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Jurnal Bioteknologi & Biosains Indonesia
Published by Badan Riset dan Inovasi Nasional
ISSN : 24422606     EISSN : 2548611X     DOI : https://doi.org/10.55981/jbbi
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
JBBI is published twice annually and provide scientific publication medium for researchers, engineers, practitioners, academicians, and observers in the field related to biotechnology and bioscience. This journal accepts original research papers, review articles, case studies, and short communications. The articles published are peer-reviewed by no less than two referees, and cover various biotechnology subjects related to the field of agriculture, industry, health, environment, bioinformatics, as well as life sciences in general. JBBI terbit dua kali setahun dan menyediakan media penerbitan ilmiah bagi para peneliti, insinyur, praktisi, akademisi, dan pemerhati di bidang yang terkait dengan bioteknologi dan biosains. Jurnal ini menerima naskah asli hasil penelitian, naskah ulasan, studi kasus, dan komunikasi singkat. Naskah yang diterbitkan adalah peer-review oleh tidak kurang dari dua orang penelaah, dan mencakup berbagai cabang bioteknologi yang terkait dengan bidang pertanian, industri, kesehatan, lingkungan, bioinformatika, serta ilmu kehidupan pada umumnya.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 146 Documents
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THE PATHOPHYSIOLOGY OF CUTANEOUS MANIFESTATIONS RELATED TO COVID-19 Mawardi, Prasetyadi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2977

Abstract

Covid-19 is a respiratory infection caused by the newly emerging coronavirus. Covid-19 can also cause skin abnormalities, although the pathophysiology of manifestations of skin disorders associated with Covid-19 has not been understood with certainty. This study aims to discuss the pathophysiology of cutaneous manifestation related to Covid-19. The study was conducted based on literature and data mining related to Covid-19 using PubMed and Google Scholar. Eligible papers provided pathophysiology of cutaneous manifestations related to Covid-19. Papers not available in English were excluded. As a result of the presence of edema, vasodilation, and cellular infiltration, skin lesions such as rash, urticarial, or extensive purpura, or even thrombosis and haemorrhage, arise if damage to the vessels became severe. The pathophysiology of Covid-19-associated skin manifestations is estimated through some different mechanisms, such as lesions found in various Covid-19 patients, namely, the presence of varicella such as eruption, non-characteristic rash, and urticarial. Further studies are required to establish a Covid-19 diagnosis based on skin manifestations.
MOLECULAR CHARACTERIZATION, PHYTOCHEMICALS SCREENING, AND MOLECULAR DOCKING OF CARDAMOM (Wurfbainia compacta), AND SAMBILOTO (Andrographis paniculata) AGAINST COVID-19 Kurniawati, Mufida Budi; Budiharjo, Anto; Kusumaningrum, Hermin Pancasakti; Ferniah, Rejeki Siti
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3005

Abstract

Cardamom and Sambiloto are phytopharmaceutical plants that produce phytochemical compounds that have the potential to be used to increase immunity against COVID-19. because they contain carotenoids, phenols, anthocyanins, saponins, alkaloids and steroids. This research aims to obtain the molecular characteristics of Cardamom and Sambiloto plants from the Gunungpati area, Semarang by ITS primer, testing phenolic phytochemicals, tannins, flavonoids, saponins and alkaloids followed by molecular docking tests with the 6WX4 protein. SARS-CoV-2. Molecular characterization results show that Cardamom and Sambiloto are similar to Wurfbainia compacta MF802556.1 (100%) and Andrographis paniculate LC646073.1 (84.47%). The results of the phytochemical test screening showed that both plants contain flavonoids. Molecular docking tests were carried out with the compounds Quercetin, Avicularin, Naringenin, 5-hydroxy-7,8,2',5' tetramethoxyflavone, and Retinoic Acid. Retinoic Acid as a test ligand has the greatest potential in inhibiting the 6WX4 protein in the SARS-CoV-2 virus with a binding affinity value of -7.28 and RMSD 0.00.
ANALYSIS AND POTENTIAL THE ECO-ENZYME OF SEVERAL TYPES OF FRUIT PEELS IN LEACHATE REMEDIATION Rasyidah; Nasution, Rizki Amelia
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3021

Abstract

This research aims to determine the potential of ecoenzymes from several types of fruit peel in the process of reducing TDS levels of COD, BOD, ammonium and phosphate as well as the number of bacterial colonies in leachate water. So the research involved activities to make ecoenzymes from 4 types of fruit peel, namely banana, dragon fruit, pineapple and orange. Next, the ecoenzyme results were applied to leachate water to test its remediation potential in a ratio of 1:2 (10% ecoenzyme). This research uses a descriptive method, which uses parameters namely TDS, COD, BOD, phosphate, ammonium, and counting bacterial colonies. The results show that ecoenzymes have the potential to remediate leachate waste during five days of incubation, where it can be seen that ecoenzymes can reduce ammonium and phosphate levels but not BOD and COD. From the results, the average reduction in ammonia levels was higher for ecoenzymes from banana peel and pineapple fruit with an average value (mg/l) of P1=14.6; P2=0.55; P3=1.44; P4=0.675 and P5=2.44 (P1: Leachate; P2: Leachate + banana peel ecoenzyme; P3: Leachate + Dragon Fruit peel ecoenzyme; P4: Leachate + Pineapple Peel; P5: Leachate + Fruit peel Orange). Meanwhile, the highest reduction in phosphate was found in remediation using ecoenzymes from orange peel where the average value was P5=3.05 < P1=8.2. The results of ecoenzyme remediation from four types of fruit peel only have the potential to reduce ammonia levels, and likewise the reduction in phosphate occurs after adding orange peel ecoenzymes.
SYNTHESIS AND CHARACTERIZATION OF CHITOSAN MEMBRANES OF CASSAVA PEEL (Manihot esculenta) AND LERI STARCH COMBINATION AS A BIODEGRADABLE PLASTIC: English Dewi, Pande Putu Indira Prima; Widhiantara, I Gede; Sandhika, I Made Gde Sudyadnyana; Wiradana, Putu Angga; Susilo, Raden Joko Kuncoroningrat
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3080

Abstract

Problems related to landfills of plastic packaging waste are a source of environmental pollution. This research provides innovation in utilizing biodegradable plastic from cassava and leri peel starch with the addition of chitosan. This study aimed to analyze the results of the synthesis and characterization of chitosan membranes with a combination of cassava and leri peel starch and determine the biodegradation time of biodegradable plastic in EM-4 bioactivation. This study characterized biodegradable plastic membranes using test parameters, namely the SEM, FTIR, Swelling, and tensile strength tests. The biodegradation test was carried out by immersing biodegradable plastic membranes in an EM-4 bioactator for 7 days. Based on the results obtained from the characterization of biodegradable plastic membranes, namely the swelling test with concentrations of 5:3, 7:3, and 9:3, with yield values ​​of 62.9921%, 69.8902%, and 71.4286%. The SEM test obtained the best results at a concentration of 7:3. FTIR test on biodegradable plastic membranes containing hydroxyl (O-H) and carbonyl (C-O) groups. The tensile test obtained optimum results at the concentration of biodegradable plastic membranes, namely 9:3. As for the biodegradation test that has been carried out, the start time for degradation is 3 days.
THE EFFECT OF THE HEALTH CARE INFECTION CONTROL COMMITTEE IN PATIENTS WITH URINARY CATHETERS ON COST CONTAINMENT Amirah, Asriwati; Fitriani, Arifah Devi; Suarayasa, Ketut; Suharto, Teguh; Asepty, M.Rizky Priyanka
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3086

Abstract

The high prevalence of healthcare-associated infections threatens hospital services. Urinary tract infections associated with the use of catheters could reach 0.2–4.8 per 1000 catheters/day. In response to this, the Centers for Disease Control and Prevention recommends using the Healthcare Infection Control Practices Advisory Committee (HICPAC) to reduce the incidence of infection in hospitals. To determine the effect of implementing HICPAC on reducing hospital costs for patients with urinary catheters at Delia Hospital, Langkat Regency, in 2019. At the Delia General Hospital in Langkat Regency, Malaysia, quantitative research using a quasi-experimental technique was carried out, in which all patients with urinary catheters were included as respondents. The paired t-test was used to evaluate the data using SPSS software. The results revealed a significant effect of the HICPAC application on the incidence of Catheter-Associated Urinary Tract Infection (CAUTI) in patients during treatment (p = 0.08). The HICPAC method can also reduce the risk of CAUTI by 3.902 times. This study did not evaluate the morbidity and mortality attributable to CAUTI. An assessment of the length of stay, cost analysis, and antibiotic resistance is needed to assess the benefits of the HICPAC guidelines. The use of HICPAC in patients with urinary catheters can reduce the cost of treatment at Delia Hospital, Langkat Regency.
CONCEPTION RATE OF ARTIFICIAL INSEMINATION OF BALI CATTLE ON DIFFERENT SEMEN DEPOSITIONS Firmiaty, Sri; Idrus, Muhammad; Amiluddin, Amiluddin; Sudirman, Sudirman; Sonjaya, Herry; Suyadi, Suyadi; Iskandar, Hikmayani
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.3097

Abstract

This study aims to analyze the pregnancy rate resulting from artificial insemination of Bali cattle with different semen depositions. The research method used was a field experiment with three treatments: semen deposition at positions 3, 4, and 4+ (right side/dexter side). Pregnancy rate data were evaluated through Non-Return Rate (NRR1 and NRR2), Service per Conception (S/C), and Conception Rate (CR). The study was conducted on 120 Bali cattle in Bulukumba District, South Sulawesi. The results showed an increase in NRR in semen deposition 3, 4, and 4+ during the observation period of NRR 31 – 60. Although some breeders reported arousal symptoms late, the increase in NRR indicates a good understanding of arousal detection. Semen deposition at position 3 produces the lowest NRR, which can be caused by reproductive function abnormalities, silent heat, endometritis, or late reporting by farmers. The results of the S/C evaluation showed the lowest value and the highest of CR at semen deposition 4, which means that the semen deposition was closer to the fertilization site. Semen deposition at positions 4+ on dexter side althrough closer to the fertilization site was lower results of CR than posisition 4, because sperma only toward in right tubafolopii. The effectiveness of AI is significantly impacted by accurately detecting and timing the insemination process based on the ovulation period. This study provides important information regarding AI techniques in Bali cattle that can be used to increase the population and genetic quality of beef cattle in Indonesia.
EFFECT OF COLCHICINE TREATMENT ON PLANT GROWTH AND FLOWER DEVELOPMENT IN Zinnia elegans Kusumawati, Eni; Haryanto, Haryanto; Wijaya, Nur Iman; Alaudin, Ahmad Muzaki Nurrah-man; Nurhayati, Sari; Fitri, Fadillya Maulidilla
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3112

Abstract

Refugia is a flowering plant that is intended to trap and destroy insects. Colchicine is reported to induce polyploidy in plants. This study aims to determine germination, growth, and refugia performance of colchicine induced Zinnia elegans at different immersion concentrations and times. This research was conducted experimentally with a completely randomized design. The treatment was immersion in colchicine solution at different times duration. Colchicine concentration 0.01% with immersion time of 6,12,24,48, and 72 hours. Colchicine induction with different immersion times showed a decrease in sprouts height (p<0.05), resulting in abnormal sprouts with three leaves and wider leaf area (correlation test r=0.560). The longer the colchicine immersion showed plant height (correlation test r=0.618). Morphologically, control and colchicine induction results were relatively the same, but flowers resulting from colchicine induction had higher flower heights (correlation test r=0.772) and flower diameter (correlation test r=0.815). Induction of colchicine immersion had a different effect on the growth and reproduction performance of Z. elegans.
EFFICIENT REGENERATION LOCAL BANANA TISSUE CULTURE USING FLORAL APICES BY CYTOKININ COMBINATION Makhsunah, Isnina Tasya; Habibi, Ali Mukit; Khofifa, Rendryana Aulia Nur; Ubaidillah, Mohammad
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.3123

Abstract

Banana (Musa sp.) is an important crop that is widely cultivated and consumed in Indonesia. Banana plants production can be increased through tissue culture with the use of explants and the right combination of hormones. This study was conducted to determine the use of flower apices explants on local banana varieties using a combination of cytokinin hormones containing BAP (Benzylaminopurine) and several levels of TDZ (Thidiazuron). The result of this research was analyzed using a one-way analysis of variance. The hormone combination in this study consists of MS + BAP 2 mg/L + three concentrations of TDZ (2 mg/L, 2.5 mg/L, and 3 mg/L) as a regeneration medium. Three local banana varieties (Kepok Putih, Kepok Kuning, and Pisang Susu) was cultured on the three combination medium. The results showed that the use of flower apices explants contained in banana flowers grown on MS media with a combination of cytokinin hormones could increase the efficiency of explant regeneration. Media MS + BAP 2 mg/L + TDZ 3 mg/L gave the best regeneration rate for Kepok Putih (62.50%), Kepok Kuning (62.50%) and Banana Susu (56.25%) compared to TDZ 2. mg/L and TDZ 3 mg/L. The novelty of this study can provide information in the propagation of local banana plants using flower apices explants.
POTENTIAL OF ENCAPSULATION Bacillus cereus BTH-22 AGAINTS BACTERIAL WILT DISEASE ON EGGPLANT: - Purnawati, Arika; Triwahyu P, Endang; Fari A, Haidar
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3736

Abstract

Endophytic bacteria are a group of bacteria that live in plant tissues, potentially as biological agents of plant diseases, especially wilt disease caused by Ralstonia solanacearum and as an inducer of eggplant (Solanum melongena) plant growth. One of these bacteria is Bacillus cereus BTH-22 which was isolated from healthy eggplant stems in Kediri. The purpose and formulation of the problem are to obtain an encapsulation formulation of B. cereus BTH-22 which has the potential as a biological agent against wilt disease caused by R. solanacearum and as an inducer of eggplant (S. melongena) plant growth. The novelty of the research is the encapsulation formulation of B. cereus which is applied to eggplant plants with wilt, because the application generally uses root soaking, watering to the soil surface, mixing with fertilizer, liquid and powder formulations but all are easily washed away by rain. The research method is as follows: (1) Making encapsulation formulation: 75% Na-alginate with 10% aloe vera extract (Na-1) and 75% Na-alginate, 0.875% zeolite and 0.875% sago flour (Na-2), (2) Sterile soil, inoculate R. solanacearum and prepare 1 month old plants, (3) Application of encapsulation formulation was carried out 3 days after inoculation of R. solanacearum (107CFU/mL) using a Completely Randomized Design with 3 replications. Observations were made on days 7, 14, 21, 28, 35, 42, 49 including : disease intensity, plant height, number of leaves, number of flowers. The results of the study showed: viability in the Na-1 and Na-2 treatments was higher than control at the 48th to 96th hours, disease intensity in the Na-1 and Na-2 treatments was lower than control at the 7th to 49th day, plant height in the Na-1 and Na-2 treatments was higher than control at the 14th to 49th day.
KIDNEY MICROANATOMY OF WHITE RATS ON THE ADMINISTRATION OF ETHANOL EXTRACT OF Spatholobus littoralis STEM ACUTE DOSE Rousdy, Diah; Azkiya, Tiara; Wardoyo, Elvi Rusmiyanto Pancaning
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.3743

Abstract

Tampala bajakah stem (Spatholobus littoralis Hassk) is empirically used by the Indonesian people to recover from disease and maintain health, but the use of tampala bajakah has not been tested for doses that are safe for consumption. The purpose of this study was to determine the type of damage caused by acute doses of bajakah tampala stem extract on white rat kidney microanatomy (Rattus norvegicus Berkenhout). This study used bajakah stem derived from Ambawang, extraction using ethanol solvent, and Wistar strain white rat (± 150g) test as a test animal. The method used a Complete Randomized Design with 4 treatments namely normal control using distilled water, treatment of doses of 300, 2000, and 5000 mg/kg BW of bajakah tampala stem extract. Each group was given 5 replicates. The extract was shown in a single dose orally and observations were made for 14 days. The results obtained that doses of 2000 and 5000 mg/kg BW caused damage to white rat kidney tissue in the form of microanatomy dilatation of tubules and loss of the brush border, and doses of 300, 2000, and 5000 mg/kg BW caused necrosis and haemorrhage. The most severe damage to kidney microanatomy is the dose of 2000 and 5000 mg/kg BW. The administration of acute doses of bajakah extract has the potential to cause damage to kidney tissue.

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