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Folia Medica Indonesiana

FMI
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Published by Universitas Airlangga

ISSN : 23558393 EISSN : 2599056X DOI : -

Core Subject : Education,

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Folia Medica Indonesiana publishes articles in the field of medical science in particular and health sciences in general, as well as a variety of other fields related to those two disciplines. Most of the articles are research article, and others are articles on case reports and literature review. In their presentation in the journal, the articles have passed meticulous editing process by the editors and review process and by competent peer reviewers, with national and international reputation, making the articles presented in this journal qualified, updated, and informative.

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Articles 547 Documents

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AMPICILLIN SULBACTAM AND CEFOTAXIME ARE SIMILARLY EFFECTIVE IN PEDIATRIC PNEUMONIA Puspitasari, Diny; Hasmono, Didik; Rahman, Taufiqur
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Pneumonia is an infection of the lungs that occurs and still cause high mortality in young children today. The main cause is bacterial or viral. Antibiotics still recommended though it is difficult to know the cause is bacterial or viral. Ampicillin be the first option some guideline. Increased resistance worldwide become one of them concerns the effectiveness of antibiotics. The main treatment of toddler pneumonia in Muhammadiyah Hospital Lamongan are ampicillin sulbactam and cefotaxime. The study was conducted to analyze the effectiveness of both antibiotics. This study aims to analyze comparison in the use of ampicillin sulbactam and cefotaxime pneumonia patients aged 3-59 months from November 2013 to March 2014. Patients who met the inclusion criteria were prospectively observed for clinical data, laboratory data, the data microbiology. After it is analyzed to know the difference between the effectiveness of antibiotics. In this study of 29 patients included in the inclusion criteria, 17 patients who received antibiotics ampicillin sulbactam and 12 patients receiving cefotaxime. In the comparison of the mean pulse pulse is known there is a significant reduction in both groups of patients on the second day and was not significantly different between the two groups (p = 0.084). Likewise, the average ratio of temperature (p = 0.117), breath rate (p = 0.839), leukocytes of patients (p = 0.429). Length of stay for ampicillin sulbactam group was 4.77 days and 5.17 days for cefotaxime group. Analysis showed no differences between the two groups for lenght (p = 0.275). Of the 22 patients who were sampled for blood culture examination only 1 patient with positive results. Based on these results we can conclude that ampicillin sulbactam and cefotaxime effective in cases of children pneumonia, and there is no distinction based on the parameters in body temperature, breath rate, pulse, leukocytes and long hospitalization of patients. Regimentation dosage is appropriate based on guidelines, and length of stay less than 10 days. Found no side effects of both drugs.

CORRELATION BETWEEN BLOOD GLUCOSE LEVEL AND THINKING CONCENTRATION Gaol Marbun, Putri Itonami; Mardiani, Tengku Helvi
Folia Medica Indonesiana Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016
Publisher : Universitas Airlangga

Cognition function specifically about thinking concentration has not much yet been studied. Society view shown that glucose has role thinking quality. Few studies shown that glucose has role in specific memory quality but not in complex thinking. This study purpose to see correlation between blood glucose level with thinking concentration before eating (preprandial), after eating (postprandial), and the effect of blood glucose rise on thinking concentration. Subjects that accomplished study's requirement were recruited until forty six people and were followed within thirty minutes. Blood Glucose level was measured by glucose meter at initial admission, thinking concentration were measured with trail making test at initial admission, and compared after eating on the thirtieth minute. Descriptive analytic shown that preprandial blood glucose level in all subject is 55-119 mg/dl with 98.2 mg/dl mean. Postprandial blood glucose level in all subject is 103-171 mg/dl with 134.5 mg/dl mean. Preprandial thinking concentration in all subject is 28-93 seconds with 56.42 seconds mean. Postprandial thinking concentration in all subject is 24-73 seconds with 47.5 seconds mean. Correlation analysis showed that no significance between preprandial blood glucose level and thinking concentration (p = 0.556), postprandial blood glucose level and thinking concentration (p = 0.533), and increase in blood glucose and thinking concentration (p= 0.928). In conclusion there is no significant correlation between blood glucose level and thinking concentration.

CORRELATION BETWEEN THE USE OF ALBUMIN INFUSION AND CONCENTRATIONS OF SERUM ALBUMIN, PROINFLAMMATORY CYTOKINES (TNF-ï¡, IL6) AND SOFA SCORE IN SEPTIC PATIENTS Utariani, Arie; Prasetyo, Budi; Nugraha, Jusak
Folia Medica Indonesiana Vol. 52 No. 4 (2016): OCTOBER - DECEMBER 2016
Publisher : Universitas Airlangga

Sepsis is a major problem causing high morbidity and mortality in patients who hospitalized in intensive care. In sepsis, there is a change in the distribution of albumin in the intravascular and extravascular compartment, so hipoalbumin is occured. Using albumin in septic patients from several studies that have been done are still controversial. Analyzing albumin infusion with changes in levels of albumin, cytokines and SOFA score in septic patients in intensive care dr. Soetomo. The design of this study is a prospective longitudinal observational. The study was conducted in the intensive care unit or ICU dr. Soetomo in February 2015. The inclusion and exclusion criteria were determined that obtained 15 research subjects. They were examined with serum albumin and proinflammatory cytokines as well as evaluating the SOFA score. Then, it measure with ANOVA test methods. Infusion of albumin positively correlated with increased levels of serum albumin and a negative correlation with the levels of IL6, TNF-a and SOFA score. It also found a correlation between changes in levels of albumin with changing levels of IL6 (p <0:01) and changes in SOFA score (p <0.05).

BODY HEIGHT ESTIMATION BASED ON PERCUTANEOUS FOOT LENGTH AND BREADTH OF JAVANESE FEMALES Mochtar, Nur Mujaddidah; Gunawan, Ari; Artaria, Myrtati Dyah; Andajani, Susilowati
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

Body height estimation is one of important parameters used for establishing the individuality in cases of mutilated bodies or found body parts. It is not rare that in the cases of mutilation the police authority would only give the body parts or remaining skeletons of the victims. The aims of the study were to find body height estimation formula based on percutaneous of foot length and foot breadth in Javanese females at Surabaya Muhammadiyah University. The type of research design was cross-sectional observational study. Samples were Javanese females student at Muhammadiyah University of Surabaya , which was selected as the sample unit . The samples are in this study was Two-hundred and twenty-two people.The variabel independent of this research are foot length and foot breath, the variabel dependent is body height. Data were analyzed using normality test with Kolmogorov Smirnoff (a>0,05), Pearson correlation test (a<0,05) and linear regression test (a <0,05) to get body height estimation formula. The results of this study is, 1) A significant correlation between foot length and body height (r = 0,731), 2) A significant correlation between foot breadth and body height (r-0,323), 3) A significant correlation between foot length, foot breadth and body height (r=0,732), 4) The body height estimation formula based on foot length is 688,435 +3,745*foot length, 5) The body height estimation formula based on foot breadth is = 1273,002 + 2,942*foot breadth, and 6) The body height estimation formula based on foot length and foot breadth is 695,227 + 3,805*foot length – 0,229*foot breadth. As a conclusion of this study is the obtained estimation formula of body height based on foot length and foot breadth of Javanese females is 695,227 + 3,805*foot length – 0,229*foot breadth.

RADIATION EFFECT OF WIRELESS FIDELITY (Wi-Fi) ON OOCYTE NUMBER OF OOCYTE STIMULATION IN MICE (Mus Musculus) Nurbayatin, Anita; Widjiati, Widjiati; Primariawan, Relly Yanuari; Poernomo, Bambang; Sulistiawati, Sulistiawati; Yudiwati, Rina
Folia Medica Indonesiana Vol. 53 No. 3 (2017): September 2017
Publisher : Universitas Airlangga

Infertility is a problem experienced by some women and men around the world. Most infertility problems in women is caused by impaired reproductive organs or disrupted ovulation.. One factor that causes impaired oocyte maturation is wireless fidelity (Wi-Fi) radiation which has a radio frequency field of 2.45 GHz. The radiation may increase the activity of free radical cells through the fenton reaction pathways that cause infertility because of the disrupted oocyte development. This study aimed to determine the effect of Wi-Fi radiation on the number of oocytes. This was an experimental study using control group design. The subjects were 32 female mice selected through complete random sampling and divided into two groups: control (R0) and exposure (R1). Each group consisted of 16 mice. The Wi-Fi radio frequency used was 2.5 GHz. Mice (R1) were placed closer to Wi-Fi source (± 15cm), and there were two types of laptop PCs and 3G mobile phones connected to internet placed next to mice for 15 hours/28 days. The mice underwent a simultaneous cycle with intraperitoneal injection of PMSG and HCG. Furthermore, the mice were mated with vasectomized male monomatingly to induce ovulation. The fertilization pouch in both oviducts were observed for oocyte collection. The number of oocytes was calculated using an inverted microscope. There was a difference in the number of oocytes between control and exposure group. Statistical tests were analyzed using Mann Whitney U and resulted in significant values (p value = 0.00). No oocytes count in exposure group. In other words, the group underwent anovulation. In conclusion, Wi-Fi radiation affected the number of oocyte stimulation in mice. Therefore, it was important to minimize the risk factors that trigger electromagnetic radiation on reproductive health.

ANALYSIS OF THE EXPRESSION OF FAS/CD95 AND HSP70 IN LOW AND HIGH GRADE UROTHELIAL CELL CARCINOMA OF THE BLADDER Heryanto Heryanto; Etty Hary Kusumastuti; Anny Setijo Rahaju
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis. Fas/CD95 has a role in apoptotic process, whereas HSP70 has an antiapoptotic role. This study aimed to analyze the expression of Fas/CD95 and HSP70 in low grade and high grade urothelial cell carcinoma in the bladder. This was an analytic observational study with cross sectional approach. Population and sample were paraffin blocks of urothelial cell carcinoma in the Laboratory of Anatomic Pathology, Dr. Soetomo Hospital, Surabaya in the period of January 2011-December 2016. Each grading of urothelial cell carcinoma was randomly sampled. Immunohistochemystry with Fas/CD95 and HSP70 were performed. Expression of Fas/CD95 and HSP70 were assessed semiquantitatively. Expression of Fas/CD95 and HSP70 were analyzed using Mann-Whitney test and Spearman test. The results showed there was significant different in expression of Fas/CD95 and HSP70 in low and high grades in urothelial cell carcinoma. There was no significant correlation between the expression of Fas/CD95 and HSP70 in urothelial cell carcinoma. As a conclusion, the role of CD95 and HSP70 expression can be useful as marker for the diagnosis, especially in the determination of the grade of differentiation.

Effects of Folic Acid Intake during Pregnancy whose Mother was Exposed to Cigarette Smoke towards Brain Neurons Apoptosis Index and Quantity of Mice (Mus musculus) Offspring Nyna Puspa Ningrum; Hermanto Tri Joewono; Widjiati Widjiati
Folia Medica Indonesiana Vol. 54 No. 1 (2018): March
Publisher : Faculty of Medicine, Universitas Airlangga

Folic acid contains 5-methyltetrahydrofolate (5-MTHF), one of antioxidants that can be used to inhibit reaction caused by cigarette smoke exposure. Folic acid is able to inhibit the levels of Reactive Oxygen Species (ROS) so as to reduce the occurrence of neuronal apoptosis. The objectives of this study was to determine the effect of folic acid intake during pregnancy whose mother was exposed to cigarette smoke on brain neurons apoptosis index and quantity of mice (Mus musculus) offspring. This study was an experimental laboratory study with posttest-only control group design. The subjects were 24 female mice divided into 4 groups consisting of one control group and three treatment groups. Sampling used simple random sampling, each group consisting of 6 animals. Control group 1 was not given treatment during pregnancy, group 2 was given with folic acid orally on days 0-17 of gestational age as much as 0.06 mg/day/mice. Group 3 was given with cigarette smoke exposure on days 7-17 of gestational age, amounting to 2 cigarettes/day. Group 4 was given with cigarette smoke exposure on days 7-17 of gestational age, amounting to 2 cigarettes/day and folic acid orally on days 0-17 of gestational age as much as 0.06 mg/day/mice. The result showed significant differences in all variables. In neurons apoptosis index, there were significant differences between groups 1 and 3, groups 2 and 3, groups 3 and 4, significant differences in the quantity of neurons between groups 1 and 3, groups 2 and 3, groups 2 and 4. The study concluded that there were significant difference in neural apoptosis index between all groups, and there were also significant differences in the quantity of neurons between all groups.

NEUROGENIC MODULATION BY NEUROKININ-1 RECEPTOR ANTAGONIST, CP-96,345 TO INHIBIT RHEUMATOID ARTHRITIS DEVELOPMENT IN ADJUVANT INDUCED ARTHRITIS RAT MODEL Wirasasmita, Yuyun; Rahmadi, Mahardian; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52 No. 2 (2016): APRIL - JUNE 2016
Publisher : Universitas Airlangga

Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain. Substance P act by binding to neurokinin-1 receptor. The present study was conducted to evaluate the effect of neurokinin-1 receptor antagonist (CP-96,345) on Adjuvant Induced Arthritis rat model, induced by Complete Freund's Adjuvant (CFA). The objective is to attenuate neurogenic inflammation which in turn will increase the latency time of hyperalgesia response, decreases neurokinin-1 receptor expression, and inhibits the development of RA in AIA rat model. Rats were intra-articularly injected with CFA 1 hour after the administration of CP-96,345 either by 0.63 µg/gr; 1.25 µg/gr; or 2.5 µg/gr also intra-articularly. Caliper measurements and hot-plate test were performed on day 0, 3, 5, 7, 9, 11, and day 13. Expression of neurokinin-1 receptor in joint tissue were evaluated by immunohistochemistry, and RA progress in joint tissue were observed hystopathologically. CP-96,345 at 2.5 µg/gr significantly increases the latency of hyperalgesia response time on CFA induced rats (p=0.044) and decreased the neurokinin-1 receptor expression in joint tissue (p=0.029) compared to CFA induced rats. There was no significant difference for caliper measurements and RA progress between CFA incduced rats and treated group. Conclusively, CP-96,345 increases the latency of hyperalgesia response time and decreases the NK-1 receptor expression in rat joint but could not inhibit RA progression.

THE EFFECTS OF PHYSICAL EXERCISES ON C-REACTIVE PROTEIN IN PATIENTS WITH POST ISCHEMIC STROKE Laswati, Hening; Andriana, Meisy; Subadi, Imam; Yuanita, Ida
Folia Medica Indonesiana Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016
Publisher : Universitas Airlangga

Several studies have recently highlighted the important role of physical exercise in regulation inflammatory status, but there is relatively little known about markers of inflammation levels after physical exercise in post ischemic stroke patients. The aims of this study to provide the effects of physical exercise using Partial Body-Weight Supported Treadmill Training –Audio Cues (PBWSTT-AC) and Traditional method on the level of inflammatory markers C-Reactive Protein (CRP). This study using pretest-postest control group design, 14 post ischemic stroke patients were randomized and allocate to two groups: Group1 (control group) received traditional walking exercise and group 2 received PBWSTT-AC. The walking exercise study were conducted for 20 minute 3 times a week for 12 sessions (4 weeks). Before and after 12 session of exercises, the serum levels of CRP were determined using immunoserology. All statistical test were carried out using SPSS 17 and statistical significance was set at p<0.05 for all analysis. The CRP levels between group were compared using Student t test or Mann-Whitney test. From multiple comparisons statistic result, no significant difference between groups (p=0.898), that seem in this study the levels of CRP of poststroke patients is not influenced by the Traditional training and PBWSTT-AC. The conclusion of this study that both traditional method and PBWTT-AC in 4 weeks exercise training seem have no effect on CRP levels.

DNA ISOLATION FROM HUMAN URINE STAIN AS AN ALTERNATIVE MATERIAL FOR PERSONAL IDENTIFICATION EXAMINATION Yudianto, Ahmad; Sispitasari, Yeti Eka
Folia Medica Indonesiana Vol. 52 No. 4 (2016): OCTOBER - DECEMBER 2016
Publisher : Universitas Airlangga

Accurate determination of personal identity is crucial for an investigation since any inaccuracy may lead to fatal consequences in the judicial process. Identification through DNA analysis involves somatic chromosomes and mtDNA. Each part of the human body can be taken as a specimen since every nucleated cell in the body of an individual has identical DNA sequence. To date, samples for identification through DNA analysis are obtained from blood stains, semen stains, bones, vaginal swab, buccal swab etc. In certain cases, urine stains on the clothing have frequently been overlooked. So far, personal identification through DNA analysis by the use of urine stains has not been commonly carried out. The present study detected bands in the loci CSF1PO, THO1, TPOX and 106bp-112bp amelogenin in all samples visualized from the results of Polymerase Chain Reaction (PCR) with Polyacrylamid Agarose Gel Electrophoreses-silver staining for exposure durations of 1, 7 and 14 days. However, for exposure duration of 20 days (the maximum in the study), bands were only detected in the loci THO1 and TPOX in all samples (100%), whereas the loci CSF1PO and 50% amelogenin exhibited obvious bands. This indicated that DNA analysis of urine stains through detection of the locus STR CSF1PO, THO1, TPOX exhibited different detection responses for different exposure durations assigned to the samples of urine stain. Successful detection of these loci was supported by the differences in amplicon product and GC content at each locus. Of the loci studied, the ratio of GC content of the primers, sorted from the lowest, were as follows: locus CSF1PO of 42.6 1%, TPOX of 56.25%, and THO1 of 63.83%. In conclusion, the loci THO1 and TPOX had the same probability of success in the STR examination compared with the locus CSF1PO.

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