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INDONESIA
Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 190 Documents
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Analisis Hubungan Polifarmasi Dengan Potensi Interaksi Obat Pada Peresepan Pasien Diabetes Melitus Tipe 2 Mulyani, Yani; Siti Balqis, Salwa; Sutrisno, Entris; Anggriani, Ani
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.332

Abstract

The IDF estimates that the prevalence of diabetes mellitus based on age will continue to increase from 2021 to 2045 (24.0% vs 24.7%). Patients with diabetes mellitus have comorbidities that result from elevated blood glucose levels, leading to polypharmacy and potential drug interactions. This study aims to determine the percentage of drug interactions and the relationship between polypharmacy and the potential for drug interactions in patients with type 2 diabetes mellitus at RSU Rama Hadi Purwakarta. The study was conducted using a cross-sectional, retrospective method, analyzing prescriptions of patients with type 2 diabetes mellitus at RSU Rama Hadi from September 1 to 30, 2022. Prescriptions were identified for interaction types and severity using drugs.com, Medscape, and Stockley's Drug Interaction Handbook, 9th edition, with results analyzed using Fisher's exact test. The study found that patients aged 56-65 years (40.1%) were more likely to suffer from type 2 diabetes mellitus, with females having a higher incidence compared to males (70.7% vs 29.3%). Among 147 prescriptions, 97% had drug interactions, with moderate severity predominating (97.8%), and pharmacodynamic interactions being the most common (76%). Fisher's exact test revealed a p-value of 0.001 (p < 0.005). Thus, it can be concluded that there is a significant relationship between polypharmacy and the potential for drug interactions in the prescriptions of type 2 diabetes mellitus patients at the pharmacy department of RSU Rama Hadi Purwakarta.
Evaluasi Efektivitas Penggunaan Obat Antihipertensi Pada Pasien Preeklampsia Rawat Inap Di RSIA Sitti Khadijah 1 Makassar Friska Adelia S; Jangga, Jangga; Kurnia Anjani, Qonita
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.336

Abstract

Preeclampsia is a medical condition that occurs during pregnancy, characterized by high blood pressure and the presence of protein in the urine (proteinuria) after 20 weeks of gestation. This condition poses a risk to pregnant women, fetuses and newborn babies. Mothers with preeclampsia suffer severe morbidity and mortality due to impaired function of organs such as the kidneys and liver, as well as blood clotting problems, which can occur in hypertension in pregnancy. Problems with the placenta and stunted fetal growth are also risks. Therefore, evaluation of the use of antihypertensive drugs is very important. The goal is to ensure that the drugs used are appropriate, effective and safe for pregnant women. This study aims to determine the profile and effectiveness of the use of antihypertensive drugs in inpatient preeclampsia patients at RSIA Sitti Khadijah 1 Makassar. This research uses a non-experimental (observational) descriptive method. The data used is retrospective, namely in the form of secondary data. The data source comes from medical records of inpatients diagnosed with preeclampsia. The research was conducted at RSIA Sitti Khadijah 1 Makassar for the period January 2023 to April 2024. The results of the study showed that the use of antihypertensive drugs in 47 preeclampsia patients, namely nifedipine monotherapy, was 87%, the combination of nifedipine and methyldopa was 9%, the combination of nifedipine and amlodipine was 4%. Most of the antihypertensives used are effective and have achieved the therapy goals of the Queensland Clinical Guideline 2021. Compliance with the use of antihypertensive drugs and doses was achieved at 96%, while 2% were declared inappropriate. As many as 94% were effective in reducing blood pressure according to therapy goals.
Penelusuran in Silico Potensi Antimalaria dari Karang Lunak Lobophytum sp. sebagai Inhibitor Dihydroorotate Dehydrogenase dari Plasmodium falciparum Arfan, Arfan; Rayani, Nur; Ode Aman, La
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.341

Abstract

Malaria is one of the infectious diseases caused by the Plasmodium parasite and remains a persistent health challenge. Therefore, exploring compounds with potential as antimalarials remains a crucial aspect. This study aims to evaluate the identified compounds from the soft coral Lobophytum sp. as antimalarial candidates using molecular docking techniques, predicting their profiles including pharmacokinetic and drug likeness. The identified compounds from this soft coral were successfully docked into the active site of the Plasmodium falciparum's enzyme dihydroorotate dehydrogenase (DHODH) using AutoDock Vina, and pharmacokinetic profiles and drug likeness were predicted using SwissADME. Compounds Saurufuran B and Oxyphyllacinol from Lobophytum sp. exhibited binding affinity energies of -9.4 kcal/mol and -8.6 kcal/mol against DHODH, which were more negative than other compounds but less negative than the inhibitor F1T (-10.7 kcal/mol). These compounds showed hydrogen bonding with amino acids His185, Lys429, Asn458, and Ser505 and hydrophobic interactions with amino acids Cys175, Leu176, Phe188, Ile263, Arg265 of the DHODH enzyme. The pharmacokinetic profile of these compounds revealed good solubility and high gastrointestinal absorption, making them suitable for drug development. These compounds are expected to inhibit the function of CYP450 isoforms as important metabolizing enzymes in the body. Furthermore, Saurufuran B and Oxyphyllacinol also exhibit a safe toxicity profile and meet the drug-likeness criteria based on Lipinski's Rule of Five. These findings suggest the potential of Saurufuran B and Oxyphyllacinol from Lobophytum sp. as DHODH enzyme inhibitors for P. falciparum with favorable affinity predictions and pharmacokinetic profiles for antimalarial drug development.
Pengembangan Gel Antiseptik Tangan Mengandung Minyak Atsiri Jeruk Lemon Menggunakan Metode Mikroemulsi Gel Husni, Patihul; Cahya Lestari, Riska; Hartono, Kusdi
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.342

Abstract

Hand antiseptic gel preparation is a product that is widely used to protect the body from the entry of bacteria through the hands because of its practical use. Lemon peel (Citrus limon (L) Burm. F) contains essential oils that can inhibit the growth of bacteria so it can be used as a natural antiseptic. This research is aimed at obtaining the best formula preparation of hand antiseptic gel containing lemon essential oil (Citrus lemon (L) Burm. F). The microemulsion formula of lemon essential oil is optimized by making variations in the concentration of surfactant (Tween 80) and cosurfactant (propyleneglycol dan glycerin) which is then formulated into gel dosage form by using a variation in the concentration of the gelling agent. The preparation of the gel carried out a physical stability test that included organoleptic testing, homogeneity, pH, and viscosity. The optimization result of the best microemulsion formula is a formula with a Tween 80 as a surfactant and propylene glycol as a cosurfactant. Hand antiseptic gel preparation containing lemon essential oil (Citrus limon (L) Burm. F) with formula F2 is the best preparation because it is more stable according to the physical stability test of the preparation.
Gambaran Penggunaan Tanaman Obat Di Desa Daya Murni Kecamatan Tumijajar Kabupaten Tulang Bawang Barat Tahun 2024 Mulatasih, Endah; Wulan Syafira, Melsya; Isnenia, Isnenia; Yulyuswarni, Yulyuswarni
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.343

Abstract

Medicinal plants have long been used by Indonesian people as an alternative traditional treatment. Plants have been an important source of medicine for thousands of years. The use of plants for healing is the oldest form of medicine in the world. The medicinal plants chosen are usually plants that can be used for first aid or light medicines such as coughs and fever. Based on a pre-research survey in Dayamurni Village, it was found that many people still use medicinal plants for various health complaints. This study aims to determine the overview of medicinal plant usage in Dayamurni Village, Tumijajar District, West Tulang Bawang Regency in 2024. This research is a quantitative descriptive study with a quota sampling technique of 100 respondents who meet the inclusion and exclusion criteria. Data collection was carried out through interviews using questionnaires. The results showed that the majority of medicinal plant users were women (83%), aged 40-44 years (19%), with high school education (55%). The most widely used type of plant was ginger (27,0%), with the method of use being drunk (92,9%), in fresh form (92,9%). Usage was generally only when sick (88%), aimed at curing diseases (65%), especially for treating coughs (23,0%). The main source of information was parents (67%), and most did not use accompanying medications (60%).
The Medication Related Burden Pada Pasien Hipertensi: Studi Kasus Di Apotek Afina Yogyakarta Kurniawan, Rendy; Supadmi, Woro; Qifari Nasrun, Rahmar; Hastuti, Dwi
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.344

Abstract

Hypertension is the cause of death in 31.5% (1.39 billion). The prevalence of hypertension is increasing in low- and middle-income countries. The prevalence of hypertension in Yogyakarta reached 35.8%, higher than the national figure (31.7%).  Hypertension requires long-term treatment which can cause a burden of treatment on patients. The purpose of this study was to determine the characteristics, treatment patterns and treatment burden of hypertension patients at Afina Pharmacy Yogyakarta. This study is an observational  descriptive approach. Data collection was carried out through direct interviews with patients about the burden of treatment with the Living With Medicine Questionaire (LMQ) questionnaire guide. The sample was in accordance with the inclusion and exclusion criteria totaling 31 respondents.  Data were analyzed using the descriptive  method.The results showed that 26 respondents (83.8%) were in the age group> 46 years, with 23 respondents (74.2%) of whom were female, the respondent's education level was at the SMA-PT level, namely 20 respondents (64.5), and 22 respondents (71%) had a previous history of hypertension.Based on patient therapy patterns, 22 respondents (70.9) used Calcium Channel Blocker class antihypertensives, namely Amlodipine and 18 respondents (58.1%) used Angiotensin Reseptor Blocker class antihypertensives, namely Candesartan 16 mg. Medication Related Burden of hypertension patients at Afina Yogyakarta Pharmacy is in the category of low burden 7 respondents (22.6%) and moderate burden 24 respondents (77.4%).
Gambaran Kejadian Efek Samping Kemoterapi Pasien Kanker Payudara Yang Menggunakan M-Health App “Pantau Kanker” Di Rumah Sakit Kota Yogyakarta Nur P, Kanindya; Zukhruf Saputri, Ginanjar; Supadmi, Woro; Akrom, Akrom; Muhlis, Muh
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.345

Abstract

Breast cancer is a type of cancer with a fairly high death rate. DIY Province has the highest prevalence of breast cancer in Indonesia. One of the medical ways to treat cancer is chemotherapy which uses cytostatic drugs, aimed at killing or slowing the growth of cancer cells. However, these drugs cause side effects in patients. Education is needed in dealing with side effects in order to monitor the patient's condition. Therefore, this research was conducted to determine the incidence of side effects of chemotherapy in breast cancer patients who use the M-Health app "Pantau Kanker" at Yogyakarta General Hospital. The research method used descriptive observational, with 41 patients as respondents. Recruitment was carried out using informed consent based on inclusion and exclusion criteria. Data collection was carried out using CRF (case report form) monitoring drug side effects. Data collection was carried out on the first, third and fifth days after chemotherapy. Monitoring is carried out through direct interviews with patients and through searching medical record data. Monitoring for nausea, vomiting and pain is carried out using the "Pantau Kanker" application based on the M-Health app with the VAS (visual analogue scale).  The results of this study showed that nausea often occurs on the first day, due to immediate side effects (24 hour duration). Then, those including delayed ADRs such as anorexia, insomnia are often found on the third day, while on the fifth day the majority occur alopecia and tingling pain. Some side effects, such as diarrhea, constipation, stomatitis (mouth ulcers), and fever, are not experienced by many patients. Some side effects, such as diarrhea, constipation, stomatitis (mouth ulcers), and fever are not experienced by many patients. The therapy regimen used is dominated by low emetogenic, so that the majority of side effects that appear are in the mild category and do not interfere with the patient's activities. The conclusion of the study shows that monitoring of side effects when using cytostatic drugs occurs between days 1 to 5, the majority are in the mild category so that the patient's daily activities can still run well.
Formulasi Dan Evaluasi Sediaan Gummy Candies Mengandung Infusa Daun Jambu Biji (Psidium guajava L.) Dengan Variasi Konsentrasi Sukrosa Christiningtyas Eryani, Mikhania; Judy Handojo, Kukuh; Safitri, Manzil; Husni, Patihul
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.347

Abstract

Guava leaves (Psidium guajava L.) are a traditional medicine used to treat diarrhea. The subtance contained in guava leaves that can have antidhiarrheal properties is tannin. Gummy candies are sweet product made from the main gel- forming ingredients such as gelatin, carrageenan, jelly, as well as sweetening ingredients such as sucrose, lactose, glukose, and others. This research aims to formulate and evaluate guava leave infused gummy candies with varying sucrose concentrations of 15 (F1)%, 20% (F2), and 25% (F3). Test data for the organoleptic physical properties of F1, F2, and F3 are chewy texture, weak melon aroma, green color, and sweet taste. In the weight uniformity test there was no difference between F1, F2, and F3. The average pH test results where F1 is 5.81, F2 is 6.16 and, F3 is 6.63. Testing the water content of gummy candies resulted in average of F1 is 12.4%, F2 is 27.5, and F3 is 43,29%. The conclusion is variation concentration of sucrose affect pH and water content but its not affect organoleptic and weight uniformity of gummy candies.
Pengembangan Bahan Farmasi: Pengaruh Variasi Suhu Pengeringan Terhadap Sifat Fisik Serbuk Kering Labu Siam Husni, Patihul; Tryani Sutisna Putri, Sussy; Erika Herawati, Irma; Christiningtyas Eryani, Mikhania
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.357

Abstract

Chayote (Sechium edule (Jacq). Swartz) is potential to be a pharmaceutical material.  Therefore, this study aimed to determine the effect of drying temperature variations on the physical properties of dry chayote powder. The temperatures used in the drying process are 100 ºC, 80 ºC, and 60 ºC. Evaluation of dry chayote powder includes organoleptic test, water content, flow time, angle of repose, compressibility index, and particle size distribution. The results showed brown powder in color with a distinctive aromatic odor and sweet taste, 2.50-2.80% of water content, 5-6 second in flow time showing good flow properties, 32.21-33.42 º in angle of repose showing powder easy to flow, and compressibility index of 10% -18%. The particle size distribution of dry chayote powder was fine powder with particle size around 0.5-0.7 mm. Statistical analysis results showed there were no significant effect of the drying temperature variations on the physical properties of dry chayote powder. The conclusion of this study is drying temperature variations (100 ºC, 80 ºC, dan 60 ºC) does not affect the physical properties of dry chayote powder.
Pemanfaatan Ekstrak Kulit Buah Naga (Hylocereus polyrhizus) Sebagai Bahan Aktif Pembuatan Sabun Cair Alami Januarti, Melinda; Husni, Patihul; Christiningtyas Eryani, Mikhania
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.358

Abstract

Nowadays, many people are paying attention to the benefits of natural soap because it is believed to be gentler on the skin and environmentally friendly. This research aims to determine the formulation of natural liquid soap with the addition of dragon fruit peel extract that is effective and meets the requirements. The method used is an experimental method by formulating a natural liquid soap containing 0.5% dragon fruit peel extract as the active ingredient and adding cocamid-DEA as a foam stabilizer in variations of 1%, 3%, and 5%. The tests conducted include organoleptic tests, pH tests, foam height tests, viscosity tests, and skin condition tests. Research shows that the natural liquid soap produced has characteristics of a reddish-purple color, a distinctive scent, and varying consistency depending on the concentration of cocamid-DEA added, where F3 has the highest viscosity at 528.9 mPa, F2 at 525.7 mPa, and F1 at 428.9 mPa. From the pH testing results, F1 has a pH of 8, while F2 and F3 have a pH of 9. In the foam height test, all formulas met the soap foam height requirement of 1.3-22 cm. The first formulation of natural liquid soap with the addition of dragon fruit peel extract as an active ingredient, based on organoleptic tests, pH tests, viscosity, and foam height tests, produced the best results and met the requirements.

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