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INDONESIA
Indonesian Journal of Global Health Research
Published by Global Health Science Group
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr
Core Subject :
Indonesian Journal of Global Health Research is a open access, peer reviewed and refereed international journal. Indonesian Journal of Global Health Research aim to publish original research paper devoted to various area of all health sciences. Indonesian Journal of Global Health Research provides a forum for sharing timely and up-to-date publication of scientific research, health care and promoting the development of nursing, public health, community, environmental and occupational health. The journal publishes original research papers of health sciences. High priority will be given to articles on public, nursing, adolescent, community, environmental and occupational health, pharmaceutical technology, social pharmacy, traditional medicine, pharmacology, and so on.
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Articles 1,005 Documents
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The Effectiveness of Date Fruit Administration on the Duration of Active Phase I and PHAsE II Labor Karningsih Karningsih; Novia Nuraini; Delmaifanis Delmaifanis; Mardeyanti Mardeyanti; Herlyssa Herlyssa; Arny Raymiti
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1712

Abstract

Prolonged labor remains a primary risk factor contributing to the rising rates of cesarean sections. This condition is commonly triggered by inadequate uterine contractions or pelvic disproportion, which, if left unmanaged, can jeopardize the safety of both mother and fetus. Given the importance of maintaining a physiological (normal) birth process, this study aims to examine the effectiveness of date consumption as a natural alternative for strengthening contractions. The active compounds in dates play a vital role in optimizing uterine function mimicking the effects of the hormone oxytocin making this research strategically significant in efforts to reduce invasive medical interventions during childbirth of this study was to determine the effectiveness of dates on the duration of active phase I and phase II labor at the Pondok Gede Bekasi TPMB. Was a quasi-experimental study with a post-test with control group design. The research sample involved 64 respondents divided into two groups. One group was given date fruit intervention, and one control group was only given sweet tea. The sampling technique used purposive sampling. Data analysis used the Independent Sample T-test because the data were normally distributed. The results showed that dates were effective in reducing the duration of active phase I labor with a p-value = 0.000 (<0.05), but were not effective in reducing the duration of stage II labor in mothers in labor because they had a p-value of 0.327 (>0.05).
The Impact of Gadget Screen Exposure in Children and Developmental Status Aged 12 - 72 Months Endah Dian Marlina; Raudhatul Munawarah; Rosita Syaripah
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1713

Abstract

In 2023, Indonesia’s population of children under five reached 30.2 million. Current data indicates that 33.44% of early childhood individuals are exposed to digital devices, with many facing risks of psychological, cognitive, and socio-emotional impairments. Objective: This study aims to analyze the relationship between gadget screen exposure and the developmental status of children aged 12–72 months. A quantitative study with a cross-sectional design was conducted at Posyandu Puskesmas Pulo Gadung, East Jakarta, in 2025. A sample of 60 respondents was selected through purposive sampling. Data were collected using the Pre-Screening Developmental Questionnaire (KPSP) and a maternal questionnaire regarding gadget usage. Data were analyzed using univariate and bivariate (Chi-square) analysis. Bivariate analysis revealed a significant relationship between gadget exposure and developmental status ($p < 0.05$). High gadget exposure was predominantly associated with "doubtful" or "deviant" developmental outcomes. Excessive gadget use negatively impacts child development. It is crucial for health workers and parents to implement early stimulation and strict screen-time monitoring to ensure optimal growth.
The Potential of Probiotics from Fermented Rice Water on Fibroblast Proliferation and Migration: A Systematic Review Nury Nur Melati Tanjung; Dian Widiyanti; Indra Kusuma; Dicky Budiman
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1715

Abstract

Fermented rice water (FRW) has been traditionally used for skin care, but its biological mechanisms on fibroblasts, key cells in wound healing, have not been fully characterized. This systematic review aims to evaluate the efficacy of FRW on fibroblast proliferation and migration and to identify the molecular pathways involved. A literature search was conducted through PubMed, Scopus, and Google Scholar using the keywords "fermented rice water," "fibroblast," and "wound healing" in publications from 2015 to 2025. Studies were included if they evaluated the effects of FRW on fibroblasts in vitro or in vivo. Risk of bias was assessed using SYRCLE RoB (Risk Of Bias). Four studies met the inclusion criteria. FRW increased fibroblast viability by up to 116% and accelerated diabetic wound closure from 27% to 71% compared to controls. Molecular analysis showed upregulation of Collagen I mRNA by 17%, Collagen III by 47%, and Elastin by 159%. FRW activated the NRF2 pathway, which increased the expression of antioxidant enzymes (SOD, CAT, HO-1) and decreased inflammatory mediators including TNF-α, NF-κB, and MMP-1. Bioactive metabolites from Lactobacillus plantarum, Bacillus cereus, and Aspergillus oryzae played a role in these therapeutic effects. FRW shows potential as a fibroblast bio-stimulator through multi-pathway modulation involving extracellular matrix synthesis, antioxidant, and anti-inflammatory effects, with prospects for application in chronic wounds and anti-aging that require further clinical validation.
Reducing Dysmenorrhea in Adolescent Girls with Yoga and Benso Relaxation Karnilan Lestari Ningsi Sam; Dewi Ari Sasanti
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1718

Abstract

The majority (70-93%) of adolescents experience discomfort related to menstruation. It has been reported that 90% of menstruating adolescents experience menstrual pain, and 21% of these experience severe pain. Their quality of life and participation in school, sports, and social activities are all affected. Dysmenorrhea leads to decreased quality of life, absenteeism, and an increased risk of depression and anxiety. Up to half of patients with dysmenorrhea miss school or work at least once, and 10% to 15% experience regular absences during menstruation. To find out decrease in dysmenorrhea in adolescent girls with yoga and Benson relaxation. Using the true experimental design method using one group design, pretest-posttest design, sampling technique using purposive sampling. The number of samples in this study is 30 samples. The adolescent girls' dysmenorrhea scale was measured using the Numeric Rating Scale (NRS) before and after treatment, data analysis is carried out univariately to describe the frequency distribution and bivariately using the Wilcoxon test. The results of the Wilcoxon signed rank test statistical test show a value of ρ < 0.001, which means that there is a decrease in dysmenorrhea in adolescent girls with yoga and Benson relaxation. Decrease in dysmenorrhea in adolescent girls with yoga and Benson relaxation.  
Development of a Herbal Formula of Breadfruit (Artocarpus altilis) Leaf Extract for Fluid Retention Management in Congestive Heart Failure Kasron Kasron; Susilawati Susilawati; Asep Nurrahman
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1720

Abstract

Congestive heart failure (CHF) is characterized by persistent fluid retention leading to edema and dyspnea, which significantly impair functional capacity and increase hospital readmission rates. Although loop and thiazide diuretics are effective in decongestion, long-term use frequently results in electrolyte imbalance, renal dysfunction, and diuretic resistance. Breadfruit leaf (Artocarpus altilis), containing flavonoids, tannins, and saponins with natural diuretic mechanisms, has been traditionally used to reduce fluid accumulation and edema. This study aimed to evaluate the effectiveness of standardized breadfruit leaf extract in improving fluid retention and dyspnea among CHF patients. This study aimed to evaluate the effectiveness of standardized breadfruit leaf (Artocarpus altilis) extract in reducing fluid retention and improving dyspnea in patients with congestive heart failure (CHF). A quasi-experimental one-group pretest–posttest design was conducted on 15 CHF patients who received standardized breadfruit leaf extract for five consecutive days. Parameters measured included body weight and dyspnea severity using the Borg Modification Scale. Data were analyzed using paired t-tests. A statistically significant reduction in body weight was observed after intervention (61.9 ± 5.2 kg to 61.7 ± 5.2 kg; p = 0.005), indicating decreased fluid retention. Dyspnea scores also showed significant improvement (5.6 ± 0.6 to 4.5 ± 0.8; p = 0.001), reflecting meaningful clinical relief in respiratory symptoms associated with congestion. Standardized breadfruit leaf extract demonstrated beneficial effects in reducing body fluid accumulation and improving dyspnea among CHF patients, supporting its potential as a complementary therapy with minimal adverse effects.
Association of Mean Platelet Volume with Response to Neoadjuvant Chemotherapy in Rectal Cancer Patients Elfiani Rusadi; Jelita Siregar; Adi Muradi Muhar
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1722

Abstract

Rectal cancer is one of the most common malignant neoplasms in humans and ranks as the second most frequent cancer of the large intestine. The management of rectal cancer requires a multidisciplinary approach, including surgery, chemotherapy, and radiotherapy administered either before or after surgery to improve the chances of cure. Mean Platelet Volume (MPV) reflects platelet size and is associated with platelet production and activation. Platelet activation plays a crucial role in the development and progression of malignancy. This study aimed to determine the relationship between Mean Platelet Volume (MPV) and the response to neoadjuvant chemotherapy in patients with rectal cancer, as assessed using the Response Evaluation Criteria in Solid Tumors (RECIST). This study was an analytical study with a cross-sectional design, in which several variables were measured simultaneously at a single point in time. Data were collected from outpatients attending the Digestive Surgery Clinic at Adam Malik General Hospital, Medan. A total of 81 patients who met the study inclusion criteria were enrolled using a consecutive sampling method. Data were analyzed using the Shapiro–Wilk test to assess the normality of data distribution. One-way ANOVA or the Kruskal–Wallis test was used to analyze differences between qualitative variables, as appropriate. Receiver Operating Characteristic (ROC) analysis was performed to determine the diagnostic performance of Mean Platelet Volume (MPV). A total of 81 patients were included in this study, with the majority being female (n = 41). The mean age of the study subjects was 53.9 years. Tumors were most commonly located in the proximal rectum (33 patients), and the predominant histopathological differentiation was well differentiated, observed in 53 patients. Most patients with low MPV values (<8.6 fL) demonstrated a better response to chemotherapy, characterized by partial response and stable disease, whereas patients with high MPV values (≥8.6 fL) more frequently experienced progressive disease. There was no statistically significant association between Mean Platelet Volume (MPV) and response to neoadjuvant chemotherapy in patients with rectal cancer, as assessed using the RECIST criteria (p = 0.075). However, clinically, patients with lower MPV values tended to demonstrate a better therapeutic response compared with those with higher MPV values.
Comparison of the Effectiveness of Octenidine Dihydrochloride and Povidone-Iodine Antiseptics on Post-Circumcision Wound Healing Time Muhammad Ardi Putrawardana; Ketut Holifah; Muhammad Alghifari Budiman; Fevi Padhila; Ratna Esmayanti; Herry Octa Winarto
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.1729

Abstract

Circumcision is a minor surgical procedure that results in an acute incision wound and requires optimal care to prevent infection and accelerate epithelialization. Povidone-iodine has long been used as a standard antiseptic, but has been reported to have potential cytotoxicity against fibroblast cells. Octenidine dihydrochloride is an alternative antiseptic with high antimicrobial efficacy and better biocompatibility. This study aims to compare the effectiveness of both antiseptics on post-circumcision wound healing time. The study used a prospective parallel randomized controlled trial (RCT) design at the Darul Khitan Clinic in Bogor City with 34 pediatric patients randomized into two groups (n = 17). The intervention group received octenidine dihydrochloride, while the control group received povidone-iodine. Wound healing was assessed on days 3 and 7 using the WINNER Scale. Data were collected through direct observation and wound assessment by trained healthcare personnel using a standardized observation form. The data were analyzed using an independent t-test (p<0.05). The results showed that the mean wound healing score of the octenidine group was higher than that of povidone-iodine (9.59±1.37 vs 7.29±1.96) with a significant difference (p<0.001; 95% CI -3.482 to -1.106). It was concluded that octenidine dihydrochloride was more effective in accelerating post-circumcision wound healing than povidone-iodine and could be considered as a more optimal antiseptic choice in clinical practice.
Comparison of Systemic Inflammatory Parameters with Anatomical Pathology Results in Differentiating Benign Prostatic Hyperplasia with and without Inflammation: Cross-Sectional Analytics Andreas Stefan Layardi; Rosadi Putra
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1732

Abstract

Chronic inflammation plays an important role in pathogenesisbenign prostatic hyperplasia (BPH). Anatomic pathology examination is the standard for detecting prostate inflammation, but it is invasive. Systemic inflammation parameters based on peripheral blood counts have the potential to be non-invasive biomarkers. Comparing inflammatory parameters based on peripheral blood counts NLR, PLR, MLR, SII and SIRI with Anatomical Pathology results in comparing BPH with and without inflammation. This research is an analytical cross-sectional study in BPH patients with and without inflammation based on the results of Anatomical Pathology. A total of 334 patients were included in this study, and the sampling technique used was consecutive sampling. Parametersneutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), systemic immune-inflammation index (SII), andsystemic inflammatory response index (SIRI) were analyzed and compared between groups. AnalysisReceiver Operating Characteristic (ROC) is used to determine the valuecut-off optimal. The median age of patients was relatively homogeneous. In the BPH group with inflammation, Total leukocyte count, absolute neutrophil count, and absolute monocyte count were higher, while absolute lymphocyte count was lower. All systemic inflammation parameters (NLR, PLR, MLR, SII, and SIRI) were significantly higher in the inflammation group (p < 0.001). SII showed the highest AUC value (0.840), followed by NLR (0.829) and SIRI (0.822). Based on our research, it can be concluded that systemic inflammatory parameters have the potential to be used as non-invasive biomarkers to determine whether a person has BPH with inflammation or not.
A Literature Review: on the Implementation of the 5S Leadership Model to Improve the Quality of Nursing Care Documentation Julaiha Julaiha; Iskim Luthfa; Dyah Wiji Puspita Sari; Iwan Ardian
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1782

Abstract

The Quality and Safety Education for Nurses (QSEN) program is an educational initiative designed to equip nurses with the knowledge, skills, and attitudes necessary to continuously improve quality and patient safety within healthcare systems. Junior nurses, as frontline providers of nursing care, require adequate competencies in patient safety aspects. This study aims to identify and synthesize scientific findings regarding the effectiveness of the QSEN program in improving the knowledge, skills, and attitudes of junior nurses. This study employed a Systematic Literature Review following the PRISMA guidelines. Articles published between 2021 and 2026 were retrieved from PubMed, Scopus, ScienceDirect, and Google Scholar. The initial search identified 3,500 records. After removing 1,150 duplicates, 1,900 records were screened. A total of 1,600 records were excluded based on title and abstract. Of the remaining 300 articles, 120 could not be retrieved. Subsequently, 180 full-text articles were assessed for eligibility, and 158 were excluded due to not meeting inclusion criteria. Finally, 22 studies were included in the synthesis. The findings indicate that the implementation of the QSEN program has a positive impact on improving junior nurses’ knowledge of patient safety (60–85%), enhancing clinical skills (55–80%), and improving professional attitudes in nursing practice (70–90%). Several factors such as organizational support, effective leadership, clinical supervision, and continuous training play a crucial role in the successful implementation of the QSEN program. The QSEN program is effective in improving the knowledge, skills, and attitudes of junior nurses. The success of its implementation is strongly influenced by organizational support, leadership, and an adequate supervision system.
Analysis of Factors Including Pulmonary Tuberculosis in Diabetes Mellitus Patients Marhamah Marhamah; Basri Aramico Ib; Meutia Zahara
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1783

Abstract

The syndemic between Pulmonary Tuberculosis (TB) and Diabetes Mellitus (DM) is a public health challenge because DM can weaken the immune system and poor glycemic control facilitates infection by Mycobacterium tuberculosis. As the prevalence of DM in Indonesia increases, identifying risk factors that contribute to the incidence of TB in DM patients becomes important. This study aims to analyze the relationship between nutritional status, glycemic control, income level, education level, and access to health services with the incidence of pulmonary TB in DM patients. The study used an observational analytical design with a cross-sectional approach conducted at Tgk. Chik Ditiro Sigli Regional Hospital from June–September 2025 with a sample of 277 DM patients selected through purposive sampling. Data were collected using mixed methods, namely secondary data from medical records for TB status, nutritional status, and glycemic control and primary data through questionnaires for income and access to health services using the Cronbach’s Alpha method with a value of ≥0.70.The results showed that the majority of respondents did not have pulmonary TB (75.09%), but the majority had poor nutritional status (68.95%) and most had controlled glycemic control (71.12%). In addition, more than half of respondents had incomes below the Provincial Minimum Wage (56.68%) and about half had poor access to health services (50.54%). The analysis showed a significant association between poor nutritional status (AOR=2.5; 95% CI=1.17–5.39), uncontrolled glycemic control (AOR=4.5; 95% CI=2.43–8.68), income <UMP (AOR=1.9; 95% CI=1.02–3.85), and poor access to health services (AOR=3.2; 95% CI=1.65–6.30) with the incidence of pulmonary TB in DM patients,

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