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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 972 Documents
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Tinjuan Pustaka: Hubungan Jenis Kelamin dan Hormon Androgen dengan Kejadian Dry-Eye Disease Fairuz Hanan, Sifa’Syaharani; Rengganis Wardani, Dyah Wulan Sumekar; Rudiyanto, Waluyo; Himayani, Rani
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.992

Abstract

Dry eye disease (DED) is a multifactorial condition on the surface of the eye that occurs due to disruption of tear film homeostasis with manifestations of symptoms such as tear film instability, hyperosmolarity, inflammation, eye surface damage, and neurosensory abnormalities. DED can occur due to decreased eye fluid production or increased tear evaporation which is generally caused by meibomian gland dysfunction. The global prevalence of DED ranges from 5-50%, with women having a higher risk than men. The prevalence of dry eye in women (3.2 million) is higher than in men (1.6 million) aged over 50 years. Asian ethnicity is the most consistent risk factor for DED. The female gender factor is a risk in the development of DED with increasing age. The pathophysiological mechanisms of DED can be influenced by differences in endocrine function related to sex, especially androgen, estrogen and other hormones. The meibomian and lacrimal glands are target organs for androgen hormones, and low androgen activity can cause meibomian gland dysfunction and inflammation of the lacrimal glands, contributing to the occurrence of DED. In addition, differences in gene expression affect mucin production by the cornea and conjunctiva, as well as other hormonal involvement can also affect eye health and cause dry eye symptoms. Further understanding of the relationship between gender, hormones, and pathophysiological mechanisms of DED may aid the development of more effective treatment strategies.
Faktor terkait Pekerjaan yang Berhubungan dengan Kejadian Migrain Zahra, Tsurayya Fathma; Sutarto, Sutarto; Utama, Winda Trijayanthi
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.993

Abstract

Migraine is a neurovascular disease which is one of the main factors of disability in adults under 50 years. Migraines are generally characterized by headache attacks that are unilateral, recurrent, hereditary and multifactorial. The prevalence of migraine in the world reaches 10-14% with the highest incidence in North America, Central America and South America. In Indonesia alone, the prevalence of migraine has reached 3.5 million people with the highest coming from individuals aged 15-24 years. Until now, the exact cause of migraines is not known. However, there are many risk factors that can influence the occurrence of migraines, including work-related factors. Occupational factors related to migraines include work stress, environmental factors, and excessive use of electronic screens. Work-related stress can be caused by workload, time pressure, and relationships with coworkers. Work environmental factors can include excessive lighting, noise, changes in temperature and air pressure, and strong odors. Meanwhile, the use of electronic screens can influence migraines because they are related to the use of blue light, computer flashes, light reflections, and prolonged exposure to light. The diagnosis of migraine can be made through the results of the history and physical examination, and if necessary, supporting examinations can also be carried out to rule out other secondary causes that may influence migraine.
Efektivitas Vaksin Human Papillomavirus Pada Anak Perempuan dalam Upaya Pencegahan Kanker Serviks Sono, Rafa Habiba; Ratna Dewi Puspita Sari; Rika Lisiswanti; Ari Irawan Romulya
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.994

Abstract

With high mortality rates worldwide, cervical cancer is a major threat to women's health. The World Health Organization (WHO) has set a global strategy for elimination through HPV vaccination. Indonesia has implemented the HPV Immunization Introduction Program, including its implementation in the School Children Immunization Month, aimed at grade 5 and 6 elementary schools. The prevalence of cervical lesions has been reduced by HPV vaccination, but screening and adapting to changing epidemiology remain challenging. The influence of socioeconomic factors on risk highlights the need for prevention strategies that address social disparities. Successful vaccination not only protects individuals but also contributes to overall public health. Therefore, it requires adaptation and collaboration across sectors to address cervical cancer globally.
Literature Review : Tatalaksana Mioma Uteri Fatahillah, Fatahillah; Hanriko, Rizki; Septiani, Linda; Sari, Ratna Dewi Puspita
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.996

Abstract

Myoma or uterine fibroids are benign tumors that often occur in the uterine wall. Myomas can be asymptomatic or cause symptoms such as abnormal bleeding, pelvic pain, and disorders of the urinary tract. Risk factors include age, race, age of menarche, parity, family history, hormonal contraceptive use, and obesity. Diagnostic examination involves pelvic examination, ultrasound, hysteroscopy, and MRI. Medical therapies used such as NSAIDs, oral contraceptives, Levonorgestrel-releasing intrauterine system (Mirena), tranexamic acid (cyclocapron), GnRH agonists and SPRMs and surgeries such as myomectomy, hysterectomy, uterine artery embolization, and MRgFUS. Management of Myoma must consider various factors, namely tumor size, patient age, symptom and the desire to maintain fertility in order to provide optimal treatment according to the patient's needs and preferences.
Diagnosis dan Tatalaksana Kalazion Eksaserbasi Akut ODS Rahmat, Aprin Nabila; Graharti, Risti; Maulana, Muhammad
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.998

Abstract

Chalazion is a granulomatous inflammation with lipogranuloma or chronic non-infectious inflammation of the eyelid, in the form of a nodule formed due to inflammation and obstruction of the tarsal meibomian gland or zeis. This chalazion often occurs in all age groups, but the chalazion occur more commonly in the productive age. We report the case of a 20-year-old man with complaints of a lump on the upper eyelid, at the left and right eye for 4 months before entering the hospital. The lump is initially small but gets bigger over time, becomes red, feels painful and lumpy. This complaint has been repeated since 10 months ago. Currently the lump no longer feels painful, itchy or hot, but the lump is now permanent. On ophthalmological examination, it was found that the superior eyelid of the right eye had a nodule measuring ±5 mm and the superior eyelid of the left eye had a nodule measuring ±3mm. The diagnosis made was acute exacerbation of chalazion of right eye, then the patient was given non-medicamentosa therapy, medicamentosa, and operative treatment.
Teknik Penyuntingan Gen Clustered Regularly Interspaced Short Palindromic Repeats-Cas9 (CRISPR-Cas9) sebagai Terapi Penyakit Genetik Bawaan: Ulasan Literatur Islami, Suryadi; Haq, Rais Amaral; Arianto, Nayla Nadhifa; Sabina, Diana Larisa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.999

Abstract

The development of therapy for inherited genetic diseases using CRISPR-Cas9 technology has shown significant progress. This article discusses the history and working principles of CRISPR-Cas9, highlighting its applications in the therapy of inherited genetic diseases. Current research focuses include diseases such as cystic fibrosis, thalassemia, and Duchenne muscular dystrophy. Genetic therapy with CRISPR-Cas9 involves editing specific genes to correct disease-causing mutations, opening up opportunities for more effective treatments. Regarding the use of this technique, there are various difficulties, such as potential off-target effects, ethical issues, and long-term safety. However, efforts continue to be made to improve the specificity and accuracy of CRISPR-Cas9 so that the development of effective delivery methods and improving safety has become a major focus of research. Potentially, CRISPR-Cas9 could become a more specific and personalized genetic therapy, opening up opportunities to treat genetic diseases at the molecular level and providing alternative therapies for diseases that were previously difficult to treat. In addition, this technology has the potential for early prevention of genetic diseases and the development of more affordable gene therapies. Interdisciplinary collaboration is key in optimizing the potential of CRISPR-Cas9 to ensure the development of genetic disease therapies that are ethical and beneficial to human health in the future.
Hubungan Antara Kualitas Ridur dan Aktivitas Fisik dengan Siklus Menstruasi pada Remaja Putri di SMAN 5 Bandar lampung Amir, Anzela; Sari, Ratna Dewi Puspita; Utama, Winda Trijayanthi; Berawi, Khairun Nisa
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1003

Abstract

Menstruation is a natural process in which the inner uterine lining of the uterus is regularly released every month in women. The most vulnerable period for a person to experience menstrual disorders is during the first year, about 75% of adolescent girls experience menstrual disorders. According to the World Health Organization (WHO), 75% of adolescent girls experience menstrual cycle disorders. Risk factors that can cause disruptions in the menstrual cycle include hormonal imbalances due to environmental stressors and excessive physical activity and low energy intake. In addition, exposure to pollutants such as cigarette smoke, stress, depression, short sleep, Body Mass Index (BMI), and certain medical conditions can also affect the menstrual cycle. This study is an analytical study with cross-sectional design. The study was conducted at SMAN 5 Bandar Lampung in October - December 2023. The research instruments used in this study were questionnaires to assess sleep quality, namely PSQI, questionnaires from who, namely GPAQ to measure physical activity, and menstrual cycle questionnaires to assess menstrual disorders in respondents. Chi-square test results with a confidence level of 95% showed a p-value of 0.265 (p-value > 0.05) on sleep quality variables and p-value of 0.006 (p-value < 0.05) on physical activity variables. There is no relationship between sleep quality and physical activity with the menstrual cycle in adolescent girls at SMAN 5 Bandar Lampung in 2023. There is a relationship physical activity with the menstrual cycle in adolescent girls at SMAN 5 Bandar Lampung in 2023.
PENATALAKSANAAN HOLISTIK PADA ANAK PEREMPUAN 6 TAHUN DENGAN VARISELA MELALUI PENDEKATAN KEDOKTERAN KELUARGA DI PUSKESMAS KEDATON Tasya Ivani Syafira, Tasya Ivani Syafira; Dewiarti, Azelia Nusa
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1004

Abstract

Varicella is a skin infection disease caused by the Varicella zoster virus. WHO estimates that the varicella disease burden is 4.2 million with complications. Applying the principles of family medicine and implementing holistic management based on the patient-centered, family-focused, and community-oriented approach grounded in Evidence Based Medicine. This study is a case report utilizing primary data obtained through anamnesis, physical examination, and home visits to get family, psychosocial, and enviromental data. Secondary data were obtained from the patient’s medical records. A 6-years-old female patient came with small pimples on the face, neck, body, back, arms, thighs from 3 days ago. Patient didn’t care about self-hygiene. Patient rarely take a shower and washing her hands. The patient was diagnosed with varicella. Holistic management was performed with a family physician-designed approach for A 6-years-old female patient, with varicella based on the initial holistic diagnosis. The intervention has improved the patient’s knowledge and changed some behaviours of the patient and her family.
Benign Prostat Hyperplasia : a review Alghani, Sulthan Rafi; Sangging, Putu Ristyaning Ayu
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1005

Abstract

The prostate gland is a vital organ that often experiences enlargement, including in a non-malignant form known as Benign Prostatic Hyperplasia (BPH). BPH, which is common in elderly men, is a leading cause of medical intervention in men over 60 years of age and affects quality of life. Epidemiology of BPH, with a prevalence reaching 70-90% in men over 60 years. Although exact data in Indonesia is not yet available, leading hospitals report BPH cases with an average age of sufferers around 66-67 years. Symptoms of BPH, such as difficulty urinating and other clinical complaints, can affect the sufferer's quality of life. Risk factors, including age, family history, obesity, employment history, and diabetes. Prevention and education are also a major concern, with an emphasis on healthy eating patterns, physical activity, reducing caffeine and alcohol consumption, and daily behavior to minimize BPH symptoms. Potential complications include urinary tract obstruction which can lead to infection and even kidney failure if left untreated.
LITERATUR REVIEW: TRIKIASIS Gerliandi, Egi Oktarian; Mustofa, Syazili; Lisiswanti, Rika; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1008

Abstract

Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. This research utilizes a method of sear Trichiasis is a pathological disorder characterized by the abnormal growth of eyelashes towards the eyeball, resulting in irritation, pain, and potential harm to the eye. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering. ching for articles on Google Scholar, PubMed, and NCBI. The search is limited to a specific year range determined by the researcher. The search is conducted using keywords such as trichiasis, etiology of trichiasis, pathophysiology of trichiasis, classification of trichiasis, clinical manifestations of trichiasis, diagnosis of trichiasis, and management of trichiasis. The study's findings revealed that the cause of trichiasis remained unknown, however it was hypothesized to be a result of infection. The pathophysiology of trichiasis originates with alterations in the structure of the eyelashes and eyelids. Trichiasis is classified into six categories according to the source and location of abnormal eyelash development. The clinical presentation of trichiasis differs according on the extent of the condition. Trichiasis can be diagnosed by assessing the patient's medical history and doing a thorough physical examination. The history encompasses the patient's medical background, record of medication usage, past eye surgical procedures, and the patient's reported symptoms. The physical examination encompasses assessments of visual acuity, biomicroscopic inspection, evaluation of eyelid margins, and the administration of the Schirmer test. The treatment for trichiasis is determined by the extent of eyelash involvement, which includes factors such as the Soft Contact Lense Base Curve. Treatment options may include eyelash removal and surgical procedures, depending on the specific form of trichiasis that the patient is suffering.

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