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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Penurunan Trigliserida dengan Suplemen Omega-3 pada Pasien Dislipidemia Lorensia, Amelia; Diputra, I Nyoman Yoga
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.42668

Abstract

Overweight dan obesitas terkait dengan berbagai penyakit pada sistem kardiovaskular, Trigliserida (TG) menjadi salah satu tanda klinis dari terjadi obesitas. Asam lemak omega-3 direkomendasikan untuk menurunkan TG pada hipertrigliseridemia. Tujuan penelitian adalah mengetahui efektifitas suplemen omega-3 dan menurunkan kadar TG pada dislipidemia. Rancangan penelitian yang digunakan adalah one grup pretest-posttest design, dengan menganalisa pemberian omega-3 dengan dosis 1 g/hari selama 4 minggu terhadap kadar TG pasien. Lokasi penelitian di sebuah rumah sakit di Sidoarjo, Jawa Timur, Indonesia, mulai bulan April-Agustus 2022. Variabel penelitian adalah suplemen omega-3 dan kadar TG. Responden adalah semua pasien dewasa dengan overweight/obesitas, yang menjalani rawat jalan di rumah sakit tersebut, dengan menggunakan teknik yaitu consecutive sampling dan purposive sampling. Analisa perbedaan kadar TG sebelum dan sesudah terapi suplemen omega-3 menggunakan uji t-test berpasangan (rasio) dan uji chi-square (ordinal). Jumlah responden yang terlibat dalam penelitian adalah 36 orang. Nilai Sig.(2-tailed) dengan nilai-P sebesar 0,421>0,05, yang berarti tidak ada perbedaan antara sebelum dan sesudah pemberian suplemen omega-3. Adanya kecenderungan penurunan kadar TG setelah pemberian suplemen omega-3 dan rata-rata penurunannya adalah 9,44 mg/dL.  Oleh karena itu , perlu dianalisa lebih lanjut terhadap parameter lipid lainnya dan faktor-faktor yang mempengaruhi TG, seperti genetic dan indeks massa tubuh (IMT).
Avocado Seed Extracts (Parsea americana Mill.) Bioactive Compounds Profile as a Source of Antioxidants Jubaidah, Siti
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.45347

Abstract

Antioxidants are compounds that may neutralize free radicals and highly reactive molecules that might damage cells, thereby protecting the body from numerous ailments. A recent study found that high dosages of synthetic antioxidants increased the risk of cancer. This made researchers start to develop natural ingredients that can be used as natural antioxidants. One of the natural antioxidants that can be used is the avocado plant.Many phytochemicals, including phenolics, flavonoids, tannins, saponins, oxalates, phytic acids, and alkaloids, are present in seed wastes. Avocado seeds have been studied primarily as antioxidants in 70% and 100% ethanol solvents using the FRAP and DPPH methods. There is no detailed information on the above test using 96% ethanol with various antioxidant testing methods such as the ABTS method (2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid), which has been linked to active phenolic compounds, flavonoids, and proanthocyanidins as a high natural antioxidant chemical compound.According to research findings, the avocado seed extract in 95% ethanol contains secondary metabolites such as alkaloids, flavonoids, saponins, tannins, and steroids. It has 62.18%GAE±0.73 phenolics, 0.157%QE±0.01 flavonoids and 2.1841 mg/L±0.25 proanthocyanidins. With IC50 of 0.6419 mg/L±0.04 ascorbic acid and 3.2467 mg/L±0.27 and a sample. This antioxidant activity has a very strong category. Keyword : Antioxidants, Avocados, ABTS, Phenolics, Flavonoids, Proanthocyanidins
Drug Plan and Control (Drug PC): Web-Based System Information of Drug and Inventory Control Diana, Khusnul; Adisaputra, Arya Dibyo; Tandah, Muhamad Rinaldhi
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52618

Abstract

Pengelolaan obat di sarana kefarmasian merupakan kegiatan yang penting di perhatikan karena berhubungan dengan keberlangsungan sarana serta kepuasan pengguna obat. Penggunaan sistem informasi dalam mengelola obat dapat mempermudah pekerjaan serta menjadikan hal tersebut efektif dan efisien. Terutama dalam kegiatan perencanaan dan pengendalian persediaan farmasi. Tujuan penelitian ini adalah membangun sistem informasi dalam perencanaan jumlah obat dan mengendalikan persediaan farmasi di sarana kefarmasian dengan metode EOQ dan ROP. Pembangunan sistem informasi ini menggunakan bahasa pemprograman PHP dan untuk databasenya menggunakan MySQL. Metode yang digunakan dalam aplikasi ini adalah metode waterfall. Kesesuaian hasil perhitungan nilai perencanaan, EOQ dan ROP dibandingkan dengan menggunakan perhitungan melalui excel. Pengujian fungsionalitas aplikasi dilakukan dengan menggunakan blackbox testing kepada beberapa responden. Sistem informasi berbasis web yang telah dibangun memiliki empat menu utama yaitu data obat, stok obat, ramalan perencanaan obat dengan metode konsumsi, pengendalian persediaan dengan metode EOQ ROP. Nilai jumlah perencanan obat, EOQ dan ROP menunjukkan hasil yang sesuai dengan dibandingkan perhitungan menggunakan excel. Sistem informasi berbasis web dapat digunakan dengan baik dan memberikan hasil yang sesuai seperti perhitungan secara manual dan excel.
Production of Anti-Recombinant Human Insulin Antibody and Validation by Indirect ELISA Ambarsari, Christy; Suryadi, Herman; Yanuar, Arry
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.40641

Abstract

Human insulin potential has become an interest and is important in maintaining the success of therapyin patients with the availability of chemical-based analytical methods, however, only a few have beenusing immunoassays. This study aimed to produce IgG polyclonal antibodies from rabbits immunizedwith 1 mg/mL rhINS subcutaneously and validated by indirect ELISA. Antibody was precipitated andfractioned on a HiTrap® Protein A HP column before being quantified with a UV spectrophotometerat λ 280 nm. The characterization was conducted by Dot Blot test on a BCIP-NBT substrate, as well asSDS-PAGE and Western Blot with polyacrylamide gel concentrations of 7.5% and 17.5%. Validationwas performed using solutions containing glycerol and m-cresol as matrices spiked with rhINS. Thelinearity test in the rhINS concentration range of 80.11-200.28 μg/mL (r = 0.99) showed the linearresult. The accuracy and precision obtained an average of 99.11%±5.01 and 3.91%, while the LODand LOQ were 22.05 μg/mL and 73.51 μg/mL, respectively. Human insulin was stable at 2-8oC for 24hours (α: 0.05, ANOVA). In conclusion, in-house produced IgG polyclonal antibodies and goat anti-IgG peroxidase conjugate can be used for routine testing of human insulin.
Chemotaxonomy Study and Antioxidant Activity of Five Phyllanthaceae Family Plants in West Java Kusriani, Herni; Naki, Maulana Isman; Budiana, Wempi
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52635

Abstract

Phyllanthaceae is one of the medicinal plants family which it’s species widely spread in Indonesia with many chemical content and various pharmacological activities. Based on the previous research, it said that plants belonging to the same family will show the same chemical compound phenomenon. The purpose of this research was to determine the similarities of anatomical characteristics, chemical contents, total flavonoid content as the main compound, and antioxidant activity of five plants of the Phyllanthaceae family (the leaves of katuk, meniran, ceremai, buni, and mareme) in West Java. Five plants of the Phyllanthaceae family were observed macroscopically and identified their chemical compounds by phytochemical screening and thin layer chromatography. Each leaf was macerated using 96% ethanol as solvent and determined total flavonoid content and antioxidant activity. Determination of total flavonoid content with AlCl3 reagent with quercetin as a standard. Antioxidant activity assay conducted by the DPPH method (1,1-diphenyl-picrylhydrazil) with acid ascorbic as standard was measured at 515 nm. The results of macroscopic observations of five leaves of the Phyllanthaceae family showed some similarities in terms of morphology, including in compound leaf type, but there are differences in terms of size. And from monitoring the compounds showed a similar distribution of compounds with flavonoid compounds as markers on Rf 0,61. The total flavonoid content of katuk, meniran, ceremai, buni, and mareme leaf extracts respectively were 9.465±0.029; 9.847±0.029; 7.504±0.090; 7.857±0.103; 7.318±0.029 mgQE/g, and their antioxidant activity expressed in IC50 values respectively were 79.720±0.18; 60.871±0.15; 80.728±0.10; 80.447±0.18; 82.676±0.10 g/mL, and ascorbic acid was 7.91±0.01 g/mL. Five plants of the Phyllanthaceae family have similar anatomical characteristics and chemical constituents and showed high levels of flavonoids with strong antioxidant activity. 
Optimization of Oral Thin Film Cetirizine HCI by Response Surface Methodology: Disintegration and Mechanical Properties Nining, Nining; Amalia, Anisa; Rahmatullah, Rizki
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.44098

Abstract

Starch is a natural biopolymer used as a film-forming polymer on oral thin film (OTF). Its solubility can increase by modifying enzymes to form maltodextrin (MDX). Sorghum is a potential plant because it contains relatively high starch, 72.3-75.1%. The concentration of film-forming and plasticizers in OTF will significantly affect its disintegration and mechanical properties. This study aimed to obtain the optimal formula for OTF cetirizine HCl based on MDX-sorghum as a film-forming and triethyl citrate as a plasticizer using the Response Surface Methodology (RSM). Sorghum starch was enzymatically modified and characterized physically and mechanically. The formula is optimized based on the disintegration and mechanical properties of the film on the contour plot using Central Composite Design (CCD) in RSM. The percentage error between the predicted and actual values in the response validates the suggested model. The results showed that the production of MDX-sorghum was successful with a characteristic value of dextrose equivalent (DE) 6,3±0,13; swelling power of 2.87; solubility of 52.9%; and a yield of 86.71%. Response data from the 14 formulas obtained include disintegration time of 85-172 seconds, elongation 64.86-109.32%, and tensile strength from 1.4 to 3.57 MPa. The optimal formula suggested a concentration of 4.56% MDX-sorghum and 10% triethyl citrate, with desirability of 0.87. The model validation results show an error percentage of <5%, so the suggested model can be accepted.
BENEFITS OF INDONESIAN SAINTIFIC JAMU IN THE TREATMENT OF VARIOUS DISEASES: A REVIEW Gondokesumo, Marisca Evalina; Muthmainnah, Anis Syabani
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53808

Abstract

One of Indonesia's treasures is herbal medicine. Jamu comes from Sanskrit, namely from the word djamoe which stands for djampi and oesodo. Djampi means healing with medicinal herbs or prayers and mantra while oesodo means health, so it is concluded that medicinal herbs are beneficial for health. Jamu is an ancestral heritage of the Indonesian Nation that has been passed down from generation to generation has high advantages because it comes from cultural diversity, local wisdom, and high biodiversity. Empirical evidence shows that herbal medicine can maintain and improve public health. The government, through the Ministry of Health, issued a regulation on the Saintification of Jamu to provide scientific evidence regarding the efficacy and safety of herbal medicine through health service-based research. Scientific herbs approved by the National Herbal Saintification Commission are sourced from research that has been conducted by the Center for Research and Development of Medicinal Plants and Traditional Medicines (B2P2TOOT). Currently there are 12 scientific jamu concoctions, but in the future it will definitely increase. This literature review uses a narrative method of grouping similar research results according to the established journal criteria. Based on the results of the literature review that has been carried out, it can be concluded that 12 scientific jamu concoctions are safe and have health benefits.
Subchronic Toxicity Test of Cincalok Oil Towards Wistar Rats Haematology Nugraha, Fajar; Kurniawan, Hadi; Fajriaty, Inarah; Nurbaeti, Siti Nani; Goh, Sri Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.43023

Abstract

Cincalok is a fermented shrimp product which has the potential to be used as pharmaceutical preparations. Its LD50 showed non-toxic. However, subchronic toxicity tests have not been performed. Therefore, this study aims to determine its subchronic toxicity assay towards haematology in male and female white rats in the Wistar strain. The animals used were divided into six groups, the control group induced with virgin coconut oil (VCO), the dose group induced with Cincalok oil (100, 400, 1000 mg/kg BW), and two satellite groups (control group VCO and 1000 mg/kg BW). Haematological parameters evaluated include hemoglobin, Red Blood Cell Count (RBC), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), leukocytes, basophils, lymphocytes, eosinophils, platelets, and neutrophils. The average level of haematological profile in this study indicated that hemoglobin, MCH, MCHC, basophils, eosinophils, stem neutrophils, neutrophil segments, lymphocytes, and monocytes platelets in female and male rats were still in the normal range.While, there was a decrease in levels below the normal range in the parameters of RBC, leukocytes, MCV and hematocrit. It was concluded that the consumption of cincalok oil orally had no effect in hemoglobin, RBC, MCV, MCH, MCHC, leukocytes, basophils, lymphocytes, eosinophils, platelets, and neutrophil.
Physical Stability and Effectivity Comparison of Nanoemulsion and Nano-emulgel of Avocado Oil with Carbopol 940 Variation Shabrina, Ayu
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53215

Abstract

Avocado oil (AV) contains of oleic acid that can prevent skin erythema. Nanoemulsion (NE) in a gel system (NG) is a one of a delivery system that increases the drug's effectivity. This study aimed to compare AV's stability and effectivity as anti-erythema in NE and NG with variations of carbopol 940. NE was made with 5% of AV and incorporated in carbopol 940 (for NG) with variations of 0.5 (F1);1 (F2), and 1.5% (F3). The samples were stored in a climatic chamber for 90 days at a temperature of 30 °C ± 2 °C RH 65% ± 5%. Samples were tested for organoleptic, pH, viscosity, particle size (PS), polydispersity index (PDI), and zeta potential (ZP). The samples were also tested based on in vitro SPF values and minimum erythema dose (MED). The results show that NE has a clear appearance whie NG showed a creamy texture. The physical parameters met the criteria for nanoemulsion delivery. F1 NG showed an increase in physical parameters, while F2 and F3 were stable for 90 days of storage. The SPF value of AV in NE and NG were not significantly different, yet the MED showed differences in each formula. Carbopol at a concentration of 0.5-1.5% can produce stable nano-emulgel. Avocado oil nanoemulsion showed better effectivity to prevent erythema than nano-emulgel.
Anti-Inflammatory Activity of Ethanolic Extract Melophlus sp. and Callyspongia sp. from Southeast Sulawesi Fristiohady, Adryan; Sahidin, Idin; Sadarun, Baru; Purnama, La O. M. J.; Rahmatika, Nur S.; Tien, Tien; Haruna, Lidya A.; Yodha, Agung W. M.; Wahyuni, Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.28809

Abstract

Marine sponges display significant potencies as an anti-inflammatory agent. Thus this study aims to investigate the effect of anti-inflammatory of Melophlus sp. and Callyspongia sp. by decreasing plasma IL-1β levels of rats. This study was conducted by detecting chemical constituents of extracts and their anti-inflammatory by measuring the plasma IL-1β level of animals.  Animals were acclimatized for seven days, followed at day-8 animals were induced by 1% carrageenan injection intraplantar. Animals were divided into ten groups (n=4) and treated orally according to groups which were C+ and K+ (diclofenac sodium 3598 ppm), C- and K- (Na CMC 0.5%), M50 (Melophlus sp 50 ppm), M100 (Melophlus sp 100 ppm), M200 ((Melophlus sp 200 ppm), C50 (Callyspongia sp. 50 ppm), C100 (Callyspongia sp. 100 ppm), and C200 (Callyspongia sp. 200 ppm). After being left out for 1 hour, blood was collected at the first, second, and third hour. Blood samples were then centrifugated and assayed with ELISA kit Rat IL-1β. Data collected were statistically analyzed. Both marine sponges contain flavonoid, saponin, alkaloid, and terpenoid. Tannin was only detected in Melophlus sp. Both marine sponges provided an effect in decreasing plasma IL-1β at the concentration of 100 ppm and 200 ppm. In conclusion, both extracts of Melophlus sp. and Callyspongia sp. have anti-inflammatory activity with effective concentration are 100 ppm. Keywords: Anti-Inflammatory; Plasma IL-1β; Melophlus sp.; Callyspongia sp.

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