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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Healing in Nurses After Assignment in Natural Disasters Solikhah, Fitriana Kurniasari; Aditya, Ronal Surya
Folia Medica Indonesiana Vol. 58, No. 4
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Abstract

Highlight : • Disasters impact a large number of people, including nurses who are deployed in the disaster relief. • Culturally sensitive psychological first aid sessions, post-assignment in crisis situations monitoring, and grit have implications in pushing the nurses to overcome their trauma and obstacles. • Government policies are also important in helping nurses to heal after deployment in disaster relief. Abstract : Disasters are defined as catastrophic occurrences that impact a large number of people quickly and with an abrupt onset. On average, one natural disaster is reported globally each day. However, the impact of a traumatic occurrence on an individual may be compared to a rock colliding with the surface of a water body. Systematic searches were conducted in Cochrane, Google Scholar, PubMed, Scopus, Embase, and Web of Science databases. The following keywords were used to perform a literature search: "nurse," "healing," and "natural catastrophes". As a result of reviewing 362 abstracts and titles, ten were determined to meet the study goals. The research methods in four of the ten literatures were qualitative, five quantitative, and one was a blend of both. Generally, culturally appropriate psychological first aid sessions, post-natural disaster assignment monitoring, and grit push people to overcome obstacles and accomplish achievements over time. Nurses who have been deployed to natural catastrophes must heal and need time to rest physically and mentally. This study aimed to find out the implications of culturally sensitive psychological first aid sessions, post-assignment in crisis situations monitoring, and grit in pushing individuals to overcome obstacles and achieve success over time; and how the government policies relate to trauma recovery.
Charateristics of Gynecological Abnormalities and Types of Urine Diversion at Dr Soetomo Hospital, Surabaya, Indonesia, in Three-Year Period Soetojo, Soetojo; Nurdin, Ambo Tuwo
Folia Medica Indonesiana Vol. 55, No. 2
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Abstract

In the case of advanced stage gynecological disorders, most patients have a disturbance in the upper urinary tract. Most patients with uterine cervical carcinoma are already in stage 3B and require urine diversion. The purpose of this study is to find and determine the profile of gynecological disorders that require urine diversion, the type of urine diversion, and urine diverted output in patients with cervical carcinoma. This descriptive analytical retrospective study was conducted at Dr. Soetomo Hospital, Surabaya, Indonesia, between 2012 and 2015. The samples of this study were all patients with gynecological disorders who underwent retrograde DJ stent procedures, underwent ureterocutaneostomy and nephrostomy at the Integrated Central Surgery Building, Dr. Soetomo Hospital, Surabaya, for three years between 2012 and 2015. Data was collected based on the medical record number of patients with gynecological disorders who underwent urine diversion procedures and were recorded in the book on the operation schedule. We find that the most common cause of gynecological abnormalities in kidney obstruction is cervical carcinoma. There are three types of urine diversions used, namely DJ stent, percutaneous nefropyelostomy, and ureterocutaneostomy, with DJ as the most commonly performed. Urine diversion can improve creatinine without being influenced by the type of diversity.
The Combination of NLCR and Enhances the Sepsis-3 Strategy Pranggono, Emmy Hermiyanti; Aini, Endah Nurul; Sumardi, Uun; Hartranti, Yovita; Sugianli, Adhi Kristianto
Folia Medica Indonesiana Vol. 58, No. 2
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Abstract

Highlights: • The combination of NLCR and PLR will improve the ability to distinguish infection rather than noninfection in the emergency setting for early antibiotic prescribing as well as the sepsis-3 strategy. • The diagnostic value of PLR in adult bacterial sepsis patients has never been studied. Abstract: According to Sepsis-3, antibiotics should be administered in the first hour of diagnosis of sepsis. Still, there is difficulty in differentiating between bacterial and nonbacterial infections and a lack of a rapid diagnostic tool to distinguish them. This study evaluated the diagnostic value of NLCR and PLR in suspected bacterial sepsis. The diagnostic value of PLR in adult bacterial sepsis patients has never been studied. This study was a retrospective study from the medical record of Dr. Hasan Sadikin Hospital Bandung. All patients at age ≥ 18 years diagnosed with sepsis based on ICD-10 code and qSOFA ≥ 2 were included. We calculated sensitivity, specificity, NPV, PPV, positive LR, and AUC of NLCR and PLR. There were 177 patients included in this study. The sensitivity of NLCR was 69.5%, specificity was 34.7%, NPV was 56.9%, PPV was 47.9%, and LR+ was 1.06, while the sensitivity of PLR was 62.2%, specificity was 38.9%, NPV was 54.4%, PPV was 46.8%, and LR+ was 1.02. We obtained cut-off values for NLCR 11.06, AUC 0.500, PLR 222.41, and AUC 0.497. The low value of AUC NLCR and PLR was due to prior antibiotic use. The combination of NLCR and PLR had higher positive LR (1.16) and specificity (54.7%), and also, according to NLCR, we had the highest sensitivity (69.5%). The combination of NLCR and PLR enhances the sepsis-3 strategy because it can be used as screening tools for bacterial sepsis, and antibiotics can also be administered in the first hour of managing sepsis, particularly in the emergency ward.
A First Step to Novel Approach for Treating Alkali Injury of the Cornea: Effect of Platelet Rich Fibrin Lysates on Cultured Rabbit (Oryctolagus cuniculus) Limbal Stem Cell Proliferation Exposed by Sodium Hydroxide Prabawati, Wahyu Endah; Suhendro, Gatut; Retnowati, Endang
Folia Medica Indonesiana Vol. 58, No. 2
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Abstract

Highlights: • Sodium hydroxide causing platelet rich fibrin stimulates limbal stem cell proliferation in chemical trauma. • Limbal stem cell niche and influences limbal stemness was repaired by Platelet Rich Fibrin. Abstract: Chemical injuries of the eye produce extensive damage to the ocular surface and limbal stem cells, resulting in permanent unilateral or bilateral visual impairment. Alkali injuries occur more frequently than acid injuries. Platelets are a rich source of potential wound healing, promoting polypeptide growth factors. This study aimed to investigate the effect of platelet-rich fibrin (PRF) lysates on limbal stem cell proliferation, which was exposed to sodium hydroxide that resembled limbal stem cell deficiency due to chemical trauma. Confluent rabbit (Oryctolagus cuniculus) limbal stem cells wounded using 20µL of 0.00625 M sodium hydroxide (pH 13) were treated with platelet-rich fibrin lysates (PRF) (0, 5, and 10%). PRF lysates were prepared from peripheral rabbit blood according to Choukroun's method without using anticoagulant and foreign factors for platelet activation. The proliferation of limbal stem cells was measured by a 3-(4,5-dimethylthiazol-2-yl)-2.50 diphenyl tetrazolium bromide (MTT) colorimetric assay at 24, 48, and 72 hours after exposure to sodium hydroxide. Proliferation significantly increased limbal stem cells with PRF lysates 5% (p<0.01) and 10% (p<0.01) group compared with the control (PRF 0%). There was no significant difference between PRF lysates of 5% and 10% (p>0.01). The highest proliferation of limbal stem cells was found in the PRF lysates 5% group after 48 hours (100.24%). PRF stimulated limbal stem cell proliferation in chemical trauma caused by the sodium hydroxide model. PRF repaired the limbal stem cell niche and influenced the limbal stemness. The present findings warrant further research on PRF as a novel alternative treatment for limbal stem cell deficiency.
Effects of Moringa oleifera Extract as an Immunomodulator of Lymphocyte Cells and Macrophages in BALB/c Mice Infected with Plasmodium berghei Jaya, Putu Khrisna Dharma; Apsari, Putu Indah Budi; Dewi, Pande Made Alitta Cantika Putri Nadya; Laksemi, Dewa Ayu Agus Sri; Sutarta, I Ketut Cahyadi Adi Winata
Folia Medica Indonesiana Vol. 59, No. 3
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Abstract

Highlights: 1. This study assessed the immunomodulatory potential of Moringa oleifera, which may serve as a natural source for antimalarial treatment. 2. Moringa oleifera extract can act as an immunomodulator due to its suppressive effect on Plasmodium berghei infection. Abstract Malaria is an infectious disease caused by protozoa of the genus Plasmodium. In Indonesia, this disease remains a health concern that must be resolved. Due to its high prevalence in eastern Indonesia, it is a challenge to eradicate this disease. Moringa oleifera contains various substances that are believed to have antimalarial activity. This study aimed to determine the effectiveness of Moringa oleifera leaf extract in increasing immune cells and eradicating parasites by using mice infected with Plasmodium berghei. The research was conducted in vivo on BALB/c strain mice (n=40) that were already infected with Plasmodium berghei. Moringa oleifera leaf extract at 25%, 50%, and 75% concentrations was administered orally every day to the mice, while a peripheral blood smear was performed to evaluate parasitemia levels and macrophage activation. A complete blood count was also performed after all tests on the mice were completed. Statistical analysis was performed using the one-way analysis of variance (ANOVA) test with a=0.05 and 95% confidence interval (CI). The results showed that the administration of Moringa oleifera leaf extract at 25%, 50%, and 75% concentrations caused varying degrees of parasitemia compared to the negative group (p<0.05). The group that received the extract at 50% concentration differed significantly from the control groups in the number of activated macrophages. The results of the complete blood count indicated immunomodulatory effects through the presence of diverse immune cell types. In conclusion, Moringa oleifera leaf extract suppresses Plasmodium berghei infection and enhances immune cell stimulation.
The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Khaerunnisa, Siti; Syafa'ah, Irmi; Wungu, Citrawati Dyah Kencono; Prabowo, Gwenny Ichsan; Handajani, Retno; Safitri, Indri; Notopuro, Harianto; Qurnianingsih, Ema; Lukitasari, Lina; Humairah, Ira; Bakhtiar, Arief; Suwandito, Suwandito; Asih, Susi Wahyuning; Anggraeni, Zuhrotul Eka Yulis; Adi, Ginanjar Sasmito; Nugrahani, Ely Rahmatika; Zulka, Ayesie Natasha; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 57, No. 2
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This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.
Thrombocytopenia in a Patient Undergoing Primary Percutaneous Coronary Intervention Oktaviono, Yudi Her; Meuthia, Feranti
Folia Medica Indonesiana Vol. 55, No. 1
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Abstract

Thrombocytopenia is a common abnormality in patients presenting with acute coronary syndrome. Baseline thrombocytopenia in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention is associated with early adverse events, related to both ischemia and bleeding. Treatment for acute coronary syndrome usually involves antiplatelet, anticoagulant, antithrombotic therapy, and the performance of percutaneous coronary intervention. The safety of antiplatelet therapy and percutaneous coronary intervention patients who have acute coronary syndrome and thrombocytopenia is unknown, and there are no guidelines or randomized studies that specifically suggest a treatment approach in such patients. One of the institutions in Italy recommends medical and interventional strategy with radialis as first choice for access site, bare metal stent (BMS) implantation, followed by double antiplatelet therapy (DAPT) for one month. After DAPT discontinuation, at least one antiplatelet drug (aspirin) is recommended for life.
Analysis of IFN-gamma and IL-10 Levels as Markers of Inflammation and Response Therapy of Anti-Tuberculosis in MDR Lung TB Patients Setyawati, Herni; Soedarsono, Soedarsono; Yulistiani, Yulistiani; Fatmawati, Umi
Folia Medica Indonesiana Vol. 55, No. 4
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Multidrug-Resistant Tuberculosis (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampisin, the two most potent TB drug. Immune response to against Mycobacterum tuberculosis infection is related to the function of immunity. The function of interferon-γ (pro-inflammatory) is to activate macrophages, to stimulate antimicrobial molecules (to reactive oxygen species and nitric oxide), and to inhibits interleukin-10. Interleukin-10 function is to triggers humoral immunity, to inhibit IFN- γ. This study aimed to analyze level changes and the correlation with clinical data, also months of MDR TB patients who received standard OAT therapy. This was an observational study using cross sectional design. There were 29 patients who received standard MDR TB OAT therapy from 1-24 months, who met the inclusion criteria. Then, the patients were divided based on duration of the therapy, which are the initial/intensive and advanced phase. The initial phase divided into 2: first one is for 1-4 months therapy's time (5 patients) and the second one is for more than 4-8 months (6 patients). Then, the advanced group divided into two groups again, which are third group with more than 8-16 months (13 patients) and fouth group with more than 16-24 months (5 patients). Then, measured serum concentration IFN-γ, IL-10 at the start of the study and 4 weeks later with the ELISA method. This research during the period July-December (6 months). IFN-γ post concentrations were decreased by 39.14 ± 139.12 pg/mL (p > 0.05). The concentration of IL-10 was decreased by 33.93 ± 109.20pg/mL (p>0.05). Based on the TB score bandim method during pre and posts results were 1 patient experienced severity change from severity class 1 to 2, 1 patient from severity class 2 to 1, 1 patient remained in severity 2 and 26 patient remained in severity 1. The results showed that serum IFN-γ and IL-10 levels in initial/intensive and advanced phase patients who received MDR TB regiment after four weeks did not changed,
In Vitro Characterization of Poly-Glycolyc Lactic-Co Acid (PLGA) –Collagen Based on Red Snapper Fish Scales (Lutjanus Sp.) Coating Chitosan as Duramater Artificial Candidate Jabbar, Hajria; Widiyanti, Prihartini; Paramadini, Adanti Wido; Putri, Dina Kartika; Isfandiary, Andini
Folia Medica Indonesiana Vol. 56, No. 3
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Head trauma was the third cause of deaths that have a high rank that can make serious head injury for 25.5%-54.9%. This study has been conducted by making a replacement layer of the brain (dura) to overcome the impact of dural defect by utilizing waste fish scales red snapper (Lutjanus sp.). Synthesis brain membranes lining processed by casting method with each various concentrations of chitosan coating of 1%, 1.5%, and 2% then dried using vacuum dry. The samples then were characterized by tensile test, FTIR, SEM and MTT Assay. FTIR test results showed that red snipperscales can produce collagen powder at amide A group with stretching of –NH functional group, amide B group has stretching of CH2 assymetry, amide I area, amide II and amide III area which show –NH bonding. Tensile test results showed that the combination between PLGA-Collagen Chitosan Coating 2% produced the highest tensile strength is 4.8 MPa which meet the standards of human duramater strength. MTT Assay results showed that the dural membrane produced no toxic seen from living cells reached 98.32%. Poly - Glycolyc Lactic - Co Acid (PLGA) - collagen coating chitosan based on red snapper fish scales (Lutjanus sp.) composites has potency as duramater artificial candidate due to the chemistry, biological and physical characteristics.
Obstacles to the Implementation of clinical practice guidelines at Mandau District General Hospital. Zelvia, Sindy; Nasution, Sri Wahyuni; Girsang, Ermi; Nasution, Sri Lestari Ramadhani
Folia Medica Indonesiana Vol. 60, No. 2
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Highlights: 1. Given the suboptimal implementation of clinical practice guidelines at Mandau District General Hospital, it is important to conduct research on potential obstacles to this problem. 2. The findings of this study can encourage hospitals to develop and apply effective clinical practice guidelines while also addressing the obstacles to their implementation. Abstract Clinical practice guidelines are procedures followed by physicians to optimize healthcare services and achieve more effective outcomes. Conducted in October 2022, this study aimed to analyze the factors that hinder the implementation of clinical practice guidelines among physicians at Mandau District General Hospital, Bengkalis, Indonesia. This study used an analytical survey design and a cross-sectional approach. This study included all 85 individuals who were employed as general practitioners at the Mandau District General Hospital. The data were subjected to univariate, bivariate, and multivariate analyses. The independent t-test was used in the data analysis, with a value of p<0.05 considered significant. The results showed that there was an association between the implementation of clinical practice guidelines and several variables, including the levels of ability in recognizing and explaining clinical pictures of diseases (p=0.008), diagnosing diseases (p=0.004), carrying out initial management (p=0.000), and carrying out independent and directed management (p=0.001). Upon conducting the follow-up analysis on logistic regression, it was found that the variables that were associated with the implementation of clinical practice guidelines were the ability to carry out initial management (p=0.000, OR=65.512, 95% CI=22.048–98.835). In conclusion, physicians' insufficient ability to perform initial management hinders the implementation of clinical practice guidelines. This study suggests incorporating the findings as input in the evaluation and development of training for physicians on the implementation of clinical practice guidelines.

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