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Nexus Biomedika
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
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Articles 292 Documents
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The Association between Exercise Activity and Postural Orthostatic Tachycardia Syndrome (POTS) in Female College Students Afifah Novita Yuliastuti; . Balgis; Ratna Kusumawati
Nexus Biomedika Vol 4, No 3 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is illness manifestations caused by autonomic dysfunction. Subjects with POTS predominantly are young women between 20-40 year old and most of them are college student. Exercise has proven can improve the function of body systems. College studentss time is mostly for academic activity and not much time for exercise. The main aim of this research was to know the association between exercise activity and the incidence of POTS in female college students. Method: This research was an analytical observational using case-control design approach. Samples were fifty eight female college students with POTS (16-23 years old) selected using purposive sampling. This study was done from November to December 2014 at Medical School of Sebelas Maret University Surakarta. Data of Exercise activity were obtained by questionnaire. Diagnosis of POTS was conducted by measuring heart rate using pulsemeter on Active Stand Test (AST) position while orthostatic symptoms were gotten by interview. Data were analyzed using Chi-Square test. Result: This study showed that most of the subjects with POTS (27.6%) had lower exercise activity than those without POTS (37.9%). The result of Chi Square analysis was p = 0.007. Conclusion: There was significant association between exercise activity and the incidence of POTS in female college students. Keywords: exercise activity, heart rate, POTS
Uji Sitotoksik Kuantitatif Ekstrak Biji Srikaya (Annona squamosa L.) pada Kultur Sel Limfosit T Pasien SLE In Vitro Anindhito Kurnia Pratama; . Balgis; . Mujosemedi
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Systemic Lupus Erythematosus is an autoimmune disease, mediated by lymphocytes. Methanol extract of Annona squamosa L. seed contains acetogenin, which can inhibit formation of ATP in the abnormal cell that acts as a source of energy that has selective properties of the abnormal cells only. The purpose of this study was to know the cytotoxic effects of Annona squamosa L. seed extract on T lymphocyte cell cultures of SLE patient in vitro. Methods: This study was an experimental laboratory research with post-test control group design. The sample was T lymphocyte cultures of SLE patients in the active phase. Cytotoxic effects of Annona squamosa L. seed extract on T lymphocyte cell culture of SLE patient in vitro were measured with the MTT assay then analyzed with regression analysis to determine the inhibitory concentration of fifty (IC50). Results: The IC50 of methanol extract of Annona squamosa L. seed on lymphocyte cell cultures of SLE patients was 0.17 g/mL, active criteria and normal sample was 0.06 g/mL., active criteria. While IC50 of cyclophosphamide for treatment of SLE samples was 16.80 g/mL and for normal sample was 39.24 g/mL. Conclusions: Based on this research, methanol extract of Annona squamosa L. seed had cytotoxic effects on lymphocyte cell cultures of SLE patient in vitro with active IC50 criteria Keywords: SLE, Annona squamosa L. seed, cytotoxic, T lymphocyte, IC50
Roxburghine B and OxoxylopinePotential as Hepcidin Antagonist Insilico for Inflammatory Anemia Safirah . Yotriana; Yuliana Heri Suselo; Muthmainah . .
Nexus Biomedika Vol 6, No 2 (2017): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Introduction: Anemia affects half a billion women in the world and become a problem, especially in pregnant women. One of the cause of anemia is inflammatory disease which also has a high prevalence in Indonesia. Therapies currently used to treat anemia are based on the underlying disease. Anticalin is a protein that works as hepcidin antagonist. Anticalin has completed the clinical phase II, but it has not been distributed to public market yet. Therefore, a new, easily accessible and more effective drug is required. Indonesian herbs have been widely used as medicinal plants in the community and are potential to be developed as drugs. The purpose of this study is to identify Indonesian phytochemicals that can act as hepcidin antagonist. Methods: The research was a bioinformatics study with molecular docking method. Three-dimensional structure of human hepcidin as a target protein and Anticalinas a standar therapy were downloaded from the website of the Protein Data Bank (PDB). The active compounds were obtained from HerbalDB and the three-dimensional structure was from PubChem National Center for Biotechnology Information (NCBI). This study was performing using AutoDock Vina 1.1.2 to analyze the binding affinity. Molecular modification was performed with Autodock Tools 1.5.6. Visualization was done with Chimera 1.10 and PyMol 1.3. Results: The docking scores between hepcidin and Anticalin was -4.6 kcal/mol at Cys13,Cys14, Arg16, and Ser17. The compound Roxburghine B and Oxoxylopine could interact with the ligand binding domain and had the docking scores lower than Anticalin. Conclusions: Roxburghine B and Oxoxylopine are potential to become hepcidin antagonists insilico for inflammatory anemia. Keywords: anemia inflamasi, phytochemical, molecular docking, hepcidin, Anticalin
Pengaruh Ekstrak Biji Kedelai Putih (Glycine max) terhadap Waktu Kematian Cacing Gelang Babi (Ascaris suum) in Vitro Pritami .; Sri Haryati; Bambang Sukilarso Sakiman
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background : White Soy beans (Glycine max) contain saponin and tripsin inhibitor that have been known having anthelmintic effect. This study aimed to determine the effect of White Soy beans extract toward death time of Ascaris suum, in vitro. Methods : The study was a laboratory experimental research using post test only controlled group design. The subjects were an adult male and female worms (Ascaris suum) that their body length were around 15 cm 35 cm. The sampling technique used was convenience sampling. The subject was arranged into 6 groups, each group consisted of 4 worms, replication was performed 4 times. NaCl 0.9 % and pirantel pamoat 5 mg/ml was added in the negative control group and in the positive control group, in a row.While white soy beans extract of concentration of 60%, 70%, 80%, and 90% w/v were added to the treatment group. Worms were immersed in 25 ml test solution and incubated at 37C. The subjects were observed every 10 minutes and the number of dead worms was counted. Data were analyzed with linear regression and Pearson correlation. Results : The data of observation showed that total death mean time of Ascaris suum in the negative control and positive control were 2817.5 minutes and 42.5 minutes, while in the treatment group of concentration of 60% , 70% , 80% , and 90% w/v of white soy beans extract were 422.5 minutes, 370 minutes, 300 minutes, and 255 minutes, successively. The Pearson correlation test showed very close relationship between variation of the concentration and time of death worms (r = - 0.962). The linear regession test showed significantly (p<0.001) and the regression equation was Y = 2653.400 30.340 X and R square was 0.926. Conclusion : White soy beans (Glycine max) extract had effects to the mortality of Ascaris suum in vitro. The most effective white soy beans extract was 90% (w/v) although it was less effective than pirantel pamoat. Keywords : White Soy beans (Glycine max) Extract, Ascaris suum, death time.
Uji Banding Terjadinya Andropause antara Laki-Laki yang Lingkar Pinggangnya Besar dan Normal di Kecamatan Jebres Surakarta Andreas Agung Kurniawan; Andri Iryawan; Bhisma Murti
Nexus Biomedika Vol 3, No 3 (2014): Nexus Biomedika
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Abstract

Background: Andropause in men can be caused by large waist circumference. The population of Asian countries, including Indonesia, tends to undergo an increase of waist circumference. This study is aimed to compare the occurrence of andropause between men with large and normal waist circumference. Methods: This study was a non-experimental analytic observational study with cross-sectional approach conducted in Jebres in September-October 2014. The subjects were 40 men selected using simple random sampling technique. The data obtained from physical measurements and questionnaire-led interviews were analyzed using multivariate logistic regression test to control confounding factors. Results: Twelve out of 15 men with large waist circumference (> 90 cm) experienced andropause and 16 out of 25 men with normal waist circumference (? 90 cm) did not experience andropause. On the other hand, 5 out of 10 men aged < 50 years experienced andropause and 23 out of 30 men aged ? 50 years did not experience andropause. Conclusion: Men with large waist circumference have risk experiencing andropause 3.06 times higher than men with normal waist circumference, although in this study the result is not significant (OR = 3.06; CI = 95% 0.59 to 15.95; p = 0.184 ). Keywords: Andropause, Waist Circumference
Toxoplasma gondii Coinfection in HIV/AIDS Patients of Dr. Moewardi Hospital in Surakarta Irvan Raharjo; Yulia Sari; Afiono Agung Prasetyo
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Coinfection of T. gondii and HIV/AIDS will result in severe clinical symptoms. Age and gender are risk factors that are often associated with the occurrence of this coinfection. This study aimed to determine the seroprevalence of T. gondii and HIV/AIDS coinfection as well as to determine its association with age and gender. Methods: Serological test, ELISA, was performed in order to determine the presence of IgM anti-Toxo and IgG anti-Toxo in 51 blood samples taken from HIV/AIDS patients at Dr. Moewardi Hospital in November 2011. Results: The positive rates of IgM anti-Toxo and IgG anti-Toxo were 25.5% (13/51) and 17.6% (9/51), respectively. IgM anti-Toxo was associated with age ? 37 years (aOR 9.34 (95% CI 1.77549.174; p = 0.008)). Unless otherwise stated, no statistical association could be drawn. Conclusions: Screening on T. gondii infection is recommended for all HIV/AIDS patients since the positivity rates of anti-Toxo antibodies were found high in these patients. Keywords: Toxoplasma gondii, HIV/AIDS coinfection
Efek Perlindungan Susu Kedelai (Glycine max) Ultra High Temperature (UHT) Terhadap Lambung Mencit Ginong Pratidina Wijnaputri; Endang Listyaningsih; Jarot Subandono
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
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Background: White Soybean (Glycine max) Milk Ultra High Temperature (UHT) is potential to protect gaster because it contains flavonoid. This study aimed to investigate the protective effect of white soybean milk UHT on mices gaster due to aspirin. Higher dose of the milk reduces the damaged on gastric mucous induced by aspirin Methods: This was a labroratory experimental research with posttest only controlled group design conducted in in Histology Laboratory of Sebelas Maret University. The samples were thirty five mice divided into 5 groups. Negative control group (KN) was given normal food and aquadest, positive control group (KP) was given aspirin dose 2,275 mg/20g Body weight (W), dan first treatment group (P1) was given cimetidine dose 0,78 mg/20g W second treatment group (P2) and third treatment group (P3) was given soybean milk UHT dose 0,7ml/20 g W and 1,4 ml/20 g W. All treatments for KN, KP, P1 , P2, P3 was given in 10 days. Aspirin was given to KP, P1 , P2, P3 with dose 2,275 mg/20g weight of mice on day 8, 9 and 10. to evaluate the level of damage based on histologic appearance, gastric staining was performed using Haem eos. Results: Kruskal-Wallis test result showed significant result among four groups. Mann-Whitney showed significant result for KN compared to KP,P1,P2 , P3 and KP compared to P1, P2 and P3 ; while P1 compared to P2, P3 and P2 compared to P3 had no significant result. Conclusion: White Soybean (Glycine max) Milk Ultra High Temperature(UHT) protect mices gastric from gastritis. However, higher dose of White Soybean (Glycine max) Milk Ultra High Temperature(UHT) does not increase the protective effect of white soybean milk UHT on mices gaster due to aspirin. Keywords: White Soybean (Glycine max) Milk Ultra High Temperature(UHT), gastric protection, gastritis, aspirin.
The Effect of Drumstick/Horseradish (Moringa oleiferaLam) Leaves Ethanol Extract to The Mortality of Anopheles aconitus L. Larvae Yuzana Maung; Sutartinah Sri Handayani; Lukman Aryoseto ..........
Nexus Biomedika Vol 6, No 1 (2017): Nexus Biomedika
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Abstract

Introduction: The use of synthetic insecticides to control Anopheles aconitus L. vector has negative impacts to nature dan resistancy, so it is necessary to use botanical larvicides as alternative substance to replace synthetic insecticides. Drumstick/Horseradish (Moringa oleifera Lam) leavesare loaded with saponin, tanin, flavonoid, dan alkaloid which have larvicide effects. The aim of this research was to find out the effect of Moringa oleifera Lam leaves ethanol extract on mortality of Anopheles aconitus L. larvae. Methods: This research is theexperimental laboratoricwith posttest only control group design which was conductedon 08-17 November 2016 at B2P2VRP, Salatiga, Central Java. In this research, ethanol extract of Moringa oleifera Lam leaves was used as larvicide to Anopheles aconitus L. third instar larvae. Larva was divided into 6 groups, each group contained 25 larvaes. For one control group was added 100ml distilled water,while the other 5 groups were added different concentration level of Moringa oleifera Lam leaves ethanol extract (1, 10, 20, 30, 40 mg per 100 ml of distilled water). Each test groups were repeated 4 times in this research. Observation was conducted after 48 hours exposure of extract and the numbers of larvae mortility were counted ofeach experimental group. The data were analyzed by using Kruskal-Wallis dan Probit tests. Results:The result of data analyzed by Kruskal-Wallis test indicates that there was significant difference on theaverage mortility of Anopheles aconitus L. larvae among 6 experimental groups. The result of Probit analysis indicate 50% of larvae mortality in 83.675 mg/100 ml (LC50) and 90% in 15318.159 mg/100 ml (LC90). Conclusions:Drumstick/Horseradish (Moringa oleifera Lam) leaves ethanol extract has mortalityeffect on Anopheles aconitus L. third instar larvae. Keywords: ethanol extract of Drumstick/Horseradish leaves, larvicide, Anopheles aconitus L. third instar larvae
Pengaruh Pemberian Ekstrak Etanol Bit Merah (Beta vulgaris) terhadap Kerusakan Histologis Sel Ginjal Mencit (Mus musculus) yang Diinduksi Parasetamol Amanda Yessica Anggara; . Muthmainah; Yulia Sari
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
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Abstract

Background: Kidney failure can happen due to intoxication of paracetamol that causes oxidative stress. Red beet (Beta vulgaris) containing various components such as vitamin A, C and E, flavonoid, Cu, Zn, Mn, selenium, betanin, and phenolic has a function as antioxidants. The aims of this research were to know the nefroprotective effect of ethanol extract of red beet to prevent renal cell damage of mice. Methods: This was laboratory experimental research with posttest only controlled group design. Subjects of this research were thirty Swiss webster male mice (Mus musculus), 2-3 months old and 20 grams of body weight (BW), each.. The subjects were divided into 5 groups randomly. The groups of this research were negative control (KK(-)), positive control (KK(+)), experimental group 1 (KP1), experimental group 2 (KP2), and experimental group 3 (KP3). The KP1, KP2 and KP3 were administered 5.6 mg, 11.2 mg and 22.4 mg per 20g BW, successively. The nefroprotective effect of ethanol extract of red beet to prevent renal cell damage of mice was assessed by counting the number of damage cells among 50 renal cells on pars convulata. Results: One-Way ANOVA analysis p=0.000 (p<0.05) followed by Post Hoc Multiple Comparisons showed a significant difference between negative control and other groups. The increasing dose of the ethanol extract of red beet was followed by the improvement of the protective effect. The linear regression test p=0.000 (p<0.05) showed a correlation between the increase of dose of ethanol extract of red beet and the improvement of the nefroprotective effect to the histological damage of mices renal cells. Conclusions: Ethanol extract of red beet showed the nefroprotective effect to the histological damage of mices renal cells induced by paracetamol. The increase of dose of the ethanol extract of red beet improved the protective effect to mices renal cells. Keywords: ethanol extract of red beet, histological damage of mices renal cells, paracetamol
Perbedaan VO2 Max antara Penarik Becak dengan Supir Taksi di Kota Surakarta Shelly Lavenia Sambodo; Balgis .; Novan Adi Setyawan
Nexus Biomedika Vol 3, No 2 (2014): Nexus Biomedika
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Background: VO2 Max (maximal oxygen uptake) is a capability of oxygen with maximal capacity that used to the body to perform maximal exercise. The factor that most influence of VO2 Max is a physical activity. Cardiorespiratory endurance can be enhanced objectively by doing exercises or sports regularly, structurally, and continuously performed. Pedicab driver does his job by pedaling a pedicab every day, whereas the taxi driver does his job by driving a taxi every day. The aims of this study are to determine the differences of VO2 Max scores between pedicab drivers and taxi drivers in Surakarta. Methods: This study was an observational analytic with cross-sectional approach. The selection of the samples from the population has been conducted with purposive sampling. This study was conducted in the base of Kosti Solo in Mojosongo and in Surakarta. Two groups of samples, 30 taxi drivers and 30 pedicab drivers with the inclusion criteria (man, age 40 - 50 years; BMI ranged from 18.5 kg/m2 25.0 kg/m2; diastolic blood pressure < 100 mmHg; willing to be responders and filling and approved informed-consent; pursue work at least 5 years) conducted a study using Multistage Fitness Test (MFT), which the test is to run back and forth 20 yards. This value can be converted into the equivalent VO2 Max score using prediction table of the VO2 Max. The data were analyzed using non paired t-test (? = 0.05). Results: The results showed the mean scores predicted of the VO2 Max in pedicab driver was 25.79, while the taxi driver was 20.87. The data were analyzed by using non paired t-test that showed significantly differences between the two study groups, p = 0.000 (p < 0.05). Conclusion: There are significant differences of VO2 Max between the pedicab drivers and taxi drivers in Surakarta. Keywords: VO2 Max, pedicab drivers, taxi drivers, cardiorespiratory endurance, MFT

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