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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Kota surabaya,
Jawa timur
INDONESIA
Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Articles 571 Documents
The Influence of Health Education on Diabetes Mellitus on Knowledge Improvement of Diabetes Mellitus Cadres in the Working Area of Medokan Ayu Health Center, Surabaya, Indonesia Andajani, Susilowati
Folia Medica Indonesiana Vol. 55, No. 3
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Abstract

This study aimed to analyze the influence of health education on improcing health cadres' knowledge about Diabetes Melitus (DM) at Ayu Medokan Health Center, Surabaya, Indonesia. The type and design of this study was non-randomized pretest-posttest design, with samples of DM cadres in the working area of Medokan Ayu Health Center, Surabaya, Indonesia. Sample size was 24 persons. The treatment variable was health education, while the dependent variable was the increase of the cadres' knowledge about DM. Normality test was performed with Kolmogorov Smirnov (a=0.05) and data analysis with Paired t-test (a=0.05). This study found that DM cadres were mostly female (23 people), with the youngest age 24 years, and the oldest 61 years. The highest age group (45.80%) was 40-49 years with a mean age of 44.37 + 9.27 years. Most of DM cadres' education (62.5%) was senior high school, then junior high school (25%). Most (58.3%) of the DM cadres did not work or as housewives. Besides being a DM cadre, most of them also posyandu and bumantik cadres, 2) There was a significant difference (p<0,0001) between the level of knowledge before and after health education. In conclusion, cadres' knowledge about DM can be improved, among others, by providing health education.
Hyperglycemia Prevalence Among Artisans and Workers in Selected Factories In Lagos, Southwest, Nigeria Yahaya, Tajudeen Olanrewaju; Sifau, Mutiu O; Oladele, Esther O; Bashar, Danlami M; Abubakar, Aminu L; Salisu, Naziru; Usman, Bello M; Koko, Jamilu D
Folia Medica Indonesiana Vol. 58, No. 2
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Highlights: • Workplace pollutants predispose people to hyperglycemia through beta cell dysfunction and insulin resistance. • The risk is increased by unhealthy lifestyles such as smoking and drinking. • Aging, due to mitochondrial function decline, also promotes hyperglycemia. Abstract: The increased global prevalence of hyperglycemia is linked partly to increasing industrial emission exposure, necessitating risk evaluations of various categories of workers worldwide. This study measured the blood glucose levels of selected non-obese artisans and workers from three companies (Imperio International, Mouka Foam, and Continental Iron) in Lagos, Nigeria. The participants' demographic data were collected using structured questionnaires, after which their blood glucose levels were measured using a glucometer. The results were compared with the World Health Organization (WHO) standards (88–126 mg/dL). On average, Imperio International participants were 32 years old, Mouka Foam and Continental Iron were 28 years old, and the artisans were 32 years old. Most of the participants were male secondary school graduates who worked an average of nine hours per day, six days a week. Artisans had the highest hyperglycemic population (46.15%), followed by Imperio International and Continental Iron (33% each), and Mouka Foam (29.41%). Smokers accounted for 10.53% of the hyperglycemic population, followed by alcoholics (36.84%), those who drank and smoked (42.11%), and those who did not drink or smoke (10.53%). Age class ≥41 accounted for 36.84% of the hyperglycemic population, class 31-40 (34.21%), and class 21-30 (28.95%). Participants with secondary school education constituted 63.16% of the hyperglycemic population, primary education (18.42%), individuals having no education (13.16%), and tertiary education (5.26%). The findings indicate that workplace pollutants predispose workers to hyperglycemia and that smoking and alcohol increase the risks. The findings necessitate exposure reduction and healthy lifestyles in the workplace.
Effect of In-Vitro Alpha Lipoic Acid Addition on Spermatozoa Motility in Sperm Preparation Process Buanayuda, Gede Wira; Lunardhi, Hamdani; Mansur, Indra Gusti
Folia Medica Indonesiana Vol. 55, No. 4
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Infertility is a problem for husband and wife, in the last 20 years the number of infertile couples has tended to increase by around 6.5 million pairs. The infertile couple can use the intrauterine insemination method to obtain offspring if a conventional method approach cannot be performed. Insemination requires a sperm preparation stage in which there are centrifugation and resuspension procedures that tend to produce excess reactive oxygen species (ROS). Excessive ROS will damage the motility of the spermatozoa. This study aims to prove the addition of alpha lipoic acid (ALA) as an antioxidant in the process of sperm preparation to improve and maintain better sperm motility. This research is a laboratory study with an experimental research design. The sample consisted of 10 infertile men who visited the Andrology section of the Sayyidah Jakarta Mother and Child Hospital (RSIA), where each ejaculate from the patient would be divided into 3 groups namely (k1) fresh semen as a control group, (k2) sperm preparation group without ALA, (k3) group of sperm preparation with the addition of ALA. The motility of spermatozoa was observed with the WHO 1999 method for 4 hours in units of percent. Progressive motility in k3 (47.95 ± 3.617) was higher than in k2 (38.05 ± 3.278) statistically significantly different after 3 hours of observation (p<0.0001). Progressive motility in k3 (78.8 ± 5.841) was higher than k1 (56.55 ± 7.511) from the initial observation (p <0.0001). The progressive motility of k2 (76.05 ± 6.768) was higher than k1 (56.55 ± 7.511) from the start of the observation (0.0001). It can be concluded that the addition of ALA in the sperm preparation process increases and maintains progressive motility that is better than sperm preparation without ALA addition after 3 hours of observation.
Effect of the role of safety officer on compliance to occupational safety and health (osh) among outsourcing workers in company x, surabaya Widajati, Noeroel; Ernawati, Meirina; Martiana, Tri
Folia Medica Indonesiana Vol. 53, No. 2
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Up to the end of 2012, Social Security showed the occurence of 103.074 work accident cases. 91.21% of the accident casualties were recovered, 3.8% were disabled, 2.61% partially disabled, and the rest died (2.419 cases) and were totally-permanently disabled (37 cases), with the average of 282 work accident cases per day. Due to the increasingly tight corporate climate, the company tries to make production cost efficiency (cost of production). One solution that may be taken is by applying outsourcing system. With this system, the company may save expenses in funding human resources (HR) who work in the company concerned. If the aspects of the application of Occupational Safety and Health (OSH) are not properly managed, the possibility of work accidents and environmental pollution that have a negative effect on the corporate image and the continuity of company product supply will increase. This may affect the company's loss, both material and corporate image. The role and responsibility of the safety officer is very influential on the achievement of zero accident, so many safety programs are developed, such as safety briefing and safety patrol, with the aim to improve the aspect of OSH. However, some employees have not complied with the provisions of OSH implementation in the company they work at.
Effect of Atorvastatin in Lipid Profile Changes and Inflammation Marker TNF-alpha on Diabetes Patient with Dyslipidemia Melasari, Wulan Panduwi; Suharjono, Suharjono; Samsulhadi, Wiwid
Folia Medica Indonesiana Vol. 57, No. 1
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Diabetes is one of the risk factors for cardiovascular disease (CVD). Diabetics patients have 2 to 4 times increased risk of cardiovascular disease compared with non-diabetics. TNF-alpha is a proinflammatory cytokine that can be used to determine the risk of atherosclerosis complications triggered by inflammation in diabetes. Statins are a class of HMG CoA reductase inhibitors that inhibit cholesterol biosynthesis and have pleioropic effects that inhibit the release of inflammatory cytokines like TNF-alpha and stabilize atherosclerotic plaques. This study aims to determine the effect of atorvastatin 20 mg/day for 30 days in reducing the lipid profile and TNF-alpha inflammatory markers in patients with diabetes dyslipidemia. Diabetes patient with dyslipidemia who included the inclusion criteria in this observational prospective cohorts studies treated with atorvastatin for 30 days (n = 19). The efficacy of statin therapy was measured by lipid profiles (LDL, TG, HDL, and total cholesterol) and TNF-alpha. The results of the study showed that atorvastatin decreased 40.55% of LDL levels, 15.34% of TG levels, and 30.70% oftotal cholesterol levels which statistically significant (P <0.05). As for HDL, there is an increase of 6.06% but statistically non-significant (P >0.05). TNF-alpha levels increased by 11.30% which statistically non-significant (P >0.05). The use of atorvastatin 20 mg for 30 days gave reduction in LDL, TG, and total cholesterol and increased in HDL. Atorvastatin does not have a reducing effect on TNF-alpha. There was no correlation between lipid profile changes with TNF-alpha changes.
Comparison effect of cv 12, st 36 and st 40 ea on short term energy balance regulation in high fat diet rat Rejeki, Purwo Sri; Harjanto, Harjanto; Argarini, Raden; Subadi, Imam
Folia Medica Indonesiana Vol. 52, No. 3
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The aim of this study was to determine the comparative effects of EA (EA) on the CV12, ST36 and ST40 to weight gain prevention over the short-term regulation of energy balance. The study was conducted with a completely randomized design. Rats were divided into five groups: negative control group (no treatment, n=5), positive control (sham EA/back, n=5), EA CV 12 (n=6), EA ST 36 (n=6) and EA ST 40 (n=7). Rats were exposed to high-fat diet for two weeks and EA was simultaneously performed once daily, five days a week for two weeks with 2 Hz, for 10 minutes with continuous wave. Body weight, BMI, front limb circumference and rear were measured during study. Levels of blood glucose, cholesterol, triglycerides, LDL and HDL were measured at the end of the study; which reflects the short-term regulation of energy homeostasis. For weight loss, EA CV12, ST36 and ST40 group have lost weight significantly compared to the negative and positive control group. The ST40 group has a significant decrease than ST36 and CV12. The most significant decrease in BMI found in the ST40 group. EA did not affect blood glucose levels, but modulated blood lipid profile. In ST 40 group there was a significant decrease in cholesterol, LDL and triglycerides. EA at point ST 40 is potential in preventing increased body weight and BMI in rats exposed to high-fat diet compared to the CV 12 and ST 36. ST 40 is a point with a potential of lowering LDL and triglycerides serum so that it can play a role in the short term regulation of energy homeostasis but also in the prevention of dyslipidemia.
Analysis of Maspin Expression in Invasive Ductal Carcinoma of the Breast on Stages IIA and IIIB Hardika, Arif Satria; Fauziah, Dyah
Folia Medica Indonesiana Vol. 54, No. 1
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Mammary Serine Protease Inhibitor (maspin) is a tumor suppressor gene, a member of the serine protease inhibitor (serpin) family that works by inhibiting motility of cell movement, invasion and metastasis. Maspin expression is expected to be a prognostic factor as well as a predictive factor in mammary tumors. However, in some recent studies, maspin has a variety of expressions. Although it is known that no maspine appears as an indicator of tumor progression and metastasis, recent study has shown that maspine expression is associated with an aggressive phenotype of breast cancer and with a poor prognosis. Correlations between maspine expression and poor prognosis have also been reported in pancreatic, ovarian, thyroid, bladder and lung cancers. Knowledge of the expression and role of this maspin as well as its relationship with the pathogenesis of breast invasive ductal carcinoma is still small. The aim of this study was to look at differences in maspin expression in breast-invasive ductal carcinoma of stage IIA and stage IIIB groups. This research method used analytic observational research with cross sectional approach. The samples were invasive carcinoma of NST paraffin at the Department of Anatomic Pathology of Dr Soetomo Hospital, Surabaya, from January to December 2015. Thirty samples were divided into two groups, namely stage IIA and stage IIIB groups and immunohistochemical examination with maspin antibody was carried out. The difference of maspin expression in stage IIA and stage IIIB was analyzed using Mann-Whitney statistic test. There were significant differences in maspin expression between stage IIA and stage IIIB groups, where stage IIA has a high maspin expression rather than stage IIIB.
Correlation between the Bacteriostatic and Bactericide Effect with Antibiofilm and Anticolony Spreading from Javanese Citronella Oil on Methicillin-Resistant Staphylococcus aureus (MRSA) Hidayah, Amaliyah Nurul; Wasito, Eddy Bagus; Debora, Kartuti; Basori, Achmad; Isnaeni, Isnaeni; Utomo, Budi
Folia Medica Indonesiana Vol. 55, No. 1
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Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that has been resistant to various types of antibiotics, so it is not easy to be treated with antibiotics and needs other solutions. Javanese citronella oil distilled from the Cymbopogon nardus plant is proven to function as an antibacterial agent (bacteriostatic and bactericidal), fungicide and repellent. This study aimed to prove that there is a positive correlation between bacteriostatic and bactericidal effects with antibiofilm and anticolony spreading from Javanese citronella oil on MRSA. The intended antibiofilm is a barrier to biofilm formation and eradication. Bacteriostatic and antibiofilm effects were tested using microtiter plates assay, bactericidal effect test with subculture into the media and anticolony spreading effect test with spot inoculation in Tryptic Soy Broth media supplemented with 0.24% agar. The bacteriostatic effect test data were analyzed using paired t-test, bactericidal effect using the Friedman test, antibiofilm effect test using Kruskall-Wallis and the results of all the tests correlated using Pearson and Spearman correlation. The statistical significance used was p<0.05. The results showed that Javanese citronella oil had a bacteriostatic concentration of 0.02% (v/v) and bactericidal concentration of 0.78% (v/v). The Pearson correlation test showed that there was a negative correlation between bacteriostatic and bactericidal effects on biofilm formation with r = -0.956 (p = 0.000), but the correlation was positive for biofilm eradication with r = 0.918 (p = 0.000) and anticolony spreading with r = 1.000 (p = 0.000).
Effect of Glutamine Supplement Administration on the Reduction of Muscular Fatigue Post-Eccentric Exercise Rusdiawan, Afif; Taufikkurrachman, Taufikkurrachman
Folia Medica Indonesiana Vol. 55, No. 4
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Menopausal period is the period of permanent cessation of menstruation due to reduced or lost ovarian activity. One of the effects of decline estrogen levels during menopause is atropic vulvovaginitis. Consumption of phytoestrogens can reduce menopausal symptoms. Phytoestrogen is found in vegetables and fruits such as tomatoes and red melon. The objective of this study was to compare the effectiveness of red melon juice and tomato on the increase of vaginal wall thickness in menopausal rats. This study revealed an alternative of phytoestrogen sources that is more effective to reduce menopausal symptoms, especially those related to vaginal atrophy to improve the quality of life of menopausal women. Subjects of this study were 27 ovariectomized Wistar strain Rattus norvegicus which were s divided into 3 groups randomly, one control group and two treatment groups with tomato juice and red melon juice at a dose of 330 mg/kgBW/day administered for 28 days. The variable of this study were the thickness of the vaginal wall which was precipitated by Hematoxiline Eosine. The highest vaginal wall thickness was found in the treatment group of red melon juice of 879.89 ± 70.52 µm and the lowest of the control group (K) of 643.3 ± 58.33 µm. The results of Anova test showed that there was a significant difference between control group and treatment groups, the tomato juice and red melon juice with a dose of 330 mg/kgBW/day, so it can be concluded that red melon juice with a dose of 330mg/Kg BW/day has the best effect in increasing the thickness of vaginal wall of menopausal rats as compared with tomato juice.
Selection of Medical Therapy in Glaucoma Patients in the Outpatient Eye Clinic Soetomo General Academic Hospital Surabaya Praba, Venansya Maulina; Primitasari, Yulia; Qorib, Mohammad Fathul; Loebis, Rozalina
Folia Medica Indonesiana Vol. 57, No. 4
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Highlight: • Medical therapy selection in the outpatient eye clinic were determined. • Treatment of prostaglandin analogue therapyfor primary open angle glaucoma was the most common glaucoma type. Abstract: Glaucoma is the second leading cause of blindness and the third cause of visual impairment. Glaucoma management includes medical therapy, laser, and incisions. This study aims to determine the selection of medical therapy in the outpatient eye clinic Soetomo General Academic Hospital Surabaya. This study was a retrospective descriptive study. The variables were type of glaucoma, visual acuity, intraocular pressure, and drug therapy. Data processing was done by collecting, grouping, and describing data. Glaucoma was mostly common in 50-64 years old (37.66%), male (50.65%), most patients lived in Surabaya (53.68%), the most common type was Primary Open-Angle Glaucoma (32.90%), the most medical therapy given in the first visit in 2019 was single medical therapy (67.97%), the most single drug therapy was latanoprost (49.68%), the most drugs combination was timolol maleat with acetazolamide (35.14%), the most commonly drugs class were prostaglandin analogues (48.48%), most of the visual acuity values were 6/6 - 6/18 (1,00 – 0,33) (37.88%), most intraocular pressure was in the 11-21 mmHg (62.55%). The most common type of glaucoma was primary open angle glaucoma with the most therapy given was prostaglandin analogue.