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JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya
Published by Universitas Negeri Malang
ISSN : 25496565     EISSN : 25496573     DOI : 10.17966
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
JC-T (Journal Cis-Trans) : jurnal kimia dan terapannya is published by Universitas Negeri Malang, Faculty of Mathematics and Science, Chemistry Department.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 101 Documents
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Pengaruh Jenis Bahan Baku Minyak di Indonesia terhadap Karakter Biodiesel Muhammad Roy Asrori; Aman Santoso; Yana Fajar Prakasa; Deni Ainur Rokhim
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 9 No. 2 (2025)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v9i22025p026

Abstract

Kebutuhan energi terbarukan terus meningkat dan penelitian terus dilakukan dalam hal pencarian efisiensi, efektivitas, dan adaptabilitas. Di Indonesia, energi terbarukan yang dipersiapkan dalam jumlah besar adalah biodiesel. Sebagai salah satu negara agraris, sumber daya alam berupa minyak nabati perlu dieksplorasi untuk menampilkan potensi bahan baku biodiesel. Berbagai jenis bahan baku tersebut dapat menghasilkan jenis biodiesel dengan kualitas yang berbeda. Pemahaman terhadap kualitas ini mengarah pada suatu karakter biodiesel, yakni densitas, viskositas, bilangan asam, dan yield. Dalam kajian ini, penulis merepresentasikan pengaruh jenis bahan baku minyak terhadap karakter biodiesel dengan menelusuri literatur jurnal. Biodiesel yang dihasilkan dari proses transesterifikasi. Hasil kajian menunjukkan bahwa pengaruh jenis bahan baku terhadap karakteristik biodiesel yang dihasilkan adalah berbeda-beda tetapi sesuai SNI SNI 04-7182-2006. Sedangkan pengaruh jenis bahan baku terhadap yield biodiesel yang dihasilkan adalah diperoleh bahan baku minyak kelapa yang memiliki yield biodiesel tertinggi (98,5%) dari reaksi optimum transesterifikasi beberapa bahan baku biomassa. Jadi, bahan baku memainkan peranan penting produksi biodiesel.
Evaluation of C-single C-bond Chemokine Ligand 2 as Biomarkers in COVID-19 Disorders Muayad Al-dulaimi; Saad M. Saeed
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 10 No. 1 (2026)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v10i12026p014

Abstract

The COVID-19 virus induces physiological alterations in blood composition and biochemical parameters, leading to elevated levels of C-reactive protein (CRP), D-dimer, ferritin, erythrocyte sedimentation rate (ESR), and human C-C motif chemokine ligand 2 (CCL2). Given their strong association with the disease, these biomarkers are considered crucial indicators of infection severity. Data analysis revealed a significant positive correlation between inflammatory biomarkers (specifically CCL2, CRP, D-dimer, ferritin, and ESR) and COVID-19 disease severity, with CCL2 levels showing a highly significant increase (P < 0.001) in patients compared to healthy controls. Patients were stratified based on disease severity in accordance with the clinical guidelines established by the Iraqi Ministry of Health. These findings highlight the practical clinical diagnostic value of CCL2 in assessing COVID-19 progression.
Visible Spectrophotometric Estimation of Mometasone Furoate in Bulk and Pharmaceutical Dosage Form by Ion-Pair Method Baidaa Adnan Jassim
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 10 No. 1 (2026)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v10i12026p025

Abstract

A straightforward, sensitive, and cost-effective spectrophotometric method was established and validated to quantify Mometasone Furoate (MOM) medication in both pure and pharmaceutical dose forms. This specific process involves creating an ion-pair combination of mometasone furoate with alizarin red dye. At a wavelength of 522 nm, the drug and dye combination was determined to have the maximum absorption. In order to improve the circumstances for complex formation, we examined and evaluated the dye concentration, temperature, reaction time, and impacts of acids and bases. The range of 5 to 40 µg/ml was accompanied by a straight line. The limits of detection were found to be 0.0134 µg/ml, whereas the limits of quantitation were 0.0407 µg/ml. The numbers 10584.42 L/mol·cm and 0.4944 µg/cm² for the molar absorptivity and Sandell sensitivity, respectively, were found. It was shown that the compound's stoichiometry was exactly one medication to one dye and vice versa using Job's method of continuous variations. The devised method was used to measure the amount of medication included in its pharmaceutical formulation.
Identifikasi Turunan Phthalazin dan Quinazolin sebagai Kandidat Inhibitor Baru Protein Transport Asam Lemak 4 (FABP4) untuk Pengembangan Obat Diabetes Tipe 2 in Silico Fredy Z. Saudale; Ivoni M. Barawisi
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 9 No. 2 (2025)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v9i22025p001

Abstract

Fatty Acid-Binding Protein 4 atau FABP4 diekspresikan pada jaringan tubuh lemak. FABP4, sebagai pembawa asam lemak untuk dioksidasi sebagai energi, berperanan penting dalam patogenesis berbagai gangguan metabolis diantaranya resistensi insulin, diabetes, dan aterosklerosis. Oleh karena itu, desain dan penemuan senyawa kimia yang mampu menghambat aktivitas FABP4 memberikan kesempatan terapi baru untuk mengobati gangguan metabolisme tersebut. Penelitian ini menerapkan metode komputasional (in silico) untuk menemukan senyawa-senyawa kimia baru yang memiliki kemampuan untuk menambat di situs aktif pengikatan dan menghambat protein FABP4. Didapatkan 3 senyawa kandidat baru turunan phthalazin dan quinazolin yang mampu menunjukkan interaksi yang kuat dengan residu-residu esensial di situs aktif pengikatan FABP4 seperti Arg130 dan Tyr132. Ditemukan juga interaksi baru demgan asam amino Thr57 dan Thr64 yang menstabilkan afinitas. Oleh sebab itu, senyawa-senyawa kandidat turunan phthalazin dan quinazolin tersebut sangat berpotensi untuk divalidasi dan diujikan lebih lanjut untuk pengembangan obat diabetes tipe 2 yang menarget protein FABP4 manusia.
Biochemical Alterations in Kidney and Liver Function in Individuals with Severe Pre-eclampsia Nuha Ali Hadi Ali_Samarrai; Maytham Mohammad Bakr; Rana Raad Zanzal
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 10 No. 1 (2026)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v10i12026p008

Abstract

Preeclampsia (PE) is a multisystem disorder that complicates 2 to 8 % of pregnancies worldwide and is a major cause of maternal and fetal morbidity and mortality. Objective: To evaluate biochemical biomarkers of kidney and liver function and inflammatory biomarkers (TNF-α and IL-6) in women with severe pre-eclampsia and compare them with healthy pregnant controls. Methods: The present cross-sectional study was performed on 70 pregnant women with preeclampsia and 30 healthy pregnant controls with gestational ages >20 weeks. Serum levels of TNF-α, IL-6 and Cystine C were estimated by Elisa-based assays and liver and kidney function Biochemical tests were performed using spectrophotometer according to the manufacturer’s instructions. Results: Significant difference was observed in blood urea nitrogen and serum creatinine in severe pre-eclampsia as compared with healthy controls (P < 0.001). Liver function tests and bilirubin was also significantly higher in severe preeclampsia (P < 0.001). In preeclamptic group, the levels of TNF- α and IL-6 were significantly increased. Conclusion: Severe preeclampsia was associated with significant changes in kidney and liver biochemical parameters and increased inflammatory biomarkers.
Evaluation of the Analgesic Efficacy of Ethanolic Extract of Majapahit (Crescentia cujete L.) Leaves in Male Swiss Webster Mice Using the Hot Plate Method Rahma Diyan Martha; Choirul Huda; Silvi Anjarsari; Danar Danar
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Article in Press
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Majapahit (Crescentia cujete L.) leaves contain secondary metabolites, particularly flavonoids, which exert analgesic effects by inhibiting cyclooxygenase activity, thereby reducing prostaglandin biosynthesis from arachidonic acid and alleviating pain. This study evaluated the analgesic efficacy of an ethanolic extract of Majapahit leaves in male Swiss Webster mice using the hot plate method. Pain responses were recorded at 0, 30, 60, 90, and 120 min post-administration. The results demonstrated that the optimal analgesic effect was achieved at a dose of 375 mg/kg body weight (BW), yielding an efficacy level of 82.80%, which was comparable to the positive control group treated with mefenamic acid. Statistical analysis performed using SPSS via one-way ANOVA followed by Tukey's HSD post-hoc test revealed no significant difference between the 375 mg/kg BW dose group and the positive control group (p > 0.05). These findings indicate that the 375 mg/kg BW dose has potential as an effective analgesic dose and may provide a basis for further investigation into its development and application as a potential analgesic agent.
Synthesis and Characterization of Silica/Carbon (SiO₂/C) Composites from Geothermal Waste-Derived Silica and Coconut Shell-Derived Carbon Siti Nurbaiti; Sintia Yulia Ningsih; Joko Suryadi; Dian Ratna Suminar
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Article in Press
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The increasing demand for energy storage devices has encouraged the development of alternative silica-based anode materials. This study aimed to synthesize and characterize a silica/carbon (SiO₂/C) composite using geothermal waste as the silica source and coconut shell charcoal as the carbon source. Silica was synthesized using the sol-gel method, while activated carbon was prepared through carbonization at 700 °C and activation with 3 M KOH. SiO₂/C composites were synthesized by the solid-state method at SiO₂-to-carbon mass ratios of 1:4, 1:9, and 1:19, followed by calcination at 500 °C.  Characterization was conducted using XRF, FTIR, XRD, SEM-EDS, and titrimetric analysis. The synthesized silica contained 93.50% SiO₂. FTIR confirmed the presence of Si–O–Si, Si–OH, and C=C groups, XRD indicated an amorphous structure, and SEM-EDS revealed irregular particle morphology. The SiO₂-to-activated carbon mass ratio influenced the composite surface area and yield, with the 1:19 ratio exhibiting the highest estimated surface area of 321.8635 m²/g and the highest yield of 96.01%.
In Silico Study of Alkaloid Compounds from Lycopodium clavatum as Anti-Alzheimer Agents Cleolansya Afiza Chinta Arnessya; I Gusti Made Sanjaya
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 9 No. 1 (2025)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v9i12025p046

Abstract

Alzheimer's disease is a neurodegenerative condition that causes cognitive deficits and accounts for 60-80% of dementia cases. Several therapeutic strategies target this disease; one of them, cholinesterase inhibition, works through inhibition of the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), for example rivastigmine. As a dual AChE/BChE inhibitor, rivastigmine causes gastrointestinal side effects, making natural compounds - particularly alkaloids - attractive alternative drug candidates. This study aimed to determine the potential of alkaloid compounds from Lycopodium clavatum as anti-Alzheimer agents in silico through a Quantitative Structure-Activity Relationship (QSAR) approach and molecular docking. Of the 20 alkaloid compounds obtained from the literature, all satisfied Lipinski's five rules, while 11 compounds passed selection based on LD50 category III values. The best QSAR model (Model 5) used the SA (surface area) descriptor with pKi against AChE as the dependent variable, yielding a coefficient of determination (R²) of 0.620 and a leave-one-out cross-validated Q² of 0.212, indicating that further validation with additional descriptors or a larger compound set is warranted. Molecular docking results identified acetylfawcettiine as the best candidate, with a binding energy of -11.70 kcal/mol and an inhibition constant of 2.66 µM against AChE, superior to rivastigmine (-6.98 kcal/mol; 7.59 µM).
Enzymatic Extraction of Gelatin from Goat Skin Using Combined Proteases from Indigenous Bacterial Isolates MSF6 and MSF11 Fanny Anggita Febrianingrum; Mieke Alvionita; Intan Kusuma Dewi; Suharti Suharti
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Article in Press
Publisher : Universitas Negeri Malang

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Abstract

Gelatin, a protein derived from collagen, is widely used in food, pharmaceutical, and cosmetic industries. The use of conventional porcine-derived gelatin raises concerns about halal compliance, highlighting the need to develop alternative gelatin sources acceptable to a broader range of consumers. This study successfully produced halal gelatin from goat skin through enzymatic extraction using a mixture of proteases produced by indigenous bacterial isolates MSF6 and MSF11. Optimal protease production was achieved on day 2 at pH 9 and 37 °C, while maximum protease activity was observed at pH 9 and 57 °C. The highest gelatin recovery (78.93%) was obtained using a 3:1 ratio of crude protease extracts from MSF6 and MSF11. ATR-FTIR analysis revealed characteristic amide A and amide I absorption bands, while SDS-PAGE analysis showed a predominant protein band with a molecular weight of 66.34 ± 2.65 kDa. The extracted gelatin exhibited a gelling temperature of 8 °C, a pH of 7.56, and a gel strength of 19.9 Bloom.
Optimization Of Keratinase Production and Characterization By Bacterial Isolates MSF6 And MSF11 Putri Kurnia; Mieke Alvionita; Intan Kusuma Dewi; Suharti Suharti
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 9 No. 2 (2025)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v9i22025p032

Abstract

Chicken feather waste is a major environmental issue in Indonesia, with an estimated 189 million kg generated by 2024 due to high poultry consumption. Composed of approximately 90% keratin, chicken feathers represent a promising substrate for bioconversion into value-added products using keratinase. This study aimed to optimize keratinase production and characterize the enzyme produced by two indigenous bacterial isolates, MSF6 and MSF11, obtained from chicken slaughterhouse soil. Laboratory experiments included the optimization of fermentation conditions (pH and temperature), enzyme activity assays, and feather degradation tests. Optimal enzyme production was achieved at pH 9 and 37°C, whereas maximum enzyme activity was observed at pH 10 and 62°C. The combined keratinase preparation (MSF6 = 3:2) exhibited the highest degradation efficiency, yielding 277.62 µg/mL of soluble protein and a 17% reduction in feather weight. These findings highlight the potential of indigenous bacteria for the sustainable management and valorization of chicken feather waste.

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