cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
mkb.fkunpad@gmail.com
Editorial Address
Gedung Rumah Sakit Pendidikan Unpad/Pamitran Unpad (Teaching Hospital Building) Faculty of Medicine Unpad, 3rd Floor Jl. Prof. Eyckman No. 38 Bandung, 40161, Indonesia
Location
Kota bandung,
Jawa barat
INDONESIA
Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 13 Documents
 1   2 
Search results for , issue "Vol 56, No 1 (2024)" : 13 Documents clear
Vitamin D Levels and Incidence of Preterm Labor Aziz, Muhammad Alamsyah; Syahbana, Chandra Garnida; Effendi, Jusuf Sulaeman; Purwara, Benny Hasan; Madjid, Tita Husnitawati; Susiarno, Hadi
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3070

Abstract

One pathophysiology of preterm delivery is maternal or fetal hypothalamus-pituitary-adrenal (HPA) axis activation. The HPA axis can be affected by vitamin D, which increases uterine contractions and affects the body’s immune mechanism against bacterial infections. A lower level of vitamin D in pregnant women is suspected to contribute to the incidence of premature conditions. This study aimed to compare the 25-hydroxy-vitamin D3 concentration in preterm parturient with non-preterm parturient, and the correlation between vitamin D level and the incidence of preterm labor. This comparative analytic study used a cross-sectional approach and involved 46 subjects who were divided into case and control groups. This study was conducted in August–September 2017 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. The Electro-chemiluminescence Immunoassay (ECLIA) method was used to examine the serum 25-hydroxy-vitamin D3 concentration in case and control groups, demonstrating that 25-hydroxy-vitamin D3 concentration in case group (17.26 ng/mL) was significantly (p<0.0001) lower than in control group (24.30 ng/mL). The correlation coefficient between the 25-hydroxy-vitamin D3 and the incidence of preterm labor was -0.837 (p<0.001).  Thus, there was a correlation between the 25-hydroxy-Vitamin D3 level and the incidence of preterm labor that vitamin D supplementation in pregnant women must be considered.
Bilateral Optic Nerve Atrophy Case Report Naqeeb, Mohammed R.; Abdulmannan, Dina M
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3334

Abstract

Wolfram syndrome, also known as DIDMOAD or juvenile onset diabetes mellitus, optic nerve atrophy, diabetes insipidus, and deafness, is a genetic neurological condition. This case report provides a description on the first instance of Wolfram syndrome in a Saudi family, which manifested as proliferative diabetic retinopathy and a powder-like cataract, among the other unusual ophthalmological findings. This case involved a 27-year-old Saudi woman with bilateral optic nerve atrophy who was first diagnosed with diabetes mellitus at the age of 8 years. At the age of 18, bilateral optic nerve atrophy was identified. At the age of 27, diabetes insipidus and hearing loss were verified. There were no signs of renal, neurological, or psychiatric issues. Atypical ophthalmological traits were examined and addressed in this study. Any individual with bilateral optic nerve atrophy and insulin-dependent diabetes mellitus within the first 30 years of life should be evaluated for the possibility of Wolfram syndrome. Microvascular diabetes is an incredibly rare complication of Wolfram syndrome. Early diagnosis, treatment, and prevention of severe consequences can result in improved survival rates and quality of life.
Self-Medication using Chlorpheniramine Maleate in Karanganyar Regency, Central Java, Indonesia Fathoni, Rifqilya Nurul; Ebtavanny, Tamara Gusti; Yunita, Ema Pristi
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3207

Abstract

Self-medication refers to the use of medications by a person without consulting health professionals and  prescription. One of the common drugs used for self-medication is chlorpheniramine maleate (CTM), a drug indicated to relieve symptoms of allergy. However, the lack of knowledge about the indications of CTM leads to its significant misuse. Long-term effects of CTM misuse include heart rate regularity disorder, central nervous system disorders, and even coma. The purpose of this study was to analyze the correlation between sociodemographic factors and the appropriateness of CTM use for self-medication from the perspective of the experience of using CTM for self-medication. This cross-sectional study was performed in Karanganyar Regency, Central Java, Indonesia, from October to November 2022 on 117 respondents sampled randomly using cluster sampling method. A questionnaire that was already proven as valid and reliable was used. Results for the appropriateness of CTM use showed that 95.7% of respondents were in good category, 3.4% were in fair category, and 0.9% were in poor category. The hypothesis tests, which were the Somers’d test and the contingency coefficient, showed no correlation between age (p=0.242), gender (p=0.307), income level (p=0.789), experience (p=0.176), and the appropriate use of CTM for self-medication. However, there is a correlation between education level (p=0.048) and the appropriate use of CTM for self-medication, albeit very weak (r=0.065). Therefore, only the level of education affects the appropriate use of CTM for self-medication.
Impact of Covid-19 Pandemics on Urology Practices and Residency Training in an Indonesian Tertiary Hospital Kusumajaya, Christopher; Tjahjodjati, Tjahjodjati
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.2657

Abstract

The World Health Organization (WHO) declared Covid-19 as a global pandemic on March 11, 2020. Alterations in health service provisions must be applied to maintain prime services and decrease the number of healthcare workers exposure to Covid-19 by reducing the number of patients and workload, as well as cancelling elective surgeries. This study aimed to describe the urological services and residency training program during a Covid-19 year at Dr. Hasan Sadikin General Hospital, Bandung, which is a tertiary health center and teaching hospital in Indonesia. This was a comparative retrospective study conducted from January 2019 to December 2020 that compared the number of patients in inpatient and outpatient settings and emergency department, as well as surgical procedures performed before and during Covid-19 pandemic. Data were obtained from the administration department of the hospital, showing a reduction of 40,94%, 7.39%, 32.3%, and 53.89% of total inpatients, outpatients, emergency cases, and surgical procedures, respectively, in the urology department of the hospital when compared to the previous year. The number of surgeries that could be performed by residents was reduced by 30-60%. This current study showed the decreased number of patients and urological operative procedures during COVID-19 pandemic. This is assumed to give negative impacts to the urological residency training due to the limited exposure to variety of cases and surgical skill procedures.
Predictive Factors of Amputation for Post-Bypass Surgery on Vascular Trauma Patients Kusworo, Afila Reza; Soebroto, Heroe; Suroto, Heri
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3107

Abstract

n Indonesia, most vascular trauma is linked to traffic collisions. According to the Statistics Indonesia (Badan Pusat Statistik, BPS), there were 116,411 accidents in 2019. Limb salvages become important in  vascular trauma, which is performed through, among others, vascular bypass surgery. However, secondary amputation still occurs after vascular bypass. This study aimed to determine the predictors of secondary amputation after vascular bypass due to vascular trauma. This study used descriptive analysis of medical records and univariate analysis. Medical records of patients with vascular trauma underwent vascular bypass in Dr Soetomo Regional Hospital, Indonesia, from January 2018 to December 2020 were collected. Independent variables were age, MESS, time interval between the incident of trauma to the first incision of bypass surgery, penetrating and blunt injury, injured arterial segment, multiple injuries, and obesity. The dependent variable was secondary amputation. Fisher Exact Test was used to analyze the correlation between dependent and independent variables. Results showed a significant difference between patients with a MESS score of >7 and those with a MESS score of  ≤7 (p=0.044), where more patients with a MESS score of >7 experienced secondary amputation. Other variables showed no significant difference (p>0.05). This study concluded that MESS could be used as a predictor of secondary amputation in vascular trauma after vascular bypass. Further studies using multivariate analysis and a larger sample need to be conducted to get further insights on this phenomenon.
Lactic Acid Level as A Predictor of Severity in Patients with Acute Appendicitis Aditya, Raka; Rudiman, Reno; Hapsari, Putie
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3086

Abstract

Perforated appendicitis is the leading cause of morbidity and mortality of all appendicitis cases in adults and children, with delayed preoperative diagnosis as the main reason. In previous studies, diagnostic modalities such as radiological examination and the current scoring system have been demonstrated as unable to predict the onset of perforated appendicitis. Serological biomarkers of lactic acid are associated with intestinal obstruction and ischemia. The serological value of lactic acid in identifying perforated appendicitis compared to acute one was shown to increase significantly by 0.25 mmol/L (p<0.05) in a previous study. This study aimed to determine the correlation between lactic acid and the severity of appendicitis. This was a cross-sectional prospective analytic observational study in patients treated in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Subjects were adult patients diagnosed with appendicitis during the period of 2021 in the Emergency Room of the hospital. Data were analyzed using the bivariate analysis and correlation test of difference. This study involved 54 subjects, divided into the complicated appendicitis (study) and control groups, with a mean of lactic acid level of 2,5093 mmol/L (0.9 mmol/L–11.8 mmol/L). In the complicated appendicitis group, 20 subjects (37%) demonstrated an increase in lactic acid level (OR 1.07; 95% CI: -0.03–0.22; p=0.14). The correlation analysis resulted in a negative correlation. This study concluded that there is no significant correlation between lactic acid levels and the severity of appendicitis in these patients.
Dysobinol Extracted from Chisocheton Macrophyllus Triggers Proliferation Inhibition, Potential Apoptosis, and Cell Cycle Arrest of He La Cancer Cell Lines Gaffar, Shabarni; Hafiz, Ersanda; Wiraswati, Hesti Lina; Ishmayana, Safri; Nurlelasari, Nurlelasari
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3249

Abstract

Dysobinol is a new limonoid from C. macrophyllus seeds reported to have an anticancer activity. This study aimed to determine the cytotoxic activity of Dysobinol against HeLa cancer cell lines and evaluate its mechanism of action by determining the expression level of several carcinogenesis genes related to apoptosis and cell cycle. In this experimental study, the cytotoxic activity was determined using the MTS assay and gene expression by real-time reverse transcriptase PCR. The result shows that Dysobinol has an anticancer activity in a dose and time-dependent manner against HeLa cells and was categorized as toxic with IC50 values of 52.92, 52.70, and 14.96 μg/ml for 24, 48, and 72 hours, respectively. Dysobinol significantly increased the expression of Bax, Cas-8, and Cas-3 and decreased the expression of Cyc D1 at both doses (IC50 and 2x IC50) but only high doses (2x IC50) could affect Cas9 and NF-κB expressions, indicating that Dysobinol can induce apoptosis via the extrinsic pathway and inhibits the cell cycle through the Cyc D1 regulator. Dysobinol has the potential to be developed as a chemotherapy drug or an adjuvant agent for cervical cancer treatment.
Correlation between Duration of Placement of Non-tunneled Hemodialysis Catheter and Positive Bacterial Culture Incidence in Hemodialysis Patients Djajakusumah, Teguh Marfen; Hapsari, Putie; Yarman, Indra Prasetya; Utomo, Hafidh Seno Radi; Lukman, Kiki; Sulastri, Dian; Ulurrosyad, Muhammad Faiz
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3042

Abstract

Non-tunneling hemodialysis catheter is one of the most convenient vascular accesses for hemodialysis in End Stage Kidney Disease (ESRD) patients. However, these catheters have the highest morbidity among all available accesses. Current guidelines recommend that non-tunneled hemodialysis catheters be placed for no more than 2 weeks to prevent bacterial contamination. This study was conducted in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, throughout January-December 2021. A correlation test with a prospective observational analysis design was applied to find the link between the duration of non-tunneled hemodialysis catheter placement and the incidence of positive bacterial culture on the catheter. Pearson correlation test was used to see the strength of the correlation, with a significance limit of 0.05. This study involved 28 subjects. The most common location for catheter placement was in the jugular vein, and laboratory examinations showed no correlation between leukocyte values and positive bacterial culture results. Hypertension and diabetes mellitus were not significant risk factors (p-value 0.887). At ≤14 days of catheter placement, only 1 (6.7%) of the subjects presented a positive culture result. Most of the positive bacterial culture results were found at a duration of 15-30 days of placement, (n=8; 53.3%). The results of the Pearson test showed a p-value of 0.036 and an r-value of 0.399, indicating a significant result with a strong correlation between the two variables. The duration of placement of hemodialysis catheters has a positive correlation with the incidence of positive bacterial cultures, which can increase the risk of systemic infection associated with hemodialysis catheters.
Correlation of Hepatocyte Growth Factor Levels with Myopia Degree and Axial Length in Outpatient Myopic Adolescents Aldy, Fithria; Yanni, Gema Nazri; Siregar, Jelita
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3281

Abstract

Myopia is the most common ophthalmic condition worldwide, with an estimated 22.9% of the population or 1.406 billion people affected. Studies of candidate gene-associated refraction abnormalities have also identified several genes that cause vulnerability myopia, including the hepatocyte growth factor (HGF) and  hepatocyte growth factor receptor (MET) genes. The purpose of the study was to analyze the correlation between hepatocyte growth factor (HGF) levels, degrees of myopia, and long axial in adolescents with myopia treated as outpatients in Universitas Sumatera Utara Hospital. This study applied the cross-sectional analytical approach. The inclusion criterion for the participants was patients diagnosed as suffering from myopia by the Ophthalmology Outpatient Clinic of the Universitas Sumatera Utara Hospital. Sampling was performed consecutively with a minimum sample size of 25 patients in control group and 25 patients in the case group. This study revealed that the mean axial length of the right eye in the case group was 23.82 mm, with a significant difference in the axial length between the case and control groups. The mean HGF level in the myopia group was 510.49 ng/mL, which was not significantly different from the mean HGF level in the control or emmetropic group. The HGF levels were highest in the group of subjects with moderate myopia, with an average of 551.87 ng/mL, and differences in HGF levels were identified in different degrees of myopia. Thus, no significant correlation is identified between the HGF levels, axial length, and myopia degree.
Association Between Screen Time, Vitamin A Consumption Behavior, and Computer Vision Syndrome in Preclinical Medical Students Prasetya, Harka; Rahmawati, Atik; Andira, Aisyah Putri; Suparmi, Suparmi
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3346

Abstract

Computer Visual Syndrome (CVS) refers to visual disturbances induced by electronic media such as computers, laptops, tablets, and smartphones. This research aimed to determine the association between screen time, vitamin A consumption behavior, and CVS symptoms among preclinical medical students. Ninety-five students from a single class at the Faculty of Medicine, Universitas Islam Sultan Agung, Indonesia, participated in this cross-sectional study. Data were collected using an online survey platform in February 2022. The screen time, vitamin A consumption behavior, and CVS were measured using a validated questionnaire. The average daily screen time of the respondents was more than 10 h, with the majority having a moderate vitamin A consumption patterns (66.3%) and experienced CVS (63.2%). The most prevalent CVS symptom identified among these respondents was eye fatigue (62.1%), while double vision and inflamed or watery eyes were the least reported CVS symptoms (9.5% and 8.4%, respectively). The Chi-Square test revealed that there was no correlation between screen time and CVS (p > 0.05), but there was a significant correlation between vitamin A consumption and CVS (p < 0.05). In conclusion, CVS is observed among preclinical medical students due to increased screen time and decreased vitamin A consumption. Therefore, there is a need to develop strategies to manage screen time and vitamin A consumption among students at risk for developing a CVS during their academic careers.

Page 1 of 2 | Total Record : 13

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol 57, No 3 (2025) Vol 57, No 2 (2025) Vol 57, No 1 (2025) Vol 56, No 4 (2024) Vol 56, No 3 (2024) Vol 56, No 2 (2024) Vol 56, No 1 (2024) Vol 55, No 4 (2023) Vol 55, No 3 (2023) Vol 55, No 2 (2023) Vol 55, No 1 (2023) Vol 54, No 4 (2022) Vol 54, No 3 (2022) Vol 54, No 2 (2022) Vol 54, No 1 (2022) Vol 53, No 4 (2021) Vol 53, No 3 (2021) Vol 53, No 2 (2021) Vol 53, No 1 (2021) Vol 52, No 4 (2020) Vol 52, No 3 (2020) Vol 52, No 2 (2020) Vol 52, No 1 (2020) Vol 51, No 4 (2019) Vol 51, No 3 (2019) Vol 51, No 2 (2019) Vol 51, No 1 (2019) Vol 50, No 4 (2018) Vol 50, No 3 (2018) Vol 50, No 2 (2018) Vol 50, No 1 (2018) Vol 49, No 4 (2017) Vol 49, No 3 (2017) Vol 49, No 2 (2017) Vol 49, No 1 (2017) Vol 48, No 4 (2016) Vol 48, No 3 (2016) Vol 48, No 2 (2016) Vol 48, No 1 (2016) Vol 47, No 4 (2015) Vol 47, No 3 (2015) Vol 47, No 2 (2015) Vol 47, No 1 (2015) Vol 46, No 4 (2014) Vol 46, No 3 (2014) Vol 46, No 2 (2014) Vol 46, No 1 (2014) Vol 45, No 4 (2013) Vol 45, No 3 (2013) Vol 45, No 2 (2013) Vol 45, No 1 (2013) Vol 42, No 3 Vol 44, No 4 (2012) Vol 44, No 3 (2012) Vol 44, No 2 (2012) Vol 44, No 1 (2012) Vol 43, No 4 Vol 43, No 3 Vol 43, No 2 Vol 43, No 1 Vol 42, No 4 Vol 42, No 2 Vol 42, No 1 Vol 41, No 4 Vol 41, No 3 Vol 41, No 2 Vol 41, No 1 More Issue