. Pharmaceutical preparations function as immunomodulators, typically in the form of syrups, tablets, capsules, suspensions, and emulsions. Until now, there has been no nanoparticle syrup on the market, even though nanoparticle preparations have the advantage of modifying particle size, controlling the release of active ingredients to reach the active side, protecting drugs from degradation, reducing toxicity, and minimizing side effects. The purpose of this study was to determine whether the syrup of nanoparticles in the ethanol extract of Sungkai leaves acts as an immunomodulator and the stability of the preparation during storage. The methods used were experimental in the laboratory with extraction using the maceration method. The extract obtained was formulated into a nanoparticle solution using the ionic gelation method, then formulated into FO syrup (Base syrup) and F1 syrup (Nanoparticles of ethanol extract of sungkai leaves) and then carried out transmittance tests, particle size analyzer tests, immunomodulatory tests and stability tests. The yield of the extract was 17.5%. The raw material examination of all the materials was in accordance with the literature. The particle size of the nanoparticle solution was 40 nm, that of F0 syrup was 670 nm, and that of F1 syrup was 964 nm. All syrup preparations fell into the nanoparticle size category of 10–1,000 nm. The leukocyte count of the negative control treatment (syrup base) was 5,011 cells/mm³, ...
POST-CHEMOTHERAPY TREATMENT IN NATIONAL HEALTH INSURANCE BREAST CANCER PATIENTS AT YOGYAKARTA CITY HOSPITAL Anggraeni, Dita Putri; Yuliastuti, Fitriana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.939

Abstract

Breast cancer accounts for approximately 16.6% of 396,914 cases of cancer and is one of the most fatal and common diseases among women. Treatment of breast cancer mostly has side effects, but the incidence of drug side effects does not always appear because the target drug does not selectively act on the target action. The aim of this study was to find a picture of post-chemotherapy treatment in breast cancer chemotherapy patients participating in the National Health Insurance at RSUD Yogyakarta. Observational method: Retrospective collection of data obtained from patients’ medical records. The subjects included patients with breast cancer at RSUD Yogyakarta who met the inclusion criteria for the primary diagnosis of breast cancer and received chemotherapy medication during the period of 2020. The univariate analysis showed the distribution of frequency and percentage of respondent characteristics, including age, gender, number of patients, single and combination chemotherapy drugs, generic and commercial drugs, and single or combination post-chemotherapy medications. The results were obtained from 72 patients who underwent 4 periods of chemotherapy. The most frequently used chemotherapy regimens for each period were the period 1 combination of Brexel, Epirubicin, Carboplatin. Period 2 combination of the Brexel and Zometa regimes. Periode 3 combination brexel, epirubicine, and carboplatin. The most widely used combination of post-chemotherapy drugs in periods 1-4 was the combination of Ranitidine and Ondansetron. Keywords: Ca Mamae, Chemotherapy, Regimen, Drugs

Page 36 of 53 | Total Record : 523

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